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Clinical factors influencing the resting and stimulated salivary flow

Open Journal of Stomatology 2012年第2期2卷 103-109页

作者： Shigeo Yamachika Ken Yamamoto yoshiaki nomura Hiroyuki Yamada Ichiro Saito Yoichi Nakagawa Department of Clinical Pathophysiology School of Dental MedicineTsurumi UniversityYokohamaJapan Department of Oral Medicine and Stomatology School of Dental MedicineTsurumi UniversityYokohamaJapan Department of Geriatric Dentistry School of Dental MedicineTsurumi UniversityYokohamaJapan Department of Translational Research School of Dental MedicineTsurumi UniversityYokohamaJapan Department of Oral and Maxillofacial Surgery School of Dental MedicineTsurumi UniversityYokohamaJapan Department of Pathology School of Dental MedicineTsurumi UniversityYokohamaJapan

Objective: The objective of this study was to examine the clinical and immunological factors influ encing sialometry in xerostomia patients. Method: The association between sialometry and other clinical examinations were investigated in a cross-sectional study. A total of 179 dry mouth patients showing hyposalivation who underwent a clinical examination were enrolled in this study. Multiple regression analyses were employed to examine the relative con-tributions of clinical and immunological factors including age, gender, parotid sialography, labial Salivary gland biopsy, anti-Ro/SS-A antibodies, and anti-La/SS-B antibodies to the resting (RSF) or stimulated saliva flow rate (SSF). Results: An increase of the stage of sialography, the grade of a labial biopsy, and the presence of anti-La/SS-B antibody had a significant correlation with a decrease of sialometry. Results of the multiple regression analysis showed that age (standardized coefficient = -0.244), grade of lip biopsy (-0.189), and anti-SS-B antibody (-0.171), were significantly associated with the RSF. The stage of sialography (?0.423) and age (-0.169) were significantly related to the sialometry in the SSF according to a multiple regression analysis. Conclusion: The results of this study suggest that the measurement of RSF reflects the immunological factors and SSF reflects the damage to the parotid gland.

关键词： Xerostomia Sialometry Sialography Labial Minor Salivary Gland Biopsy Sjogren’s Syndrome

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Functional performance levels of strength and power needed for independence in 80-year-old individuals

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Open Journal of Epidemiology 2012年第3期2卷 61-69页

作者： Mieko Shimada yoshiaki nomura Yasuo Kimura Naoki Nakagawa Hiroshi Nagayama Mitsumasa Tazawa Tamotsu Sato Daisuke Inaba Masami Yonemitsu Yutaka Yoshitake 9Department for Interdisciplinary Studies of Lifelong Sport and Physical Activity National Institute of Fitness & Sports in Kanoya Kagoshima Japan Department of Oral Medicine Division of Preventive Dentistry Iwate Medical University Iwate Japan Faculty of culture and education Saga University Saga Japan Faculty of Health Care Sciences Chiba Prefectural University of Health Sciences Chiba Japan Fukuoka University Fukuoka Japan Iwate Dental Association Iwate Japan Office Tazawa Company Iwate Japan School of Dental Medicine Tsurumi University Yokohama-shi Japan School of Information-oriented Management Sports Management Research Center SANNO University Kanagawa Japan

