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中华结核和呼吸杂志 1997年第Z1期20卷 74-74页

作者： Mizuki M Miyazaki E Abe Y yoshimatsu t Shigenaga t tsuda t 费贵军(译) thirdDepartmentofMedicine OitaMedicalUniversityOitaJapan

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Orexin-a regulates body temperature in coordination with control of arousal state

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中国病理生理杂志 2001年第8期 77-78页

作者： G.Yoshimichi H.yoshimatsu t.Masaki t.Sakata Department of Internal Medicine I School of Medicine Oita Medical University Oita Japan

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Clinical impact of minimal cancer cell detection in various colorectal cancer specimens

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World Journal of Gastroenterology 2014年第35期20卷 12458-12461页

作者： Kazuhiko yoshimatsu Hajime Yokomizo Yoshihiko Naritaka Department of Surgery Tokyo Women’s Medical UniversityMedical Center East

Detection of cancer cells using molecular targets is achieved by combining immunochemical reactions with gene amplification *** enables the detection of cancer cells in specimens that are traditionally determined to be *** improvements in detection can lead to prognoses that are different from those derived by conventional pathological *** is worse when cancer cells are detected in regional lymph nodes compared to when the nodes are ***,the circulating tumor cell(CtC) count increases as the cancer ***,there is a correlation between CtC count and ***,large-scale prospective studies are required to confirm *** development of more convenient and cost-effective analysis techniques will facilitate the practical application of these findings.

关键词： Micrometastasis Circulating tumor cell Colorectal cancer Prognosis Molecular marker

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Utility of co-transplanting mesenchymal stem cells in islet transplantation

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World Journal of Gastroenterology 2011年第47期17卷 5150-5155页

作者： Naoaki Sakata Masafumi Goto Gumpei yoshimatsu Shinichi Egawa Michiaki Unno Division of Hepato-Biliary-Pancreatic Surgery Department of Surgery Tohoku University Graduate School of Medicine 1-1 Seiryo-machi Aoba-ku Sendai Miyagi 980-8574 Japan Division of Advanced Surgical Science and technology Tohoku University Graduate School of Medicine 1-1 Seiryo-machi Aoba-ku Sendai Miyagi 980-8574 Japan New Industry Creation Hatchery Center Tohoku University Graduate School of Medicine 1-1 Seiryomachi Aoba-ku Sendai Miyagi 980-8574 Japan

Islet transplantation is characterized by the transplantation of isolated islets from donor pancreata into a diabetic recipient. Although it is a viable choice in the treatment of insulin dependent diabetes mellitus, most patients (approximately 90%) require insulin five years after transplantation. Recently, the co-transplantation of mesenchymal stem cells (MSCs) and islets in animal studies has revealed the effectiveness of MSCs co-transplantation for improving islet function. themechanisms underlying the beneficial impact of MSCs include immunomodulation and the promotion of angiogenesis. In this review, we discuss MSCs and how they support improved graft survival and function.

关键词： Mesenchymal stem cell Islet transplanta-tion Bone marrow Immunomodulatory Regulatory tcell Angiogenesis Vascular endothelial growth factor Diabetes mellitus

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Music effect on pain threshold evaluated with current perception threshold

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中国病理生理杂志 2001年第8期 78-79页

作者： t.Fukagawa K.Fukagawa K.Goto H.yoshimatsu t.Sakata First Department of Internal Medicine Oita Medical University Oita-gun Oita 879-5593 Japan

