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Challenges and Possibilities of Cell-Based Tissue-Engineered Vascular Grafts

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Cyborg and Bionic Systems 2021年第1期2021卷 16-31页

作者： Junichi Saito Makoto Kaneko yoshihiro ishikawa Utako Yokoyama Department of Physiology Tokyo Medical UniversityShinjuku-kuTokyoJapan Cardiovascular Research Institute Yokohama City UniversityYokohamaKanagawaJapan Faculty of Science and Technology Meijo UniversityNagoyaAichiJapan

There is urgent demand for biologically compatible vascular grafts for both adult and pediatric *** utility of conventional nonbiodegradable materials is limited because of their thrombogenicity and inability to grow,while autologous vascular grafts involve considerable disadvantages,including the invasive procedures required to obtain these healthy vessels from patients and insufficient availability in patients with systemic *** of these issues could be overcome by tissue-engineered vascular grafts(TEVGs).A large body of evidence has recently emerged in support of TEVG technologies,introducing diverse cell sources(e.g.,somatic cells and stem cells)and novel fabrication methods(e.g.,scaffold-guided and self-assembled approaches).Before TEVG can be applied in a clinical setting,however,several aspects of the technology must be improved,such as the feasibility of obtaining cells,their biocompatibility and mechanical properties,and the time needed for fabrication,while the safety of supplemented materials,the patency and nonthrombogenicity of TEVGs,their growth potential,and the long-term influence of implanted TEVGs in the body must be *** recent advances in TEVG fabrication have yielded promising results,more research is needed to achieve the most feasible methods for generating optimal *** article reviews multiple aspects of TEVG fabrication,including mechanical requirements,extracellular matrix components,cell sources,and tissue engineering *** potential of periodic hydrostatic pressurization in the production of scaffold-free TEVGs with optimal elasticity and stiffness is also *** the future,the integration of multiple technologies is expected to enable improved TEVG performance.

关键词： optimal Engine elasticity

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晚清“睡狮”形象探源

中山大学学报（社会科学版） 2009年第5期49卷 87-96页

作者：石川祯浩日本京都大学人文科学研究所

在20世纪初,"睡狮"、"醒狮"成为中国士人普遍接受的一个象征性说法。最近几年来,随着中国在政治、经济上的崛起,"睡狮/醒狮"形象作为洗雪近百年屈辱的民族主义情绪符号,再次引起人们热议。不过,清末"睡狮"说的起源还有待进一步探讨。笔... 详细信息

在20世纪初,"睡狮"、"醒狮"成为中国士人普遍接受的一个象征性说法。最近几年来,随着中国在政治、经济上的崛起,"睡狮/醒狮"形象作为洗雪近百年屈辱的民族主义情绪符号,再次引起人们热议。不过,清末"睡狮"说的起源还有待进一步探讨。笔者在涉猎了众多资料后,发现"睡狮"形象最早是在戊戌时期由梁启超创造出来的。值得一提的是,当时梁提出的"睡狮"实际上是指弗兰肯斯坦之怪物。梁之所以作这样的解释,是因为他受天津《国闻报》的一篇文章(和严复按语)的启发而把弗兰肯斯坦误解为状如狮子的人造机巧怪物。"睡狮"说的发生过程可能是:梁启超在戊戌变法时期,对其间接得到的有关吴士礼(Wolse-ley)、弗兰肯斯坦之怪物的知识,发挥想象力与其读过的曾纪泽的《中国先睡后醒论》结合起来,于1898-1899年创造出来的。与我们现在的常识不同,在那之前外国没有称中国为"睡狮"的例子。应该说,清末"睡狮"形象急速而广泛的传播是基于梁启超创造、发明的"睡狮"而出现的文化现象。中国="睡狮"(Sleeping Lion)这个表述,首先是在清末中国人之间迅速流行,然后才流传到包括日本在内的外国舆论界的。

关键词：睡狮弗兰肯斯坦之怪物梁启超曾纪泽

李大钊早期思想中的日本因素——以茅原华山为例

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社会科学研究 2007年第3期 141-149页

作者：石川祯浩日本京都大学人文科学研究所

李大钊早期著作充满着复杂性和神秘性。长期以来,有很多学者提出了各种各样的解释来试图阐明他早期思想的特色及来源。笔者经过考察发现,对李大钊的早期思想产生最大最直接影响的是日本评论家茅原华山的一系列著作。更具体地说,以《青... 详细信息