Background: The ability to climb stairs (ascending and descending stair without using a handrail) and rise from a chair (rising from chairs without using an elbow rest) are among the most important measures of physical function for ADL evaluation for the independent living, and assessed by the questioners on many epidemiological studies in elderly. But little is known about the relationship between the self-reported performance level of the tasks and lower leg strength and power in very elderly people. The purpose of this study was to ascertain the relationship between the self-reported performance level of two tasks and the lower leg function in community-dwelling 80-year-old population. Methods: Out of 994 persons who were 80 years old living in Morioka City, Iwate Prefecture, Japan, 607 individuals (236 men and 371 women) underwent a physical fitness test that included measurements of leg extensor power and knee extensor strength. The ability to climb up stair and to rise from a chair was assessed by self- reported questionnaire which was ranked in three levels. The area under the receiver-operating characteristic (ROC) curve (AUC) was used to evaluate the measurements. Results: The cut-off points for the leg extensor power of subjects who could completely perform the stair-climbing and chair-rising functions were determined to be approximately 8.6 watt/kg body mass for men and 5.6 watt/kg body mass for women. In addition, the cut-off points for the knee extensor strength of subjects who could completely perform the stair-climbing and chair-rising functions were determined to be approximately 0.97 kg/kg body mass for men and 0.84 kg/kg body mass for women. Conclusions: From a practical viewpoint, the present study suggested that the cut-off points of leg extensor power and knee extensor strength can be used as targets in simple self-reported questionnaires to help in screening for mobility in 80-year-old

关键词： Elderly Leg Extensor Power Knee Extensor Strength ADL Independence Cut-Off Point

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光催化剂在牙科研究中的应用进展

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上海理工大学学报 2023年第1期45卷 1-7,35页

作者：野村义明花田信弘刘艳飞上海理工大学光化学与光材料研究院上海200093

光催化剂有两个主要作用:有机化合物的降解和超亲水性,这些作用使其具有抗菌和自清洁的效果。目前,光催化剂已经被应用于医学临床实践。两种主要的口腔疾病(龋齿和牙周病)影响着全球几十亿人,而治疗口腔疾病则可以直接接触到口腔内的病... 详细信息

光催化剂有两个主要作用:有机化合物的降解和超亲水性,这些作用使其具有抗菌和自清洁的效果。目前,光催化剂已经被应用于医学临床实践。两种主要的口腔疾病(龋齿和牙周病)影响着全球几十亿人,而治疗口腔疾病则可以直接接触到口腔内的病灶。牙科领域会使用到各种先进的牙科材料。因此,光催化剂可以成为牙科临床实践的有用工具。本文综述了光催化剂在牙科研究中的应用研究,并展望了光催化剂在牙科研究中的未来前景。

关键词：光催化剂牙科临床实践牙科研究牙科材料

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Postoperative functional evaluation of gastrectomy for gastric cancer

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Chinese Journal of Cancer Research 2022年第6期34卷 567-574页

作者： Eiji nomura Department of Gastroenterological and General Surgery Tokai University Hachioji HospitalTokyo 192-0032Japan

To improve the quality of surgical procedures for gastric cancer,it is essential to consider many components comprehensively,including gastric motility,small intestinal absorption,hormones that affect gastric motility and appetite,presence or absence of vagus nerve preservation,esophageal regurgitation on endoscopic findings,in addition to whether or not there is a physiological route for food passage through the ***,proper functional evaluation cannot be performed without considering the form and amount of energy in the nutritional supplement to be loaded,and the posture at the time of *** results of functional evaluation vary according to the method selected from many available options,but we believe that use of the most physiologically accurate,appropriate and selectable option will enable us to arrive at the best resection/reconstruction *** have reported that it is important to consider the preservation of three elements when performing gastrectomy:1)reduction of the extent of gastrectomy,2)preservation of the pylorus,and 3)preservation of the vagus nerve;among which preservation of the remnant stomach is the most ***,the selection of a reconstruction method that maintains secretion of hormones beneficial to gastric motility preserves the energy balance inherent in the human body,and also provides better quality of life.

