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Neuroprotective Effect of Chunghyuldan(Qing Xue Dan)on hypoxia-Reoxygenation Induced Damage of Neuroblastoma 2a Cell Lines

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Chinese Journal of Integrative Medicine 2013年第12期19卷 940-944页

作者： Chang-Nam ko In-Seo Park Seong-Uk Park Woo-Sang Jung Sang-Kwan Moon Jung-Mi Park Chulhun Kang Ki-ho Cho Department of Cardiology and Neurology Diseases College of Korean MedicineKyung Hee University Department of Medical Science Graduate School of East-West Medical ScienceKyung Hee University

Objectives： Chunghyuldan （ChD）, a combinatorial drug that has anti-hyperlipidemic and anti inflammatory activities, has been shown to reduce infarct volume in a focal ischemia-reperfusion rat model. To explore the molecular basis of ChD＇s neuroprotective effect, we examined whether ChD shows a cell-protective activity and has a regulatory effect on Bax and/or B-cell leukemia/lymphoma 2 （Bcl-2） expression in mouse neuroblastoma 2a （N2a） cells subjected to hypoxia-reoxygenation （h/R）. Methods： In order to evaluate the effects of ChD on the cytotoxicity induced from hypoxia or h/R condition, lactate dehydrogenase （LDh） assay was performed. To explore whether the suppression of neural damage when pre-treated with ChD is associated with its anti-apoptotic effect, the ChD effect on the expression of Bcl-2 and Bax was analyzed by Western blotting analysis. Results： Cytotoxicity of N2a cell line was slightly increased in 42 h hypoxia condition and dramatically increased under the h/R condition. ChD treatment markedly decreased the cytotoxicity in both conditions （P〈0.01, P〈0.05）. h/R markedly increased the expression of the pro-apoptotic protein, Bax, but slightly increased the expression of the anti-apoptotic protein, Bcl-2, compared with the normoxia or hypoxia group. ChD significantly decreased Bax expression （P〈0.01） and slightly decreased Bcl-2 expression （P〉0.05）, resulted in a reduction of Bax/Bcl-2 ratio in N2a cells subjected to h/R. Conclusion： ChD has neuroprotective effect in N2a cells subjected to h/R, which might be derived at least in part from its ability to decrease the expression of the pro-apoptotic protein, Bax.

关键词： apoptosis stroke Chunghyuldan herbal

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持续存在的肺亚实性结节（>5 mm和<20 mm）中局灶间质纤维化与腺癌的鉴别:冠状面薄层CT影像的价值

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国际医学放射学杂志 2022年第1期 117-118页

作者： K.h.ko T.W.huang W.C.Chang h.K.huang W.C.Tsai h.h.hsu 任燕

摘要目的探讨5～20 mm肺亚实性结节（SSN）的薄层CT特征，以确定区分局灶性间质纤维化（FIF）与腺癌的预测因素。方法纳入2017年1月—2018年12月持续存在5～

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Influence of night duty on endoscopic therapy for bile duct stones

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World Journal of Gastroenterology 2016年第42期22卷 9387-9393页

作者： Mitsuru Sugimoto Tadayuki Takagi Rei Suzuki Naoki konno hiroyuki Asama ko Watanabe Jun Nakamura hitomi Kikuchi Yuichi Waragai Mika Takasumi Takuto hikichi hiromasa Ohira Department of Gastroenterology and Rheumatology Fukushima Medical University School of Medicine Department of Endoscopy Fukushima Medical University Hospital

AIM To examine the influence of night duty(ND) on endoscopic therapy for biliary duct *** The subjects consisted of 133 patients who received initial endoscopic therapy for biliary duct stones performed by eight endoscopists after they had been on(ND group, n = 34 patients) or not [day duty(DD) group, n = 99 patients]. Patient characteristics(age, gender, history of abdominal surgery, transverse diameter of the largest stone, number of stones), years of experience of the endoscopists, endoscopic procedures [sphincterotomy, papillary balloon dilation(EPBD), papillary large balloon dilation(EPLBD)], and outcomes of initial endoscopy(procedure time; rate of stone removal by the first endoscopist; proceduresuccess rate by the first endoscopist: removal of stones or endoscopic retrograde biliary drainage; rate of final stone removal; final procedure success rate; complications; hospitalization after the procedure) were compared retrospectively between the two groups. history of abdominal surgery and treatment outcomes were also compared between the groups for each of the four endoscopists who performed most of the procedures in the ND *** There were no significant differences regarding the number of treatments performed by each endoscopist or the years of experience between the ND and DD groups. The frequency of endoscopic retrograde cholangiopancreatography procedures did not differ significantly between the groups. There were also no significant differences regarding patient characteristics: age, gender, history of abdominal surgery(ND 7: Billroth II 4, R-Y 3; DD 18: double tract reconstruction 1, Billroth I 3, Billroth II 6, R-Y 7, duodenoduodenostomy for annular pancreas 1), transverse diameter of largest stone, and number of stones between the two groups. Among the treatment procedures, the endoscopic s p h i n c t e r o t o m y a n d E P B D r a t e s d i d n o t d i f f e r significantly between the groups. however, EPLBD was performed more fr

