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The Impact of Variation in Bladder Volume on the Doses of Target and Organ-at-Risk in Intensity-Modulated Radiation Therapy for Localized Prostate Cancer

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Journal of Cancer Therapy 2016年第10期7卷 741-751页

作者： Shogo Hatanaka yoshito Kawada Kana Washizu Nobuko Utsumi Takafumi Yamano Keiichiro Nishimura Tetsuya Watanabe Katsuhito Hosaka Keisuke Todoroki Go Nakajima Munefumi Shimbo Takeo Takahashi Department of Radiation Oncology Saitama Medical Center Saitama Medical University Kawagoe City Japan Department of Radiology JCHO Tokyo Shinjuku Medical Center Tokyo Japan

Intensity-modulated radiation therapy (IMRT) has become the mainstay of treatment for localized prostate cancer. In IMRT, minimizing differences between the conditions used during planning CT and daily treatment is important to prevent adverse events in normal tissues. In the present study, we evaluated the impact of variation in bladder volume on the doses to various organs. A total of 35 patients underwent definitive radiotherapy at Saitama Medical Center. A Light Speed RT16 (GE Healthcare) was used for planning and to obtain examination CT images. Such images were acquired after 4 - 6 days of planning CT image acquisition. The IMRT plans were optimized using the planning CT data to satisfy the dose constraints set by our in-house protocols for the PTV and the OARs. The dose distributions were then re-calculated using the same IMRT beams, and checked on examination CT images. It was clear that bladder volume affected the doses to certain organs. We focused on the prostate, bladder, rectum, small bowel, and large bowel. Regression coefficients were calculated for variables that correlated strongly with bladder volume (p 3] predicted deviations in the bladder V70Gy, V50Gy, and V30Gy [%];the maximum dose to the small bowel [cGy];and the maximum dose to the large bowel [cGy]. The regression coefficients were -0.065, -0.125, -0.180, -10.22, and -9.831, respectively. We evaluated the impacts of such variation on organ doses. These may be helpful when checking a patient’s bladder volume before daily IMRT for localized prostate cancer.

关键词： Bladder Volume Localized Prostate Cancer Intensity-Modulated Radiation Therapy Dose to Organs at Risk Computed Tomography

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Human papillomavirus in esophageal squamous cell carcinoma in Colombia and Chile

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World Journal of Gastroenterology 2006年第38期12卷 6188-6192页

作者： Andres Castillo Francisco Aguayo Chihaya Koriyama Miyerlandi Torres Edwin Carrascal Alejandro Corvalan Juan P Roblero Cecilia Naquira Mariana Palma Claudia Backhouse Jorge Argandona Tetsuhiko Itoh Karem Shuyama yoshito Eizuru Suminori Akiba Department of Epidemiology and Preventive Medicine Kagoshima University Graduate School of Medical and Dental Sciences Kagoshima Japan Division of Persistent and Oncogenic Viruses Center for Chronic Viral Diseases Kagoshima University Graduate School of Medical and Dental Sciences Kagoshima Japan Department of Pathology University of Valle Faculty of Health Sciences Sede San Fernando Cali Colombia Department of Pathology P. Catholic University Santiago Chile Gastroenterology and Pathologic Unit Hospital San Camilo San Felipe Chile Institute for Digestive Diseases Chileno-Japones at San Borja- Arriaran Hospital Santiago Chile Geriatric Health Services Facility Kagoshima Japan

