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International Journal of Biomathematics 2012年第1期5卷 127-155页

作者： YUKIHIKO NAKATA YOICHI ENATSU yoshiaki MUROYA Basque Center for Applied Mathematics Mazarredo 14 E-48009BilbaoSpain Department of Pure and Applied Mathematics Waseda University3-4-10hkubo Shinjuku-ku Tokyo169-8555Japan Department of Mathematics Waseda University 3-4-1 Ohkubo Shinjuku-ku Tokyo 169-8555Japan

We study global asymptotic stability for an SIS epidemic model with maturation delay proposed by K. Cooke, P. van den Driessche and X. Zou, Interaction of maturation delay and nonlinear birth in population and epidemic models, J. Math. Biol. 39（4）（1999） 332-352. It is assumed that the population has a nonlinear birth term and disease causes death of infective individuals. By using a monotone iterative method, we establish sufficient conditions for the global stability of an endemic equilibrium when it exists dependently on the monotone property of the birth rate function. Based on the analysis, we further study the model with two specific birth rate functions BI（N） = be-aN and B3（N） = A/N ＋ c, where N denotes the total population. For each model, we obtain the disease induced death rate which guarantees the global stability of the endemic equilibrium and this gives a positive answer for an open problem by X. Q. Zhao and X. Zou, Threshold dynamics in a delayed SIS epidemic model, J. Math. Anal. Appl. 257（2）（2001） 282-291.

关键词： SIS epidemic models nonlinear birth rate function disease induced deathrate global asymptotic stability the basic reproduction number permanence.

Effect of Microstructure of Cementite on Interphase Stress State in Carbon Steel

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Journal of Iron and Steel Research International 2007年第4期14卷 31-38页

作者： CHE Lei GOTOH Masahide HORIMOTO yoshiaki HIROSE Yukio Graduate School Kanazawa University Kanazawa 920-1192 Japan Department of Materials Science and Engineering Kanazawa University Kanazawa 920-1192 Japan

The experiments related to stress states of ferrite and cementite in carbon steels were carried out including in situ four-point bending and tensile test by X-ray diffraction technique. Stresses in the cementite phase can be measured by conventional X-ray diffraction instrument after a specific treatment on the specimen surface. In order to estimate the stress states in two phases, the X-ray elastic constants of two phases in single-phase state （PXEC） are determined by the experimental X-ray elastic constants of them in composite state （CXEC）. The effects of volume fraction and particle size of spheroidal cementite on the interphase stress state are estimated. The experimental results are in good agreement with the theoretical relationships reported in the previous studies.

关键词： multi-phase material surface treatment plastic deformation residual stress X-ray diffraction

Effects of inner sleeves on the inner frictional resistance of open-ended piles driven into sand

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Frontiers of Structural and Civil Engineering 2016年第4期10卷 499-505页

作者： Janaka J. KUMARA yoshiaki KIKUCHI Takashi KURASHINA Takahiro YAJIMA Department of Civil Engineering Tokyo University of Seience Noda 278-8510 Japan Maeda Corporation Tokyo 102-8151 Japan

In open-ended piles, inner friction is developed between inner pile shaf and the inner soil. Inner frictional resistance depends largely on the degree of soil plugging, which is influenced by many factors including pile diameter, relative density and end conditions of piles. In this paper, effects of inner sleeves on inner frictional resistance are discussed. The experiments were conducted on a medium-dense sandy ground using laboratory-scale piles. It was observed that the piles penetrated under partially-plugged or unplugged state. The results suggest that inner fiictional resistance, Qin increases with sleeve height, l linearly and requires 2D （D is pile outer diameter） of l to produce a large as 50% of Qt by Qin （Qt is total resistance）. The results also indicate that bearing capacity increases with wall thickness at the pile tip, which can be attributed to the increase in annular area. The results also indicate that soil plug height is independent of sleeve height. The results also reveal that the penetration of straight piles is closer to unplugged state than the sleeved piles. The results of incremental filling ratio and plug length ratio also indicate that the degree of soil plugging is affected by the sleeve height.