关键词： Night duty Endoscopic therap Bile duct stone Removal of stones Procedure time

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自组织生长CdSe-ZnSe量子点的光致发光

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中国科学（A辑） 2000年第4期30卷 342-346页

作者：郑宏 K.Okamoto h.C.ko Y.Kawakami Sg.Fujita 中国科学院长春物理研究所中国科学院激发态物理开放实验室长春130021 Venture Business Laboratory Department of Electronic Science and Engineering

利用不同温度下的光致发光和时间分辨光谱研究了生长在GaAs( 1 1 0 )衬底上的CdSe ZnSe自组织量子点的发光特性 ,发现浸润层量子阱的激子发光淬灭比量子点的淬灭过程快得多 ,量子点的激子辐射复合寿命远大于浸润层量子阱的激子复合寿命 ... 详细信息

利用不同温度下的光致发光和时间分辨光谱研究了生长在GaAs( 1 1 0 )衬底上的CdSe ZnSe自组织量子点的发光特性 ,发现浸润层量子阱的激子发光淬灭比量子点的淬灭过程快得多 ,量子点的激子辐射复合寿命远大于浸润层量子阱的激子复合寿命 .根据不同尺寸的量子点复合寿命的差异。

关键词：自组织生长光致发光硒化镉硒化锌量子点

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Differential Effects of Ursolic Acid and Oleanolic Acid on Mitochondrial ATP Generation in h9c2 Cardiomyocytes and Lipopolysaccharide-Induced Cell Proliferation in Mouse Splenocytes: Yang versus Yin

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Chinese Medicine 2021年第3期12卷 37-46页

作者： hoi Yan Leung Kai Chit Cheung Kam Ming ko Division of Life Science Hong Kong University of Science & Technology Hong Kong China

In the present study, two cell-based systems for assessing Yang and Yin activities were for the first time used to investigate the effect of ursolic acid (UA) and oleanolic acid (OA). The results indicated that while UA was only active in the Yang assay, OA produced activity in the Yin assay. The Yang/Yin activity of UA/OA may be attributed to their distinct molecular structures, which confer their differential ability to interact with mitochondrial membrane or cellular membrane lipids, with resultant membrane fluidization and potentiation of biological responses.

关键词： Yang Yin Ursolic Acid Oleanolic Acid Mitochondrial ATP Generation Splenocytes

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A critical role of IL-17 in modulating the B-cell response during h5N1 influenza virus infection

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Cellular & Molecular Immunology 2011年第6期8卷 462-468页

作者： Xiaohui Wang Chris CS Chan Min Yang Jun Deng Vincent KM Poon Virtual hC Leung King-hung ko Jie Zhou Kwok Yung Yuen Bo-Jian Zheng Liwei Lu Department of Pathology The University of Hong KongHong KongChina Department of Microbiology The University of Hong KongHong KongChina Center of Infection and Immunology The University of Hong KongHong KongChina

Interleukin-17(IL-17),a member of the IL-17 cytokine family,plays a crucial role in mediating the immune response against extracellular bacteria and fungi in the *** there is increasing evidence that IL-17 is involved in protective immunity against h1 and h3 influenza virus infections,little is known about the role of IL-17 in the highly pathogenic h5N1 influenza virus *** this study,we show that h5N1-infected IL-17 knockout(ko)mice exhibit markedly increased weight loss,more pronounced lung immunopathology and significantly reduced survival rates as compared with infected wild-type ***,the frequency of B cells in the lung were substantially decreased in IL-17 ko mice after virus infection,which correlated with reduced CXCR5 expression in B cells and decreased CXCL13 production in the lung tissue of IL-17 ko *** with this observation,B cells from IL-17 ko mice exhibited a significant reduction in chemokine-mediated migration in *** together,these findings demonstrate a critical role for IL-17 in mediating the recruitment of B cells to the site of pulmonary influenza virus infection in mice.

