Sorafenib-based combined molecule targeting in treatment of hepatocellular carcinoma
Sorafenib-based combined molecule targeting in treatment of hepatocellular carcinoma作者机构：Department of PharmacologySchool of Pharmaceutical Sciences Qingdao University Hepato-Biliary-Pancreatic Surgery Division Department of Surgery Graduate School of MedicineThe University of Tokyo
出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)
年 卷 期：2015年第21卷第42期
页 面：12059-12070页
核心收录：
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
主 题：Angiogenesis Mammalian target of rapamycin Extrace
摘 要：Sorafenib is the only and standard systematic chemotherapy drug for treatment of advanced hepatocellular carcinoma(HCC) at the current stage. Although sorafenib showed survival benefits in large randomized phase Ⅲ studies, its clinical benefits remain modest and most often consist of temporary tumor stabilization, indicating that more effective first-line treatment regimens or second-line salvage therapies are required. The molecular pathogenesis of HCC is very complex, involving hyperactivated signal transduction pathways such as RAS/RAF/MEK/ERK and PI3K/AKT/m TOR and aberrant expression of molecules such as receptor tyrosine kinases and histone deacetylases. Simultaneous or sequential abrogation of these critical pathways or the functions of these key molecules involved in angiogenesis, proliferation, and apoptosis may yield major improvements in the management of HCC. In this review, we summarize the emerging sorafenib-based combined molecule targeting for HCC treatment and analyze the rationales of these combinations.
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