AIM: Music relieves anxiety and psychotic tension. this effect of music is applied to surgical operation in the hospital and dental office. It is still unclear whether this music effect is only limited to the psychological aspect but not to the physical aspect or whether its music effect is influenced by the mood or emotion of audience. to elucidate these issues, we evaluated the music effect on pain threshold by current perception threshold (CPt) and profile of mood states (POMC) test. MEtHODS: Healthy 30 subjects (12 men, 18 women, 25-49 years old, mean age 34.9) were tested. (1)After POMC test, all subjects were evaluated pain threshold with CPt by Neurometer (Radionics, USA) under 6 conditions, silence, listening to the slow tempo classic music, nursery music, hard rock music, classic paino music and relaxation music with 30 seconds interval. (2)After Stroop color word test as the stresser, pain threshold was evaluated with CPt under 2 conditions, silence and listening to the slow tempo classic music. RESULtS: Under litening to the music, CPt sores increased, especially 2 000 Hz level related with compression, warm and pain sensation. type of music, preference of music and stress also affected CPt score. CONCLUSION: the present study demonstrated that the concentration on the music raise the pain threshold and that stress and mood influence the music effect on pain threshold.

关键词： Music effect on pain threshold evaluated with current perception threshold

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Mucosal patterns change after Helicobacter pylori eradication:Evaluation using blue laser imaging in patients with atrophic gastritis

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World Journal of Gastroenterology 2023年第17期29卷 2657-2665页

作者： Yoshiyuki Nishikawa Yoshio Ikeda Hidehiro Murakami Shin-Ichiro Hori Megumi yoshimatsu Naoki Nishikawa Department of Gastroenterology Nishikawa Gastrointestinal ClinicMatsuyama 790-0878EhimeJapan Endoscopy Center Ehime University HospitalToon 791-0295EhimeJapan Department of Internal Medicine Saiseikai Matsuyama HospitalMatsuyama 791-8026EhimeJapan Department of Gastroenterology Himeji Red Cross HospitalHimeji 670-8540HyogoJapan Department of Gastroenterology National Hospital Organization Shikoku Cancer CenterMatsuyama 791-0280EhimeJapan Department of Gastroenterology Matsuyama Shimin HospitalMatsuyama 790-0067EhimeJapan

BACKGROUND Mucosal patterns(MPs)observed on blue laser imaging in patients with atrophic gastritis can be classified as spotty,cracked,and ***,we hypothesized that the spotty pattern may change to the cracked pattern after Helicobacter pylori(***)*** to further substantiate and comprehensively investigate MP changes after *** eradication in a larger number of *** We included 768 patients who were diagnosed with atrophic gastritis with evaluable MP using upper gastrointestinal endoscopy at the Nishikawa Gastrointestinal Clinic,*** them,325 patients were ***-positive,and of them,101 patients who underwent upper gastrointestinal endoscopy before and after *** eradication were evaluated for post-eradication MP *** patients’MPs were interpreted by three experienced endoscopists who were blinded to their clinical *** Among 76 patients with the spotty pattern before or after *** eradication,the pattern disappeared or decreased in 67 patients[88.2%,95%confidence interval(CI):79.0%-93.6%),appeared or increased in 8 patients(10.5%,95%CI:5.4%-19.4%),and showed no change in 1 patient(1.3%,95%CI:0.2%-7.1%).In 90 patients with the cracked pattern before or after *** eradication,the pattern disappeared or decreased in 7 patients(7.8%,95%CI:3.8%-15.2%),appeared or increased in 79 patients(87.8%,95%CI:79.4%-93.0%),and showed no change in 4 patients(4.4%,95%CI:1.7%-10.9%).In 70 patients with the mottled pattern before or after *** eradication,the pattern disappeared or decreased in 28 patients(40.0%,95%CI:29.3%-51.7%),appeared or increased in 35 patients(50.0%,95%CI:38.6%-61.4%),and showed no change in 7 patients(10.0%,95%CI:4.9%-19.2%).CONCLUSION After *** eradication,MPs changed from spotty to cracked in most patients,which may help endoscopists easily and precisely evaluate ***-related gastritis status.

