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Biosurface and Biotribology 2018年第1期4卷 24-33页

作者： Nobuo Sakai Seido Yarimitsu yoshinori Sawae Mochimitsu Komori Teruo Murakami Integrated System Engineering Kyushu Institute of TechnologyKitakyushuJapan Intelligent Mechanical Systems System DesignTokyo Metropolitan UniversityTokyoJapan Mechanical Engineering Kyushu UniversityFukuokaJapan Research Center for Advanced Biomechanics Kyushu UniversityFukuokaJapan Medical Technology Teikyo UniversityOmutaJapan

The soft hydrogel material is expected for a candidate material as biomimetic artificial cartilage with synergisticfunctionalities of adaptive multimode *** boundary lubrication mode of hydrogel material,the biphasiclubrication mechanism cooperatively exerts its *** hydrodynamic lubrication mode,it is preferable that thelubricating surfaces be impermeable to trap the fluid pressure in contact surfaces,whereas the actual biphasic materiallike a hydrogel is a permeable material with surface *** is indicated that the interstitial fluid pressurisation inthe permeable biphasic material can contribute to significant fluid load support under lower sliding speed ***,the authors examined how the contrary fluid pressure effect appears in the transition from the boundarylubrication mode to soft elastohydrodynamic lubrication *** the experiment,a small pressure sensor was utilisedto measure the in-situ fluid pressure in sliding *** the experimental condition of this study wasselective,the result showed a possibility of the negative effect of the biphasic surface,in which the permeable surfacediminished the hydrodynamic fluid *** means that one should manage and enhance the biphasic lubricationabilities in wide operation range when the hydrogel material was used as a load bearing material.

关键词： hydrogel behaviour synergistic

Interactions among dwarf bamboo, litter and consumption by small vertebrates place multiple constraints on the establishment of native tree seedlings in a Japanese agricultural landscape

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Journal of Plant Ecology 2019年第2期12卷 292-305页

作者： yoshinori Tokuoka Kentaro Ohigashi Koji Watanabe Hiroshi Yamaguchi Takahiro Ara Nobukazu Nakagoshi Division of Biodiversity Institute for Agro-Environmental SciencesNational Agriculture and Food Research Organization3-1-3KannondaiTsukuba-shiIbaraki 305-8604Japan Division of Informatics and Inventory Institute for Agro-Environmental SciencesNational Agriculture and Food Research Organization3-1-3KannondaiTsukuba-shiIbaraki 305-8604Japan Department of Planning and Coordination Tsukuba Technical Support CenterNational Agriculture and Food Research Organization3-1-3KannondaiTsukuba-shiIbaraki 305-8604Japan Graduate School for International Development and Cooperation Hiroshima University1-5-1 KagamiyamaHigashi-Hiroshima 739-8529Japan

Aims Faunal assemblage alterations due to anthropogenic impacts have changed herbivore-vegetation relationships in various ecosystems,but the influences of small vertebrates on revegetation processes remain *** a peri-urban agricultural landscape in eastern Japan that lacks large ungulates but supports small generalist herbivores,fewer native seedlings have become established in thickets dominated by native dwarf bamboo,Pleioblastus chino(*** Sav.)*** mechanisms limiting tree seedling establishment are *** aim here was to evaluate the influence of interactions among the dwarf bamboo,its litter cover and small vertebrate herbivores on the micro-site conditions governing the establishment of native tree seedlings from different successional stages in an old field in temperate *** First,seedling emergence and survival of seeded Pinus densiflora Siebold et Zucc.,Celtis sinensis Pers.,Aphananthe aspera(Thunb.)Planch.,Quercus serrata Murray,Quercus myrsinifolia Blume and Castanopsis sieboldii(Makino)*** *** Mashiba were observed in a factorial design that accounted for the presence or absence of dwarf bamboo and its litter cover,as well as the exclu-sion or access of small vertebrate fauna,in 2009 and *** identify small vertebrate herbivores that reduced the emergence or survival of tree seedlings in the first experiment,reseeding experi-ments using ***,***,*** and *** were conducted by video trapping in 2011 and video and still-cam-era trapping in *** Findings The abiotic conditions under the dwarf bamboo were lethal to early-to mid-successional ***,***,*** and *** but led to better survival-although spindly growth-of late-succes-sional *** and *** main consumers and the plants they found palatable differed between the bamboo thickets and the intervening *** by mice appeared to have severely limited the emergence of

