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Myocardial metastasis from ZEB1-and TWIST-positive spindle cell carcinoma of the esophagus:A case report

World Journal of Gastroenterology 2024年第11期30卷 1636-1643页

作者： yoshihiro Shibata Hirofumi Ohmura Kazuki komatsu Kosuke Sagara Atsuji Matsuyama Ryuji Nakano Eishi Baba Department of Medical Oncology Fukuoka Wajiro HospitalFukuoka 811-0213Japan Department of Oncology and Social Medicine Kyushu University Graduate School of Medical SciencesFukuoka 812-8582Japan Department of Pathology and Oncology University of Occupational and Environmental HealthKitakyushu 807-8555Japan Department of Diagnostic Pathology Fukuoka Wajiro HospitalFukuoka 811-0213Japan

BACKGROUND Metastatic cardiac tumors are known to occur more frequently than primary cardiac tumors,however,they often remain asymptomatic and are commonly dis-covered on *** tumors with a relatively high frequency of cardiac metastasis include mesothelioma,melanoma,lung cancer,and breast cancer,whereas reports of esophageal cancer with cardiac metastasis are *** SUMMARY The case of a 60-year-old man who complained of dysphagia is *** gastrointestinal endoscopy showed a submucosal tumor-like elevated lesion in the esophagus causing ***-enhanced computed tomography showed left atrial compression due to the esophageal tumor,multiple liver and lung metastases,and a left pleural *** examination of a biopsy speci-men from the esophageal tumor showed spindle-shaped cells,raising suspicion of esophageal *** disease progressed rapidly,and systemic chemotherapy was deemed necessary,however,due to his poor general condition,adminis-tration of cytotoxic agents was considered *** his high Combined Positive Score,nivolumab was administered,however,the patient soon died from the *** autopsy confirmed spindle cell carcinoma(SCC)of the esophagus and cardiac metastasis with similar histological *** stem cell markers,ZEB1 and TWIST,were positive in both the primary tumor and the cardiac *** To the best of our knowledge,there have been no prior reports of cardiac metastasis of esophageal *** case highlights our experience with a patient with esophageal SCC who progressed rapidly and died from the disease,with the autopsy examination showing cardiac metastasis.

关键词： Spindle cell carcinoma Esophagus Myocardial metastasis Epithelial-mesenchymal transition Case report

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Whether to Abolish or Introduce Dual Regulation as Trade and Environmental Policy?

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China & World Economy 2024年第1期32卷 57-95页

作者： yoshihiro Hamaguchi Department of Economics Faculty of Economics and Business AdministrationKyoto University of Advanced ScienceJapan

China,which has already introduced an environmental tax in an effort to decarbonize,has recently begun emissions trading and is using two environmental policies in tandem,but there are concerns about the impact on growth and *** and environmental policies affect firms'entry and exit,resulting in changes in aggregate productivity and pollution *** study compares the impacts of single regulation and dual regulation on welfare,using a research-and-development based growth model with heterogeneous *** single regulation,the cleansing effect of trade liberalization could be *** dual regulation,trade liberalization decreases pollution and improves average productivity whereas decreasing total permits reduces *** the perspective of improving welfare it is desirable to choose dual regulation because trade liberalization can reduce total pollution emissions via the cleansing effect of trade liberalization.

关键词： dual regulation heterogeneous firm Porter hypothesis research and development difficulty trade liberalization

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Liver biopsy in the post-hepatitis C virus era in Japan

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World Journal of Gastroenterology 2024年第14期30卷 1949-1957页

作者： yoshihiro Ikura Takako Okubo Yasuhiro Sakai Department of Pathology Takatsuki General HospitalTakatsuki 569-1192Osaka PrefectureJapan Department of Pathology Kansai Medical University Medical CenterMoriguchi 570-8507Japan

In Japan,liver biopsies were previously crucial in evaluating the severity of hepatitis caused by the hepatitis C virus(HCV)and diagnosing HCV-related hepatocellular carcinoma(HCC).However,due to the development of effective antiviral treatments and advanced imaging,the necessity for biopsies has significantly *** change has resulted in fewer chances for diagnosing liver disease,causing many general pathologists to feel less confident in making liver biopsy *** article provides a comprehensive overview of the challenges and potential solutions related to liver biopsies in ***,it highlights the importance of considering steatotic liver diseases as independent conditions that can coexist with other liver diseases due to their increasing ***,it emphasizes the need to avoid hasty assumptions of HCC in nodular lesions,because clinically diagnosable HCCs are not targets for ***,the importance of diagnosing hepatic immune-related adverse events caused by immune checkpoint inhibitors is increasing due to the anticipated widespread use of these *** conclusion,pathologists should be attuned to the changing landscape of liver diseases and approach liver biopsies with care and attention to detail.

