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利用铸坯表层组织控制预防横向裂纹发生

利用铸坯表层组织控制预防横向裂纹发生

Molecular design and application of luminescent materials composed of group 13 elements with an aggregation-induced emission property

2005中国钢铁年会

作者： Toru KATO Noriaki BABA yoshiki ito Akihiro YAMANAKA Corporate R＆D Labs. Sumitomo Metal Industries Ltd. Japan Kashima Steel Works Sumitomo Metal IndustriesLtd.Japan Corporate R＆D Labs. Sumitomo Metal IndustriesLtd.Japan Corporate R＆D Labs. Sumitomo Metal IndustriesLtd.Japan

板坯的表面横裂多发现于连铸的弯曲或矫直处,并与γ-α相变温度区域的热延性有关。许多研究表明,裂纹是由于晶界处片层状铁素体的应变集中所导致的。在传统流程中的弯曲矫直期间,板坯的表面温度主要考虑来避开脆化温度区的。在该研究中... 详细信息

板坯的表面横裂多发现于连铸的弯曲或矫直处,并与γ-α相变温度区域的热延性有关。许多研究表明,裂纹是由于晶界处片层状铁素体的应变集中所导致的。在传统流程中的弯曲矫直期间,板坯的表面温度主要考虑来避开脆化温度区的。在该研究中,提出了一个新的概念:利用铸坯表层微观组织控制来预防横向裂纹。通过板坯表层组织控制（SSC）能够抑制晶界处片层状铁素体的形成,方法有二冷区初期的强冷却和随后的潜热引起的再加热。现场的凝固高温拉伸试验证明,通过微观结构控制可以消除脆性极限。SSC对裂纹敏感性的影响已经通过半工业化连铸机在试验上得到了验证。在浇铸之后进行的是弯曲。在钢坯表面上的慢冷使横裂纹在实验上再现,即传统冷却方式可以产生具有片层状铁素体的正常微观结构。通过表层组织控制（SSC）裂纹是可以预防的。传统连铸也可采用这些操作方法。

关键词：连铸横裂纹二次冷却微观结构热延性析出物低合金钢

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National Science Review 2021年第6期8卷 80-93页

作者： Shunichiro ito Masayuki Gon Kazuo Tanaka yoshiki Chujo Department of Polymer Chemistry Graduate School of EngineeringKyoto University

Complexation of π-conjugated ligands by metal or semimetal ions leads to the enhancement of the planarity and rigidity of π-conjugated systems. Boron, especially, has played a central role in the design of luminescent main-group complexes. However, these complexes still suffer the disadvantage of aggregation-caused quenching as well as typical organic fluorophores. It has recently been reported that some types of boron complexes exhibit the aggregation-induced emission(AIE) property. Moreover, AIE behavior from complexes and organometallic compounds composed of the other group 13 elements, such as aluminum and gallium, has emerged in this decade. These observations greatly encourage us to develop advanced functional materials based on the group 13 elements. Indeed, recent research has demonstrated that these classes of materials are potentially versatile scaffolds for constructing chromic luminophores,efficiently emissive π-conjugated polymers and so on. This review mainly describes AIE-active group 13 complexes with four-coordinate structures and their application as photo-functional materials. Proposed mechanisms of the origins of AIE behavior are briefly discussed.

关键词： aggregation-induced emission crystallization-induced emission chromism conjugated polymer group 13

Real-time gradation-expressible amplitude-modulationtype electroholography based on binary-weighted computer-generated hologram

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Chinese Optics Letters 2021年第11期19卷 8-15页

作者： Ren Noguchi Kohei Suzuki yoshiki Moriguchi Minoru Oikawa Yuichiro Mori Takashi Kakue Tomoyoshi Shimobaba Tomoyoshi ito Naoki Takada Graduate School of Integrated Arts and Sciences Kochi UniversityKochi 780-8520Japan Research and Education Faculty Kochi UniversityKochi 780-8520Japan Graduate School of Engineering Chiba UniversityChiba 263-8522Japan