AIM： To examine the presence of human papillomavirus （HPV） in esophageal squamous cell carcinoma （ESCC） specimens collected from Colombia and Chile located in the northern and southern ends of the continent, respectively.METHODS： We examined 47 and 26 formalin-fixed and paraffin-embedded ESCC specimens from Colombia and Chile, respectively. HPV was detected using GP5＋/GP6＋ primer pair for PCR, and confirmed by Southern blot analysis. Sequencing analysis of L1 region fragment was used to identify HPV genotype. In addition, P16^INK4A protein immunostaining of all the specimens was conducted.RESULTS： HPV was detected in 21 ESCC specimens （29%）. Sequencing analysis of L1 region fragment identified HPV-16 genome in 6 Colombian cases （13%） and in 5 Chilean cases （19%）. HPV-18 was detected in i0 cases （21%） in Colombia but not in any Chilean case. Since Chilean ESCC cases had a higher prevalence of HPV-16 （without statistical significance）, but a significantly lower prevalence of HPV-18 than in Colombian cases （P = 0.011） even though the two countries have similar ESCC incidence rates, the frequency of HPV-related ESCC may not be strongly affected by risk factors affecting the incidence of ESCC. HPV-16 genome was more frequently detected in p16 positive carcinomas, although the difference was not statistically significant. HPV-18 detection rate did not show any association with p16 expression. Well-differentiated tumors tended to have either HPV-16 or HPV-18 but the association was not statistically significant. HPV genotypes other than HPV-16 or 18 were not detected in either country.CONCLUSION： HPV-16 and HPV-18 genotypes can be found in ESCC specimens collected from two South American countries. Further studies on the relationship between HPV-16 presence and p16 expression in ESCC would aid understanding of the mechanism underlying the presence of HPV in ESCC.

关键词： Human papillomavirus Esophageal squamous cell cancer Colombia Chile

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Choroidal and cutaneous metastasis from gastric adenocarcinoma

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World Journal of Gastroenterology 2013年第9期19卷 1485-1488页

作者： Shoichiro Kawai Tsutomu Nishida yoshito Hayashi Hisao Ezaki Takuya Yamada Shinichiro Shinzaki Masanori Miyazaki Kei Nakai Takayuki Yakushijin Kenji Watabe Hideki Iijima Masahiko Tsujii Kohji Nishida Tetsuo Takehara Department of Gastroenterology and Hepatology Osaka University Graduate School of Medicine Osaka 565-0871 Japan Department of Ophthalmology Osaka University Graduate School of Medicine Osaka 565-0871 Japan

Choroidal or cutaneous metastasis of gastric cancer is rare. Gastrointestinal cancer was found in only 4% in patients with uveal metastasis. Choroidal metastasis from gastric cancer was reported in two cases in earlier literature. The frequency of gastric cancer as a primary lesion was 6% in cutaneous metastasis of men, and cutaneous metastasis occurs in 0.8% of all gastric cancers. We report a patient with gastric adenocarcinoma who presented with visual disorder in his left eye and skin pain on his head as his initial symptoms. These symptoms were diagnosed to be caused by choroidal and cutaneous metastasis of gastric adenocarcinoma. Two cycles of chemotherapy consisted of oral S-1 and intravenous cisplatin (SPIRITS regimen); this was markedly effective to reduce the primary gastric lesion and almost all the metastatic lesions.

关键词： Stomach neoplasms Neoplasm metastasis Choroid neoplasms Skin neoplasms

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THE FOLLOW-UP STUDY IN α-KETOADIPIC ACIDURIA

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Medical Bulletin of Shanghai Jiaotong University 2000年第2期21卷 95-98页

作者：夏振炜 Now working in the Department of Pediatrics Ruijin Hospital SSMU Shanghai 200025 Division of Human Genetics Medical Research Institute Kanazawa Medical University Japan

Objective To follow up study on α-ketoadipic aciduria , which is a rare inborn error of metabolism of L-ly sine, hydroxy-L-lysine, and L-tryptophan. Methods The case with α-ketoadipic aciduria was investigated clinically and metabolites were detected by using gas chromatography-mass spectrometry techniques during a period of 15 years (9months～ 15years). Results The case had growth retardation at the onset but later grew normally. The urinary metabolites showed persisent abnormality compatible with α-ketoadipic aciduria. The concentrations of α-ketoadipate , α-aminoadipate and α-hy droxyadipate were 33mmol/mol creatinine, 92～266mmol/mol creatinine and 17～28mmol/mol creatinine , respectively. Glutarate also increased in their urine. Conclusion The study suggested the clinical course of a-ketoadipic aciduria is benign and the clinical manifestations are various. The follow-up study on this case with α-ketoadipic aciduria must be continued.

