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Cytopathic effects and local immune responses in repeated neoadjuvant HSV-tk+ ganciclovir gene therapy for prostate cancer

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Asian Journal of Urology 2021年第3期8卷 280-288页

作者： Nobuyuki Yanagisawa Takefumi Satoh Ken-ichi Tabata Hideyasu Tsumura Yasutomo Nasu Masami Watanabe Timothy C.Thompson Isao Okayasu yoshiki Murakumo Shiro Baba Masatsugu Iwamura Department of Pathology St.Marianna University School of Medicine Yokohama-City Seibu HospitalYokohamaKanagawaJapan Department of Pathology Kitasato University School of MedicineSagamiharaKanagawaJapan Department of Urology Kitasato University School of MedicineSagamiharaKanagawaJapan Takefumi Satoh Prostate Clinic MachidaTokyoJapan Department of Urology Okayama UniversityOkayamaJapan Center for Innovative Clinical Medicine Okayama University HospitalOkayamaJapan Department of Genitourinary Medical Oncology-Research Division of Cancer MedicineThe University of Texas MD Anderson Cancer CenterHoustonTXUSA Division of Nutrition School of Health CareKiryu UniversityMidori-City GunmaJapan

Objective:Cytopathic effects and local immune response were analyzed histologically in prostatic cancer(PCa)with in situ herpes simplex virus-thymidine kinase(HSV-tk)/ganciclovir(GCV)gene therapy(GT).Methods:Four high-risk PCa patients who received HSV-tk/GCV GT were *** two cycles of intraprostatic injection of HSV-tk and administration of GCV,radical prostatectomy was ***-fixed,paraffin-embedded sections were evaluated using *** with hormone therapy(HT,n=3)or without neoadjuvant therapy(NT,n=4)that were equivalent in terms of risk were also examined as ***-positive cells were counted in at least three areas in cancer *** indices(LI)were calculated as percentage ***:ssDNA LI in GT increased,indicating apoptosis,as well as tumor-infiltrating lymphocytes and CD68-positive macrophages,compared with their *** cases showed significantly higher numbers of single-stranded DNA(ssDNA)LI,CD4/CD8-positive T cells and CD68-positive macrophages including M1/M2 macrophages than HT or NT ***,there was no significant difference in CD20-positive B cells among the types of *** were strong correlations between CD8+T cells and CD68+macrophages(ρ=0.656,p<0.0001)as well as CD4+T cells and CD20+B cells(ρ=0.644,p<0.0001)in PCa with ***:Enhanced cytopathic effect and local immune response might be indicated in PCa patients with HSV-tk/GCV gene therapy.

关键词： Suicide genetherapy Prostatecarcinoma HSV-tk Ganciclovir Immuno histochemistry

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Inferior mesenteric arteriovenous fistula during treatment with bevacizumab in colorectal cancer patient: A case report

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World Journal of Gastrointestinal Oncology 2020年第11期12卷 1364-1371页

作者： Ayako Doi Hiroyuki Takeda Kumiko Umemoto Ryosuke Oumi Shinji Wada Shingo Hamaguchi Hidefumi Mimura Hiroyuki Arai yoshiki Horie Takuro Mizukami Naoki Izawa Takashi Ogura Takako EguchiNakajima Yu Sunakawa Department of Clinical Oncology St.Marianna University School of MedicineKanagawa 216-8511Japan Department of Gastroenterology St.Marianna University School of MedicineKanagawa 216-8511Japan Department of Radiology St.Marianna University School of MedicineKanagawa 216-8511Japan Innovation Center for Next Generation Clinical Trials and iPS Cell Therapy Kyoto University HospitalKyoto 606-8507Japan

