检索结果-南通市图书馆

Research of Power Take-off System for “Sharp Eagle Ⅱ” Wave Energy Converter

在线全文

学校读者我要写书评

暂无评论

China Ocean Engineering 2019年第5期33卷 618-627页

作者： YE Yin WANG Kun-lin you Ya-ge SHENG Song-wei Guangzhou Institute of Energy Conversion Chinese Academy of Sciences Guangzhou 510640 China Key Laboratory of Renewable Energy Chinese Academy of Sciences Guangzhou 510640 China Guangdong Provincial Key Laboratory of New and Renewable Energy Research and Development Guangzhou 510640 China

The " Sharp Eagle” device is a wave energy converter of a hinged double floating body. The wave-absorbing floating body hinges on the semi-submerged floating body structure. Under the action of wave, the wave-absorbing floating body rotates around the hinge point, and the wave energy can be converted into kinetic energy. In this paper, the power take-off system of " Sharp Eagle Ⅱ” wave energy converter (the second generation of " Sharp Eagle”) was studied, which adopts the hydraulic type power take-off system. The 0-1 power generation mode was applied in this system to make the " Sharp Eagle Ⅱ” operate under various wave conditions. The principle of power generation was introduced in detail, and the power take-off system was simulated. Three groups of different movement period inputs were used to simulate three kinds of wave conditions, and the simulation results were obtained under three different working conditions. In addition, the prototype of " Sharp Eagle Ⅱ” wave energy converter was tested on land and in real sea conditions. The experimental data have been collected, and the experimental data and simulation results were compared and validated. This work has laid a foundation for the design and application of the following " Sharp Eagle” series of devices.

关键词： Sharp Eagle Wave Energy Converter power take-off power generation mode hydraulic system

Single Mode Simulation Calculation of Oscillating Buoy Wave Energy Converter with A Slider

在线全文

学校读者我要写书评

暂无评论

China Ocean Engineering 2020年第4期34卷 547-557页

作者： XIAO Lei you Ya-ge WANG Zhen-peng ZHANG Ya-qun HUANG Shuo WANG Wen-sheng Guangzhou Institute of Energy Conversion Chinese Academy of SciencesGuangzhou 510640China Guangdong Provincial Key Laboratory of New and Renewable Energy Research and Development Guangzhou 510640China Southern Marine Science and Engineering Guangdong Laboratory Guangzhou 511458China Key Laboratory of Renewable Energy Chinese Academy of SciencesGuangzhou 510640China Innovation Academy of South China Sea Ecology and Environmental Engineering Chinese Academy of SciencesGuangzhou 510640China University of Chinese Academy of Sciences Beijing 100049China

This paper presents an oscillating slider wave energy device which is based on a seabed anchoring and uses eagle beak as the *** self-compiled program uses the boundary element theory based on the simple Green’s function to solve the wave forces and hydrodynamic *** the equation of motion,the oscillation of the float and the capture width ratio are obtained by the modal *** influences of the shape of the eagle beak,the angle of the slider and the wave heading on the capture ability of the device are *** to the calculation results and the wave resources in the sea area,the optimal shape of the eagle beak and external damping can be selected to maximize the wave energy capture capability.

关键词： wave energy converter(WEC) Sharp Eagle hydrodynamic calculation eagle beak

Core signaling pathways and new therapeutic targets in pancreatic cancer

在线全文

学校读者我要写书评

暂无评论

Chinese Medical Journal 2010年第9期123卷 1210-1215页

作者： you Lei CHEN ge ZHAO Yu-pei Department of general Surgery Peking Union Medical College HospitalBeijing 100730China

