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Severe aconite poisoning successfully treated with veno-arterial extracorporeal membrane oxygenation:A case report

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World Journal of Clinical Cases 2024年第2期12卷 399-404页

作者： Saeko Kohara yoshito Kamijo Ryoko Kyan Ichiro Okada Eiju Hasegawa Soichiro Yamada Koichi Imai Asuka Kaizaki-Mitsumoto Satoshi Numazawa Department of Critical Care Medicine and Trauma National Hospital Organization Disaster Medical CenterTokyo 1900014Japan Department of Clinical Toxicology Saitama Medical UniversitySaitama 3500495Japan Saitama Prefectural Institute of Public Health Saitama Prefectural Institute of Public HealthSaitama 3550133Japan Division of Toxicology Department of PharmacologyToxicology and TherapeuticsShowa University School of PharmacyTokyo 1428555Japan

BACKGROUND Most species of aconite contain highly toxic aconitines,the oral ingestion of which can be fatal,primarily because they cause ventricular *** describe a case of severe aconite poisoning that was successfully treated through venoarterial extracorporeal membrane oxygenation(VA-ECMO)and in which detailed toxicological analyses of the aconite roots and biological samples were performed using liquid chromatography-tandem mass spectrometry(LC-MS/MS).CASE SUMMARY A 23-year-old male presented to the emergency room with circulatory collapse and ventricular arrhythmia after ingesting approximately half of a root labeled,“Aconitum japonicum Thunb”.Two hours after arrival,VA-ECMO was initiated as circulatory collapse became refractory to antiarrhythmics and *** hours after arrival,an electrocardiogram revealed a return to sinus *** patient was weaned off VA-ECMO and the ventilator on hospital days 3 and 5,*** hospital day 15,he was transferred to a psychiatric *** other half of the root and his biological samples were toxicologically analyzed using LC-MS/MS,revealing 244.3 mg/kg of aconitine and 24.7 mg/kg of mesaconitine in the *** on admission contained 1.50 ng/mL of *** hospital day 2,neither were *** on admission showed 149.09 ng/mL of aconitine and 3.59 ng/mL of mesaconitine,but these rapidly decreased after hospital day *** The key to saving the life of a patient with severe aconite poisoning is to introduce VA-ECMO as soon as possible.

关键词： Aconite poisoning Fatal arrhythmia Veno-arterial extracorporeal membrane oxygenation Aconitine Mesaconitine Case report

Limitations of liver biopsy and non-invasive diagnostic tests for the diagnosis of nonalcoholic fatty liver disease/nonalcoholic steatohepatitis

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World Journal of Gastroenterology 2014年第2期20卷 475-485页

作者： Yoshio Sumida Atsushi Nakajima yoshito Itoh Department of Gastroenterology and Hepatology Kyoto Prefectural University of MedicineKyoto 602-8566Japan Division of Gastroenterology Yokohama City University Graduate School of MedicineYokohama 236-0004Japan

It is estimated that 30% of the adult population in Japan is affected by nonalcoholic fatty liver disease (NAFLD). Fatty changes of the liver are generally diagnosed using imaging methods such as abdominal ultrasonography (US) and computed tomography (CT), but the sensitivity of these imaging techniques is low in cases of mild steatosis. Alanine aminotransferase levels may be normal in some of these patients, warranting the necessity to establish a set of parameters useful for detecting NAFLD, and the more severe form of the disease, nonalcoholic steatohepatitis (NASH). Although liver biopsy is currently the gold standard for diagnosing progressive NASH, it has many drawbacks, such as sampling error, cost, and risk of complications. Furthermore, it is not realistic to perform liver biopsies on all NAFLD patients. Diagnosis of NASH using various biomarkers, scoring systems and imaging methods, such as elastography, has recently been attempted. The NAFIC score, calculated from the levels of ferritin, fasting insulin, and type IV collagen 7S, is useful for the diagnosis of NASH, while the NAFLD fibrosis score and the FIB-4 index are useful for excluding NASH in cases of advanced fibrosis. This article reviews the limitations and merits of liver biopsy and noninvasive diagnostic tests in the diagnosis of NAFLD/NASH.