关键词： B cell h5N1 influenza virus IL-17 lung infection

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Mixed-dimensional stacked nanocomposite structures for a specific wavelength-selectable ambipolar photoresponse

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Nano Research 2024年第6期17卷 5549-5558页

作者： Young Jae Park Jaeho Shim Joo Song Lee Kyu Seung Lee Ji-Yeon Kim Kang Bok ko Sang-Youp Yim Seongjun Kim hoon-Kyu Shin Donghee Park Yong Ju Yun Dong Ick Son Institute of Advanced Composite Materials Korea Institute of Science and TechnologyJeollabuk-do 55324Republic of Korea National Institute for Nanomaterials Technology Pohang University of Science and TechnologyGyeongsangbuk-do 37673Republic of Korea Department of Semiconductor Science and Technology Semiconductor Physics Research CenterJeonbuk National UniversityJeonju 54896Republic of Korea Advanced Photonics Research Institute Gwangju Institute of Science and TechnologyGwangju 61005Republic of Korea Center for Opto-Electronic Materials and Devices Post-Silicon Semiconductor InstituteKorea Institute of Science and TechnologySeoul 02792Republic of Korea Graduate School of Energy and Environment(KU-KIST Green School) Korea UniversitySeoul 02841Republic of Korea KIST School Department of Nanomaterials and Nano ScienceUniversity of Science and Technology(UST)Daejeon 34113Republic of Korea

Mixed-dimensional composite structures using zero-dimensional(0D)quantum dots(QDs)and two-dimensional(2D)transition metal dichalcogenides(TMDs)materials are expected to attract great interest in optoelectronics due to the potential to generate new optical ***,we report on the unique optical characteristics of a devices with mixed dimensional vertically stacked structures based on tungsten diselenide(WSe_(2))/CdSeS QDs monolayer/molybdenum disulfide(MoS_(2))(2D/0D/2D).Specifically,it exhibits an ambipolar photoresponse characteristic,with a negative photoresponse observed in the 400-600 nm wavelength range and a positive photoresponse appeared at 700 nm *** resulted in the high negative responsivity of up to 52.22 mA·W^(−1)under 400 nm,which is 163 times higher than that of the photodetector without CdSeS *** also demonstrated the negative photoresponse,which could be due to increased carrier collision probability and non-radiative *** modeling and simulation reveal that Auger recombination among the types of non-radiative recombination is the main cause of negative photocurrent ***,we discovered ambipolar photoresponse near a specific wavelength corresponding to the energy of quantum *** study revealed interesting phenomenon in the mixed low-dimensional stacked structure and paved the way to exploit it for the development of innovative photodetection materials as well as for optoelectronic applications.

关键词： mixed-dimension quantum dot heterostructure photodetector ambipolar photoresponse

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h1-antihistamine use and head and neck cancer risk in type 2 diabetes mellitus

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Oncology Research 2023年第1期31卷 23-34页

作者： YI-NONG ChEN YING-LIN ChEN WAN-MING ChEN MINGChIh ChEN BEN-ChANG ShIA JENQ-YUh ko SZU-YUAN WU Department of Otorhinolaryngology Lo-Hsu Medical FoundationLotung Poh-Ai HospitalYilanTaiwanChina Graduate Institute of Business Administration College of ManagementFu Jen Catholic UniversityTaipeiTaiwanChina Artificial Intelligence Development Center Fu Jen Catholic UniversityTaipeiTaiwanChina Department of Otolaryngology National Taiwan University Hospital and National Taiwan University College of MedicineTaipeiTaiwanChina Department of Food Nutrition and health Biotechnology College of Medical and Health ScienceAsia UniversityTaichungTaiwanChina Division of Radiation Oncology Lo-Hsu Medical FoundationLotung Poh-Ai HospitalYilanTaiwanChina Big Data Center Lo-Hsu Medical FoundationLotung Poh-Ai HospitalYilanTaiwanChina Department of healthcare Administration College of Medical and Health ScienceAsia UniversityTaichungTaiwanChina Cancer Center Lo-Hsu Medical FoundationLotung Poh-Ai HospitalYilanTaiwanChina Centers for Regional Anesthesia and Pain Medicine Taipei Municipal Wan Fang HospitalTaipei Medical UniversityTaipeiTaiwanChina Department of Management College of ManagementFo Guang UniversityYilanTaiwanChina