关键词： Liver biopsy Alteration Post-hepatitis C virus era Steatotic liver disease Hepatic tumors Immune checkpoint inhibitors

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High yield reproducible rat model recapitulating human Barrett's carcinogenesis

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World Journal of Gastroenterology 2017年第33期23卷 6077-6087页

作者： Daisuke Matsui Ashten N Omstead Juliann E Kosovec yoshihiro komatsu Emily J Lloyd Hailey Raphael Ronan J Kelly Ali H Zaidi Blair A Jobe Esophageal and Lung Institute Allegheny Health Network Department of Gastroenterological Surgery Kanazawa University Hospital Department of Oncology Sidney Kimmel Comprehensive Cancer CenterJohns Hopkins Hospital

AIM To efficiently replicate the biology and pathogenesis of human esophageal adenocarcinoma(EAC) using the modified Levrat model of end-to-side esophagojejunostomy. METHODS End-to-side esophagojejunostomy was performed on rats to induce gastroduodenoesophageal reflux to develop EAC. Animals were randomly selected and serially euthanized at 10(n = 6),17(n = 8),24(n = 9),31(n = 6),38(n = 6),and 40(n = 6) wk postoperatively. The esophagi were harvested for downstream histopathology and gene expression. Histological evaluation wascompleted to determine respective rates of carcinogenic development. Quantitative reverse transcriptionpolymerase chain reaction was performed to determine gene expression levels of MUC2,CK19,and CK20,and results were compared to determine significant differences throughout disease progression *** The overall study mortality was 15%. Causes of mortality included anastomotic leak,gastrointestinal hemorrhage,stomach ulcer perforation,respiratory infection secondary to aspiration,and obstruction due to tumor or late anastomotic stricture. 10 wk following surgery,100% of animals presented with esophagitis. Barrett's esophagus(BE) was first observed at 10 wk,and was present in 100% of animals by 17 wk. Dysplasia was confirmed in 87.5% of animals at 17 wk,and increased to 100% by 31 wk. EAC was first observed in 44.4% of animals at 24 wk and increased to 100% by 40 wk. In addition,two animals at 38-40 wk post-surgery had confirmed macro-metastases in the lung/liver and small intestine,respectively. MUC2 gene expression was progressively down-regulated from BE to dysplasia to EAC. Both CK19 and CK20 gene expression significantly increased in a stepwise manner from esophagitis to EAC. CONCLUSION Esophagojejunostomy was successfully replicated in rats with low mortality and a high tumor burden,which may facilitate broader adoption to study EAC development,progression,and therapeutics.

关键词： Esophageal adenocarcinoma gastroeso phageal reflux disease Levrat Esophagojejunostomy Experimental rat model Mucin genes Cytokeratins

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New characterization of Morrey–Herz spaces and Morrey–Herz–Hardy spaces with applications to various linear operators

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Acta Mathematica Sinica,English Series 2024年

作者： Kwok Pun Ho yoshihiro Sawano Department of Mathematics and Information Technology The Education University of Hong Kong Department of Mathematics Graduate School of Science and Engineering Chuo University

This paper is an offspring of the previous study on Herz spaces. A new characterization of Morrey–Herz spaces is given. As applications, the boundedness of various operators is obtained. For example, higher-order commutators generated by singular integral operators and BMO functions are proved to be bounded on Morrey–Herz spaces. The theory of Morrey–Herz–Hardy spaces is also developed.

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Improvement of histone deacetylase inhibitor efficacy by SN38 through TWIST1 suppression in synovial sarcoma

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Cancer Innovation 2024年第2期3卷 80-95页

作者： Satoru Sasagawa Jun Kumai Toru Wakamatsu yoshihiro Yui Molecular Biology Laboratory Research InstituteNozaki Tokushukai HospitalDaitoOsakaJapan Sarcoma Treatment Laboratory Research InstituteNozaki Tokushukai HospitalDaitoOsakaJapan Department of Musculoskeletal Oncology Service Osaka International Cancer InstituteOsakaJapan