关键词： bamboo cover farmland abandonment microsite limitation selective herbivory Pleioblastus chino

Novel multi-parametric diagnosis of non-alcoholic fatty liver disease using ultrasonography,body mass index,and Fib-4 index

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World Journal of Gastroenterology 2023年第23期29卷 3703-3714页

作者： Kei Funada Yumi Kusano yoshinori Gyotoku Ryosaku Shirahashi Toshikuni Suda Masaya Tamano Department of Gastroenterology Dokkyo Medical University Saitama Medical CenterKoshigaya-shi 343-8555SaitamaJapan

BACKGROUND Shear wave speed(SWS),shear wave dispersion(SWD),and attenuation imaging(ATI)are new diagnostic parameters for non-alcoholic fatty liver *** differentiate between non-alcoholic steatohepatitis(NASH)and non-alcoholic fatty liver(NAFL),we developed a clinical index we refer to as the“NASH pentagon”consisting of the 3 abovementioned parameters,body mass index(BMI),and Fib-4 *** To investigate whether the area of the NASH pentagon we propose is useful in discriminating between NASH and *** This non-invasive,prospective,observational study included patients diagnosed with fatty liver by abdominal ultrasound between September 2021 and August 2022 in whom shear wave elastography,SWD,and ATI were *** diagnosis based on liver biopsy was performed in 31 *** large pentagon group(LP group)and the small pentagon group(SP group),using an area of 100 as the cutoff,were compared;the NASH diagnosis rate was also *** patients with a histologically confirmed diagnosis,receiveroperating characteristic(ROC)curve analyses were *** One hundred-seven patients(61 men,46 women;mean age 55.1 years;mean BMI 26.8 kg/m2)were *** LP group was significantly older(mean age:60.8±15.2 years vs 46.4±13.2 years;P<0.0001).Twenty-five patients who underwent liver biopsies were diagnosed with NASH,and 6 were diagnosed with *** ROC curve analyses,the areas under the ROC curves for SWS,dispersion slope,ATI value,BMI,Fib-4 index,and the area of the NASH pentagon were 0.88000,0.82000,0.58730,0.63000,0.59333,and 0.93651,respectively;the largest was that for the area of the NASH *** The NASH pentagon area appears useful for discriminating between patients with NASH and those with NAFL.

关键词： Non-alcoholic fatty liver disease Non-alcoholic steatohepatitis Attenuation imaging Shear wave elastography Shear wave dispersion Diagnosis

Clinicopathological utility of sialoglycoconjugates in diagnosing and treating colorectal cancer

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World Journal of Gastroenterology 2014年第20期20卷 6123-6132页

作者： yoshinori Inagaki Jianjun Gao Peipei Song Norihiro Kokudo Munehiro Nakata Wei Tang Hepato-Biliary-Pancreatic Surgery Division Department of Surgery Graduate School of Medicine the University of Tokyo Tokyo 113-8655 Japan Department of Applied Biochemistry Tokai University Hiratsuka Kanagawa 259-1292 Japan

Aberrant expression of glycoconjugates occurs during malignant transformation of cancer *** of sialoglycoconjugates in particular may play an important role in the progression,i.e.,invasion or metastasis,of *** types of sialoglycoconjugates have been investigated to clarify their biological significance and clinical utility in diagnosing and treating colorectal *** review focuses specifically on expression of mucin(MUC)1 and it suggests that MUC1with the specific structure of a sialo-oligosaccharide has biological significance in determining the metastatic potential of colorectal cancer cells and clinicopathological utility in evaluating the effectiveness of treatments and the prognosis for patients with colorectal *** studies are expected to contribute to the expanded use of cancer-associated sialoglycoconjugates in cancer diagnosis and therapy.