This study aimed to examine the association between the use of h1-antihistamines(Ahs)and head and neck cancer(hNC)risk in patients with type 2 diabetes mellitus(T2DM).Data from the National health Insurance Research Database of Taiwan were analyzed for the period from 2008 to 2018.A propensity-score-matched cohort of 54,384 patients each in the Ah user and nonuser groups was created and analyzed using Kaplan-Meier method and Cox proportional hazards *** results showed that the risk of hNC was significantly lower in Ah users(adjusted hazard ratio:0.55,95%CI:0.48 to 0.64)and the incidence rate was also lower(5.16 vs.8.10 per 100,000 person-years).The lower hNC incidence rate in Ah users(95%CI:0.63;0.55 to 0.73)suggests that Ah use may reduce the risk of hNC in T2DM patients.

关键词： Type 2 diabetes h1-Antihistamine head and neck cancer Incidence Incidence rate

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Nanoimprint lithography for high-throughput fabrication of metasurfaces

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Frontiers of Optoelectronics 2021年第2期14卷 229-251页

作者： Dong Kyo Oh Taejun LEE Byoungsu ko Trevon BADLOE Jong G.OK Junsuk RhO Department of Mechanical Engineering Pohang University of Science and Technology(POSTECH)Pohang 37673.Republic of Korea Department of Mechanical and Automotive Engineering Seoul National University of Science and Technology(SEOULTECH)Seoul 01811Republic of Korea Department of Chemical Engineering Pohang University of Science and Technology(POSTECH)Pohang 37673Republic of Korea

Metasurfaces are composed of periodic subwavelength nanostructures and exhibit optical properties that are not found in *** have been widely investigated for optical applications such as holograms,wavefront shaping,and structural color printing,however,electron-beam lithography is not suitable to produce large-area metasurfaces because of the high fabrication cost and low *** alternative optical technologies,such as holographic lithography and plasmonic lithography,can overcome these drawbacks,such methods are still constrained by the optical diffraction *** break through this fundamental problem,mechanical nanopatteming processes have been actively studied in many fields,with nanoimprint lithography(NIL)coming to the *** NIL replicates the nanopattem of the mold regardless of the diffraction limit,NIL can achieve sufficiently high productivity and patterning resolution,giving rise to an explosive development in the fabrication of *** this review,we focus on various NIL technologies for the manufacturing of ***,we briefly describe conventional NIL and then present various NIL methods for the scalable fabrication of *** also discuss recent applications of NIL in the realization of ***,we conclude with an outlook on each method and suggest perspectives for future research on the high-throughput fabrication of active metasurfaces.

关键词： nanoimprint scalable fabrication large-area metasurface tailored nanostructure hierarchical nanostructures

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Annealing time dependent structural, morphological, optical and electrical properties of RF sputtered p-type transparent conducting SnO_2/Al/SnO_2 thin films

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Transactions of Nonferrous Metals Society of China 2014年第S1期24卷 129-133页

作者： Keun Young PARK ho Je ChO Tae Kwon SONG hang Joo ko Bon heun koO School of Materials Science & Engineering Changwon National University Photovoltaic and Optoelectronic device center Korea Photonics Technology Institute

Transparent p-type conducting SnO2/Al/SnO2 multilayer films were fabricated on quartz substrates by radio frequency(RF) sputtering using SnO2 and Al targets. The deposited films were annealed at a fix temperature of 500 °C for different time durations(1-8 h). The effect of annealing time on the structural, morphological, optical and electrical performances of SnO2/Al/SnO2 multilayer films was studied. X-ray diffraction(XRD) results show that all the p-type conducting films possess polycrystalline SnO2 with tetragonal rutile structure. hall-effect results indicate that 500 °C for 1 h is the optimum annealing condition for p-type SnO2/Al/SnO2 multilayer films, resulting in a hole concentration of 1.14×1018 cm-3 and a low resistivity of 1.38 ?·cm, respectively. The optical transmittance of the p-type SnO2/Al/SnO2 multilayer films is above 80% within annealing time range of 1-8 h, showing maximum for the films annealed for 1 h.

关键词： pulsed laser deposition(PLD) transparent conducting oxide(TCO) p-type multi-layer transmittance

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