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Journal of Cancer Therapy 2013年第2期4卷 632-639页

作者： Soichiro Uehara Katsuhiro Gotoh Hiroshi Handa yoshiyuki maki Department of Internal Medicine and Gastroenterology Hizirigaoka Hospital Hunaoka Japan Primary Cell Co. Ltd. Sapporo Japan.

The aim of this study was to determine the plasma levels of vitamin K-dependent protein growth arrest-specific protein 6 (Gas6) and its soluble receptor Axl (sAxl) in patients with hepatocellular carcinoma (HCC), acute hepatitis (AH), fulminant hepatitis(FH), chronic hepatitis (CH), and liver cirrhosis (LC) and to determine whether Gas6 and sAxl can be used as biomarkers. Immunoassys were used to measure levels of plasma Gas6 and sAxl in 40 patients with HCC, 13 patients with AH, 3 patients with FH, 7 patients with LC, and 20 healthy normal adult controls (NC). Furthermore, urinary γ-carboxyglutamic acid (Gla) was measured by high performance liquid chromatography. We have addressed this issue by conducting a cross-sectional study to determine whether plasma Gas6 and sAxl levels are associated with DCP, urinary γ-Gla, and liver functions in humans. Levels of Gas6, sAxl, and γ-Gla were significantly higher in HCC as compared to those in NC, and they were significantly positive correlated. Gas6/sAxl molar ratios in HCC were significantly higher than in NC, but those ratios in AH, FH, and LC were significantly lower in NC. Furthermore, Gas6/sAxl molar ratios in HCC increased significantly in comparison with those AH and LC. The increase of Gas6, sAxl and Gas6/sAxl molar ratio were correlated with the progression and poor prognosis of HCC. Thus, Gas6 and sAxl may be useful biomarkers for HCC.

关键词： Gas6 Soluble Axl (sAxl) Receptor Tyrosine Kinase γ-Carboxyglutamic Acid (γ-Gla) Vitamin K Hepatocellular Carcinoma (HCC)

GATA4 mutations are uncommon in patients with 46,XY disorders of sex development without heart anomaly

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Asian Journal of Andrology 2018年第6期20卷 629-631页

作者： maki Igarashi Kentaro Mizuno Masafumi Kon Satoshi Narumi yoshiyuki Kojima Yutaro Hayashi Tsutomu Ogata maki Fukami Department of Molecular Endocrinology National Research Institute for Child Health and Development Tokyo 157-8535 Japan Department of Nephro-Urology Nagoya City University Graduate School of Medical Sciences Nagoya 467-8601 Japan Department of Urology Fukushima Medical University Fukushima 960-1295 Japan Department of Pediatrics Hamamatsu University School of Medicine Hamamatsu 431-3192 Japan

Dear Editor, Disorders of sex development （DSDs） are a group of conditions in which chromosomal, gonadal, or anatomical sex is atypical.1 DSD in genetic males （46,XY DSD） primarily results from impaired androgen production or action or perturbed genital morphogenesis？ The current understanding of the genetic basis of 46,XY DSD remains fragmentary. For example, although more than 15 genes have been implicated in the development ofnonsyndromic hypospadias,2 one of the most common forms of 46,XY DSD,~ mutations in these genes account for 〈20% of the cases.3

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Effect of the Arrangement of a New-Type of Turbulator Inserts on Heat Pipe Exchanger Performances

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Fluid Dynamics & Materials Processing 2023年第10期19卷 2749-2759页

作者： Ibtisam A.Hasan Wafa maki Department of Electromechanical Engineering The University of TechnologyBaghdadIraq

This research tests the effect of introducing turbulators of a new type into a circular tube heat exchanger under a constant and uniform longitudinal heatﬂux condition.A 45 mm diameter copper tube with a length of 1,350 mm is utilized with a solid disk being inserted inside the tube,which consists of three sections,each one containing two *** slot is cut at a 45 degree angle toward the inner tube surface,which results in diverging theﬂow toward the inner hot tube surface in order to enhance the heat transfer *** is considered as the workingﬂuid with Prandtl number *** Reynolds number spans the interval from 6,000–13,500,which indicates that the consideredﬂow is *** heat exchanger performance is studied and analyzed in terms of average Nusselt *** experimental results show that the Nusselt number value is directly proportional to the increase of the Reynolds number,and the number of turbulators *** the use of three novel turbulators,the heat transfer was about 3.15 times higher than that in the smooth tube and the friction factor was about 1.11.