关键词： Sialoglycoconjugates Sialic acid Mucin 1 Colorectal cancer Invasion Metastasis

Supramolecular photoresponsive polyurethane with movable crosslinks based on photoisomerization of azobenzene

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Aggregate 2024年第2期5卷 336-344页

作者： Xin Zhou Ryohei Ikura Changming Jin Kenji Yamaoka Junsu Park yoshinori Takashima Department of Macromolecular Science Graduate School of ScienceOsaka UniversityToyonakaJapan Forefront Research Center Graduate School of ScienceOsaka UniversityToyonakaJapan Innovative Catalysis Science Division Institute for Open and Transdisciplinary Research Initiatives(OTRI)Osaka UniversitySuitaJapan

Light-driven actuators are widely used for smart devices such as soft *** of the main challenges for actuators is achieving rapid responsiveness,in addition to ensuring favorable mechanical ***,we focused on photoresponsive polyurethane(CD-Azo-PU)based on controlling the crystallization of the hard segments in polyurethane(PU)by complexation between azobenzene(Azo)and cyclodextrins(CDs).CD-Azo-PU incorporated polyurethane as the main chain and a 1:2 inclusion complex between Azo andγCD as a movable crosslink *** ultraviolet light(UV,λ=365 nm)irradiation,the photoresponsiveness of CD-Azo-PU bent toward the light source(defined as positive),while that of the linear Azo polyurethane(Azo-LPU)without peracetylatedγ-cyclodextrin diol(TAcγCD-diOH)as a movable crosslinker bent in the direction opposite the light *** bending rates were determined to be 0.25◦/s for CD-Azo-PU and 0.083◦/s for Azo-LPU,indicating that the bending rate for CD-Azo-PU was faster than that for *** incorporating movable crosslinks into CD-Azo-PU,we successfully achieved specific photoresponsive actuation with an enhanced rate.

关键词： hydrogen bonding movable crosslink photoresponsive polyurethane supramolecular materials UV irradiation

Combining the age-male-albumin-bilirubin-platelets score and shear wave elastography stratifies carcinogenic risk in hepatitis C patients after viral clearance

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World Journal of Clinical Cases 2023年第22期11卷 5204-5214页

作者： Rion Masaoka yoshinori Gyotoku Ryosaku Shirahashi Toshikuni Suda Masaya Tamano Department of Gastroenterology Dokkyo Medical University Saitama Medical CenterKoshigaya 343-8555SaitamaJapan

BACKGROUND The treatment of hepatitis C with direct-acting antiviral agents(DAAs)produces a high rate of sustained virological response(SVR)with fewer adverse events than interferon(IFN)therapy with a similar effect in inhibiting carcinogenesis as IFN *** age-male-albumin-bilirubin-platelets(aMAP)score is useful for stratifying the risk of hepatocellular carcinoma in chronic hepatitis patients,and the velocity of shear waves(Vs)measured by shear wave elastography has also been shown to be useful for diagnosing the level of fibrotic progression in hepatitis C and predicting carcinogenic *** these two may improve the prediction of carcinogenic *** To determine whether combining the aMAP score with Vs improves carcinogenic risk stratification in medium-to-high-risk hepatitis C *** This retrospective,observational study involved hepatitis C patients treated with DAAs who achieved *** was measured before treatment(baseline),at the end of treatment(EOT),and 12 wk(follow-up 12)and 24 wk(follow-up 24)after *** patients were followed for at least six months after EOT to determine whether cancer *** regression analysis was used to identify factors contributing to hepatic *** diagnostic performances of clinical parameters for predicting the presence of hepatocellular carcinoma were evaluated using receiver-operating characteristic(ROC)curve *** A total of 279 patients(mean age 65.9 years,118 males,161 females)were included in the *** regression analysis was performed with carcinogenesis as the target variable and alanine aminotransferase,platelets,α-fetoprotein,Vs,and the Fib-4 index as explanatory variables;only Vs was found to be significant(P=0.0296).The cut-off value for Vs for liver carcinogenesis calculated using the ROC curve was 1.53 m/*** developed in 2.0%(3/151)of those with Vs<1.53 m/s and in 10.5%(9/86)of those with Vs≥1.53 m/*** In hepatitis