BACKGROUND Fistula formation is a severe adverse event related to antiangiogenetic agents such as bevacizumab and inferior mesenteric arteriovenous fistula(IMAVF) is a result of acquired factor, especially colon surgery. However, IMAVF occurs very rarely and there are few reports in patients during chemotherapy. We report a case of a patient who developed IMAVF during treatment with bevacizumab in metastatic colorectal cancer(mCRC) after colon *** SUMMARY An 81-year-old man was diagnosed with descending colon cancer and underwent left hemicolectomy without any complications. He was definitely diagnosed with high-risk stage 2 and received tegafur-uracil plus leucovorin as adjuvant chemotherapy. Three years and 6 mo after the operation, the cancer relapsed with peritoneal dissemination. The patient underwent CyberKnife radiosurgery targeting the recurrent tumor and received chemotherapy with S-1 plus bevacizumab. At 1 year after chemotherapy, he complained of severe diarrhea, which is suspected drug-induced colitis. As diarrhea worsened despite the termination of treatment, he underwent colonoscopy and computed tomography (CT) scans that revealed edematous change from sigmoid to rectosigmoid colon. CT scans also revealed an aneurysm adjacent to the inferior mesenteric vein and multidetector CT angiography showed the IMAVF. Elective angiography confirmed the diagnosis of an IMAVF and it was successfully treated by arterial embolization. The patient resumed chemotherapy with only S-1 6 mo after *** Clinicians should keep in mind the probability of severe diarrhea arose from IMAVF in mCRC patients treated with bevacizumab.

关键词： Metastatic cancer Colon surgery Chemotherapy Fistula formation Inferior mesenteric artery Interventional radiology Case report

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A Case with XXXX Syndrome Who Was Incidentally Diagnosed during Examination for Suspected Post-Human Papillomavirus Vaccination Syndrome

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Case Reports in Clinical Medicine 2019年第9期8卷 239-244页

作者： Akiyo Hineno Tomoki Kosho Hiroyuki Kato yoshiki Sekijima Shu-ichi Ikeda Intractable Disease Care Center Shinshu University Hospital Matsumoto Japan Department of Medicine (Neurology and Rheumatology) Shinshu University School of Medicine Matsumoto Japan Department of Medical Genetics Shinshu University Hospital Matsumoto Japan Department of Orthopaedic Surgery Shinshu University School of Medicine Matsumoto Japan

A 19-year-old Japanese woman was referred to us with the complaints of arthralgia and meralgia following human papillomavirus (HPV) vaccination. She received HPV vaccination at the age of 15 years and three years later, she developed intermittent arthralgia, meralgia, and numbness in limbs. There were no orthostatic dysregulation symptoms. She had hypertelorism, and brachydactyly in both the hands, and revealed mild cubitus varus deformity with lateral instability. X-ray examination disclosed hypoplasia of the humeral capitellum and trochlea in elbow joints. G-banded chromosomes were shown to be composed of 48, XXXX. She was, therefore, diagnosed with XXXX syndrome, which explained the reason for her limb symptoms. Although some girls with HPV vaccination complain of various symptoms including limb pain and numbness, exact underlying cause of these symptoms needs to be ascertained carefully for reaching a final diagnosis.

关键词： XXXX Syndrome Tetrasomy X Human Papillomavirus Vaccine Arthralgia Complex Regional Pain Syndrome

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Safety Evaluations of Long-Term and Excessive Intakes of Bifidobacterium longum CLA8013: A Placebo-Controlled, Randomized, Double-Blind Study

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Food and Nutrition Sciences 2023年第10期14卷 997-1012页

作者： Daisuke Takami Keisuke Okada Yutaka Makizaki yoshiki Tanaka Hiroshi Ohno Daisuke Tsuge R&D Center Biofermin Pharmaceutical Co. Ltd. Kobe Japan Shinagawa Season Terrace Health Care Clinic Shinagawa Season Terrace Minato-ku Japan

Heat-killed Bifidobacterium longum CLA8013 has been demonstrated to improve the frequency of defecation, straining, and pain during defecation in human placebo-controlled, double-blind, parallel-group studies. We conducted a randomized, double-blind, placebo-controlled, parallel-group study to evaluate the safety of both long-term and excessive intakes of heat-killed B. longum CLA8013, when used as a food with functional claims. In both tests, 30 healthy volunteers were divided into two groups: an active group that ingested heat-killed B. longum CLA8013 and a placebo group. In the long-term intake safety study, participants in the active group ingested 25 billion cells/day for 12 weeks. In the excessive intake safety study, participants in the active group ingested 125 billion cells/day for 4 weeks. Physical, hematological, biochemical, and urine examinations were conducted, and adverse events were evaluated in both studies. The studies revealed no abnormalities in any of the safety tests. In conclusion, no safety-related issues were identified with long-term or excessive intake of heat-killed B. longum CLA8013.