关键词： a-aminoadipic/a-ketoadipic aciduria gas chromatography-mass spectrometry symptom

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世界设计史研究回顾及对我国设计史研究的展望

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建筑与文化 2021年第5期 29-30页

作者：贺佳尾方义人日本九州大学艺术工学府日本九州大学艺术工学研究院

从英国的威廉·莫里斯到德国的彼得·贝伦斯,从德国工业同盟到荷兰风格派,现代设计的历史在颠覆与创新中不断前进。对于设计史的研究是整个设计学界的重要课题,也是更好地推动现代设计发展的必然途径。文章在梳理欧洲设计史研究与日本... 详细信息

从英国的威廉·莫里斯到德国的彼得·贝伦斯,从德国工业同盟到荷兰风格派,现代设计的历史在颠覆与创新中不断前进。对于设计史的研究是整个设计学界的重要课题,也是更好地推动现代设计发展的必然途径。文章在梳理欧洲设计史研究与日本设计史研究的基础上,分析我国设计史研究现状,展望我国设计史研究发展的未来。

关键词：设计设计史现代设计工艺美术史

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RESS软件与数量化-Ⅱ类分析方法在区域危险度评价中的应用

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工程地质学报 2014年第1期22卷 38-45页

作者：潘芷加朱寿增北园芳人桂林理工大学博文管理学院桂林541006 桂林理工大学土木工程与建筑学院桂林541004 熊本大学工学部环境岩土教研室日本熊本860-8555

2012年7月中旬日本熊本县迎来特大暴雨,暴雨在熊本县市区内引发洪水,并在位于其东北部的阿苏地区引发了数量巨大、后果严重的地质灾害。通过同年10月到11月之间多次现场灾害调查,发现当地的地质灾害主要类型有崩塌、滑坡和泥石流。当地... 详细信息

2012年7月中旬日本熊本县迎来特大暴雨,暴雨在熊本县市区内引发洪水,并在位于其东北部的阿苏地区引发了数量巨大、后果严重的地质灾害。通过同年10月到11月之间多次现场灾害调查,发现当地的地质灾害主要类型有崩塌、滑坡和泥石流。当地的地理环境给相关部门后续的治理和修复工作带来了极大的不便利,同时耗费了大量的时间和资金,因而相对于灾后进行治理和修复工作,事前对于当地可能发生地质灾害的区域进行危险度评价,在危险度大的地方提前建立防护措施具有更大的实际和经济价值。本文运用日本熊本大学工学部环境岩土研究室自主研发的危险度评价RESS软件对选取的阿苏—坂梨区域进行危险度评价,获得了被研究区域的地势起伏度、横断面形状、斜面倾斜角度、集水面积、土地利用信息、土体表层地质、灾害场所变化情况等7个类别的解析图像和数据。结合使用数量化—Ⅱ类分析方法,对危险度评价的结果进行验证和扩展,危险度评价的准确率和灾害场所的判断准确率均高于研究要求,另外也获得了由RESS软件解析出来的各个类别的因子对于地质灾害事件的贡献度大小。依据危险度评价的结果绘制出被研究区域的地质灾害预测预警地图,该地图简单易懂,具有一定的社会共享意义和专业参考价值。

关键词：地质灾害危险度评价数量化—Ⅱ类分析方法地质灾害预测预警地图

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Audit study of the new hospitalization for assessment scheme for forensic mental health in Japan

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World Journal of Psychiatry 2015年第2期5卷 234-242页

作者： Akihiro Shiina Masaomi Iyo Toyoaki Hirata yoshito Igarashi Department of Psychiatry Chiba University Hospital Chiba Psychiatric Medical Center Center for Forensic Mental Health Chiba University

AIM: To clarify the components of hospitalization for assessment(HfA) and the management changes from the beginning of the scheme to the ***: This study is composed of two surveys. In 2013 survey, we created two paper questionnaires(facility and case questionnaires) for psychiatrists working in psychiatric hospitals accepting HfA patients. Questionnaires were sent to 205 hospitals that were identified as accepting the Hf A cases, and responses were requested via mail. The facility questionnaire was designed to clarify the following specifications and characteristics of each facility: the facility organizer(public sector or private hospital), and the number of beds, psychiatrists, psychiatric nurses, occupational therapists, psychiatric social workers, psychotherapists, public health nurses, and patients treated through Hf A during the survey period. The case questionnaire was then used to collect data of the patients under Hf A based on the Medical Treatment and Supervision(MTS) Act who were discharged between July 1, 2012 and June 30, 2013. Gathered information included: legal information of each case, demographic data, past history of the offenders, issued offense and the relationship to the victim, information regarding past psychiatric testimonies, psychiatric diagnoses, contents of the treatment during Hf A, information regarding seclusion and restraint during the Hf A, the verdict of the District Court panel, and so forth. Next, we compared those results with relevant data obtained in 2007. The 2007 survey comprised data of Hf A patients from July 15, 2005(the date the MTS Act was enforced) to January 15, ***: We obtained 171 cases, approximately a half of whole contemporary cases of HfA, from 134 facilities, of which 46 were national, prefectural, or semi-official hospitals, and 88 were private hospitals, in 2013 survey. The majority of subjects were male, schizophrenic, and experienced previous psychiatric treatment. The most frequent ty