关键词： Heat pipe exchanger heat transfer inserts(NT inserts) turbulators(novel turbulators) disk(solid disk)

Serum metabolome profiles characterized by patients with hepatocellular carcinoma associated with hepatitis B and C

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World Journal of Gastroenterology 2016年第27期22卷 6224-6234页

作者： Takafumi Saito Masahiro Sugimoto Kazuo Okumoto Hiroaki Haga Tomohiro Katsumi Kei Mizuno Taketo Nishina Sonoko Sato Kaori Igarashi Hiroko maki Masaru Tomita yoshiyuki Ueno Tomoyoshi Soga Department of Gastroenterology Yamagata University School of Medicine Institute for Advanced Biosciences Keio University

AIM: To clarify the characteristics of metabolite profiles in virus-related hepatocellular carcinoma (HCC) patients using serum metabolome ***: The serum levels of low-molecular-weight metabolites in 68 patients with HCC were quantified using capillary electrophoresis chromatography and mass spectrometry. Thirty and 38 of the patients suffered from hepatitis B virus-related HCC (HCC-B) and hepatitis C virus-related HCC (HCC-C), ***: The main metabolites characteristic of HCC were those associated with glutathione metabolism, notably 13 γ-glutamyl peptides, which are by-products of glutathione induction. Two major profiles, i.e., concentration patterns, of metabolites were identified in HCC patients, and these were classified into two groups: an HCC-B group and an HCC-C group including some of the HCC-B cases. The receiver operating characteristic curve for the multiple logistic regression model discriminating HCC-B from HCC-C incorporating the concentrations of glutamic acid, methionine and γ-glutamyl-glycine-glycine showed a highly significant area under the curve value of 0.94 (95%CI: 0.89-1.0, P < 0.0001).CONCLUSION: The serum levels of γ-glutamyl peptides, as well as their concentration patterns, contribute to the development of potential biomarkers for virus-related HCC. The difference in metabolite profiles between HCC-B and HCC-C may reflect the respective metabolic reactions that underlie the different pathogeneses of these two types of HCC.

关键词： Metabolome Hepatocellular carcinoma γ -glutamyl peptides Glutathione Oxidative stress

Direct ethanol production from rice straw by coculture with two high-performing fungi

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Frontiers of Chemical Science and Engineering 2012年第2期6卷 139-145页

作者： maki TAKANO Kazuhiro HOSHINO Graduate School of Science and Engineering University of Toyama Toyama 930-8555 Japan

To develop efficient and economical direct ethanol production from fine rice straw crashed mechanically, two high-performing fungi, which can secret hyperactive cellulases and/or ferment effectively various sugars, were selected from some strains belong to Mucor circinelloides preserved in our laboratory. The simultaneous saccharification and fermentation （SSF） by coculture with these fungi was investigated. The screening of high- performing fungi resulted in the selection of NBRC 4572 as an ethanol-producing fungus and NBRC 5398 as a cellulase-secreting fungus. The strain 4572 produced ethanol aerobically from glucose and xylose in high yields of 0.420 g/g at 36 h and 0.478 g/g at 60 h, respectively, but secreted fairly low cellulases. On the other hand, the strain 5398 also produced ethanol from glucose in yield of 0.340 g/g though it had a little growth in xylose culture. However, it secreted hyperactive cellulases that are essential for hydrolysis of rice straw in culture and the maximum activities of endo-β-glucanase and β-glucosi- dase were 2.11 U/L and 1.47 U/L, respectively. In SSF of rice straw by coculture with two fungi selected, the ethanol production reached 1.28 g/L after 96 h when the inoculation ratio of the strain 5398 to the strain 4572 was 9.