Objective Pancreatic cancer is a highly aggressive malignancy that has been resistant to treatment. Advances in cancer genetics have improved our understanding of this disease, but the genetics of pancreatic cancer remain poorly understood. A better understanding of the pathogenic role of specific gene mutations and core signaling pathways would propel the development of more effective treatments. The objective in this review was to highlight recent research that shows promise for new treatments for pancreatic cancer. Data sources All articles cited in this review were mainly searched from PubMed, which were published in English from 1993 to 2009. Study selection Original articles and critical reviews selected were relevant to the molecular mechanisms of pancreatic cancer. Results Dysregulation of core signaling pathways and processes through frequently genetic alterations can explain the major features of pancreatic tumorigenesis. New therapeutic targets based on recent research are emerging that hold promise for the future management of pancreatic cancer. Conclusion New agents used in conjunction with standard radiotherapy and chemotherapy might help to overcome drug resistance by targeting multiple signaling pathways to induce responsiveness of pancreatic cancer cells to death signals.

关键词： pancreatic cancer signaling pathway therapeutic target

Construction and evaluation of a liver cancer risk prediction model based on machine learning

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastrointestinal Oncology 2024年第9期16卷 3839-3850页

作者： Ying-Ying Wang Wan-Xia Yang Qia-Jun Du Zhen-Hua Liu Ming-Hua Lu Chong-ge you Laboratory Medicine Center The Second Hospital&Clinical Medical SchoolLanzhou UniversityLanzhou 730030Gansu ProvinceChina

BACKGROUND Liver cancer is one of the most prevalent malignant tumors worldwide,and its early detection and treatment are crucial for enhancing patient survival rates and quality of ***,the early symptoms of liver cancer are often not obvious,resulting in a late-stage diagnosis in many patients,which significantly reduces the effectiveness of *** a highly targeted,widely applicable,and practical risk prediction model for liver cancer is crucial for enhancing the early diagnosis and long-term survival rates among affected *** To develop a liver cancer risk prediction model by employing machine learning techniques,and subsequently assess its *** In this study,a total of 550 patients were enrolled,with 190 hepatocellular carcinoma(HCC)and 195 cirrhosis patients serving as the training cohort,and 83 HCC and 82 cirrhosis patients forming the validation *** regression(LR),support vector machine(SVM),random forest(RF),and least absolute shrinkage and selection operator(LASSO)regression models were developed in the training *** performance was assessed in the validation ***,this study conducted a comparative evaluation of the diagnostic efficacy between the ASAP model and the model developed in this study using receiver operating characteristic curve,calibration curve,and decision curve analysis(DCA)to determine the optimal predictive model for assessing liver cancer *** Six variables including age,white blood cell,red blood cell,platelet counts,alpha-fetoprotein and protein induced by vitamin K absence or antagonist II levels were used to develop LR,SVM,RF,and LASSO regression *** RF model exhibited superior discrimination,and the area under curve of the training and validation sets was 0.969 and 0.858,*** values significantly surpassed those of the LR(0.850 and 0.827),SVM(0.860 and 0.803),LASSO regression(0.845 and 0.831),and ASAP(0.866 and 0.813)model

关键词： Hepatocellular carcinoma Cirrhosis Prediction model Machine learning Random forest

Krüppel-like factor 8 is a potential prognostic factor for pancreatic cancer

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Medical Journal 2014年第5期127卷 856-859页

作者： Wei Yingxin Chen ge you Lei Zhao Yupei Department of general Surgery Peking Union Medical College Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100730 China

Background Pancreatic cancer is a lethal disease that is often diagnosed at an advanced *** is a lack of information to predict the prognosis of pancreatic ***üppel-like factor （KLF） 8 has been found to be deregulated in multiple cancers,and its high expression was correlated with poor ***,so far,no information was reported about the expression of KLF8 in pancreatic *** the present study,we investigated,possibly for the first time,the expression of KLF8 in pancreatic cancer samples and analyzed its correlation with clinical parameters and overall survival （OS） *** We used immunohistochemical staining to detect KLF8 in 68 samples from patients who underwent surgery and its correlation with the clinicopathological *** used Kaplan-Meier curve to analyze the relationship between KLF8 expression and the OS *** analysis was performed in addition to multivariate hazard models with clinicopathological features to assess KLF8 as an independent prognostic *** KLF8 was present in the cytoplasm of pancreatic cancer cells and 52.9％ of the 68 cases had positive ***8 expression was not associated with sex,age,tumor location,lymph node stage,and metastasis stage,but was associated with tumor stage （P=0.04）.Kaplan-Meier method demonstrated that patients with negative expression of KLF8 had a better *** univariate and multivariate models,KLF8 was a significant predictor of OS in pancreatic *** Our results revealed that KLF8 may be a potential prognostic factor for pancreatic cancer.