In amplitude-modulation-type electroholography, the binary-weighted computer-generated hologram(BW-CGH) facilitates the gradation-expressible reconstruction of three-dimensional(3 D) objects. To realize real-time gradation-expressible electroholography, we propose an efficient and high-speed method for calculating bit planes consisting of BW-CGHs. The proposed method is implemented on a multiple graphics processing unit(GPU) cluster system comprising 13 GPUs. The proposed BW-CGH method realizes eight-gradation-expressible electroholography at approximately the same calculation speed as that of conventional electroholography based on binary computer-generated holograms. Consequently, we were able to successfully reconstruct a real-time electroholographic 3 D video comprising approximately 180,000 points expressed in eight gradations at 30 frames per second.

关键词： gradation-expressible electroholography binary-weighted computer-generated hologram digital micromirror device computer-generated hologram

Developing Thick Cardiac Tissue with a Multilayer Fiber Sheet for Treating Myocardial Infarction

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Advanced Fiber Materials 2023年第6期5卷 1905-1918页

作者： Junjun Li Xiang Qu Li Liu Lingjun Li Ying Hua Jingbo Zhang Masako Ishida Noriko Yoshida Akiko Tabata Nagako Sougawa Emiko ito Noriko Mochizuki‑Oda Akima Harada Takuji Kawamura Ryohei Matsuura Yingzhe Wang Keisuke Morishima Shigeru Miyagawa yoshiki Sawa Department of Cardiovascular Surgery Osaka University Graduate School of Medicine2‑2 YamadaokaSuita 565‑0871Japan Frontier of regenerative medicine Osaka University Graduate School of Medicine2‑2 YamadaokaSuita 565‑0871Japan Department of Physiology Osaka Dental University8‑1 Kuzuha Hanazono‑choHirakata 573‑1121Japan Department of Mechanical Engineering Graduate School of EngineeringOsaka UniversitySuita 565‑0871Japan Global Center for Medical Engineering and Informatics Osaka UniversityOsaka 565‑0071Japan Division of Health Sciences Osaka University Graduate School of MedicineSuita 565‑0871Japan

Human-induced pluripotent stem cell (hiPSC)-derived cardiac patches have been extensively used for treating myocardialinfarction and have shown potential for clinical application. However, the limited patch thickness can hamper its therapeuticeffect. We previously developed a fibrous scaffold that allowed the formation of well-organized cardiac tissue constructs. Inthe present study, based on the above technology, we developed a three-dimensional multilayer fibrous scaffold with dynamicperfusion, on which approximately 20 million hiPSC-derived cardiomyocytes (CMs) could be seeded in a single step andorganized into 1 mm thick and viable tissue. The multilayer cardiac tissue demonstrated enhanced contractile properties andupregulated cytokine secretion compared with the control group. Notably, when used on the myocardial infarction model,the multilayer group showed improved functional recovery and less fibrosis. These results indicated that the appropriatehiPSC-CM dose requires careful evaluation in developing clinical therapy. The multilayer cardiac tissue group demonstratedsignificant improvement than the control group, indicating that higher doses of transplanted cells may have improvedtherapeutic effects in treating myocardial infarction.

关键词： Fiber Tissue engineering Pluripotent stem cell Cardiomyocyte Myocardial infarction Regenerative therapy

Usefulness of Basic Fibroblast Growth Factor (bFGF) Loaded Dissolving Microneedles for Local Therapy of Skin Wounds

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Journal of Biomaterials and Nanobiotechnology 2013年第3期4卷 256-264页