关键词： Mucor circinelloides ethanol production cellulase secretion SSF coculture rice straw

Development of Educational Programs for System Creators and Business Producers in Future Strategy Design Based on Action Project Group Activities through Industry-University Cooperation

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Journal of Mechanics Engineering and Automation 2019年第7期9卷 243-247页

作者： Kinya Tamaki Masahiro Arakawa maki Arame yoshiyuki Ono School of Business Aoyama Gakuin University4-4-25 ShibuyaShibuya-kuTokyo 150-8366Japan Nagoya Institute Technology Nagoya 466-8555Japan Polytechnic University Tokyo 164-8678Japan AOYAMA Hicon Tokyo 150-8366Japan

Our Japanese industry-university project group of Aoyama Gakuin University investigated and studied new educational programs to cultivate“future strategy design”human resources over several *** purpose of this research paper is to describe two types of educational *** first program proposes the system creator,which is capable of new product design and innovative management that use advanced technologies such as internet of things(IoT),artificial intelligence(AI),and augmented and virtual *** second program proposes the business producer that is capable of platform service business modeling,product development and strategy,and customer *** characteristics of these programs involve applying new educational methods to combine project-based learning(PBL)and active learning.

关键词： PBL active learning new product development platform service IoT AI

Antibodies in celiac disease:implications beyond diagnostics

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Cellular & Molecular Immunology 2011年第2期8卷 103-109页

作者： Sergio Caja Markku maki Katri Kaukinen Katri Lindfors Pediatric Research Centre University of Tampere and Tampere University HospitalTampereFinland Medical School University of Tampere and Department of Gastroenterology and Alimentary Tract SurgeryTampere University HospitalTampereFinland

Celiac disease is a multisystemic dietary,gluten-induced autoimmune disorder characterized by the presence of transglutaminase(TG)2 serum *** autoantibodies targeting members of the TG family(TG2,TG3 and TG6)are found deposited in small-bowel mucosa and in extraintestinal tissues affected by the *** autoantibodies against other self-antigens also emerge in untreated celiac disease *** villous atrophy and crypt hyperplasia in small-bowel biopsy samples are still the gold standards in diagnostics,celiac disease-specific antibodies are widely used as diagnostic ***-induced small-bowel mucosal T-cell response is the cornerstone in the pathogenesis of the disorder,but humoral immunity may also play a central *** review article is focused on the autoantibodies that occur in the context of celiac *** article summarizes the diagnostic utility of different celiac-related antibodies and discusses their roles in the pathogenesis of the disease.

关键词： antibody celiacdisease diagnostics pathogenesis

Structure and function of ALG-2,a penta-EF-hand calcium-dependent adaptor protein

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Science China(Life Sciences) 2011年第8期54卷 770-779页

作者： Masatoshi maki Hironori SUZUKI Hideki SHIBATA Department of Applied Molecular Biosciences Graduate School of Bioagricultural SciencesNagoya University Structural Biology Research Center Photon FactoryInstitute of Materials Structure ScienceHigh Energy Accelerator Research Organization