关键词： Hepatitis C Hepatocellular carcinoma Direct-acting antiviral therapy Shear wave elastography Sustained virological response Age-male-albumin-bilirubin-platelets score

Heat and mass transfer through spiral tubes in absorber of absorption heat pump system for waste heat recovery

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Propulsion and Power Research 2017年第2期6卷 140-146页

作者： yoshinori Itaya Masatoshi Yamada Kenji Marumo Nobusuke Kobayashi Environmental and Renewable Energy System Division.Graduate School of Engineering.Gifu University 501-1193 GifuJapa Research and Development Section Morimatsu Research Institute Co.Ltd.1057-1 Yai501-0417 MotosuJapan

Heat and mass transfer of a LiBr/water absorption heat pump system(AHP)was experimentally studied during working a heating-up *** examination was performed for a single spiral tube,which was simulated for heat transfer tubes in an *** inside and outside of the tube were subjected to a film flow of the absorption liquid and exposed to the atmosphere,*** maximum temperature of the absorption liquid was observed not at the entrance but in the region a little downward from the entrance in the *** steam absorption convective heat transfer coefficient between the liquid film flowing down and the inside wall of the temperature and the film temperature at the maximum temperature location and the *** film heat and mass transfer coefficients rose with increasing Reynolds number of the liquid film *** coefficients showed opposite trend to the empirical correlation reported for laminar film flow on a straight smooth tube in a refrigeration mode in the past *** fact can be caused due to a turbulent promotion effect of the liquid in a spiral tube.

关键词： Absorption heat pump A single spiral tube Heat and mass transfer Lithium bromide/water Film heat transfer coefficient Mass transfer coefficient Waste heat recovery

Analysis of Synchronization of n Metronomes on a Hanging Plate via Describing Function Method without Assumption on Amplitudes of Metronomes 36

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Analysis of Synchronization of n Metronomes on a Hanging Pla...

Sorafenib-based combined molecule targeting in treatment of hepatocellular carcinoma

第36届中国控制会议

作者： Xin Xin yoshinori Muraoka Shinsaku Izumi Taiga Yamasaki Faculty of Computer Science and Systems Engineering Okayama Prefectural University

ISBN: (纸本)9781538629185

This paper aims to analyze the synchronization phenomena in the system consisting of n identical metronomes on a hanging plate by using the describing function（DF） method, which deals with the driving torque as a discontinuous function of the angle and angular velocity of each metronome. Different from a previous study on the synchronization of the system with the first harmonic of the angle of each metronome having the same amplitude, this paper analyzes the synchronization without any assumption on the amplitudes of n metronomes. By investigating the relation between the motion of the hanging plate（common base） and n metronomes, this paper characterizes the synchronization phenomena by the following two types of synchronization:One is the inherent synchronization, whose frequency and amplitude of all synchronized metronomes are the same as those of a single metronome on a fixed base. The other is the non-inherent synchronization, which includes the in-phase synchronization with the same amplitude, and the synchronization with different amplitudes. The analytical results are validated by numerical simulation for three metronomes about the synchronization with the same or different amplitudes.

