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Non-transmissible Sendai virus vector encoding c-myc suppressor FBP-interacting repressor for cancer therapy

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World Journal of Gastroenterology 2014年第15期20卷 4316-4328页

作者： Kazuyuki Matsushita Hideaki Shimada Yasuji Ueda Makoto Inoue Mamoru Hasegawa Takeshi Tomonaga Hisahiro Matsubara Fumio nomura Department of Molecular Diagnosis Graduate School of MedicineChiba UniversityChiba 260-8670Japan Department of Surgery School of MedicineToho UniversityTokyo 143-8541Japan DNAVEC Corporation 6 OhkuboTsukuba CityIbaraki 300-2611Japan Proteome Research Center Proteome Research ProjectNational Institute of Biomedical InnovationOsaka 567-0085Japan Department of Frontier Surgery Chiba UniversityGraduate School of MedicineChiba 260-8670Japan

AIM: To investigate a novel therapeutic strategy to target and suppress c-myc in human cancers using far up stream element (FUSE)-binding protein-interacting repressor (FIR).

关键词： Cancer gene therapy c-myc suppressor Far up stream element-binding protein-interacting repressor Sendai virus vector

Colon cancer arising from colonic diverticulum:A case report

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World Journal of Clinical Cases 2019年第13期7卷 1643-1651页

作者： Hajime Kayano Yusuhiko Ueda Takashi Machida Shinichiro Hiraiwa Hidenori Zakoji Takuma Tajiri Masaya Mukai Eiji nomura Department of Gastroenterological and General Surgery Tokai University Hachioji Hospital Tokyo Hachioji 192-0032 Japan Departments of Pathology Tokai University Hachioji Hospital Tokyo Hachioji 192-0032 Japan Departments of Urology Tokai University Hachioji Hospital Tokyo Hachioji 192-0032 Japan

BACKGROUND Colonic diverticulosis is a common disease, and the coexistence of colonic diverticulosis and colorectal cancer is often seen clinically. It is very rare that colon cancer arises from the mucosa of a colonic diverticulum. When colon cancer arises in a diverticulum and then tends to develop outside the wall, without developing within the lumen, the differential diagnosis from complicating lesions due to colonic diverticulitis is difficult. CASE SUMMARY A 76-year-old man was admitted to a nearby clinic with a chief complaint of discomfort and urinary frequency. Since a vesicosigmoidal fistula was seen on abdominal computed tomography, he was referred to our hospital. Laparoscopic sigmoidectomy was performed because the various diagnostic findings were diagnosed as a vesicosigmoidal fistula with diverticulitis of the sigmoid colon. However, on histopathological examination, it was diagnosed as a vesicosigmoidal fistula due to colon cancer arising in the diverticulum. Laparoscopic partial resection of the bladder was performed because local recurrence was observed in the bladder wall one and a half years after surgery. It is currently one year after reoperation, but there has been no recurrence or metastasis. CONCLUSION Colon cancer arising in a diverticulum of the colon should be considered when diverticulitis with complications is observed.

关键词： Colon cancer Diverticulum Colovesical fistula Laparoscopic surgery Diverticulitis Case report

Neoadjuvant chemoradiotherapy for locally advanced gastric cancer with bulky lymph node metastasis:Five case reports

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World Journal of Clinical Cases 2020年第18期8卷 4177-4185页

作者： Eiji nomura Hajime Kayano Takashi Machida Hideki Izumi Soichiro Yamamoto Akitomo Sugawara Masaya Mukai Terumitsu Hasebe Department of Gastroenterological and General Surgery Tokai University Hachioji HospitalHachioji 192-0032TokyoJapan Department of Radiology Tokai University Hachioji HospitalHachioji 192-0032TokyoJapan

BACKGROUND Neoadjuvant chemoradiotherapy(NACRT)has not been accepted as a general therapy for gastric cancer because of its localized effect and toxicity for radiosensitive ***,if radiation therapy could compensate for the limited or inadequate treatment choices available for elderly patients and/or those at high risk,the available therapeutic options for advanced gastric cancer might *** this perspective,we present our experiences of five patients with advanced gastric cancer in whom we used NACRT therapy with interesting *** SUMMARY We admitted five patients with clinical Stage III gastric cancer and bulky lymph node metastasis or adjacent organ invasion at the time of diagnosis.A total of 50 Gy of preoperative intensity modulated radiation therapy was delivered to the patients in doses of 2.0 Gy/d,together with a regimen of concomitant chemotherapy comprising two courses of oral tegafur/gimeracil/oteracil(S-1;65 mg/m2 per day)for three consecutive weeks followed by two weeks of rest,starting at the same time as *** patients underwent no residual tumor resection and a pathological complete response of the primary tumors was achieved in two *** incidence of hematological toxicity was low,although the digestive toxicities of anorexia and diarrhea developed in three of the five patients,necessitating termination of radiation therapy at 30 Gy and S-1 at three ***,even 30 Gy of irradiation and half the dose of S-1 resulted in sufficient downstaging,indicating that even a reduced amount of NACRT could confer considerable *** Slightly reduced NACRT might be useful and safe for patients with locally advanced gastric cancer.

