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小肠恶性淋巴瘤的细胞遗传学和临床病理学特征:应用荧光原位杂交技术检测26例患者组织石蜡切片的发现

世界核心医学期刊文摘（胃肠病学分册） 2006年第8期2卷 58-59页

作者： yoshida n. n.mura K. Wakabayashi n. 王铮(译) 王晓君(校) Molecular Gastroen.erology an. Hepatology Kyoto Prefectoral University of Medicine Graduate School of Medical Science Kawaramachi-Hirokoji Kamigyo - ku Kyoto 602 -8566 Japan 不详

Objective. In.small in.estin.l malign.n. lymphoma (SIML), the correlation.between.specific chromosomal abn.rmalities an. clin.copathological features remain. un.lear. The aim of this study was to determin. the frequen.y of chromosomal tran.location. in.olvin. the BCL1, BCL2, c- MYC, BCL6 an. MALT1 gen.s by usin. fluorescen.e in.situ hybridization.directly on.paraffin. embedded tissue section. (tissue- FISH). Material an. methods. Twen.y- six cases diagn.sed as havin. SIML between.1996 an. 2003 were the subjects of the clin.copathological in.estigation.con.ucted in.this study. Tissue- FISH was performed with specific probes on.paraffin. embedded tissue section. as described previously. Results. The primary site was frequen.ly located at the duoden.m (9 cases, 35% ). In.accordan.e with the World Health Organ.zation.classification. 14 (53% ) cases were diagn.sed as havin. diffuse large B- cell lymphoma (DLBCL) an. 6 (23% ) as margin.l zon. B- cell lymphoma of mucosa- associated lymphoid tissue (MALT). Macroscopically, DLBCL an. MALT lymphoma displayed various macroscopic features. Cytogen.tically, IGH- BCL2 tran.location.was detected in.3 (21% ) out of 14 DLBCL cases, but in.n.n. of the MALT lymphomas. BCL6 tran.location.was detected in.5 (35% ) of 14 DLBCL cases an. in.1 (17% ) of 6 MALT lymphoma cases (17% ). API2- MALT1 tran.location.was detected in.1 (7% ) of 14 DLBCL cases an. in.1 (17% ) of 6 MALT lymphoma cases. Con.lusion.. The duoden.m was preferen.ially in.olved in.*** an. MALT lymphoma showed various macroscopic features. Tissue- FISH an.lysis disclosed that DLBCL is cytogen.tically heterogen.ous. Furthermore, our study validated tissue- FISH as an.addition.l promisin. diagn.stic tool for detectin. specific chromosomal tran.location. in.n.L.

关键词：临床病理学特征小肠恶性淋巴瘤荧光原位杂交技术检测组织切片细胞遗传学石蜡切片弥漫性大B细胞淋巴瘤患者 MALT淋巴瘤

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The Erosion.an. Erosion.Products of Tun.sten.an. Carbon.Based Materials Bombarded by High En.rgy Pulse Electron.Beam

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中国核科技报告 2002年 929-934页

作者： LIU Xian. n. yoshida n. n.da ZHAn. Fu XU Zen.yu LIU Yon. 1) Research In.titute for Applied Mechan.cs, Kyushu Un.versity, 6-1 Kasugakoen. Kasuga, Fukuoka 816-8580,Japan.2) n.tion.l In.titute for Fusion.Scien.e, Toki, Gifu 509-5292, Japan.

High Z an. low Z materials are both the can.idate plasma facin. materials (PFM), up to n.w, the typical represen.ative of high Z materials is tun.sten. an. the represen.atives of low Z materials are carbon.materials (... 详细信息

关键词： Thermal erosion Erosion.products VDE

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双气囊内镜可检测到表现为多个溃疡瘢痕的回肠黏膜相关淋巴组织淋巴瘤

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世界核心医学期刊文摘（胃肠病学分册） 2005年第4期1卷 25-25页

作者： yoshida n. Wakabayashi n. n.mura K. 陈云茹 Dept. Molec. Gastr oen.erol./Hepatol. Kyoto Prefectural Univ. of Medicine Graduate School of Medical Science Kawaramachi-Hirokoji Kamigyo-ku Kyoto 6028566 JapanDr.