关键词： Atrophic gastritis Helicobacter pylori Gastrointestinal endoscopy Image enhancement Classification

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Effect of dietary docosahexaenoic acid on lipogenesis and lipolysis in black sea bream,Acanthopagrus schlegeli

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Acta Oceanologica Sinica 2007年第1期26卷 112-121页

作者： JI Hong OM Ahamd Daud yoshimatsu takao UMINO testuya NAKAGAWA Heisuke FURUHASHI Makoto SAKAMOtO Shuichi College of Animal Science and technology Northwest Agriculture and Forestry University Shaanxi 712100 China Graduate School of Biosphere Science Hiroshima University Higashi - hiroshima 739 - 8528 Japan Marine Finfish Production and Research Center Terengganu 22200 Malaysia Farming System Division National Research Institute of Aquaculture Fisheries Research Agency Mie 516 -0913 Japan Oriental Yeast Co Ltd Chiba 281 -0002 Japan

Hatchery-roared juvenile black sea breams are characterized by a low level of highly unsaturated fatty acids in their bodies, as compared with wild fish. to assess the effect of docosahaxaenoic acid （DHA） on lipegenic and lipelysis enzymes, one-year fish were roared on a casein-based purified diet and a DHA fortified diet （ 1.5% DHA ethyl ester/kg diet） for 60 d, followed with a period of 55 d for starvation. Dietary DHA was effectively incorporated into the fish body. Fortification of DHA depressed activities of glucose-6-phosphate dehydrogenase and NADP-isocitrate dehydrogenase as lipogenic enzymes in the hepatopancroas and intraperitoneal fat body. Carnitine palmitoyltransferase as lipolysis enzyme in the hepatopancreas was active in the DHA fortified fish. Starvation after feeding experiment induced increased carnitine palmitoyltransferase activity in both control and DHA fortified fish and the activity remained higher in the DHA fortified fish, while the monoenes were selectively consumed prior to highly unsaturated fatty acids. these results indicated that dietary DHA depressed lipogenesis and activated lipolysis.

关键词： DHA enzyme lipogenesis lipolysis black sea bream

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Anti-obesity and anti-diabetic actions of histamine neurons

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中国病理生理杂志 2001年第8期 66-66页

作者： t.Sakata t Masaki H yoshimatsu Department of Internal Medicine School of Medicine Oita University Hasama Oita 879-5593 Japan

the present study aimed to examine roles of histamine neurons in leptin signaling pathways and leptin resistant states. H1-receptor knockout (H1KO) mice showed no change in daily food intake, adiposity, growth curve, basal expression of hypothalamic neuropeptides, uncoupling proteins (UCPs) or ob gene. However, H1KO mice fed with high fat diet increased fat deposition and ob gene expression more excessively. Leptin-induced feeding suppression was attenuated in H1KO mice. Chronic leptin treatment decreased visceral fat and up-regulated UCPs expression in brown and white fat. these effects of leptin were attenuated in pair-fed H1KO mice. Chronic histamine or histidine treatment decreased body weight, body fat deposition, and serum glucose and insulin in diet-induced obese, ob/ob and db/db mice. Activation of histamine neurons suppressed ob gene expression in the fat tissue together with elevation of seurm leptin and UCPs mRNA. these actions of neuronal histamine were attenuated in the double knockout mice, i.e., db/db mice with H1KO. taken together, H1KO mice, a novel leptin resistant model, elucidate essential roles of H1-R in energy intake and expenditure as a down-stream-signaling message of leptin actions in the brain. the anti-obesity and anti-diabetic effects of histamine neurons provide a new insight into therapeutic strategies on human obesity and diabetes with leptin resistance.

关键词： Anti-obesity and anti-diabetic actions of histamine neurons

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Anti-obesity and anti-diabetic actions of histamine neurons

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中国病理生理杂志 2001年第9期17卷 923-923页

作者： t.Sakata t.Masaki H.yoshimatsu

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Orexin -Aregulates body temperature in coordination with control of arousal state

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中国病理生理杂志 2001年第9期17卷 925-925页

作者： G.Yoshimichi H.yoshimatsu t.Masaki t.Sakata

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