关键词： Constipation Safety Bifidobacterium longum Long-Term Excessive

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日本视觉摇滚乐中的图腾崇拜

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大舞台 2001年第16期 18-19页

作者： yoshiki

摇滚乐中其实一直存在善对图腾的崇拜,从欧美摇滚歌手热衷于纹身可见一斑。“图腾”一词是我国清代学者严复于1903年译英国学者甄克思的《社会通诠》一书时,将“tatem”一词音译而成的并由此成为中国学术界的通用译名。严复在解释中指出... 详细信息

摇滚乐中其实一直存在善对图腾的崇拜,从欧美摇滚歌手热衷于纹身可见一斑。“图腾”一词是我国清代学者严复于1903年译英国学者甄克思的《社会通诠》一书时,将“tatem”一词音译而成的并由此成为中国学术界的通用译名。严复在解释中指出:图腾是群体的标志,旨在区分群体。而摇滚乐基本上都是反射出对社会上的某些事物与不公正规则的不满情绪和呼声;或者生活的压力所促使的积压精绪的宣泄。这类音乐者选择以“喧闹”的音乐来表达心声,也就是我们所说的摇滚乐。本身受欧美朋克音乐影响较深的日本视觉摇滚的初期理所当然也承袭了朋克乐者的装扮,并且,又有着日本传统的一些文化鼓噪其中,最明显的就是表现在日本的妖怪图腾的化妆上。

关键词：摇滚乐图腾崇拜视觉音乐人日本传统音乐风格重金属自然现象纹身严复

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Gastric submucosa-invasive carcinoma associated with EpsteinBarr virus and endoscopic submucosal dissection: A case report

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World Journal of Gastrointestinal Oncology 2019年第10期11卷 925-932页

作者： Yu Kobayashi Takehito Kunogi Hiroki Tanabe Yuki Murakami Takuya Iwama Takahiro Sasaki Keitaro Takahashi Katsuyoshi Ando yoshiki Nomura Nobuhiro Ueno Shin Kashima Kentaro Moriichi Hidehiro Takei Mikihiro Fujiya Toshikatsu Okumura Division of Gastroenterology and Hematology/Oncology Department of Medicine Asahikawa Medical UniversityAsahikawa 078-8510Japan Pathological Department of Asahikawa Medical University Hospital Asahikawa Medical UniversityAsahikawa 078-8510Japan

BACKGROUND Epstein-Barr virus(EBV)-associated carcinoma is a gastric cancer subtype with a morphology characterized by gastric carcinoma with lymphoid stroma(GCLS).Clinicopathological studies have indicated a better prognosis for GCLS than for common gastric *** previous cases of early gastric cancer associated with EBV had been diagnosed by endoscopic *** SUMMARY We present two GCLS cases subjected to endoscopic submucosal dissection(ESD)for a definitive diagnosis.A protruded gastric lesion was identified by routine endoscopic examination,but forceps biopsy showed no atypical cells before *** resected specimen showed a poorly differentiated adenocarcinoma with lymphoid cells involving the mucosa and *** final diagnosis was submucosa-invasive poorly differentiated gastric ***,additional gastrectomy was recommended to obtain a complete *** patient underwent additional distal gastrectomy with lymph node dissection,but the other was refused because of cardiovascular *** patients remained in remission for more than half a *** positivity was determined by EBV-encoded RNA in situ *** also conducted a literature review of cases of early gastric cancer associated with EBV that had been diagnosed by *** Submucosa-invasive GCLS could be dissected using ESD,and EBV positivity should be subsequently assessed to determine whether or not any additional curative surgery is *** prospective investigations on the prevalence of lymph node metastasis in EBV-associated carcinoma should be performed to expand the indications for endoscopic resection.