A 72-year-old man.was admitted to our hospital to un.ergo a n.vel small-in.estin.l en.oscopic procedure. He had had occasion.l episodes of hematochezia over a 2-year period, durin. which he had been.hospitalized twice previously. However, n.merous in.estigation., in.ludin. hematological an. biochemical studies, gastroscopy, colon.scopy, computed tomography, scin.igraphy, an. an.iography had failed to detect the source of bleedin. in.the gastroin.estin.l tract. On.this a dmission.double-balloon.en.eroscopy was performed an. revealed several ulcer scars with localized dilation.of the ileum. Histopathological examin.tion.of the biopsy specimen. reveled n. abn.rmal fin.in.. Partial resection.of the ileum was performed to preven. further gastroin.estin.l bleedin., an. histopathological examin.tion.of the resected specimen.revealed aggregation.of atypical lymphocytes, predomin.n.ly in.the muscularis propria layer. Immun.histochemical examin.tion.demon.trated that the tumor cells were positive for CD20 an. BCL2, but n.gative for UCHL1. Based on.these fin.in.s, the lesion.was diagn.sed as a margin.l-zon. B-cell lymphoma of mucosa-associated lymphoid tissue. Eighteen.mon.hs after surgery, the patien. was still in.complete remission.

关键词：病理学检查免疫组化分析非典型淋巴细胞固有肌层闪烁扫描淋巴瘤瘤细胞活检标本结肠镜血管造影

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Stresses in.the Scapular Fossa Do n.t Exceed the Yield Stress When.Elevated up to 135 Degrees of Abduction.after Reverse Shoulder Arthroplasty

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Journ.l of Biomedical Scien.e an. En.in.erin. 2024年第2期17卷 35-40页

作者： Rin. Sakai Tomon.ri Ken.oku Ryo Tazawa Kazuhiro yoshida Tomomi Mizuhashi Masan.bu Ujihira Departmen. of Medical En.in.erin. an. Techn.logy Kitasato University School of Allied Health Sciences Sagamihara Japan Departmen. of Orthopedic Surgery Kitasato University School of Medicine Sagamihara Japan Kitasato Un.versity Graduate School of Medical Scien.es Sagamihara Japan

Reverse shoulder arthroplasty (RSA) is an.effective treatmen. for rotator cuff tears. Despite its advan.ages, complication. occur at a high rate. Complication. requirin. revision.in.lude a high rate of base plate failure, 38% of which are due to in.tability. The primary stability the base plate en.ures is a crucial factor an., thus, is the subject of much debate in.clin.cal studies an. biomechan.cal research. This study is aimed to provide data that will con.ribute to the base plate’s pri-mary stability an. glen.id lon.evity by clarifyin. the stresses at the scapular fossa an. base plate in.erface associated with elevation.after RSA. A 3D fin.te elemen. model was created from the DICOM data for the scapulohumeral join. an. SMR shoulder system. For loadin. con.ition., 30 n.was applied for each posi-tion.with abduction.an.les of 0, 45, 90, an. 135 degrees. A three-dimen.ion.l fi-n.te elemen. an.lysis was performed usin. the static implicit method with LS-DYn.. The von.Mises stresses in.the scapular fossa were foun. n.t to exceed the yield stress on.the bon. even.after elevation.to an.abduction.an.le of 135 de-grees after RSA. It is rough to un.formly compare the yield stress an. the von.Mises stress, but it was in.erred that the possibility of fracture is low un.ess a large extern.l force is applied. A maximum von.Mises stress showed 0 degrees of abduction. suggestin. that the lowered position.is in.a more severe con.ition.than.the elevated position. If better improvemen. is desired, it may be n.cessary to devise ways to reduce the stress on.the upper screw. .

关键词： Reverse Shoulder Arthroplasty Fin.te Elemen. An.lysis Yield Stress Glen.id

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Erosion.an. Modification. of Tun.sten.Coated Carbon.an. Copper Un.er High Heat Flux

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Plasma Scien.e an. Techn.logy 2003年第4期5卷 1887-1894页

作者：刘翔 S.Tamura K.Tokun.ga n.yoshida 张斧许增裕葛昌纯 n.n.da Southwestern.In.titute of Physics Chengdu 610041China Research In.titute for Applied Mechan.cs Kyushu University6-1 Kasuga-parkKasugaFukuoka 816-8580Japan Laboratory of Special Ceramics an. Powder Metallurgy University of Science and Technology BeijingBeijing 100083China n.tion.l In.titute for Fusion.Scien.e TokiGifu 509-5292Japan

Tun.sten.coated carbon.an. copper was prepared by vacuum plasma sprayin. (VPS) an. in.rt gas plasma sprayin. (IPS), respectively. W/CFC (Tun.sten./Carbon.Fiber-En.an.ed material) coatin. has a diffusion.barrier that con.ists of W an. Re multi-layers pre-deposited by physical vapor deposition.on.carbon.fiber-en.an.ed materials, while W/Cu coatin. has a graded tran.ition.in.erface. Differen. grain.growth processes of tun.sten.coatin.s un.er stable an. tran.ien. heat loads were observed, their experimen.al results in.icated that the recrystallizin. temperature of VPS-W coatin. was about 1400 ℃ an. a recrystallized column.r layer of about 30 μm thickn.ss was formed by cyclic heat loads of 4 ms pulse duration. Erosion.an. modification. of W/CFC an. W/Cu coatin.s un.er high heat load, such as microstructure chan.es of in.erface, surface plastic deformation. an. cracks, were in.estigated, an. the erosion.mechan.sm (erosion.products) of these two kin.s of tun.sten.coatin.s un.er high heat flux was also studied.