李大钊早期著作充满着复杂性和神秘性。长期以来,有很多学者提出了各种各样的解释来试图阐明他早期思想的特色及来源。笔者经过考察发现,对李大钊的早期思想产生最大最直接影响的是日本评论家茅原华山的一系列著作。更具体地说,以《青春》为代表的李大钊著作所表现出的时间观、历史观、文明观,是直接受了茅原华山的《悲壮精神》、《人类生活史》及其主办的《第三帝国》杂志的影响。李大钊早期著作所具有的茫漠及难解,也只是所依据的茅原华山著作的茫漠性及难解性的反映。李大钊的早期思想与茅原华山的奇异交错,给我们分析中国1910年代思想史提供了一个有利的暗示,即1910年代的中国知识分子卷入到同时代的世界思潮中,并与世界思潮紧紧结合在一起。

关键词：李大钊茅原华山《青春》第三文明

Three-dimensional crystal defect imaging by STEM depth sectioning

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Chinese Physics B 2024年第8期33卷 2-7页

作者： Ryo ishikawa Naoya Shibata Yuichi Ikuhara Institute of Engineering Innovation The University of TokyoBunkyoTokyo 113-8656Japan

One of the major innovations awaiting in electron microscopy is full three-dimensional imaging at atomic *** the success of aberration correction to deep sub-angstrom lateral resolution,spatial resolution in depth is still far from atomic *** scanning transmission electron microscopy(STEM),this poor depth resolution is due to the limitation of the illumination *** overcome this physical limitation,it is essential to implement a next-generation aberration corrector in STEM that can significantly improve the depth *** review discusses the capability of depth sectioning for three-dimensional imaging combined with large-angle illumination ***,the statistical analysis approach remarkably improves the depth resolution,making it possible to achieve three-dimensional atomic resolution imaging at oxide *** will also discuss the future prospects of three-dimensional imaging at atomic resolution by STEM depth sectioning.

关键词： atomic-resolution STEM STEM depth sectioning depth resolution dopants surface topography

Adenylyl Cyclase Type 2 and 6 Differentially Regulate Vascular Tone and Remodeling in the Ductus Arteriosus

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Adenylyl Cyclase Type 2 and 6 Differentially Regulate Vascul...

The 2024 M_(j) 7.6 Noto Peninsula, Japan earthquake caused by the fluid flow in the crust

第五届亚洲儿科研究大会

作者： Utako Yokoyama Susumu Minamisawa Ayako Katayama Toru Akaike Shumpei Yokota yoshihiro ishikawa Yokohama City University Graduate School of Medicine Waseda University

＜正＞Prostaglandin E（PGE）-adenylyl cyclase（AC）-cyclic AMP（cAMP） signaling plays two opposing roles in ductus arteriosus（DA）;opening by vasodilatation and closing by hyaluronan-mediated neointimal ***,distinct...

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Earthquake Research Advances 2024年第3期4卷 1-6页

作者： Yuzo ishikawa Ling Bai Center for Integrated Research and Education of Natural Hazards Shizuoka UniversityShizuoka422-8529Japan State Key Laboratory of Tibetan Plateau Earth System Environment and Resources(TPESER)Institute of Tibetan Plateau ResearchChinese Academy of SciencesBeijing100101China University of Chinese Academy of Sciences Beijing100049China

On January 1, 2024 at 16:10:09 JST, an M_(j) 7.6 earthquake struck the Noto Peninsula in the southern part of the Sea of Japan. This location has been experiencing an earthquake swarm for more than three years. Here, we provide an overview of this earthquake, focusing on the slip distribution of the mainshock and its relationship with the preceding swarm. We also reexamined the source areas of other large earthquakes that occurred around the Sea of Japan in the past and compared them with the Matsushiro earthquake swarm in central Japan from1964 to 1968. The difference between the Matsushiro earthquake swarm and the Noto earthquake swarm is the surrounding stress field. The Matsushiro earthquake swarm was a strike-slip stress field, so the cracks in the crust were oriented vertically. This allowed fluids seeped from the depths to rise and flow out to the surface. On the other hand, the Noto area was a reverse fault stress field. Therefore, the cracks in the earth's crust were oriented horizontally. Fluids flowing underground in deep areas could not rise and spread over a wide area in the horizontal plane. This may have caused a large amount of fluid to accumulate underground, triggering a large earthquake. Although our proposed mechanism does not take into account other complex geological conditions into consideration, it may provide a simple way to explain why the Noto swarm is followed by a large earthquake while other swarms are not.