关键词： Herpesvirus 4 Human Stomach neoplasms Gastric carcinoma with lymphoid stroma Epstein-Barr virus-associated gastric carcinoma Case report

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Fibrosis in nonalcoholic fatty liver disease: Noninvasive assessment using computed tomography volumetry

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World Journal of Gastroenterology 2016年第40期22卷 8949-8955页

作者： Nobuhiro Fujita Akihiro Nishie yoshiki Asayama Kousei Ishigami Yasuhiro Ushijima Yukihisa Takayama Daisuke Okamoto Ken Shirabe Tomoharu Yoshizumi Kazuhiro Kotoh Norihiro Furusyo Tomoyuki Hida Yoshinao Oda Taisuke Fujioka Hiroshi Honda Department of Clinical Radiology Graduate School of Medical Sciences Kyushu University Department of Advanced Imaging and Interventional Radiology Graduate School of Medical Sciences Kyushu University Department of Radiology Informatics and Network Graduate School of Medical Sciences Kyushu University Department of Surgery and Sciences Graduate School of Medical Sciences Kyushu University Department of Medicine and Bioregulatory Science Graduate School of Medical Sciences Kyushu University Department of General Internal Medicine Graduate School of Medical Sciences Kyushu University Department of Anatomic Pathology Graduate School of Medical Sciences Kyushu University CT Application Philips Electronics Japan Medical Systems

AIM To evaluate the diagnostic performance of computed tomography(CT) volumetry for discriminating the fibrosis stage in patients with nonalcoholic fatty liver disease(NAFLD).METHODS A total of 38 NAFLD patients were enrolled. On the basis of CT imaging, the volumes of total, left lateral segment(LLS), left medial segment, caudate lobe, and right lobe(RL) of the liver were calculated with a dedicated liver application. The relationship between the volume percentage of each area and fibrosis stage was analyzed using Spearman's rank correlation coefficient. A receiver operating characteristic(ROC) curve analysis was performed to determine the accuracy of CT volumetry for discriminating fibrosis *** The volume percentages of the caudate lobe and the LLS significantly increased with the fibrosis stage(r = 0.815, P < 0.001; and r = 0.465, P = 0.003, respectively). Contrarily, the volume percentage of the RL significantly decreased with fibrosis stage(r =-0.563, P < 0.001). The volume percentage of the caudate lobe had the best diagnostic accuracy for staging fibrosis, and the area under the ROC curve values for discriminating fibrosis stage were as follows: ≥ F1, 0.896; ≥ F2, 0.929; ≥ F3, 0.955; and ≥ F4, 0.923. The best cut-off for advanced fibrosis(F3-F4) was 4.789%, 85.7% sensitivity and 94.1% *** The volume percentage of the caudate lobe calculated by CT volumetry is a useful diagnostic parameter for staging fibrosis in NAFLD patients.

关键词： Nonalcoholic fatty liver disease Computed tomography volumetry Fibrosis stage Nonalcoholic steatohepatitis

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变幻莫测灰色银币Dir en grey

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大舞台 2001年第20期 47-,46页

作者： yoshiki

传说中的灰色银币是会随着光线的改变而改变色泽的, 今年一整年都处于半充电半休息状态的DIR EN GREY一度让歌迷紧张起他们的聚散问题,万万没有想到。

关键词：银币灰色传说充电色泽光线改变冲刺状态音乐

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一个人的西川贵教***

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大舞台 2001年第15期 44-45页

作者： yoshiki

近来 *** 的西川贵教活动减少了很多,令海外的西川歌迷极为沮丧内地的歌迷也因为他的曝光率降低而渐渐淡忘了这个美型王子。(谁让内地连西川贵教的 CD 及 VCD 都没有引进呢!)对西川贵教的认识,大多喜欢日本音乐的歌迷都是以图片和文字... 详细信息

近来 *** 的西川贵教活动减少了很多,令海外的西川歌迷极为沮丧内地的歌迷也因为他的曝光率降低而渐渐淡忘了这个美型王子。(谁让内地连西川贵教的 CD 及 VCD 都没有引进呢!)对西川贵教的认识,大多喜欢日本音乐的歌迷都是以图片和文字的形式来获得,而西川百变的造型似乎被他矮小的身材遮掩了光彩,所以很难有人真正了解 *** 的西川贵教。

关键词：西川日本音乐内地造型曝光海外文字图片引进矮小

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Study on feasibility of cervical lymph node metastases in squamous cell carcinoma of the tongue evaluated by morphometric analyses

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中国口腔颌面外科杂志 2008年第B5期6卷 89-90页

作者： Masaaki Karino Hiroaki Ishibashi yoshiki Nariai Seiji Kondou Jouji Sekine Department of Oral and Maxillofacial Surgery ShimaneUniversity Faculty of Medicine Japan

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