关键词： bearing capacity inner frictional resistance inner sleeve open-ended piles soil plugging

Functional relationship between p53 and RUNX proteins

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Journal of Molecular Cell Biology 2019年第3期11卷 224-230页

作者： Suk-Chul Bae Arun Mouli Kolinjivadi yoshiaki Ito Department of Biochemistry School of Medicineand Institute for Tumour ResearchChungbuk National UniversityCheongju 28644South Korea Cancer Science Institute of Singapore National University of SingaporeSingapore 117599Singapore

RUNX genes belong to a three-membered family of transcription factors,which are well established as master regulators of *** them,aberrations in RUNX3 expression are frequently observed in human malignancies primarily due to epigenetic silencing,which is often *** the G1 phase of the cell cycle,RUNX3 regulates the restriction(R)-point,a mechanism that decides cell cycle *** at the R-point or loss of RUNX3 results in premature entry into S phase,leading to a proliferative *** of Runxl and Runx2 induce immortalization of mouse embryo *** a consequence,RUNX loss induces pre-cancerous lesions independent of oncogene activation.p53 is the most extensively studied tumour suppressor.p53 plays an important role to prevent tumour progression but not tumour ***,upon oncogene activation,early inactivation of RUNX genes and subsequent mutation of p53 appear to result in tumour initiation and ***,transcription-independent DNA repairing roles of RUNX3 and p53 are *** evolutionarily old genes,it appears that the primordial function of p53 is to protect genome integrity,a function that likely extends to the RUNX gene as *** this review,we examine the mechanism and sequence of actions of these tumour suppressors in detail.

关键词： RUNX tumour suppressor p53

DESIGN OF AN EXPERT CONTROL SYSTEM FOR LEACHING PROCESS

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中国有色金属学会会刊：英文版 1999年第1期9卷 139-146页

作者： Wu, Min Peng, Zhihong Gui, Weihua nakano, Michio Jinhua, She Central South Univ of Technology Changsha China

ＩＮＴＲＯＤＵＣＴＩＯＮＴｈｅｍａｉｎｐｒｏｃｅｓｅｓｉｎｚｉｎｃｈｙｄｒｏｍｅｔａｌｕｒｇｙａｒｅｌｅａｃｈｉｎｇ，ｐｕｒｉｆｉｃａｔｉｏｎａｎｄｅｌｅｃｔｒｏｌｙｓｉｓ［１，２］．Ｔｈｅｌｅａｃｈｉｎｇｉｎｖｏｌ... 详细信息

ＩＮＴＲＯＤＵＣＴＩＯＮＴｈｅｍａｉｎｐｒｏｃｅｓｅｓｉｎｚｉｎｃｈｙｄｒｏｍｅｔａｌｕｒｇｙａｒｅｌｅａｃｈｉｎｇ，ｐｕｒｉｆｉｃａｔｉｏｎａｎｄｅｌｅｃｔｒｏｌｙｓｉｓ［１，２］．Ｔｈｅｌｅａｃｈｉｎｇｉｎｖｏｌｖｅｓｄｉｓｏｌｖｉｎｇｚｉｎｃ?..

关键词： leaching process expert control system mathematical model rule model

COEXISTENCE FOR MULTIPLE LARGEST REPRODUCTION RATIOS OF A MULTI-STRAIN SIS EPIDEMIC MODEL

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Acta Mathematica Scientia 2016年第5期36卷 1524-1530页

作者： yoshiaki MUROYA Eleonora MESSINA Elvira RUSSO Antonia VECCHIO Department of Mathematics Waseda University Dipartimento di Matematica e Applicazioni Università degli Studi di Napoli "Federico Ⅱ"-Via Cintia Istituto per Applicazioni del Calcolo "M. Picone" Sede di Napoli-CNR-Via P.Castellino

In this paper, to complete the global dynamics of a multi-strains SIS epidemic model, we establish a precise result on coexistence for the cases of the partial and complete duplicated multiple largest reproduction rat... 详细信息

关键词： multi-strains SIS epidemic model global attractivity Lyapunov function coexistence

Natural purification effects in the river in consideration with domestic wastewater pollutant discharge reduction effects

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Journal of Environmental Sciences 2010年第6期22卷 892-897页

作者： yoshiaki Tsuzuki Masato Fujii Yasuo Mochihara Kouki Matsuda Minoru Yoneda Research Center for Coastal Lagoon Environments Shimane University Ministry of Land InfrastructureTransportation and Tourism Environmental Engineering Graduate School of EngineeringKyoto University

