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Angiogenesis and neuronal remodeling after ischemic stroke

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Neural Regeneration Research 2020年第1期15卷 16-19页

作者： Masahiro Hatakeyama Itaru Ninomiya Masato kanazawa Department of Neurology Brain Research Institute Niigata University

Increased microvessel density in the peri-infarct region has been reported and has been correlated with longer survival times in ischemic stroke patients and has improved outcomes in ischemic animal *** raises the possibility that enhancement of angiogenesis is one of the strategies to facilitate functional recovery after ischemic *** vessels and neuronal cells communicate with each other using various mediators and contribute to the pathophysiology of cerebral ischemia as a *** this mini-review,we discuss how angiogenesis might couple with axonal outgrowth/neurogenesis and work for functional recovery after cerebral *** occurs within 4 to 7 days after cerebral ischemia in the border of the ischemic core and ***-ischemic angiogenesis may contribute to neuronal remodeling in at least two ways and is thought to contribute to functional ***,new blood vessels that are formed after ischemia are thought to have a role in the guidance of sprouting axons by vascular endothelial growth factor and laminin/β1-integrin ***,blood vessels are thought to enhance neurogenesis in three stages:1)Blood vessels enhance proliferation of neural stem/progenitor cells by expression of several extracellular signals,2)microvessels support the migration of neural stem/progenitor cells toward the peri-infarct region by supplying oxygen,nutrients,and soluble factors as well as serving as a scaffold for migration,and 3)oxygenation induced by angiogenesis in the ischemic core is thought to facilitate the differentiation of migrated neural stem/progenitor cells into mature ***,the regions of angiogenesis and surrounding tissue may be coupled,representing novel treatment targets.

关键词： angiogenesis axonal outgrowth cerebral ischemia coupling functional recovery guidance neurogenesis stroke

A NOVEL SECOND-ORDER TRANSITION IN ORGANIC HYBRIDS CONSISTING OF POLYMERS AND SMALL MOLECULES

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Chinese Journal of Polymer Science 2001年第5期19卷 455-466页

作者： Chi-fei Wu Department of Chemistry and Chemical Engineering kanazawa University 2-40-20 Kodatsuno kanazawa, Ishikawa 920-8667 Japan kanazawa Univ Dept Chem & Chem Engn Kanazawa Ishikawa 9208667 Japan

A novel transition appeared above thc glass transition temperature of chlorinated polyethylene (CPE) for binaryblends of CPE and additives such as organic small molecules or oligomers. This transition was assigned to the dissociation ofintermolecular hydrogen bonds between the polymer ard additive within the edditive rich phase. Of particular interest is thata novel pyramid crystal was observed in the annealed CPE/hindered phenol blends. Another intriguing observation is thatthese polymer/small molecule blends organized by intermolecular hydrogen bonding have several potential properties, suchas shape-memorization, self-restoration, self-adhesiveness and super damping.

关键词： Organic hybrid Second-order transition Shape memory effect Damping Self restoration

Chromium(VI) Reduction in Wheat Rhizosphere

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Pedosphere 2000年第1期10卷 31-36页

作者： CHENNENGCHANG S.kanazawa 等 LabPlantNutrition FacultyofAgricultureKagoshinaUniversityJapan DivistionofBioresourceandBioenvicronmentalScienceGraduateSchool KyushuUniversityJapan

Reduction of Cr(VI) to Cr(III) were studied in a fresh wheat rhizosphere soil (Kuroboku, high humic andosol) pretreated with a basal fertilizer consisting of (NH4)2SO4, P2O5 and KH2PO4 and with K2Cr2O7 by using a rhizobox system. It was found that rhizosphere exerted a positive effect on Cr(VI) reduction. Part of the reason was the decrease of pH in the rhizosphere due to application of (NH4)2SO4, implying that application of physiologically acid fertilizers would reduce Cr(VI) toxicity to plants.

关键词： Cr reduction rhizosphere wheat

THEORETICAL AND EXPERIMENTAL STUDIES OF STRESS DISTRIBUTION IN WEDGE-SHAPED GRANULAR HEAPS

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Acta Mechanica Solida Sinica 2014年第1期27卷 28-40页

作者： Thirapong Pipatpongsa Tadaki Matsushita Maho Tanaka Shinichi kanazawa Katsuyuki Kawai Global Scientific Information and Computing Center Tokyo Institute of Technology Department of International Development Engineering Tokyo Institute of Technology Maeda Corporation Nishimatsu Construction Co. Ltd Research Center for Urban Safety and Security Kobe University

The present work explains the statics of self-weight transmission restricted to a long prismatic heap inclined at an angle of repose and symmetrically formed on a rigid base. The closure of polarized principal axes with the mobilized state of stress along the slope surface is employed by imposing the orientation of principal stresses on the equilibrium equations. Comparisons were made with calculations based on the finite element method using an elastic model. Moreover, experiments on sand heaps deposited on a rectangular rigid base were conducted to validate the theoretical study. The measured pressure profile generally agreed well with theoretical results.