作者： Kanji Takada Yukako ito Kengo Matsumoto Yuka Sato Maimi Nishio Yurie Tadano Yuri Kamei Yutaro Takemura Nana Inoue yoshiki Akasaka Ichiro Ono BioSerenTach Inc. Shimogyo- Ku Kyoto Japan Department of Dermatology Sapporo Medical University School of Medicine Chuo- Ku Sapporo Japan. Department of Pharmacokinetics Kyoto Pharmaceutical University Yamashina-Ku Kyoto Japan Department of Pharmacokinetics Kyoto Pharmaceutical University Yamashina-Ku Kyoto Japan Devision of Chronic Inflammatory Diseases Advanced Medical Research Center Toho University Graduate School of Medicine Ota-Ku Tokyo Japan

Purpose: The usefulness of dissolving microneedles (DMs) for local skin therapy by basic fibroblast growth factor (bFGF) was studied in rats. Methods: We prepared four kinds of bFGF-loaded DMs, approximately 500 μm length and 300 μm diameter at the bottom. Long-term stability and dissolution studies were performed by HPLC method. Pharmacokinetic and pharmacological evaluations were performed after administration of bFGF loaded DMs to rats. Results: The bFGF contents were 2.15 ± 0.07, 1.07 ± 0.04, 0.56 ± 0.07 and 0.12 ± 0.03 μg. The 100.2 ± 3.4%, 100.2 ± 3.3%, 99.3 ± 1.4% and 100.4 ± 3.0% of bFGF were recovered after 1, 3 and 6 months and 1 year incubation at 40°C. The bFGF was released from DMs within 5 min. In a pharmacokinetic study using 2.0 and 1.0 μg bFGF-loaded DMs, no systemic exposure of bFGF was detected. The initial bFGF concentrations in the rat skin tissue after administration of bFGF-loaded DMs to the hair-removed rat abdominal skin were 510.2 ± 20.1 ng/g wet weight for 2 μg bFGF DMs and 264.2 ± 56.5 ng/g wet weight for 1 μg DMs, declining slowly thereafter to 226.3 ± 33.5 and 105.1 ± 27.4 ng/g wet weight at 6 hr after administration. Good dose-dependency was observed. Pharmacological evaluation of bFGF-loaded DMs of 2.0, 1.0, 0.5, and 0.1 μg, in the wound healing rat model, all used DMs, but 0.1 μg DMs, showed good healing effects. Considered collectively, these results suggest the usefulness of bFGF-loaded DMs for local therapy of skin wound disease.

关键词： Basic Fibroblast Growth Factor (bFGF) Dissolving Microneedles (DMs) Transdermal Delivery Wound Healing Rats

Imaging pitfalls of pancreatic serous cystic neoplasm and its potential mimickers

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World Journal of Radiology 2014年第3期6卷 36-47页

作者： Kousei Ishigami Akihiro Nishie yoshiki Asayama Yasuhiro Ushijima Yukihisa Takayama Nobuhiro Fujita Shunichi Takahata Takao Ohtsuka Tetsuhide ito Hisato Igarashi Shuji Ikari Catherine M Metz Hiroshi Honda Department of Radiology University of Iowa Hospitals and Clinics Department of Clinical Radiology Kyushu University Department of Surgery and Oncology Kyushu University Department of Medicine and Bioregulatory Science Kyushu University Department of Internal Medicine Hokkaido Gastroenterology Hospital

The aim of this article is to clarify diagnostic pitfalls of pancreatic serous cystic neoplasm(SCN) that may result in erroneous characterization. Usual and unusual imaging findings of SCN as well as potential SCN mimickers are presented. The diagnostic key of SCN is to look for a cluster of microcysts(honeycomb pattern), which may not be always found in the center. Fibrosis in SCN may be mistaken for a mural nodule of intraductal papillary mucinous neoplasm(IPMN). The absence of cyst wall enhancement may be helpful to distinguish SCN from mucinous cystic neoplasm. However, oligocystic SCN and branch duct type IPMN may morphologically overlap. In addition, solid serous adenoma, an extremely rare variant of SCN, is difficult to distinguish from neuroendocrine tumor.

关键词： Serous cystic neoplasm Intraductal papil-lary mucinous neoplasm Mucinous cystic neoplasm Computed tomography Magnetic resonance imaging