关键词： Nonalcoholic fatty liver disease Liver biopsy Steatosis Fibrosis Nonalcoholic steatohepatitis

Mathematically modelling and controlling prostate cancer under intermittent hormone therapy

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Asian Journal of Andrology 2012年第2期14卷 270-277页

作者： yoshito Hirata Gouhei Tanaka Nicholas Bruchovsky Kazuyuki Aihara Institute of Industrial Science University of Tokyo Tokyo 153-8505 Japan Vancouver Prostate Centre Vancouver General Hospital Vancouver BC V6H 3Z6 Canada

In this review, we summarize our recently developed mathematical models that predict the effects of intermittent androgen suppression therapy on prostate cancer （PCa）. Although hormone therapy for PCa shows remarkable results at the beginning of treatment, cancer cells frequently acquire the ability to grow without androgens during long-term therapy, resulting in an eventual relapse. To circumvent hormone resistance, intermittent androgen suppression was investigated as an alternative treatment option. However, at the present time, it is not possible to select an optimal schedule of on- and off-treatment cycles for any given patient. In addition, clinical trials have revealed that intermittent androgen suppression is effective for some patients but not for others. To resolve these two problems, we have developed mathematical models for PCa under intermittent androgen suppression. The mathematical models not only explain the mechanisms of intermittent androgen suppression but also provide an optimal treatment schedule for the on- and off-treatment periods.

关键词： diagnosis intermittent androgen suppression mathematical models personalized treatment schedule prognosis prostate cancer

Lattice Boltzmann Simulation of Nucleate Pool Boiling in Saturated Liquid

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Communications in Computational Physics 2011年第5期9卷 1347-1361页

作者： yoshito Tanaka Masato Yoshino Tetsuo Hirata Department of Mathematics and System Development Engineering Interdisciplinary Graduate School of Science and TechnologyShinshu University4-17-1WakasatoNagano-shiNagano 380-8553Japan Department of Mechanical Systems Engineering Faculty of EngineeringShinshu UniversityNagano-shiNagano 380-8553Japan CREST Japan Science and Technology Agency4-1-8HonchoKawaguchi-shiSaitama 332-0012Japan

A thermal lattice Boltzmann method(LBM)for two-phase fluid flows in nucleate pool boiling process is *** the present method,a new function for heat transfer is introduced to the isothermal LBM for two-phase immiscible fluids with large density *** calculated temperature is substituted into the pressure tensor,which is used for the calculation of an order parameter representing two phases so that bubbles can be formed by nucleate *** using this method,twodimensional simulations of nucleate pool boiling by a heat source on a solid wall are carried out with the boundary condition for a constant heat *** flow characteristics and temperature distribution in the nucleate pool boiling process are *** is seen that a bubble nucleation is formed at first and then the bubble grows and leaves the wall,finally going up with deformation by the buoyant *** addition,the effects of the gravity and the surface wettability on the bubble diameter at departure are numerically *** calculated results are in qualitative agreement with other theoretical predictions with available experimental data.

关键词： Lattice Boltzmann method(LBM) two-phase fluid flows heat transfer nucleate pool boiling wettability

A study on α-ketoadipic aciduria by gas chromatographic-mass spectrometry

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World Journal of Gastroenterology 2000年第5期6卷 766-769页

作者： yoshito Inoue Morimasa Ohse Toshihiro Shinka Tomiko Kuhara Division of Human Genetics Medical Research InstituteKanazawa Medical UniversityJapan

INTRODUCTIONα-ketoadipate(α-KA),an intermediate in thecatabolism of L-lysine,hydroxylysine,and L-tryptophan,undergoes oxidative deearboxylation toform glutaryl-CoA and then dehydrogenates to formcrotonyl-CoA,the latter undergoes furtherdegradation and enters in TCA cycle,as shown inFigure 1.α-ketoadipic aciduria (Mckusick 245130)is a rare inborn error in the metabolism of α-KA

关键词： L-lysine hydroxylysine Ltryptophan alpha-aminoadipic alpha-ketoadipic aciduria metabolism inborn error mass fragmentography chromatography gas

A Review of Non-operative Treatments for Hepatocellular Carcinoma with Advanced Portal Vein Tumor Thrombus

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Journal of Clinical and Translational Hepatology 2017年第2期5卷 177-183页

作者： Michihisa Moriguchi Mitsuhiro Furuta yoshito Itoh Department of Molecular Gastroenterology and Hepatology Kyoto Prefectural University of Medicine Graduate School of Medical Science Kyoto Japan

Portal vein tumor thrombus (PVTT) frequently occurs with the progression of hepatocellular carcinoma (HCC) and is an important factor in determining the prognosis of *** many cases of HCC with advanced PVTT,treatment is difficult because the tumor has considerable extension into the liver,and portal hypertension is a frequent *** standard therapy for unresectable HCC with advanced PVTT is sorafenib therapy in patients with good hepatic ***,the outcomes of sorafenib therapy are not completely satisfactory,making the development of another therapy an urgent ***,this review aims to summarize non-operative treatments for HCC with advanced PVTT and discuss future perspectives based on those therapies,including therapies still being developed.