The first social experiment program in Japan to reduce domestic wastewater pollutant discharge by ＂soft interventions＂ in households has been conducted in the Yamato-gawa River drainage area since 2005. The Yamato-gawa River has been listed as one of the worst water quality rivers in Japan because of the larger annual average BOD. ＂Hard interventions＂ including deployment of wastewater treatment facilities and artificial installation of natural purification facilities in the river has been conducted in these years to improve river water quality. At the first Yamato-gawa River social experiment program （YR-SEP） in March 2005, BOD at the monitoring point near the river mouth decreased about 6% during the Program. Natural purification effect along the river was evaluated in this article with one-dimensional water quality model for the six river sections. Larger biological oxygen consumption rate, kb, was estimated in the sections with artificially installed natural purification facilities. The effect of ＂soft interventions＂ in households in the YR-SEP was estimated as 25% BOD decrease in the nearest monitoring point to the river mouth, when all the households participate in the Program and BOD discharge reduction rate with ＂soft interventions＂ in households was 40%.

关键词： Yamato-gawa River "soft interventions" in households one-dimensional water quality model

Effects of Vertical Angle of Conical Punch on Stretch Flangeability of High Strength Steel

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Acta Metallurgica Sinica(English Letters) 2015年第12期28卷 1503-1509页

作者： Yasuhiro Ito yoshiaki Nakazawa Yukihisa Kuriyama Katsuyuki Suzuk Noriyuki Suzuki Nippon Steel and Sumitomo Metal Corporation The University of Tokyo

To clarify the effects of the vertical angle of a conical punch on stretch flangeability, hole expansion forming tests were conducted. Test results showed that the hole expansion ratio becomes larger as the vertical angle *** also showed that the fracture strain at the fracture location on the hole edge was constant and independent of the vertical angle. This is because the hole expansion ratio was controlled not only by the fracture strain, which is independent of the vertical angle, but also by deformation uniformity along the hole edge. From the result of numerical analyses, it was determined that deformation uniformity depends on the gradient of circumferential stress along the radius direction. When the vertical angle is sharp, the circumferential stress showed a steep decline and the deformation localization was suppressed. Consequently, the hole edge deformed more uniformly and the hole expansion ratio became larger. It is concluded that in order to improve stretch flangeability of high strength steel, it is important to uniformly deform the hole edge by applying a conical punch with a sharp vertical angle.

关键词： Formability Ductile fracture Finite element analysis Hole expansion test

Chemically oligomerizable TDP-43:a novel chemogenetic tool for studying the pathophysiology of amyotrophic lateral sclerosis

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Neural Regeneration Research 2022年第11期17卷 2434-2436页

作者： Kohsuke Kanekura yoshiaki Yamanaka Tamami Miyagi Masahiko Kuroda Department of Molecular Pathology Tokyo Medical University

Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease characterized by the progressive loss of both upper and lower motor *** ALS cases are sporadic,but approximately 5-10%of patients have a f... 详细信息

关键词： sclerosis familial

Enhanced electrical property of graphite/Al_(2)O_(3) composite fabricated by reductive sintering of gel-casted body using cross-linked epoxy polymer

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Journal of Advanced Ceramics 2022年第4期11卷 523-531页

作者： yoshiaki FUNAHASHI Yunzi XIN Kunihiko KATO Huu Hien NGUYEN Takashi SHIRAI Department of Life Science and Applied Chemistry Graduate School of EngineeringNagoya Institute of TechnologyGokiso-choShowa-kuNagoyaAichi 466-8555Japan Advanced Ceramics Research Center Nagoya Institute of TechnologyGokiso-choShowa-kuNagoyaAichi 466-8555Japan

In the present study,graphite/alumina composites are fabricated via reductive sintering of gel-casted green bodies with structurally controlled cross-linked epoxy polymers for the first *** cross-linking degrees of polymers are tuned by the amount ratio of epoxy monomer/polyvinyl alcohol cross-linker utilized in gel-casting *** electrical properties with respect to 5-fold enhanced electrical conductivity and 2-fold higher carrier mobility are successfully achieved in graphite/alumina composite fabricated from cross-linked epoxy polymer,whose phenomenon is attributed to the excellent conductive path in ceramic matrix established by highly uniform network with improved graphitization degree.

关键词： ceramic composite gel-casting reductive sintering cross-linking electrical property graphitization