关键词： Krüppel-like factor 8 prognostic factor pancreatic cancer survival

ATRX mutations as predictive biomarker for immune checkpoint inhibitors in female patients with MSI-prone tumors

在线全文

学校读者我要写书评

暂无评论

ATRX mutations as predictive biomarker for immune checkpoint...

Fluoride passivation of ZnO electron transport layers for efcient PbSe colloidal quantum dot photovoltaics

2021年中国肿瘤标志物学术大会暨第十五届肿瘤标志物青年科学家论坛

作者： you ge Pingmin Wei School of Public Health Southeast University

Background: Microsatellite instability-high(MSI-H), the main predictor of immune checkpoint inhibitors(ICIs) response, cannot be effective enough for the patients with MSI-prone tumors. It still needs to identify other predictive biomarkers of ICI response in MSI-prone tumors. Studies have confirmed the association of homologous recombination(HR) defects with improved ICIs efficacy. ATRX plays an important role in HR repair. A previous study reported female-biased injury caused by loss of ***, we hypothesize that ATRX mutations may be associated with ICIs efficacy in female patients with MSI-prone ***: The genomic, transcriptomic and clinical data were extracted from two published ICIs-treated cohorts and The Cancer genome Atlas(TCGA). We integrated multiple immunotherapy-related indicators to explore the association of ATRX mutations with anti-tumor immunity and tumor microenvironment. The indicators of anti-tumor immunity included tumor mutation burden(TMB),tumor neoantigen level, cytolytic activity score, inflammation signature score, immunologic constant of rejection score, IFN-γ signaling score, TGF-β pathway score and expression of eight immune checkpoint genes. The tumor microenvironment was characterized by 29 knowledge-based functional gene expression signatures with conserved immunotherapeutic predictive function and the abundance of tumor-infiltrating lymphocytes. We further made MSI-stratified analyses to investigate the independent role of ATRX mutation in anti-tumor immunity and tumor microenvironment. The prediction of chemotherapy and anti-PD1/anti-CTLA4 therapy sensitivity was performed by pRRophetic R package and method of subclass mapping, ***: We found that ATRX mutations were correlated with better response and survival benefits from ICIs treatment in exclusively female patient. Only female ATRX mutated patients(ATRX-mt) showed enhanced anti-tumor immunity and inflamed tumor microenvironment. MSI-stratified

关键词： ATRX mutations biomarker immune checkpoint inhibitor female patients MSI

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

Frontiers of Optoelectronics 2023年第3期16卷 141-151页

作者： Jungang He you ge Ya Wang Mohan Yuan Hang Xia Xingchen Zhang Xiao Chen Xia Wang Xianchang Zhou Kanghua Li Chao Chen Jiang Tang Hubei Key Laboratory of Plasma Chemistry and Advanced Materials Hubei Engineering Technology Research Center of Optoelectronic and New Energy MaterialsSchool of Materials Science and EngineeringWuhan Institute of TechnologyWuhan 430205China Wuhan National Laboratory for Optoelectronics(WNLO) School of Optical and Electronic InformationSchool of Integrated CircuitsHuazhong University of Science and TechnologyWuhan 430074China

Lead selenide(PbSe)colloidal quantum dots(CQDs)are suitable for the development of the next-generation of photovoltaics(PVs)because of efcient multiple-exciton generation and strong charge coupling *** date,the reported high-efcient PbSe CQD PVs use spin-coated zinc oxide(ZnO)as the electron transport layer(ETL).However,it is found that the surface defects of ZnO present a difculty in completion of passivation,and this impedes the continuous progress of *** address this disadvantage,fuoride(F)anions are employed for the surface passivation of ZnO through a chemical bath deposition method(CBD).The F-passivated ZnO ETL possesses decreased densities of oxygen vacancy and a favorable band *** from these improvements,PbSe CQD PVs report an efciency of 10.04%,comparatively 9.4%higher than that of devices using sol-gel(SG)ZnO as *** are optimistic that this interface passivation strategy has great potential in the development of solution-processed CQD optoelectronic devices.