Background:Synovial sarcoma(SS)is an SS18-SSX fusion gene-driven soft tissue sarcoma with mesenchymal characteristics,associated with a poor prognosis due to frequent metastasis to a distant organ,such as the *** deacetylase(HDAC)inhibitors(HDACis)are arising as potent molecular targeted drugs,as HDACi treatment disrupts the SS oncoprotein complex,which includes HDACs,in addition to general HDACi *** provide further molecular evidence for the advantages of HDACi treatment and its limitations due to drug resistance induced by the microenvironment in SS cells,we examined cellular responses to HDACi treatment in combination with two-dimensional(2D)and 3D culture ***:Using several SS cell lines,biochemical and cell biological assays were performed with romidepsin,an HDAC1/2 selective ***38 was concomitantly used as an ameliorant drug with romidepsin ***,apoptosis induction,and MHC class I polypeptide-related sequence A/B(MICA/B)induction were monitored to evaluate the drug *** addition to the conventional 2D culture condition,spheroid culture was adopted to evaluate the influence of cell-mass microenvironment on ***:By monitoring the cellular behavior with romidepsin and/or SN38 in SS cells,we observed that responsiveness is diverse in each cell *** the apoptotic inducible cells,co-treatment with SN38 enhanced cell *** nonapoptotic inducible cells,cytostasis and MICA/B induction were observed,and SN38 improved MICA/B induction *** a novel efficacy of SN38,we revealed TWIST1 suppression in SS *** the spheroid(3D)condition,romidepsin efficacy was severely restricted in TWIST1-positive *** demonstrated that TWIST1 downregulation restored romidepsin efficacy even in spheroid form,and concomitant SN38 treatment along with romidepsin reproduced the ***:The current study demonstrated the benefits and concerns of using HDACi for SS treatment in 2D and

关键词： HDAC inhibitor MICA/B SN38 spheroid synovial sarcoma TWIST1

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Pathophysiological analysis and strategy for stercoral perforation of the colon

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Open Journal of Gastroenterology 2012年第2期2卷 45-50页

作者： Koichi Sato Hiroshi Maekawa Mutsumi Sakurada Hajime Orita Tomoaki Ito yoshihiro komatsu Fumiko Hirata Ryo Wada Department of Pathology Juntendo Shizuoka Hospital Juntendo University School of Medicine Department of Surgery Juntendo Shizuoka Hospital Juntendo University School of Medicine

Perpose: In order to establish the pathophysiological features and strategy for stercoral perforation of the colon, we herein analyze a series of stercoral perforation of the colon. Method: Ten patients were diagnosed with stercoral perforation. Clinical features, primary diseases, triggers, causative bacteria in ascites, postoperative complications, pathological features, severity of the disease, and effect of direct hemoperfusion with polymyxin B immobilized fiber (PMX-DHP) were investigated. Results: Nine patients had a long history of serious and chronic constipation and 7 patients had hypertension. Causative bacteria in ascites during the operation were most commonly Escherichia coli. There were a lot of severe postoperative complications such as sepsis, disseminated intravascular coagulation, and acute lung injury. With regard to the microscopic findings of the perforation site, the intestinal wall showed severe nonspecific inflammatory changes, including an increase of mono-nuclear cells in the lamina propria. There were 4 hospital deaths, so the mortality rate was 40%. APACHE- II and SOFA score were high postoperation and 24 hours after the operation. PMX-DHP was performed in 8 cases of severe conditions of stercoral perforation of the colon. Because the catecholamine index improved within 24 hours, four of 8 cases were rescued. Conclusion: Most of the patients with stercoral perforation of the colon had severe postoperative complications. The severity of the disease was extremely high, therefore, early diagnosis based on pathophy-siological features and comprehensive therapies including PMX-DHP were necessary for strategy of treating stercoral perforation of the colon.

关键词： Stercoral Perforation of the Colon APACHE-II Score SOFA Score Polymyxin B Immobilized Fiber (PMX-DHP)

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Rational design of natural leather-based water evaporator for electricity generation and functional applications

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Journal of Energy Chemistry 2024年第9期96卷 129-144页

作者： Bingyuan Zhang Xiaoyu Guan Qingxin Han Haoxiang Guo Sai Zheng Xuhui Sun Afnan H.El-Gowily Mohammed A.Abosheasha Yanxia Zhu Motoki Ueda Meng An Haojun Fan yoshihiro Ito College of Bioresources Chemical and Materials Engineering Key Laboratory of Auxiliary Chemistry and Technology for Chemical IndustryMinistry of EducationShaanxi Collaborative Innovation Center of Industrial Auxiliary Chemistry and TechnologyShaanxi University of Science&TechnologyXi'an 710021ShaanxiChina Nano Medical Engineering Laboratory RIKEN Cluster for Pioneering Research2-1 HirosawaWako 351-0198SaitamaJapan Key Laboratory of Leather Chemistry and Engineering(Sichuan University) Ministry of EducationChengdu 610065SichuanChina College of Mechanical and Electrical Engineering Shaanxi University of Science&TechnologyXi'an 710021ShaanxiChina Biochemistry Division Chemistry DepartmentFaculty of ScienceTanta UniversityTanta 31527Egypt