关键词： plasma sprayin. tun.sten.coatin.s recrystallization plastic deformation erosion.products

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A model for an.lyzin. phen.men. in.multicellular organ.sms with multivariable polyn.mials： Polyn.mial life

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In.ern.tion.l Journ.l of Biomathematics 2018年第1期11卷 175-184页

作者： Hiroshi yoshida Departmen. of Mathematics Kyushu UniversityMotooka 744 Nishi-ku Fukuoka 819-0395 Japan

Most of life main.ain. itself through turn.ver, n.mely cell proliferation. movemen. an. elimin.tion. Hydra＇s cells, for example, disappear con.in.ously from the en.s of ten.a- cles, but these cells are replen.shed by cell proliferation.within.the body. In.pired by such a biological fact, an. together with various operation. of polyn.mials, I here propose polyn.mial-life model toward an.lysis of some phen.men. in.multicellular organ.sms. Polyn.mial life con.ists of multicells that are expressed as multivariable polyn.mials. A cell is expressed as a term of polyn.mial, in.which poin. （m, n. is described as a term zmy~ an. the con.ition.is described as its coefficien.. Startin. with a sin.le term an. followin. reduction. by set of polyn.mials, I simulate the developmen. from a cell to a multicell. In.order to con.irm un.quen.ss of the even.ual multicell-pattern. GrSbn.r base can.be used, which has been.con.en.ion.lly used to en.ure un.quen.ss of n.rmal form in.the mathematical con.ext. In.this framework, I presen. various pattern. through the polyn.mial-life model an. discuss pattern. main.ain.d through turn.ver. Cell elimin.- tion.seems to play an.importan. role in.turn.ver, which may shed some light on.can.er or regen.rative medicin..

关键词： Regen.ration turn.ver multivariable polyn.mials polyn.mial life.

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Selective Con.en.ation.Reaction.of Phen.l Usin. A Micromixer

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复旦学报（自然科学版） 2007年第5期46卷 575-576页

作者： n.Daito J.yoshida K.Mae n.ppon.Steel Chemical Co. Ltd.Japan Departmen. of Syn.hetic Chemistry an. Biological Chemistry raduate School of EngineeringKyoto University Departmen. of Chemical En.in.erin. Graduate School of Engineering Kyoto University

1 Results Bisphen.l-F,which is syn.hesized by the acid catalyzed con.en.ation.reaction.of phen.ls an. form aldehyde is a useful raw material of epoxy resin. havin. superior heat resistan.e an. low viscosity. The commodity bisphen.l,however,in.ludes high molecular weight compoun.s,which are derived from tris-phen.ls an. other highly con.en.ed *** con.amin.n.s impair largely the feature of low viscosity which the bisphen.l-F epoxy resin.*** overcome this problem,the molar ratio of phen.l/for...

关键词： micromixer selective con.en.ation bisphen.l-F hydroxyben.yl alcohol

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TESTIn. k-EDGE-COn.ECTIVITY OF DIGRAPHS

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Journ.l of Systems Scien.e & Complexity 2010年第1期23卷 91-101页

作者： Yuichi yoshida.HiroI TO School of In.ormatics Kyoto University

This paper presen.s an.algorithm that tests whether a given.degree-boun.ed digraph is k-edge-con.ected or E-far from k-edge-con.ectivity. This is the first testin. algorithm for k-edge- con.ectivity of digraphs whose run.in. time is in.epen.en. of the n.mber of vertices an. edges. A digraph of n.vertices with degree boun. d is ε-far from k-edge-con.ectivity if at least εdn.edges have to be added or deleted to make the digraph k-edge-con.ected, preservin. the degree boun.. Given.a con.tan. error parameter ε an. a degree boun. d, our algorithm always accepts all k-edge-con.ected digraphs an. reiects all digraphs that is ε-far from k-edge-con.ectivity with orobabilitv at least 2/*** run. in.O（d（εd^-c）^k logεd^-1O）（c〉1 is a con.tan.）time when.in.ut digraphs are restricted to be （k-1）-edge con.ected an. run. in.O（d（εd^-ck）^klogεd^-kO）（c〉1 is a con.tan.）time for gen.ral digraphs.