关键词： Advanced gastric cancer Neoadjuvant chemoradiotherapy Intensity modulated radiation therapy Tegafur/gimeracil/oteracil Curative resection Case report Gastrectomy

FLUIDIZATION COOLING OF RETURN SANDS AND ENERGY ANALYSIS

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Chinese Journal of Mechanical Engineering 1998年第3期11卷 26-32页

作者： Wang Chengzhi Xia Wuyong Liu Zhiming Department of Material Engineering, Shenyang Institute of Technology nomura Hiroyuki Nagoya University, Nagoya, 64 Japan Nagoya Univ Nagoya Japan

In order to find out the optimal operation condition for return sands cooler, a cooling model including heat and mass transfer is constructed, and computer simulation is carried out. The results are compared with the operation data obtained from a fluidized bed sand cooler. A method is proposed for the evaluation whether the practical cooling system provides a reasonable energy cost performance. Several key points are discussed concerning enhancement of particles to air heat removal and improvement of energy effciency for cooling.

关键词： Fluidization cooling Return sands Computer simulation

Multiobjective genetic training and uncertainty quantification of reactive force fields

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npj Computational Materials 2018年第1期4卷 305-311页

作者： Ankit Mishra Sungwook Hong Pankaj Rajak Chunyang Sheng Ken-ichi nomura Rajiv K.Kalia Aiichiro Nakano Priya Vashishta Collaboratory for Advanced Computing and Simulations University of Southern CaliforniaLos AngelesCA 90089-0242USA Department of Chemical Engineering&Materials Science University of Southern CaliforniaLos AngelesCA 90089-1211USA Department of Physics&Astronomy University of Southern CaliforniaLos AngelesCA 90089-0484USA Department of Computer Science University of Southern CaliforniaLos AngelesCA 90089-0781USA Department of Biological Sciences University of Southern CaliforniaLos AngelesCA 90089-0371USA

The ReaxFF reactive force-field approach has significantly extended the applicability of reactive molecular dynamics simulations to a wide range of material properties and *** parameters are commonly trained to fit a predefined set of quantummechanical data,but it remains uncertain how accurately the quantities of interest are described when applied to complex chemical ***,we present a dynamic approach based on multiobjective genetic algorithm for the training of ReaxFF parameters and uncertainty quantification of simulated quantities of *** parameters are trained by directly fitting reactive molecular dynamics trajectories against quantum molecular dynamics trajectories on the fly,where the Pareto optimal front for the multiple quantities of interest provides an ensemble of ReaxFF models for uncertainty *** in situ multiobjective genetic algorithm workflow achieves scalability by eliminating the file I/O bottleneck using interprocess *** in situ multiobjective genetic algorithm workflow has been applied to high-temperature sulfidation of MoO_(3) by H_(2)S precursor,which is an essential reaction step for chemical vapor deposition synthesis of MoS_(2) *** work suggests a new reactive molecular dynamics simulation approach for far-from-equilibrium chemical processes,which quantitatively reproduces quantum molecular dynamics simulations while providing error bars.

关键词： quantities multiobjective uncertainty

Large edge magnetism in oxidized few-layer black phosphorus nanomeshes

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Nano Research 2017年第2期10卷 718-728页

作者： Yudai Nakanishi Ayumi Ishi Chika Ohata David Soriano Ryo Iwaki Kyoko nomura~ Miki Hasegawa Taketomo Nakamura Shingo Katsumoto Stephan Roche Junji Haruyama Faculty of Science and Engineering Aoyama Gakuin University 5- I0-1 Fuchinobe Sagamihara Kanagawa 252-5258 Japan Chemistry and Biological Science Aoyama Gakuin University 5-10-1 Fuchinobe Sagamihara Kanagawa 252-5258 Japan Catalan Institute of Nanoscience and Nanotechnology (ICN2) CSIC and The Barcelona Institute of Science and Technology Campus UAB Bellaterra 08193 Barcelona Spain Institucio Catalana de Recercai Estudis Avancats (ICREA) 08010 Barcelona Spain Institute for solid state physics The University of Tokyo 5- I-5 Kashiwanoha Kashiwa Chiba 277-8581 Japan

The formation and control of a room-temperature magnetic order in two- dimensional （2D） materials is a challenging quest for the advent of innovative magnetic- and spintronic-based technologies. To date, edge magnetism in 2D materials has been experimentally observed in hydrogen （H）-terminated graphene nanoribbons （GNRs） and graphene nanomeshes （GNMs）, but the measured magnetization remains far too small to allow envisioning practical applications. Herein, we report experimental evidences of large room-temperature edge ferromagnetism （FM） obtained from oxygen （O）-terminated zigzag pore edges of few-layer black phosphorus （P） nanomeshes （BPNMs）. The magnetization values per unit area are -100 times larger than those reported for H-terminated GNMs, while the magnetism is absent for H-terminated BPNMs. The magnetization measurements and the first-principles simulations suggest that the origin of such a magnetic order could stem from ferromagnetic spin coupling between edge P with O atoms, resulting in a strong spin localization at the edge valence band, and from uniform oxidation of full pore edges over a large area and interlayer spin interaction. Our findings pave the way for realizing high-efficiency 2D flexible magnetic and spintronic devices without the use of rare magnetic elements.

