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Preserved egg white alleviates DSS-induced colitis in mice through the reduction of oxidative stress,modulation of inflammatory cytokines,NF-κB,MAPK and gut microbiota composition

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Food Science and Human Wellness 2023年第1期12卷 312-323页

作者： Lingyu Li Ning Qiu Yaqi Meng Chenyan Wang yoshinori mine Russell Keast Vincent Guyonnet Key Laboratory of Environment Correlative Dietology Ministry of EducationCollege of Food Science and TechnologyHuazhong Agricultural UniversityWuhan 430070China Department of Food Science University of GuelphGuelphOntario N1G 2W1Canada CASS Food Research Centre School of Exercise and Nutrition SciencesDeakin UniversityBurwoodVictoria 3125Australia FFI Consulting Ltd 2488 Lyn RoadBrockville ON K6V 5T3Canada

Traditional Chinese preserved egg products have exhibited some anti-inflammatory effects,but their mechanisms of action remain *** study aimed to investigate the anti-inflammatory effects of preserved egg white(PEW)treatment on dextran sulfate sodium(DSS)-induced colitis in mice and the underlying *** results showed that treatment with PEW in mice with DSS-induced colitis for 14 days effectively improved the clinical signs,inhibited the secretion and gene expression of pro-inflammatory cytokines,and reduced myeloperoxidase(MPO)activity and oxidative stress *** addition,western blotting results showed that PEW significantly suppressed DSS-induced phosphorylation levels of nuclear factor-kappa B(NF-κB)p65 and p38 mitogen-activated protein kinase(MAPK)in colon tissues of mice with *** also enhanced the production of short-chain fatty acids(SCFAs)and modulated gut microbiota composition in mice with DSS-induced colitis,including increasing the relative abundance of beneficial bacteria Lachnospiraceae,Ruminococcaceae and Muribaculaceae,and reducing the relative abundance of harmful bacteria *** together,our study demonstrated that preserved egg white could alleviate DSS-induced colitis in mice through the reduction of oxidative stress,modulation of inflammatory cytokines,NF-κB,MAPK and gut microbiota composition.

关键词： Preserved egg white Colitis Oxidative stress NF-κB MAPK Gut microbiota

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Lactobacillus pentosus S-PT84 and Rubus suavissimus leaf extract suppress lipopolysaccharide-induced gut permeability and egg allergen uptake

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食物生产加工与营养(英文) 2020年第1期2卷 33-40页

作者： Hiroaki Kanouchi Kaustav Majumder Hiroshi Shibata yoshinori mine Department of Food Science University of GuelphGuelphOntario N1G 2W1Canada Present Address:Department of Clinical Nutrition Osaka Prefecture University3-7-30Habikino-cityOsaka 583-8555Japan Present Address:Food Science and Technology Department University of NebraskaLincolnNE 68528USA Institute for Health Care Science Suntory Wellness Limited8-1-1 SeikadaiSeika-choSoraku-gunKyoto 619-0284Japan

Increased gut permeability facilitates the uptake of food allergens into the bloodstream and triggers allergenic *** present study aimed to evaluate the effect of Lactobacillus pentosus S-PT84(S-PT84)and Rubus suavissimus leaf extract(RSLE)against egg ovomucoid(OVM)-uptake in lipopolysaccharide(LPS)-induced increased gut-permeability mice model of food ***-eight weeks old,female C57BL6 mice were continuously fed with LPS(300μg/kg BW),for 3 months to increase gut *** in the expression of sealing claudin-4,increase in the expression of pore-forming claudin-2,and increase in D-mannitol absorption into the blood plasma in the LPS treated groups suggested the increase in gut permeability after LPS *** oral administration of major egg allergen,OVM,after LPS intervention,significantly increased the plasma mast cell protease-1 and OVMspecific IgE compared to the negative control *** results indicated that continuous LPS intervention developed OVM-induced food ***,both the treatment of S-PT84 and RSLE suppressed the claudin-2 expression and the gut permeability induced by ***,S-PT84 and RSLE treatment also reduced the plasma mast cell protease-1 and OVM-specific IgE,indicating the potential beneficial effect against LPS intervention developed OVM-induced food *** findings suggest that S-PT84 and RSLE ameliorated LPS induced gut permeability and food allergic reactions.