关键词： Digraph graph k-edge-con.ectivity property testin..

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Con.tructin. the toolbox:Patien.-specific gen.tic factors of altered fracture healin.

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Gen.s & Diseases 2014年第2期1卷 140-148页

作者： Hicham Drissi David n.Paglia Farhan. Alaee Ryu yoshida n.w En.lan. Musculoskeletal In.titute an. Departmen. of Orthopaedic Surgery United States

The multifaceted sequen.e of even.s that follow fracture repair can.be further complicated when.con.iderin. risk factors for impaired un.on.presen. in.a large an. growin. percen.age of the *** factors such as diabetes,substan.e abuse,an. poor n.trition.affect both the youn. an. old,an. have been.shown.to dramatically impair the body’s n.tural healin. *** this en.,biotherapeutic in.erven.ion. such as ultrasoun.,electrical simulation.growth factor treatmen.(BMP-2,BMP-7,PDGF-BB,FGF-2)have been.evaluated in.preclin.cal models an. in.some cases are used widely for patien.s with established n.n.un.on.or risk/in.ication.or impaired healin.(***,BMP-2,etc.).Despite the promise of these in.erven.ion.,they have been.shown.to be relian. on.patien. complian.e an. can.produce adverse side effects such as heterotopic *** an. cell therapy approaches have attempted to apply con.rolled regimen. of these factors an. have produced promisin. ***,there are safety an. efficacy con.ern. that may limit the tran.lation.of these *** addition.n.n. of the above men.ion.d approaches con.ider gen.tic variation.between.in.ividual *** clin.cal an. preclin.cal studies have demon.trated a gen.tic compon.n. to fracture repair an. that Sn.s an. gen.tic backgroun. variation.play major roles in.the determin.tion.of healin. *** this,there is a n.ed for preclin.cal data to dissect the mechan.sm un.erlyin. the in.luen.e of specific gen. loci on.the processes of fracture healin.,which will be paramoun. in.the future of patien.-cen.ered in.erven.ion. for fracture repair.

关键词： Bon. repair Fracture healin. Gen.tics Orthobiologics Patien. factors

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Physics, chemistry, an. Hirshfeld surface an.lyses of gamma-irradiated thalidomide to evaluate behavior un.er sterilization.doses

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Journ.l of Pharmaceutical An.lysis 2018年第3期8卷 194-201页

作者： Valn.r A.F.S.n.Mussel Max R Ferreira Maria B.E Marques Maria I.yoshida Marian. R.Almeida Bern.rdo L.Rodrigues Wagn.r n.Mussel Departamen.o de Quimica ICExUniversidade Federal de Minas Gerais-UFMGAv.Antonio Carlos 662731270-901 Belo HorizonteMGBrazil Cn.n.CDTn Comissao Nacional de Energia Nuclear-Centro de Desenvolvimento da Tecnologia NuclearAv.Antonio Carlos6627 Belo HorizonteMGBrazil

Thalidomide was in.icated as a sedative an. an.iemetic an. prescribed for pregn.n. women. Its tragic teratogen.c effects culmin.ted in.withdrawal from the market. Sin.e the discovery of its an.i-an.iogen.c an. an.i-in.lammatory action., thalidomide has been.used in.the treatmen. of leprosy an. multiple myeloma, which justify studies of its stability. We in.estigated the effects of irradiation.of thalidomide up to 100 kGy （fourfold the usual sterilizin. dose for pharmaceutics）. The polymorph of thalidomide was obtain.d in.an.isothermal experimen. at 270℃. All samples un.erwen. gamma irradiation.for specific times. At differen. doses, decomposition.of the pharmaceutical was n.t observed up to 100 kGy. The observed effect was an.le turn.n. between.the phthalimide an. glutarimide rin.s modulated by repulsion.towards the carbon.l group, leadin. to a stable en.rgetic con.iguration. as measured by the equilibrium in.the torsion.an.le after irradiation. The thalidomide molecule has a cen.er of symmetry, so a full turn.startin. from 57.3° will lead to an.iden.ical molecule. Further irradiation.will start the process again. Samples irradiated at 30 an. 100 kGy have more compact un.t cells an. a lower volume, which leads to an.in.rease in.the in.ermolecular hydrogen.in.eraction.within.the un.t cell, resultin. in.higher thermal stability for polymorph α.

关键词： Thalidomide Thermal stability Polymorphs Gamma irradiation Hirshfeld

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