关键词： black phosphorus nanomesh edge magnetism spintronics zigzag edge oxygen termination rare-metal free

Strength of plastic with various helical wheels meshed types of worms

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材料与冶金学报 2015年第3期14卷 232-235,238页

作者： Makoto nomura Takao Koide Akio Ueda Yusuke Ishida Atsutaka Tamura Tottori University 4 - 101 Minami Koyama - cho Tottori 680 - 8552 Japan Amtec INC. BayTower 2510 1-2-1 Minato-ku Benten Osaka 552-0007 Japan

ADMET Polymerization: Greener Method for Synthesis of End-Functionalized Poly(Arylene Vinylene)s

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Green and Sustainable Chemistry 2017年第1期7卷 1-19页

作者： Tahmina Haque Kotohiro nomura Department of Chemistry Jahangirnagar University Dhaka Bangladesh Department of Chemistry Tokyo Metropolitan University Tokyo Japan

Recent results for synthesis of conjugated polymers, poly(arylene vinylene)s exemplified as poly(fluorene vinylene)s and poly(phenylene vinylene)s, by acyclic diene metathesis (ADMET) polymerization have been introduced. The methods using molybdenum and ruthenium catalysts afforded defect-free, high molecular weight polymers with all trans olefinic double bonds, and significant reduction of by-products (halogen, sulfur etc.) in addition of decrease of structurally defects have been attained. The methods also demonstrated precise synthesis of end-functionalized polymers that showed unique optical properties combined with the end groups. Catalytic one-pot syntheses of end-functionalized poly(9,9-dialkylfluorene-2,7-vinylene)s have been attained by both ruthenium (by chain-transfer) and molybdenum catalysts and the method should provide more green route for synthesis of conjugated materials with better device performance.

关键词： Conjugated Polymers Olefin Metathesis Precision Polymerization Defect-Free End-Functionalization

Confirming Stereochemical Structures of Strigolactones Produced by Rice and Tobacco

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Molecular Plant 2013年第1期6卷 153-163页

作者： Xiaonan Xie Kaori Yoneyama Takaya Kisugi Kenichi Uchida Seisuke Ito Kohki Akiyama Hideo Hayashi Takao Yokota Takahito nomura Koichi Yoneyama Weed Science Center Utsunomiya University 350 Mine-machi Utsunomiya 321-8505 Japan Department of Biosciences Faculty of Science and Technology Teikyo University 1-1 Toyosatodai Utsunomiya 320-8851 Japan Graduate School of Life and Environmental Sciences Osaka Prefecture University 1-1 Gakuen-cho Nakaku Sakai Osaka 599-8531 Japan

Major strigolactones （SLs） produced by rice （Oryza sativa L. cv. Nipponbare） and tobacco （Nicotiana tabacum L. cv. Michinoku No. 1） were purified and their stereochemical structures were determined by comparing with optically pure synthetic standards for their NMR and CD data and retention times and mass fragmentations in ESI-LC/MS and GC-MS. SLs purified from root exudates of rice plants were orobanchol, orobanchyl acetate, and ent-2＂-epi-5-deoxystr- igol. In addition to these SLs, 7-oxoorobanchyl acetate and the putative three methoxy-5~deoxystrigol isomers were detected by LC-MS/MS. The production of 7-oxoorobanchyl acetate seemed to occur in the early growth stage, as it was detected only in the root exudates collected during the first week of incubation. The root exudates of tobacco contained at least 11 SLs, including solanacol, solanacyl acetate, orobanchol, ent-2＂-epi-orobanchol, orobanchyl acetate, ent-2＇- epi-orobanchyl acetate, 5-deoxystrigol, ent-2＂-epi-5-deoxystrigol, and three isomers of putative didehydro-orobanchol whose structures remain to be clarified. Furthermore, two sorgolactone isomers but not sorgolactone were detected as minor SLs by LC-MS/MS analysis. It is intriguing to note that rice plants produced only orobanchol-type SLs, derived from ent-2＂-epi-5-deoxystrigol, but both orobanchol-type and strigol-type SLs, derived from 5-deoxystrigol were detected in tobacco plants.

关键词： germination stimulant Orobanche rice root parasitic plant Striga strigolactone tobacco.