关键词： Medical treatment and supervision act Hospitalization for assessment Forensic mental health Audit study

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Design of Blended Learning with WBT in Higher Education

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通讯和计算机（中英文版） 2013年第1期10卷 97-103页

作者： Hiroshi Ichikawa Yasuko Hayashibara Hiroo Hirose yoshito Yamamoto Faculty of Home Economics Otsuma Women's University Tokyo 1028357 Japan Faculty of Management of A dministration and Information To kyo University of Science Nagano 3910292 Japan Faculty of Science Tokyo University of Science Tokyo 1628601 Japan

The effectiveness of e-learning is being examined in higher education with the support of the advanced ICT (information and communication technology) and the educational policy research. However, e-learning is not steadily becoming popular due to a large number of processes for creating the e-learning contents, the e-learning cost problems and the public"s lack of understanding of the importance and necessity of e-learning. On the assumption that especially the students in regular day school programs will attend classes on campus, the authors can not explain completely the importance and necessity of e-learning only under the time and space advantages that the students can learn whenever and wherever they want. Hereafter, the authors will report the practical use of "Blended Learning" combining the WBT (web based training) and the face-to-face class that could be a solution to the above problem.

关键词：电子学习高等教育 WBT 混合式设计教育政策通信技术学习内容

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CORBA:面向对象的分布式计算平台

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深圳大学学报（理工版） 1999年第2期16卷 42-49页

作者：王振宇上野义人深圳大学信息工程学院深圳518060 创价大学信息系统系

介绍了公共对象请求代理体系结构（CORBA：CommonObjectRequestBrokerArchitecture）的概念和基本原理，包括CORBA体系结构、界面描述语言、支持远程对象调用的静态调用SII和动态调用DII，讨论对象请求代理（ORB）和对象适配器（ObjectA... 详细信息

介绍了公共对象请求代理体系结构（CORBA：CommonObjectRequestBrokerArchitecture）的概念和基本原理，包括CORBA体系结构、界面描述语言、支持远程对象调用的静态调用SII和动态调用DII，讨论对象请求代理（ORB）和对象适配器（ObjectAdapter）对服务对象的管理、ORBs间的互操作性问题，及Javabeans带来的影响．

关键词：分布式对象分布式计算平台面向对象 CORBA

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简易贯入实验和塑性图在地质灾害中的研究应用

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土工基础 2015年第1期29卷 120-123页

作者：潘芷加北园芳人桂林理工大学博文管理学院广西桂林541006 熊本大学工学部环境岩土教研室

介绍了简易贯入实验和塑性图的原理、应用和分析过程,通过国内外贯入实验和塑性图比较,总结了其优点以及推广的可能性。利用简易贯入实验数据可以简便、迅速地绘制出贯入曲线图,了解到灾害场地土层的大致分布,以及各土层土壤的软弱特性... 详细信息

介绍了简易贯入实验和塑性图的原理、应用和分析过程,通过国内外贯入实验和塑性图比较,总结了其优点以及推广的可能性。利用简易贯入实验数据可以简便、迅速地绘制出贯入曲线图,了解到灾害场地土层的大致分布,以及各土层土壤的软弱特性。从现场采取土壤试样进行室内密度、含水率、液、塑限实验,拟合液性界限和塑性指数的数据绘制出塑性图,可以直观地了解到土壤试样的物理性质。结合粒度实验的相关数据,准确地判断出土壤试样的工学分类。简易贯入实验和塑性图的使用,可以为地质灾害领域的实验研究提供多方位的参考价值。

关键词：简易贯入实验标准贯入实验塑性图地质灾害

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