ALG-2(a gene product of PDCD6) is a 22-kD protein containing five serially repetitive EF-hand structures and belongs to the penta-EF-hand(PEF) family,including the subunits of typical ***-2 is the most conserved protein among the PEF family members and its homologs are widely found in eukaryotes.X-ray crystal structures of various PEF proteins including ALG-2 have common features:presence of eightα-helices and dimer formation via paired EF5s that are positioned in anti-parallel ***-2 forms a homodimer and a heterodimer with its closest paralog *** calmodulin,a well-known four-EF-hand protein,ALG-2 interacts with various proteins in a Ca2+-dependent fashion,but the binding motifs are completely *** some exceptions,ALG-2-interacting proteins commonly contain Pro-rich regions,and ALG-2 recognizes at least two distinct Pro-containing motifs:PPYP(X) nYP(X,variable;n=4 in ALIX and PLSCR3) and PXPGF(represented by Sec31A) .A shorter alternatively spliced isoform,lacking two residues and designated ALG-2 GF122,does not bind ALIX but maintains binding capacity to Sec31A.X-ray crystal structural analyses have revealed that binding of calcium ions induces the configuration of the side chain of R125 so that it opens Pocket 1,which accepts PPYP,but Pocket 1 remains closed in the case of ALG-2 ***-2 dimer has two ligand-binding sites,each in a monomer molecule,and appears to function as a Ca2+-dependent adaptor protein to either stabilize a preformed complex or to bridge two proteins on scaffolds in systems of the endosomal sorting complex required for transport(ESCRT) and ER-to-Golgi transport.

关键词： ALG-2 calcium penta-EF-hand X-ray crystal structure protein-protein interaction membrane trafficking

Machining Robot with Vibrational Motion and 3D Printer-like Data Interface

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International Journal of Automation and computing 2018年第1期15卷 1-12页

作者： Fusaomi Nagata Keigo Watanabe maki K. Habib Department of Mechanical Engineering Faculty of Engineering Tokyo University of Science Yamaguchi 1-1-1 Daigaku-Dori Sanyo-Onoda 756-0884 Japan Department of Intelligent Mechanical Systems Division of Industrial Innovation Sciences Graduate School of Natural Science and Technology Okayama University 3-1-1 Tsushima-naka Kita-ku Okayama 700-8530 Japan American University 113 Kasr E1 Eini Street Cairo 11511 Egypt

In this paper, a vibration motion control is proposed and implemented on a foamed polystyrene machining robot to suppress the generation of undesirable cusp marks, and the basic performance of the controller is verified through machining experiments of foamed polystyrene. Then, a 3 dimensional （3D） printer-like data interface is proposed for the machining robot. The 3D data inter- face enables to control the machining robot directly using stereolithography （STL） data without conducting any computer-aided man- ufacturing （CAM） process. This is done by developing a robotic preprocessor that helps to remove the need for the conventional CAM process by directly converting the STL data into cutter location source data called cutter location （CL） or cutter location source （CLS） data. The STL is a file format proposed by 3D systems, and recently is supported by many computer aided design （CAD）/CAM soft- waxes. The STL is widely used for rapid prototyping with a 3D printer which is a typical additive manufacturing system. The STL deals with a triangular representation of a curved surface geometry. The developed 3D printer-like data interface allows to directly control the machining robot through a zigzag path, rectangular spiral path and circular spiral path generated according to the information included in STL data. The effectiveness and usefulness of the developed system are demonstrated through actual machining experiments.

关键词： Computer integrated manufacturing machining robot computer aided design (CAD)/computer-aided manufacturing(CAM) cutter location (CL) data vibrational motion stereolithography (STL) data preprocessor 3 dimensional (3D) printer-likedata interface.

Comparison of electronic structure between monolayer silicenes on Ag(111)

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Chinese Physics B 2015年第8期24卷 120-124页

作者： Chun-Liang Lin Ryuichi Arafune maki Kawai Noriaki Takagi Department of Advanced Materials Science Graduate School of Frontier ScienceThe University of Tokyo International Center for Materials Nanoarchitectonics (WPI-MANA) National Institute for Materials Science

√√The electronic structures of monolayer silicenes(4 × 4 and■ ×■R13.9o) grown on Ag(111) surface are studied by scanning tunneling spectroscopy(STS) and density functional theory(DFT) calculations. While both phases have similar electronic structures around the Fermi level, significant differences are observed in the higher energy unoccupied *** DFT calculations show that the contributions of Si 3pz orbitals to the unoccupied states are different because of their different buckled configurations.

关键词： silicene electronic structure STM DFT