关键词： Gastro-intestinal tract Gut-permeability Food allergy Tight junction Claudin-2 Lipopolysaccharide Ovomucoid Rubus suavissimus Lactobacillus pentosus

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热处理后蛋白质及MTGase对猪肉糜凝胶特性的影响

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华南理工大学学报（自然科学版） 2007年第4期35卷 127-133页

作者： Upul Marapana 江波 yoshinori mine 江南大学食品学院江苏无锡214036 圭尔夫大学食品科学系

通过检测猪肉糜的流变特性、质构及颜色变化,研究了水浴、加压蒸煮和微波辐射3种热处理方式下,蛋白质及转谷氨酰胺酶(MTGase)添加量对猪肉糜凝胶特性的影响.结果表明:3种热处理方法下,一定量的转谷氨酰胺酶及肌肉蛋白使猪肉糜表现出不... 详细信息

通过检测猪肉糜的流变特性、质构及颜色变化,研究了水浴、加压蒸煮和微波辐射3种热处理方式下,蛋白质及转谷氨酰胺酶(MTGase)添加量对猪肉糜凝胶特性的影响.结果表明:3种热处理方法下,一定量的转谷氨酰胺酶及肌肉蛋白使猪肉糜表现出不同的颜色和质构特性;与其他两种方法相比,水浴加热使猪肉糜更具有弹性;加入MTGase后,样品的储能模量G′增大,表明MTGase的加入影响了猪肉糜的流变特性、颜色以及质构,其效力取决于猪肉糜的热处理方法.

关键词：热处理肌肉蛋白转谷氨酰胺酶猪肉糜凝胶特性

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Experimental study on boundary lubricity of superficial area of articular cartilage and synovial fluid

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Friction 2024年第5期12卷 981-996页

作者： Wenxiao LI Takehiro MORITA yoshinori SAWAE Departure of Mechanical Engineering Kyushu UniversityFukuoka8190395Japan International Institute for Carton-Neutral Energy Research Kyushu UniversityFukuoka8190395Japan Advanced Research Center for Biomechanics Kyushu UniversityFukuoka8190395Japan

The boundary lubrication mechanism at the articulating surface of natural synovial joints has been the subject of much discussion in *** this study,to elucidate the lubricating function of the superficial area of articular cartilage and synovial fluid(SF),cartilage specimens were processed with four different treatments:gentle and severe washing with detergent,incubation in NaCl solution,and trypsin digestion to selectively remove certain constituents from the cartilage ***,the frictional characteristics were examined in phosphate-buffered saline(PBS)and SF against *** reciprocating sliding tests with a spherical glass probe and square articular cartilage specimens were performed at low contact loads in the mN range to extract the frictional behavior in the superficial area of the cartilage ***,the cartilage surface was observed to confirm the effects of treatments on the morphology of the cartilage surface using a fluorescence microscope and water-immersion *** coefficient of friction(COF)of the prepared cartilage specimens was varied from 0.05 to over 0.3 in ***,a certain group of cartilage specimens exhibited a low COF of less than 0.1 with limited *** the low COF group of specimens,all four treatments increased the COF in PBS to different extents,and fluorescence microscopy revealed that the integrity of the cartilage surface was deteriorated by *** means that the intact cartilage surface had lubricating constituents to maintain low friction,and the removal of such constituents resulted in the loss of the intrinsic boundary lubricity of the cartilage *** variation in the COF of the cartilage specimens was suppressed in SF because it had a clear boundary lubrication effect on the cartilage *** lubricating effect of SF could be confirmed even after degenerative treatment.

