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The Friction Welding Method with Intermediate Material

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Journal of Mechanics Engineering and Automation 2013年第11期3卷 677-684页

作者： Ryoji Tsujino Takeshi Higashi Kiyoshi Matsuura yoshiaki ueda Manabu Iguchi Faculty of Science and Engineering Setsunan University Neyagawa 672-8508 Japan Faculty of Engineering Setsunan University Neyagawa 672-8508 Japan Taiyu Corp. Neyagawa 572-0077 Japan Division of Materials Science and Engineering Graduate School of Engineering Hokkaido University Hokkaido 060-8628 Japan Faculty of Engineering Osaka Electro-Communication University Neyagawa 572-8530 Japan

For the purpose of improving the defects of the conventional friction welding method, the new friction welding technology has been examined. That is, the aim of the study is producing the joint of dissimilar materials evaluated to be difficult for friction welding and non-round shape joints. In this process, after the intermediate material generates the independent friction heat on every side of the specimens, it is removed instantaneously and upset process begins to weld the specimens for a joint. In this study, similar joint of A2017 aluminum alloy and one of S45C steel were examined. On the other hand, thermal elastic-plastic stress analysis by the finite element method was carried out using ANSYS mechanical.

关键词：摩擦焊接焊接方法中间材料焊接试样 ANSYS 焊接技术异种材料应力分析

Numerical Simulation of New Friction Welded Joints

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Journal of Mechanics Engineering and Automation 2013年第10期3卷 595-601页

作者： Takeshi Higashi Ryoji Tsujino Kiyoshi Matsuura yoshiaki ueda Manabu Iguchi Faculty of Engineering Setsunan University Neyagawa 672-8508 Japan Faculty of Science and Engineering Setsunan University Neyagawa 672-8508 Japan Taiyu Corp. Neyagawa 572-0077 Japan Division of Materials Science and Engineering Graduate School of Engineering Hokkaido University Hokkaido 060-8628 Japan Faculty of Engineering Osaka Electro-Communication University Neyagawa 572-8530 Japan

In developing the new friction welding technology, the thermal elastic-plastic stress analysis by the finite element method was carried out to seek the suitable welding conditions such as the friction pressure, the friction speed and the upset pressure. The results obtained are as follows: Heat transfer to the specimens and the intermediate material during friction process was made clear; The operational conditions such as the rotation number of the intermediate material and the friction pressure to reach the liquidus in the interface could be estimated; Further, as the overhang length near the interface is well related to the joint efficiency, we tried to obtain the operational conditions by numerical analysis to acquire a certain length of the overhang length near the interface.

关键词：摩擦焊接头数值模拟热弹塑性应力摩擦压力中间材料操作条件伸长度焊接技术

Immunotherapy for esophageal cancer:Where are we now and where can we go

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World Journal of Gastroenterology 2024年第19期30卷 2496-2501页

作者： yoshiaki Shoji Kazuo Koyanagi Kohei Kanamori Kohei Tajima Mika Ogimi Yamato Ninomiya Miho Yamamoto Akihito Kazuno Kazuhito Nabeshima Takayuki Nishi Masaki Mori Department of Gastroenterological Surgery Tokai University School of MedicineKanagawa 259-1193Japan

Immune checkpoint inhibitor therapy has dramatically improved patient prognosis,and thereby transformed the treatment in various cancer types including esophageal squamous cell carcinoma(ESCC)in the past decade.Monoclonal antibodies that selectively inhibit programmed cell death-1(PD-1)activity has now become standard of care in the treatment of ESCC in metastatic settings,and has a high expectation to provide clinical benefit during perioperative period.Further,anti-cytotoxic T-lymphocyte–associated protein 4(CTLA-4)monoclonal antibody has also been approved in the treatment of recurrent/metastatic ESCC in combination with anti-PD-1 antibody.Well understanding of the existing evidence of immune-based treatments for ESCC,as well as recent clinical trials on various combinations with chemotherapy for different clinical settings including neoadjuvant,adjuvant,and metastatic diseases,may provide future prospects of ESCC treatment for better patient outcomes.