关键词： Synchronization metronomes pendulum clocks describing function phasor representation

来源： cnki会议评论

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World Journal of Gastroenterology 2015年第42期21卷 12059-12070页

作者： Jian-Jun Gao Zhen-Yan Shi Ju-Feng Xia yoshinori Inagaki Wei Tang Department of Pharmacology School of Pharmaceutical Sciences Qingdao University Hepato-Biliary-Pancreatic Surgery Division Department of Surgery Graduate School of MedicineThe University of Tokyo

Sorafenib is the only and standard systematic chemotherapy drug for treatment of advanced hepatocellular carcinoma(HCC) at the current stage. Although sorafenib showed survival benefits in large randomized phase Ⅲ studies, its clinical benefits remain modest and most often consist of temporary tumor stabilization, indicating that more effective first-line treatment regimens or second-line salvage therapies are required. The molecular pathogenesis of HCC is very complex, involving hyperactivated signal transduction pathways such as RAS/RAF/MEK/ERK and PI3K/AKT/m TOR and aberrant expression of molecules such as receptor tyrosine kinases and histone deacetylases. Simultaneous or sequential abrogation of these critical pathways or the functions of these key molecules involved in angiogenesis, proliferation, and apoptosis may yield major improvements in the management of HCC. In this review, we summarize the emerging sorafenib-based combined molecule targeting for HCC treatment and analyze the rationales of these combinations.

关键词： Angiogenesis Mammalian target of rapamycin Extrace

Slip-draft embedded control system by adaptively adjusting the battery position for electric tractor

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International Journal of Agricultural and Biological Engineering 2023年第5期16卷 155-164页

作者： Minghui Wang Pucai Ning Ke Su Gejima yoshinori Wei Wang Yongjie Cui Gongpei Cui College of Mechanical and Electronic Engineering Northwest A&F UniversityYangling 712100ShaanxiChina SAIC Motor Technical Center Shanghai 201804China School of Arts and Design Qilu University of Technology(Shandong Academy of Sciences)Jinan 250353China Faculty of Agriculture.University of Miyazaki Miyazaki 8892192Japan Key Laboratory of Agricultural Internet of Things Ministry of Agriculture and Rural AffairsYangling 712100ShaanxiChina Shaanxi Key Laboratory of Agricultural Information Perception and Intelligent Service Yangling 712100ShaanxiChina College of Mechanical&Electrical Engineering Henan Agricultural UniversityZhengzhou 450002China

A slip-draft embedded control system was designed and developed for an independent developed 2WD(two-wheel drive)electric tractor,to improve the traction efficiency,operation performance and ploughing depth stability of the electric *** this system,the battery of electric tractor was innovatively equivalent to the original counterweight of the fuel *** through dynamic analysis of electric tractor during ploughing,the mathematical model of adjusting the center of gravity about draft force and slip rate was *** the automatic adjustment of the center of gravity for electric tractor was realized through the adaptive adjustment of battery ***,the system was carried on electric tractor for performance evaluation under different ploughing conditions,the traction efficiency,slip rate and front wheel load of electric tractor were measured and controlled synchronously to make it close to the set *** the comparative experiments of ploughing operation were carried out under the two modes of adaptive adjustment of center of gravity and fixed center of *** test results showed that,based on the developed control system,the center of gravity of electric tractor can be adjusted in real time according to the complex changes of working *** ploughing operation with adjusting adaptively battery position,the average values of traction efficiency,slip rate,front wheel load and relative error of tillage depth of electric tractor were 64.5%,22.2%,2045.0 N and 2.0%*** were optimized by 15.0%,29.5%,19.6%and 80.0%respectively,compared with electric tractor with fixed battery *** slip-draft embedded control system can not only realize the adaptive adjustment of the center of gravity position in the ploughing process of electric tractor,but also improve the traction efficiency and the stability of ploughing depth,which can provide reference for the actual production operation of electric tractor.

关键词： electric tractor embedded control system adjusting adaptively center of gravity position performance test