关键词： articular cartilage synovial fluid the uppermost superficial layer boundary lubrication

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鸡消化道的重要天然免疫效应分子-抗菌肽

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中国预防兽医学报 2008年第12期30卷 987-991页

作者：黎观红游金明瞿明仁 mine yoshinori 江西农业大学动物科技学院江西南昌330045 Ontario Agricultural College University of Guelph Guelph Ontario N1G 2W1 Canada

抗菌肽广泛分布于动植物及昆虫体内，是天然免疫（非特异性免疫）防御系统的重要组成部分。抗菌肽不仅有广谱抗细菌能力，还可以抗真菌、被膜病毒等多种微生物及抗寄生虫，而且对一些恶性肿瘤细胞和艾滋病毒等也有杀伤作用。动物内源性... 详细信息

抗菌肽广泛分布于动植物及昆虫体内，是天然免疫（非特异性免疫）防御系统的重要组成部分。抗菌肽不仅有广谱抗细菌能力，还可以抗真菌、被膜病毒等多种微生物及抗寄生虫，而且对一些恶性肿瘤细胞和艾滋病毒等也有杀伤作用。动物内源性抗菌肽是基因编码的阳离子多肽，在机体组织中分布广泛，尤其是那些与微生物密切接触的上皮组织如消化道、呼吸道、生殖道粘膜上皮和皮肤，抗菌肽在机体局部抗感染与免疫方面发挥着重要作用。

关键词：非特异性免疫抗菌肽消化道效应分子天然恶性肿瘤细胞艾滋病毒机体组织

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不同大豆分离蛋白凝胶的流变学性质

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中国粮油学报 2003年第6期18卷 43-48页

作者：华欲飞 Steve W.Cui Qi Wang yoshinori mine 江南大学食品学院无锡210036

本文比较研究了三种不同大豆分离蛋白 (分别为SG、ADM和ON)的凝胶性能。三种大豆分离蛋白的 7S/ 11S比率和变性热焓类似 ,但表面疏水性和混浊度却明显不同。通过小变形振荡流变分析研究了三种大豆分离蛋白的热凝胶性能。在去离子水中 ,S... 详细信息

本文比较研究了三种不同大豆分离蛋白 (分别为SG、ADM和ON)的凝胶性能。三种大豆分离蛋白的 7S/ 11S比率和变性热焓类似 ,但表面疏水性和混浊度却明显不同。通过小变形振荡流变分析研究了三种大豆分离蛋白的热凝胶性能。在去离子水中 ,SG和ADM的凝胶浓度均是 90mg/ml,且两者的凝胶强度接近 ;ON的凝胶浓度是 110mg/ml。在 1.0mol/LNaCl溶液中 ,ADM的凝胶强度高于SG。在NaSCN存在的情况下 ,ON的凝胶强度明显增加。尽管N -乙基马来酰亚胺 (NEM )能够封闭巯基 ,但该试剂可增强三种大豆分离蛋白的凝胶强度。结果显示SG和ADM之间的凝胶性能的差别主要是由于表面疏水性不同。

关键词：大豆大豆分离蛋白流变学性质凝胶性能小变形振荡流变分析

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前景广阔的鸡蛋生物活性物质

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中国家禽 2004年第14期26卷 43-48页

作者：刘向萍 yoshinori mine Jennifer Kovacs-Nolan

鸡蛋作为一种食品营养的来源已广为人所知,但是进一步的研究证实了鸡蛋中存在生物活性物质,现在证明鸡蛋的特定成分与很多种生物功能如疾病防治、抵抗细菌、抵抗病毒、抵抗癌症、免疫调节等有关,这表明了鸡蛋和鸡蛋内容物在人类健康中... 详细信息

鸡蛋作为一种食品营养的来源已广为人所知,但是进一步的研究证实了鸡蛋中存在生物活性物质,现在证明鸡蛋的特定成分与很多种生物功能如疾病防治、抵抗细菌、抵抗病毒、抵抗癌症、免疫调节等有关,这表明了鸡蛋和鸡蛋内容物在人类健康中的重要性。这些生物活性物质已经受到广泛重视,有些已形成产业化发展,并且已应用于人都揭示了鸡蛋中的生物活性物质将在医学、营养保健和食品强化等方面得到更为广泛的应用。和卵磷脂。所有这些信息都揭示了鸡蛋中的生物活性物质将在医学、营养保健和食品强化等方面得到更为广泛的应用。

关键词：鸡蛋生物活性物质营养人类健康

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Regeneration mechanisms and therapeutic strategies for neuromuscular junctions in aging and diseases