关键词： Esophageal cancer Immunotherapy Immune checkpoint inhibitor Programmed cell death-1 Anti-cytotoxic T-lymphocyte-associated protein 4 Neoadjuvant therapy Adjuvant therapy Clinical trials Combination therapy

Tumor size discrepancy between endoscopic and pathological evaluations in colorectal endoscopic submucosal dissection

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World Journal of Gastrointestinal Endoscopy 2024年第3期16卷 136-147页

作者： Takeshi Onda Osamu Goto Toshiaki Otsuka yoshiaki Hayasaka Shun Nakagome Tsugumi Habu Yumiko Ishikawa Kumiko Kirita Eriko Koizumi Hiroto Noda Kazutoshi Higuchi Jun Omori Naohiko Akimoto Katsuhiko Iwakiri Department of Gastroenterology Nippon Medical SchoolGraduate School of MedicineBunkyo-ku 113-8603TokyoJapan Endoscopy Center Nippon Medical School HospitalBunkyo-ku 113-8603TokyoJapan Department of Hygiene and Public Health Nippon Medical SchoolBunkyoku 113-8603TokyoJapan Center for Medical Education Nippon Medical SchoolBunkyo-ku 113-8603TokyoJapan

BACKGROUND Tumor size impacts the technical difficulty and histological curability of colorectal endoscopic submucosal dissection(ESD);however,the preoperative evaluation of tumor size is often different from histological assessment.Analyzing influential factors on failure to obtain an accurate tumor size evaluation could help prepare optimal conditions for safer and more reliable ESD.METHODS This was a retrospective study conducted at a single institution.A total of 377 lesions removed by colorectal ESD at our hospital between April 2018 and March 2022 were collected.We first assessed the difference in size with an absolute per-centage of the scaling discrepancy.Subsequently,we compared the clinicopatho-logical characteristics of the correct scaling group(>-33%and33%),which was further subdivided into the underscaling group(-33%or less of the discrepancy)and overscaling group(33%or more of the discrepancy),respectively.As secondary outcome measures,parameters on size estimation were compared between the underscaling and correct scaling groups,as well as between the overscaling and correct scaling groups.Finally,multivariate analysis was performed in terms of the following relevant parameters on size estimation:Pathological size,location,and possible influential factors(P<0.1)in the univariate analysis.RESULTS The mean of absolute percentage in the scaling discordance was 21%,and 91 lesions were considered to be incorrectly estimated in size.The incorrect scaling was significantly remarkable in larger lesions(40 mm vs 28 mm;P<0.001)and less experience(P<0.001),and these two factors were influential on the underscaling(75 lesions;P<0.001).Conversely,compared with the correct scaling group,16 lesions in the overscaling group were significantly small(20 mm vs 28 mm;P<0.001),and the small lesion size was influential on the overscaling(P=0.002).CONCLUSION Lesions indicated for colorectal ESD tended to be underestimated in large tumors,but overestimated in small one

关键词： Endoscopic submucosal dissection Colorectal tumor Tumor size Size estimation Size discrepancy

Integrating the effect of abutments in estimating the average vertical stress of elastic hard rock pillars by combining numerical modelling and artificial neural networks

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Underground Space 2023年第6期13卷 121-135页

作者： Nevaid Dzimunya yoshiaki Fujii Youhei Kawamura Faculty of Engineering Hokkaido UniversitySapporo N13W8Japan

Estimating average vertical pillar stresses is a critical step in designing room-and-pillar mines.Several analytical methods can be used to estimate the vertical stresses acting on the pillars.However,the present analytical methods fail to adequately account for the influence of abutments on the distribution of vertical stresses,especially when applied to narrow panel widths and pillar layouts comprising evenly spaced barriers.In this study,a multi-layer perceptron neural network(MLPNN)was applied to predict the vertical loads of regular pillars more accurately.Hundreds of room-and-pillar mine layouts were modeled using a displacement discontinuity method(DDM),and a database of 2355 sampled pillar cases was compiled.The MLPNN was trained based on this database,and its prediction capabilities were further validated using simulations by a finite difference code(i.e.,FLAC3D).The model predictions and the FLAC3D simulations reasonably agreed with a regression coefficient of 0.99.The model was also adapted for mine cases with evenly spaced barrier pillars,and its application to a real case study mine has shown to provide accurate pillar stress estimations;hence,this model is suitable for practical use at mines.Even though the MLPNN model cannot be applied universally to all mine situations,it seems as a significant improvement over existing analytical techniques in terms of accounting for the influence of abutments on pillar stresses.