关键词： granular materials sand continuum medium analytical method finite element method experimental techniques

Next-generation regenerative therapy for ischemic stroke using peripheral blood mononuclear cells

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Neural Regeneration Research 2024年第11期19卷 2341-2342页

作者： Masato kanazawa Itaru Ninomiya Yutaka Otsu Masahiro Hatakeyama Department of Neurology Brain Research InstituteNiigata UniversityNiigataJapan

Stroke is the second leading cause of death and the third leading cause of disability worldwide after heart *** predict that stroke deaths and permanent disabilities will increase worldwide by the year ***-target therapies may be insufficient,because ischemic cerebral injury involves several ***-mediated therapies are ideal,because they target multiple cell types to enhance protection and recovery.

关键词： ischemic death cerebral

What Defines a Crystal Structure? Effects of Chalcogen Atoms in 3,7-Bis(methylchalcogeno)benzo[1,2-b:4,5-b′]dichalcogenophene-Based Organic Semiconductors

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Chinese Journal of Chemistry 2022年第21期40卷 2546-2558页

作者： Kazuo Takimiya Kirill Bulgarevich Kamon Sahara Kiseki kanazawa Hiroyuki Takenaka Kohsuke Kawabata Department of Chemistry Graduate School of ScienceTohoku University6-3AobaAramakiAoba-kuSendaiMiyagi 980-8578Japan RIKEN Center for Emergent MatterScience(CEMS) 2-1HirosawaWakoSaitama351-0198Japan Advanced Institute for Materials Research Tohoku University(WPl-A/MR)2-1-1KatahiraAoba-kuSendaiMiyagi 980-8577Japan

To understand the effects of chalcogen atoms on the crystal structure of the series of 3,7-bis(methylchalcogeno)benzo[1,2-b:4,5-b′]dichalcogenophene-based organic semiconductors,three benzodifuran derivatives(1—3)and dimethoxy derivatives of benzodithiophene and benzodiselenophene(4 and 7)were newly synthesized to complete the“3×3 matrix”of the oxygen-,sulfur-,and selenium-derivatives(1—9).The crystal structures of 1—9 were classified into four classes,sandwich pitchedπ-stack(1),dimeric(2 and 3),pitchedπ-stack(4,5,7,8,9),and brickwork structure(6 and 9).The causes for the different crystal structures depending on the chalcogen atoms were investigated by the theoretical calculations,indicating that the chalcogen atoms in the core and substituents primarily affected the packing *** the crystal growth in the vapor phase afforded different polymorphs,the relationship between the crystal structure and the carrier transport property was carefully investigated.

关键词： Organic semiconductor Crystal structure Mobility Intermolecular interaction Chalcogen atom

Microcystin accumulation and biochemical responses in the edible clam Corbicula leana P. exposed to cyanobacterial crude extract

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Journal of Environmental Sciences 2016年第6期28卷 120-130页

作者： Thanh-Luu Pham Kazuya Shimizu Ayako kanazawa Yu Gao Thanh-Son Dao Motoo Utsumi Graduate School of Life and Environmental Sciences University of Tsukuba 1-1-1 Tennodai Tsukuba Ibaraki 305-8572 Japan Faculty of Life Sciences Toyo University Ora-gun Gunma 374-0193 Japan College of Chemical and Environmental Engineering Shandong University of Science and Technology qingdao 266590 China Ho Chi Minh City University of Technology 268 Ly Thuon9 Kiet St. Dist. 10 Ho Chi Mirth City Viet Nam Vietnam Academy of Science and Technology （VAST) Institute of Tropical Biology 85 Tran Quoc Toan St. Dist. 3 Ho Chi Minh City Viet Nam

We investigated the accumulation and effects of cyanobacterial crude extract（CCE）containing microcystins（MCs） on the edible clam Corbicula leana P. Toxic effects were evaluated through the activity of antioxidant and detoxification enzymes： catalase（CAT）,superoxide dismutase（SOD）, and glutathione-S-transferases（GSTs） from gills, foot, mantle and remaining soft tissues. Clams were exposed to CCE containing 400 μg MC-LReq/L for10 days and were then kept in toxin-free water for 5 days. Clam accumulated MCs（up to 3.41 ± 0.63 μg/g dry weight（DW） of unbound MC and 0.31 ± 0.013 μg/g DW of covalently bound MC）. Detoxification and antioxidant enzymes in different organs responded differently to CCE during the experiment. The activity of SOD, CAT, and GST in the gills and mantle increased in MC-treated clams. In contrast, CAT and GST activity was significantly inhibited in the foot and mostly only slightly changed in the remaining tissues. The responses of biotransformation, antioxidant enzyme activity to CCE and the fast elimination of MCs during depuration help to explain how the clam can survive for long periods（over a week） during the decay of toxic cyanobacterial blooms in nature.