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Neural Regeneration Research 2025年第1期20卷 193-194页

作者： Masashi Fujitani Abu Md Mamun Tarif yoshinori Otani Department of Anatomy and Neuroscience Faculty of MedicineShimane UniversityShimaneJapan

The neuromuscular junction(NMJ)is an essential synaptic structure composed of motor neurons,skeletal muscles,and glial cells that orchestrate the critical process of muscle contraction(Li et al.,2018).The typical NMJ structure is classically described as having a“pretzel-like”shape in mice(Figure 1),whereas human NMJs have a smaller,fragmented structure throughout *** NMJs exhibit smaller or fragmented endplates,partial denervation,reduced numbers of synaptic vesicles,abnormal presynaptic mitochondria,and dysfunctional perisynaptic Schwann cells(Alhindi et al.,2022).

关键词： aging structure Figure

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Development of a scintillating-fiber-based beam monitor for the coherent muon-to-electron transition experiment

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Nuclear Science and Techniques 2024年第4期35卷 156-164页

作者： Yu Xu Yun-Song Ning Zhi-Zhen Qin Yao Teng Chang-Qing Feng Jian Tang Yu Chen yoshinori Fukao Satoshi Mihara Kou Oishi School of Physics Sun Yat-sen UniversityGuangzhou 510275China State Key Laboratory of Particle Detection and Electronics University of Science and Technology of ChinaHefei 230026China Department of Modern Physics University of Science and Technology of ChinaHefei 230026China High Energy Accelerator Research Organization(KEK) Ibaraki 305‑0801Japan Department of Physics Imperial College LondonLondon SW72AZUK

The coherent muon-to-electron transition(COMET)experiment is a leading experiment for the coherent conversion of μ^(-)N→e^(-)N using a high-intensity pulsed muon beamline,produced using innovative slow-extraction ***,it is critical to measure the muon beam *** set up a muon beam monitor(MBM),where scintillating fibers woven in a cross shape were coupled to silicon photomultipliers to measure the spatial profile and timing structure of the extracted muon beam for the *** MBM detector was tested successfully with a proton beamline at the China Spallation Neutron Source and took data with good performance in the commissioning *** development of the MBM,including its mechanical structure,electronic readout,and beam measurement results,are discussed.

关键词： Beam instrumentation Profile monitor Scintillating fiber Silicon photomultipliers

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Ssu72磷酸酶缺失导致减数第二次分裂过程中纺锤体交叉

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遗传 2024年第6期46卷 502-508页

作者：闫静亮马玲玲渡边嘉典江南大学未来食品科学中心无锡214122 江南大学生物工程学院无锡214122

Ssu72磷酸酶是酵母裂解/多聚腺苷化因子(cleavage/polyadenylation factor,CPF)复合物的组成成分,可以催化RNA聚合酶II的C末端结构域(C-terminal domain,CTD)S5-P、S7-P的去磷酸化。后又有研究指出Ssu72磷酸酶参与有丝分裂过程中染色体... 详细信息

Ssu72磷酸酶是酵母裂解/多聚腺苷化因子(cleavage/polyadenylation factor,CPF)复合物的组成成分,可以催化RNA聚合酶II的C末端结构域(C-terminal domain,CTD)S5-P、S7-P的去磷酸化。后又有研究指出Ssu72磷酸酶参与有丝分裂过程中染色体凝聚力的调控。为进一步明确Ssu72磷酸酶是否会影响裂殖酵母减数分裂过程中染色体的分离,本研究利用绿色荧光蛋白(green fluorescent protein,GFP)标记着丝粒、红色荧光蛋白标记微管蛋白Atb2,并在荧光显微镜下实时观察ssu72Δ细胞的整个减数分裂染色体分离过程。结果表明,ssu72Δ细胞在减数第二次分裂中后期发生纺锤体交叉,并且这种纺锤体的交叉产生了一种新型的孢子排布缺陷模式。本研究为高等生物中磷酸酶Ssu72的研究提供重要的借鉴意义。

关键词：裂殖酵母减数分裂 Ssu72 纺锤体交叉

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