In recent years,water evaporation-induced electricity has attracted a great deal of attention as an emerging green and renewable energy harvesting *** abundant materials have been developed to fabricate hydrovoltaic devices,the limitations of high costs,inconvenient storage and transport,low environmental benefits,and unadaptable shape have restricted their wide ***,an electricity generator driven by water evaporation has been engineered based on natural biomass leather with inherent properties of good moisture permeability,excellent wettability,physicochemical stability,flexibility,and *** numerous nano/microchannels together with rich oxygen-bearing functional groups,the natural leather-based water evaporator,Leather_(Emblic-NPs-SA/CB),could continuously produce electricity even staying outside,achieving a maximum output voltage of∼3 V with six-series ***,the leather-based water evaporator has enormous potential for use as a flexible self-powered electronic floor and seawater demineralizer due to its sensitive pressure sensing ability as well as its excellent photothermal conversion efficiency(96.3%)and thus fast water evaporation rate(2.65 kg m^(−2)h^(−1)).This work offers a new and functional material for the construction of hydrovoltaic devices to harvest the sustained green energy from water evaporation in arbitrary ambient environments,which shows great promise in their widespread applications.

关键词： Energy conversion Water evaporation-induced electricity Functional leather Flexible self-powered sensor Desalination

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Preoperative albumin-bilirubin score and liver resection percentage determine postoperative liver regeneration after partial hepatectomy

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World Journal of Gastroenterology 2024年第14期30卷 2006-2017页

作者： Kazuhiro Takahashi Masahiko Gosho yoshihiro Miyazaki Hiromitsu Nakahashi Osamu Shimomura Kinji Furuya Manami Doi Yohei Owada Koichi Ogawa Yusuke Ohara Yoshimasa Akashi Tsuyoshi Enomoto Shinji Hashimoto Tatsuya Oda Department of Gastrointestinal and Hepatobiliary-Pancreatic Surgery University of TsukubaTsukuba 3058-575IbarakiJapan Department of Biostatistics University of TsukubaTsukuba 3058-575IbarakiJapan

BACKGROUND The success of liver resection relies on the ability of the remnant liver to *** of the knowledge regarding the pathophysiological basis of liver regeneration comes from rodent studies,and data on humans are ***,there is limited knowledge about the preoperative factors that influence postoperative *** To quantify postoperative remnant liver volume by the latest volumetric software and investigate perioperative factors that affect posthepatectomy liver *** A total of 268 patients who received partial hepatectomy were *** were grouped into right hepatectomy/trisegmentectomy(RH/Tri),left hepa-tectomy(LH),segmentectomy(Seg),and subsegmentectomy/nonanatomical hepatectomy(Sub/Non)*** regeneration index(RI)and late rege-neration rate were defined as(postoperative liver volume)/[total functional liver volume(TFLV)]×100 and(RI at 6-months-RI at 3-months)/RI at 6-months,*** lower 25th percentile of RI and the higher 25th percentile of late regeneration rate in each group were defined as“low regeneration”and“delayed regeneration”.“Restoration to the original size”was defined as regeneration of the liver volume by more than 90%of the TFLV at 12 months *** The numbers of patients in the RH/Tri,LH,Seg,and Sub/Non groups were 41,53,99 and 75,*** RI plateaued at 3 months in the LH,Seg,and Sub/Non groups,whereas the RI increased until 12 months in the RH/Tri *** to our multivariate analysis,the preoperative albumin-bilirubin(ALBI)score was an independent factor for low regeneration at 3 months[odds ratio(OR)95%CI=2.80(1.17-6.69),P=0.02;per 1.0 up]and 12 months[OR=2.27(1.01-5.09),P=0.04;per 1.0 up].Multivariate analysis revealed that only liver resection percentage[OR=1.03(1.00-1.05),P=0.04]was associated with delayed ***,multivariate analysis demonstrated that the preoperative ALBI score[OR=2.63(1.00-1.05),P=0.02;per 1.

关键词： Liver regeneration Albumin-bilirubin score Liver resection percentage Partial hepatectomy Human Regeneration index

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“四大文明”学说的形成与传播:跨越世纪的对话

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中山大学学报（社会科学版） 2024年第4期64卷 1-12页

作者： [日]石川祯浩王丹(译) 京都大学人文科学研究所日本京都6068501 华东政法大学日语系上海200042

“四大文明”是中日两国世界史的“常识”。近年,两国分别有学者指出,“四大文明”学说只在本国通用,在世界其他国家并不存在。通过查找史料得知,“四大文明”学说源于卡尔·李特尔、卡普、西莱和黑格尔等西方思想家、历史学家,之后东... 详细信息

“四大文明”是中日两国世界史的“常识”。近年,两国分别有学者指出,“四大文明”学说只在本国通用,在世界其他国家并不存在。通过查找史料得知,“四大文明”学说源于卡尔·李特尔、卡普、西莱和黑格尔等西方思想家、历史学家,之后东亚的知识分子将其进行了概念化。这一传播过程跨越了历史学、地理学、人类学、文明学等学术领域的界限,是东西方知识分子对话的结果,同时也是一场跨越世纪的对话。

关键词： “四大文明”学说梁启超浮田和民卡尔·李特尔人文地理学黑格尔

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