关键词： Pillar stress Abutments Multi-layer perceptron neural network Numerical simulation Room-and-pillar mine

Chemically oligomerizable TDP-43:a novel chemogenetic tool for studying the pathophysiology of amyotrophic lateral sclerosis

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Neural Regeneration Research 2022年第11期17卷 2434-2436页

作者： Kohsuke Kanekura yoshiaki Yamanaka Tamami Miyagi Masahiko Kuroda Department of Molecular Pathology Tokyo Medical University

Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease characterized by the progressive loss of both upper and lower motor neurons.Most ALS cases are sporadic,but approximately 5-10%of patients have a familial background.To date,more than 30 familial ALS-causative genes have been identified (Maurel et al., 2018).

关键词： sclerosis familial

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工资和物价:过去、现在和未来

金融市场研究 2024年第3期 80-89页

作者：植田和男徐恒革(编译) 日本央行不详

一、引言2022年,日本央行前行长黑田东彦在日本经济团体联合会(Keidanren)会议上指出,日本“正在接近打破长期低通胀和低增长的关键时刻”。回首望去,2023年的确是朝着转型迈进的一年。日本经济已转向温和复苏,主要体现在经济活动正常... 详细信息

一、引言2022年,日本央行前行长黑田东彦在日本经济团体联合会(Keidanren)会议上指出,日本“正在接近打破长期低通胀和低增长的关键时刻”。回首望去,2023年的确是朝着转型迈进的一年。日本经济已转向温和复苏,主要体现在经济活动正常化、供给侧约束减弱,产出缺口已改善至0%左右。以消费者价格指数(CPI)衡量的日本通胀率持续超过2%,这主要是由于过去进口价格上涨传递至消费价格.

关键词：供给侧产出缺口消费价格日本央行通胀率低通胀黑田东彦工资

A modified generalized scaling law for the similitude of dynamic strain in centrifuge modeling

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Earthquake Engineering and Engineering Vibration 2023年第3期22卷 589-600页

作者： Ma Qiang Ling Daosheng Meng Di Kyohei ueda Zhou Yanguo MOE Key Laboratory of Soft Soils and Geoenvironmental Engineering Institute of Geotechnical EngineeringCenter for Hypergravity Experiment and Interdisciplinary ResearchZhejiang UniversityHangzhou 310058China Disaster Prevention Research Institute Kyoto UniversityGokashoUjiKyoto 611-0011Japan

Soil strain is the key parameter to control the elasto-plastic deformation and even the failure processes.To overcome the defect that the strain of the model soil is always smaller than that of the prototype in Iai′s generalized scaling law(GSL),a modified scaling law was proposed based on Iai′s GSL to secure the same dynamic shear strain between the centrifuge model and the prototype by modulating the amplitude and frequency of the input motion at the base.A suite of dynamic centrifuge model tests of dry sand level ground was conducted with the same overall scaling factor(λ=200)under different centrifugal accelerations by using the technique of“modeling of models”to validate the modified GSL.The test results show that the modified GSL could achieve the same dynamic strain in model as that of the prototype,leading to better modeling for geotechnical problems where dynamic strain dominates the response or failure of soils.Finally,the applicability of the proposed scaling law and possible constraints on geometry scaling due to the capability limits of existing centrifuge shaking tables are discussed.

关键词： deep deposit seismic response generalized scaling law centrifuge model test

Enhanced electrical property of graphite/Al_(2)O_(3) composite fabricated by reductive sintering of gel-casted body using cross-linked epoxy polymer

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Journal of Advanced Ceramics 2022年第4期11卷 523-531页

作者： yoshiaki FUNAHASHI Yunzi XIN Kunihiko KATO Huu Hien NGUYEN Takashi SHIRAI Department of Life Science and Applied Chemistry Graduate School of EngineeringNagoya Institute of TechnologyGokiso-choShowa-kuNagoyaAichi 466-8555Japan Advanced Ceramics Research Center Nagoya Institute of TechnologyGokiso-choShowa-kuNagoyaAichi 466-8555Japan

In the present study,graphite/alumina composites are fabricated via reductive sintering of gel-casted green bodies with structurally controlled cross-linked epoxy polymers for the first time.The cross-linking degrees of polymers are tuned by the amount ratio of epoxy monomer/polyvinyl alcohol cross-linker utilized in gel-casting process.Superior electrical properties with respect to 5-fold enhanced electrical conductivity and 2-fold higher carrier mobility are successfully achieved in graphite/alumina composite fabricated from cross-linked epoxy polymer,whose phenomenon is attributed to the excellent conductive path in ceramic matrix established by highly uniform network with improved graphitization degree.

关键词： ceramic composite gel-casting reductive sintering cross-linking electrical property graphitization