关键词： Bioaccumulation Cyanotoxins Covalently bound microcystins Aqueous extracts

Unraveling the mystery of enhanced cell-killing effect around the Bragg peak region of a double irradiation source^(9)C-ion beam

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Chinese Science Bulletin 2005年第22期50卷 2546-2551页

作者： LI Qiang Y. Furusawa M. kanazawa A. Kitagawa Institute of Modern Physics Chinese Academy of Sciences Lanzhou 730000 China National Institute of Radiological Sciences Chiba 263-8555. Japan

An enhanced cell-killing effect at the penetra- tion depths around the Bragg peak of a β-delayed particle decay 9C-ion beam has been observed in our preceding ra- diobiological experiments in comparison with a therapeutic 12C beam under the same conditions, and RBE values of the 9C beam were revealed to be higher than those of the comparative 12C beam by a factor of up to 2. This study is aimed at investigating the biophysical mechanisms underlying the important experimental phenomenon. First of all, a model for calculating the stopping probability density of the experimentally applied 9C beam is worked out, where all determinants such as the initial momentum spread of the 9C beam, the fluence attenuation with penetration depth due to the projectile-target nuclear reaction and the energy strag- gling effect are taken into account. On the basis of the calcu- lated 9C-ion stopping distribution, it has been found that the area corresponding to the enhanced cell-killing effect of the 9C beam appears at the stopping region of the incident 9C ions. The stopping 9C-ion density in depth, then, is derived from the calculated probability density. Moreover, taking entrance dose 1 Gy for the 9C beam as an example, the aver- age stopping 9C-ion numbers per cell at various depths are deduced. Meanwhile, the mean lethal damage events induced by the 9C and comparative 12C beams at the depths with al- most equal dose-averaged LETs are derived from the meas- ured cell surviving fractions at these depths for the 9C and 12C beams. Under the condition of the same absorbed doses, there are indeed good agreements between the average stop- ping 9C-ion number pre cell and the difference of the mean lethal damage events between the 9C and 12C beams at the depths of similar dose-averaged LETs. It can be inferred that if a 9C ion comes to rest in a cell, the cell would undergo dy- ing. In view of the decay property of 9C nuclide, clustered damage would be caused in the cell by the emitted low-

关键词：放射源细胞损伤离子分布致死因子离子束

Kawasaki disease without changes in inflammatory biomarkers:A case report

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World Journal of Clinical Cases 2022年第35期10卷 13038-13043页

作者： Kosei Yamashita Takeru kanazawa Yoshifusa Abe Takuya Naruto Masaaki Mori Children’s Medical Center Showa University Koto Toyosu HospitalTokyo 135-8577Japan Lifetime Clinical Immunology Graduate School of Medical and Dental SciencesTokyo Medical and Dental UniversityTokyo 113-8510Japan Department of Rheumatology Clinical Immunology and AllergologySt.Marianna University School of MedicineKanagawa 216-8511Japan

BACKGROUND Kawasaki disease(KD)is diagnosed based on clinical *** tests and other tests are auxiliary diagnostic *** KD is a disease caused by arterial inflammation,many patients with KD have elevated levels of inflammatory biomarkers,such as C-reactive protein(CRP),erythrocyte sedimentation rate(ESR),and serum amyloid A protein(SAA)in blood *** report our experience of a patient with KD who did not have elevated levels of inflammatory *** SUMMARY A 1-year-old boy presented with a 3-day history of *** of the six symptoms of KD were observed,except for changes in the lips and oral *** tests revealed no elevation in CRP,ESR,or SAA *** the blood test results were atypical,the patient was diagnosed with KD based on clinical symptoms and was admitted to the hospital for *** patient was administered intravenous immunoglobulin(IVIG)and *** commencing treatment,the fever persisted;therefore,additional IVIG was administered,the dosage of aspirin was increased,and ulinastatin was *** doses of IVIG were administered and the fever resolved on day 11 of KD symptoms *** tests performed during hospitalization showed normal levels of inflammatory *** examined leucine-rich alpha-2-glycoprotein 1-a protein that is elevated during the acute phase of *** protein levels did not increase during *** This case suggests the need to identify criteria and biomarkers for detecting KD conditions that do not require KD treatment.

关键词： Blood test C-reactive protein Erythrocyte sedimentation rate Intravenous immunoglobulin Kawasaki disease Case report