关键词： Gastric cancer gastrectomy functional evaluation

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(Arylimido)vanadium(V)-Alkylidene Complexes as Catalysts for Ring-opening Metathesis Polymerization(ROMP) of Cyclic Olefins: Ligand Design for Exhibiting the High Activity

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Chinese Journal of Polymer Science 2019年第10期37卷 943-950,I0002页

作者： Kotohiro nomura Sapanna Chaimongkolkunasin Department of Chemistry Graduate School of Science Tokyo Metropolitan University

(Imido)vanadium(V)-alkylidene complexes of type V(CHSiMe3)(NR)(OR?)(PMe3)2 [R = Ad, C6H5, 2,6-Me2C6H3, 2,6-Cl2C6H3;R?= 2,6-Me2C6H3, 2,6-i Pr2C6H3, 2,6-F2C6H3, C6F5, C6Cl5] exhibited from moderate to remarkable catalytic activities for ringopening metathesis polymerization(ROMP) of norbornene(NBE). The catalytic activities were affected by the ligand substituents, and V(CHSiMe3)(N-2,6-Cl2C6H3)(OC6X5)(PMe3)2(X = F, Cl) demonstrated the exceptionally high catalytic activities for ROMP of *** complexes polymerized cycloheptene(CHPE) and cis-cyclooctene(COE), and ROMP of COE by the OC6 Cl5 analogue proceeded in a living manner even at 80℃, and the activity increased with increasing the temperature up to 120 ℃. Highly active catalysts for ROMP of cyclic olefins(NBE, cyclopentene, and CHPE) can be generated in situ by premixing isolated V(CHSiMe3)(NC6F5)(O-2,6-iPr2C6H3)(PMe3)2 with 1.0 equiv. of C6F5OH or C6Cl5OH via immediate phenoxy exchange;the activity was affected by the kind of phenol added [TOF in the ROMPs of NBE: 4.62 × 10^4 min^–1(upon addition of C6F5OH) versus 37.3 min^–1(none)].

关键词： Olefin metathesis Molecular catalyst Ring-opening metathesis polymerization Cyclic olefin Vanadium catalyst

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NONBRIDGED HALF-TITANOCENES CONTAINING ANIONIC ANCILLARY DONOR LIGANDS:PROMISING NEW CATALYSTS FOR PRECISE SYNTHESIS OF CYCLIC OLEFIN COPOLYMERS(COCs)

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Chinese Journal of Polymer Science 2008年第5期26卷 513-523页

作者： Kotohiro nomura Graduate School of Materials Science Nara Institute of Science and Technology(NAIST)Japan

Precise,efficient copolymerizations of ethylene with cyclic olefins[norbornene(NBE),cyclopentene(CPE)]using nonbridged half-titanocenes of type,Cp TiCl_2(L)(Cp =cyclopentadienyl group,L=aryloxo,ketimide)-MAO catalyst systems have been ***_2(N=C Bu_2)exhibited both remarkable catalytic activity and efficient NBE incorporation for ethylene/NBE copolymerization:the NBE incorporation by Cp TiCl_2(X)(X=N=C Bu_2,O-2,6- Pr_2C_6H_3; Cp =Cp,C_5Me_5,indenyl)was related to the calculated coordination ene...

关键词： Titanium Cyclic olefin copolymers Copolymerization Ethylene Homogeneous catalysts

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Linear seesaw model with a modular S_(4)flavor symmetry

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Chinese Physics C 2022年第5期46卷 11-19页

作者： Takaaki nomura Hiroshi Okada College of Physics Sichuan UniversityChengdu 610065China Asia Pacific Center for Theoretical Physics(APCTP)-Headquarters San 31 Hyoja-dongNam-guPohang 790-784Korea Department of Physics Pohang University of Science and TechnologyPohang 37673Korea

We discuss a linear seesaw model with a field content as minimum as possible,introducing a modular S_(4)using gauged U(1)_(B−L) *** to the rank two neutrino mass matrix,we obtain a vanishing neutrino mass eigenvalue,and only the normal mass hierarchy of neutrinos is favored via the modular S_(4)*** our numericalΔχ^(2)analysis,we especially determine a relatively sharp prediction on the sum of neutrino masses to be approximately 60 meV,in addition to other predictions.