关键词： Keywords Hepatocellular carcinoma Medical therapy management Portal vein Thrombus

Coexpression of Escherichia coli RNase III in silkworm cells improves the efficiency of RNA interference induced by long hairpin dsRNAs

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Insect Science 2013年第1期20卷 69-77页

作者： Jae Man Lee yoshito Kojin Tsuneyuki Tatsuke Hiroaki Mon Yoshitaka Miyagawa Takahiro Kusakabe Laboratory of Silkworm Sciences Kyushu University Graduate School of Bioresource and Bioenvironmental Sciences Fukuoka Department of Developmental Biology National Research Institute for Child Health and Development 2-10-1 Okura Setagaya-ku Tokyo Japan

Long hairpin dsRNA transcribed from chromosomal DNA can induce RNA interference in Bombyx mori cells, although its gene silencing efficiency is lower than that of exogenously introduced double-stranded RNAs （dsRNAs）. To solve this problem, we monitored the nuclear cytoplasmic translocation of the transcribed hairpin dsRNA and analyzed the processing efficiency into mature small interfering RNA （siRNA）. Northem blot analysis revealed that the transcribed hairpin dsRNAs were spliced and transported into the cytoplasm, but were not effectively diced into siRNAs. Interestingly, RNAi with hairpin dsRNAs from genome-integrated IR transgene was stimulated by the coexpression of Escherichia coli RNase III, although this exogenous enzyme seemed to bring about nonspecific cleavage of cellular mRNA.

关键词： Bombyx mori dsRNA RNA interference RNase III siRNA

Epidemiology of hepatocellular carcinoma in nonalcoholic fatty liver disease

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Hepatoma Research 2019年第12期5卷 12-25页

作者： Michihisa Moriguchi Yuya Seko Aya Takahashi yoshito Itoh Department of Molecular Gastroenterology and Hepatology Kyoto Prefectural University of Medicine Graduate School of Medical ScienceKyoto 602-8566Japan

Along with the changes in our food culture and lifestyle,conditions such as obesity,diabetes mellitus,and metabolicsyndrome have been on the rise,and the incidence of nonalcoholic fatty liver disease(NAFLD),which is closelyrelated to these diseases,has also increased *** being a risk factor for the development of hepatocellularcarcinoma(HCC),NAFLD has no established screening method,and HCC originating from NAFLD often tends to be discovered in its advanced and symptomatic stages,which has become an important clinical *** though the carcinogenicity rate among the entire population of NAFLD patients is not high compared to that of patients with viral hepatitis,since HCC also often develops from non-cirrhotic livers,it is difficult to narrow down the cases that need to be under *** forward,it will be important to clarify the clinical characteristics and genetic background of NAFLD-related HCC and establish not only a useful surveillance method but also preventive methods.

关键词： Hepatocellular carcinoma nonalcoholic fatty liver disease epidemiology

Pitfalls and promises of bile duct alternatives:A narrative review

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World Journal of Gastroenterology 2022年第39期28卷 5707-5722页

作者： Mitsuo Miyazawa Masayasu Aikawa Junpei Takashima Hirotoshi Kobayashi Shunsuke Ohnishi yoshito Ikada Department of Surgery Teikyo University Mizonokuch HospitalKanagawa 213-8507Japan Department of Surgery Saitama Medical University International Medical CenterSaitama 350-1298Japan Department of Gastroenterology and Hepatology Hokkaido University Faculty of Medicine and Graduate School of MedicineSapporo 060-8638Japan Department of Bioenvironmental Medicine Nara Medical UniversityNara 634-8521Japan

Biliodigestive anastomosis between the extrahepatic bile duct and the intestine for bile duct disease is a gastrointestinal reconstruction that abolishes duodenal papilla function and frequently causes retrograde *** chronic inflammation can cause liver dysfunction,liver abscess,and even bile duct *** research has been conducted for over 100 years to directly repair bile duct defects with alternatives,no bile duct substitute(BDS)has been *** narrative review confirms our understanding of why bile duct alternatives have not been developed and explains the clinical applicability of BDSs in the near *** searched the PubMed electronic database to identify studies conducted to develop BDSs until December 2021 and identified studies in *** independent reviewers reviewed studies on large animals with 8 or more *** types of BDSs prevail:Autologous tissue,non-bioabsorbable material,bioabsorbable material,and others(decellularized tissue,3D-printed structures,etc.).In most studies,BDSs failed due to obstruction of the lumen or stenosis of the anastomosis with the native bile *** has not been developed primarily because control of bile duct wound healing and regeneration has not been elucidated.A BDS expected to be clinically applied in the near future incorporates a bioabsorbable material that allows for regeneration of the bile duct outside the BDS.

关键词： Bile duct alternative Bile duct substitute Biliary regeneration Bile duct reconstruction Peribiliary gland Bioabsorbable polymer