关键词： The M 7.6 Noto Peninsular earthquake Earthquake swarm Fluid triggering Strike-slip fault Reverse fault

The 2023 Turkey earthquake doublet: Earthquake relocation, seismic tomography, and stress field inversion

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Earth and Planetary Physics 2024年第3期8卷 535-548页

作者： HuiLi Zhan Ling Bai Bagus Adi Wibowo ChaoYa Liu Kazuo Oike Yuzo ishikawa State Key Laboratory of Tibetan Plateau Earth System Environment and Resources(TPESER)Institute of Tibetan Plateau ResearchChinese Academy of SciencesBeijing 100101China University of Chinese Academy of Sciences Beijing 100049China Center of Earthquake and Tsunami Agency of MeteorologyClimatology and GeophysicsJakarta 10610Indonesia University of Shizuoka Shizuoka 422-8526Japan Shizuoka University Shizuoka 422-8529Japan

On February 6,2023,two earthquakes with magnitudes of M_(W) 7.8 and M_(W) 7.5 struck southeastern Turkey,causing significant casualties and economic *** seismic events occurred along the East Anatolian Fault Zone,a convergent boundary between the Arabian Plate and the Anatolian *** this study,we analyze the M_(W) 7.8 and M_(W) 7.5 earthquakes by comparing their aftershock relocations,tomographic images,and stress field *** earthquakes were localized in the upper crust and exhibited steep dip ***,the aftershocks occurred either close to the boundaries of low and high P-wave velocity anomaly zones or within the low P-wave velocity anomaly *** East Anatolia Fault,associated with the M_(W) 7.8 earthquake,and the SürgüFault,related to the M_(W) 7.5 earthquake,predominantly experienced shear ***,their western sections experienced a combination of strike-slip and tensile stresses in addition to shear *** ruptures of the M_(W) 7.8 and M_(W) 7.5 earthquakes appear to have bridged a seismic gap that had seen sparse seismicity over the past 200 years prior to the 2023 Turkey earthquake sequence.

关键词： Turkey earthquake doublet earthquake relocation seismic tomography stress field seismicity

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中共一大研究与回忆录

中共创建史研究 2018年第1期 87-93页

作者：石川祯浩日本京都大学

进一步深入中共创建史研究的一个方法,是对中共一大代表的回忆录重新加以探究。使用回忆录时,必须对各种回忆录产生的背景和经过进行具体的分析,这些分析不仅在评估不同回忆录的可靠性时非常有必要,而且对人们了解中华人民共和国成立以... 详细信息

进一步深入中共创建史研究的一个方法,是对中共一大代表的回忆录重新加以探究。使用回忆录时,必须对各种回忆录产生的背景和经过进行具体的分析,这些分析不仅在评估不同回忆录的可靠性时非常有必要,而且对人们了解中华人民共和国成立以后党史与政治紧密联系的情况,也会有所帮助。回忆者的社会地位、政治立场、产生回忆的时间,以及写回忆时参考的资料、党史著作的影响等因素,都会影响回忆录的内容。研究中共一大的人最需要注意和探讨的,与其说是一大会议本身举行得如何,不如说是1949年以后一大研究是在什么样的资料状况下,以及在什么样的意识形态下进行的。

关键词：中共一大回忆录研究开会日期

History of Western Philosophy and Quantum Language (Including Quantum Mechanics, Statistics, Fuzzy Logic, etc.)

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Journal of Applied Mathematics and Physics 2024年第5期12卷 1769-1795页

作者： Shiro ishikawa Department of Mathematics Faculty of Science and Technology Keio University Yokohama Japan

Although there are many different types of philosophy, many philosophers agree that the mainstream of Western philosophy (Socrates, Plato, Aristotle, Descartes, Kant, Wittgenstein) developed toward the perfection of Socrates’ absolutism. But can the absolutism maintain its central position after analytic philosophy? There are pessimistic views on this problem, such as that of R. Rorty, the standard-bearer of neo-pragmatism. Recently, I proposed quantum language (which is including quantum mechanics, statistics, fuzzy sets, etc.). I think that that this theory is not only one of the most fundamental scientific theories, but also the scientific final destination of Western philosophy. If so, Socrates’ dream has come true. The purpose of this paper is to discuss the above and to inform readers that quantum language has the power to create a paradigm shift from the classical mechanical world view to the quantum mechanical worldview.

关键词： Quantum Language Linguistic Copenhagen Interpretation Fuzzy Logic