关键词： neutrino mass linear seesaw mechanism modular S_(4)flavor symmetry

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Calcium Signaling in Plant Endosymbiotic Organelles： Mechanism and Role in Physiology

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Molecular Plant 2014年第7期7卷 1094-1104页

作者： Hironari nomura Takashi Shiinab Department of Health and Nutrition Gifu Women's University 80 Taromaru Gifu 501-2592 Japan Graduate School of Life and Environmental Sciences Kyoto Prefectural University Sakyo-ku Kyoto 606-8522 Japan

Recent studies have demonstrated that chloroplasts and mitochondria evoke specific Ca2＋ signals in response to biotic and abiotic stresses in a stress-dependent manner. The identification of Ca2＋ transporters and Ca2＋signaling mol- ecules in chloroplasts and mitochondria implies that they play roles in controlling not only intra-organellar functions, but also extra-organellar processes such as plant immunity and stress responses. It appears that organellar Ca2＋ signaling might be more important to plant cell functions than previously thought. This review briefly summarizes what is known about the molecular basis of Ca2＋ signaling in plant mitochondria and chloroplasts.

关键词： biotic stress abiotic stress calcium signaling calcium transport CAS chloroplast mitochondria.

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A multi-charged particle model with local U(1)_(μ-τ) to explain muon g-2,flavor physics,and possible collider signature

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Chinese Physics C 2022年第4期46卷 57-69页

作者： Nilanjana Kumar Takaaki nomura Hiroshi Okada Department of Physics and Astrophysics University of DelhiDelhi 110007India School of Physics KIASSeoul 02455Korea Asia Pacific Center for Theoretical Physics(APCTP)-Headquarters San 31 Hyoja-dongNam-guPohang 790-784Korea Department of Physics Pohang University of Science and TechnologyPohang 37673Korea

We consider a model with multi-charged particles,including vector-like fermions,and a charged scalar under a local U(1)_(μ−τ) *** search for an allowed parameter region explaining muon anomalous magnetic moment(muon g−2)and b→sℓ^(+)ℓ^(−) anomalies,satisfying constraints from the lepton flavor violations,Z boson decays,meson anti-meson mixing,and collider *** numerical analysis,we explore the typical size of the muon g−2 and Wilson coefficients to explain the b→sℓ^(+)ℓ^(−) anomalies in our model when all other experimental constraints are ***,we discuss the collider physics of the multicharged vectorlike fermions,considering a number of benchmark points in the allowed parameter space.

关键词： new gauge boson new gauge symmetry muon anomalous magnetic moment B meson decay anomalies collider physics

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Gene expression during genital morphogenesis in the ground beetle Carabus maiyasanus

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Insect Science 2020年第5期27卷 975-986页

作者： Shota nomura Tomochika Fujisawa Teiji Sota Department of Zoology Graduate School of ScienceKyoto UniversitySakyoKyotoJapan

To investigate the developmental genetics of genital formation in the carabid beetle Carabus maiyasanus,we compared gene expression patterns among five stages using transcriptomic RNA sequencing data from abdominal segments and genitalia in the third(last)larval instar(including prepupa)and pupal *** identified 18839 genes,of which 10796 were differentially expressed among stages or between *** were relatively few differentially expressed genes(DEGs)between the sexes(3%).The DEGs were clustered into six groups,mainly according to stage-specific expression *** in clusters 1-3 showed high expression levels before pupation and low expression levels during the pupal period,whereas genes in clusters 46 showed high expression levels from the prepupal to the pupal *** related to the initial pupation process and differentiation of genital discs in Drosophila were involved in clusters 4 and 6 and showed low expression levels at early third instar and elevated expression levels from the early prepupal stage,suggesting that the pupation process and genital differentiation started in the prepupal *** 4 and 5 included developmental genes related to organ size control,which may be important in the formation of internal genital structures during the pupal stage.

关键词： Carabus genitalia Ohomopterus pupation RNA-seq transcriptome

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