关键词： Zinc oxide Surface passivation Band alignment Quantum-dot solar cells

Bidirectional regulation of the brain-gut-microbiota axis following traumatic brain injury

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第8期20卷 2153-2168页

作者： Xinyu you Lin Niu Jiafeng Fu Shining ge Jiangwei Shi Yanjun Zhang Pengwei Zhuang National Key Laboratory of Chinese Medicine Modernization Tianjin University of Traditional Chinese MedicineTianjinChina Haihe Laboratory of Modern Chinese Medicine Tianjin University of Traditional Chinese MedicineTianjinChina First Teaching Hospital of Tianjin University of Traditional Chinese Medicine TianjinChina National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion TianjinChina

Traumatic brain injury is a prevalent disorder of the central nervous *** addition to primary brain parenchymal damage,the enduring biological consequences of traumatic brain injury pose long-term risks for patients with traumatic brain injury;however,the underlying pathogenesis remains unclear,and effective intervention methods are *** dysfunction is a significant consequence of traumatic brain *** the most densely innervated peripheral tissue in the body,the gut possesses multiple pathways for the establishment of a bidirectional“brain-gut axis”with the central nervous *** gut harbors a vast microbial community,and alterations of the gut niche contribute to the progression of traumatic brain injury and its unfavorable prognosis through neuronal,hormonal,and immune pathways.A comprehensive understanding of microbiota-mediated peripheral neuroimmunomodulation mechanisms is needed to enhance treatment strategies for traumatic brain injury and its associated *** comprehensively reviewed alterations in the gut microecological environment following traumatic brain injury,with a specific focus on the complex biological processes of peripheral nerves,immunity,and microbes triggered by traumatic brain injury,encompassing autonomic dysfunction,neuroendocrine disturbances,peripheral immunosuppression,increased intestinal barrier permeability,compromised responses of sensory nerves to microorganisms,and potential effector nuclei in the central nervous system influenced by gut ***,we reviewed the mechanisms underlying secondary biological injury and the dynamic pathological responses that occur following injury to enhance our current understanding of how peripheral pathways impact the outcome of patients with traumatic brain *** review aimed to propose a conceptual model for future risk assessment of central nervous system-related diseases while elucidating novel insights into the bidirectional effec

关键词： traumatic brain injury brain-gut-microbiome axis gut microbiota neuroimmune immunosuppression host defense vagal afferents bacterial infection dorsal root ganglia nociception neural circuitry

Application of Boundary Collocation Method to Two-Dimensional Wave Propagation

在线全文

学校读者我要写书评

暂无评论

China Ocean Engineering 2015年第4期29卷 579-587页

作者：曹雪玲游亚戈盛松伟彭雯叶寅 Guangzhou Institute of Energy Conversion Chinese Academy of Sciences Key Laboratory of Renewable Energy and Gas Hydrate Chinese Academy of Sciences University of Chinese Academy of Sciences

Boundary Collocation Method （BCM） based on Eigenfunction Expansion Method （EEM）, a new numerical method for solving two-dimensional wave problems, is developed. To verify the method, wave problems on a series of beaches with different geometries are solved, and the errors of the method are analyzed. The calculation firmly confirms that the results will be more precise if we choose more rational points on the beach. The application of BCM, available for the problems with irregular domains and arbitrary boundary conditions, can effectively avoid complex calculation and programming. It can be widely used in ocean engineering.

关键词： boundary collocation method eigenfunction expansion method wave propagation beach