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Combination could be another tool for bowel preparation?

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World Journal of Gastroenterology 2016年第10期22卷 2915-2921页

作者： Jae Seung Soh kyung-Jo kim Division of Gastroenterology Department of Internal MedicineHallym University Sacred Heart HospitalUniversity of Hallym College of Medicine Department of Gastroenterology Asan Medical CenterUniversity of Ulsan College of Medicine

Optimal bowel preparation increases the cecal intubation rate and detection of neoplastic lesions while decreasing the procedural time and procedural-related complications. Although high-volume polyethylene glycol(PEG) solution is the most frequently used preparation for bowel cleansing, patients are often unwilling to take PEG solution due to its large volume, poor palatability, and high incidence of adverse events, such as abdominal bloating and nausea. Other purgatives include osmotic agents(e.g., sodium phosphate, magnesium citrate, and sodium sulfate), stimulant agents(e.g., senna, bisacodyl, and sodium picosulfate), and prokinetic agents(e.g., cisapride, mosapride, and itopride). A combination of PEG with an osmotic, stimulant, or prokinetic agent could effectively reduce the PEG solution volume and increase patients' adherence. Some such solutions have been found in several published studies to not be inferior to PEG alone in terms of bowel cleansing quality. Although combination methods showed similar efficacy and safety, the value of these studies is limited by shortcomings in study design. New effective and well-tolerated combination preparations are required, in addition to rigorous new validated studies.

关键词： Bowel preparation Colonoscopy Inadequate bowel cleansing Combination methods Intolerance

Stability of neodymium:YAG laser posterior capsulotomy in eyes with capsular tension rings

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International Journal of Ophthalmology(English edition) 2023年第6期16卷 891-896页

作者： Yang kyung Cho Min Sun kim Department of Ophthalmology St.Vincent’s HospitalCollege of MedicineThe Catholic University of KoreaSeoul 06591Republic of Korea

·AIM: To evaluate the stability of neodymium(Nd):YAG laser posterior capsulotomy in eyes with capsular tension rings(CTRs).·METHODS: A total of 60 eyes that underwent cataract surgery and laser posterior capsulotomy postoperatively were included in this retrospective cohort study. To evaluate the safety and stability of capsulotomy, changes in the size of posterior capsulotomy and anterior chamber depth(ACD) in three groups: the group without CTR, the group with 12 mm CTRs, and the group with 13 mm CTRs, at 1wk, 3, 12, and 15mo after capsulotomy, were compared. ·RESULTS: In the group without CTR and the group with 12 mm CTR, there was no significant change in ACD at every post-laser follow-up. In the group with 13 mm CTR, the ACD change was significant until 3mo after capsulotomy. In all groups, there was a significant increase in the area of capsulotomy between 1wk and 3mo post-laser. Between 3 and 12mo post-laser, only the group with 13 mm CTR showed a significant increase in the area of capsulotomy(P<0.01). ·CONCLUSION: Laser posterior capsulotomy is safe in all three groups. The capsulotomy and ACD become stabilized and have not shown significant changes since 1y postlaser, even with larger CTRs. The maintenance of centrifugal capsular tension can last longer with larger CTRs, and the stability of the capsulotomy site can be reached about 12mo after capsulotomy in pseudophakic eyes with larger CTRs.

关键词： Nd:YAG laser capsulotomy capsular tension ring

Small RNA- and DNA-based gene therapy for the treatment of liver cirrhosis, where we are?

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World Journal of Gastroenterology 2014年第40期20卷 14696-14705页

作者： kyung-Hyun kim Kwan-Kyu Park Department of Pathology College of Medicine Catholic University of Daegu Daegu 705-718 South Korea

Chronic liver diseases with different aetiologies rely on the chronic activation of liver injuries which result in a fibrogenesis progression to the end stage of cirrhosis and liver *** on the underlying cellular and molecular mechanisms of a liver fibrosis,there has been proposed several kinds of approaches for the treatment of liver ***,liver gene therapy has been developed as an alternative way to liver transplantation,which is the only effective therapy for chronic liver *** activation of hepatic stellate cells,a subsequent release of inflammatory cytokines and an accumulation of extracellular matrix during the liver fibrogenesis are the major obstacles to the treatment of liver *** targeted strategies have been developed,such as antisense oligodeoxynucleotides,RNA interference and decoy oligodeoxynucleotides to overcome this *** this report an overview will be provided of targeted strategies for the treatment of liver cirrhosis,and particularly,of the targeted gene therapy using short RNA and DNA segments.

关键词： Liver cirrhosis Gene therapy Oligodeoxynucleotides Antisense Small interfering RNA Micro RNA Decoy

Colorectal cancer in inflammatory bowel disease:The risk,pathogenesis,prevention and diagnosis

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World Journal of Gastroenterology 2014年第29期20卷 9872-9881页

作者： Eun Ran kim Dong kyung Chang Division of Gastroenterology Department of Internal MedicineSamsung Medical CenterSungkyunkwan University School of Medicine

Patients with inflammatory bowel disease(IBD)are at increased risk for developing colorectal cancer(CRC),although the overall incidence of IBD-associated CRC has been diminishing in recent decades in western *** demonstrated in previous studies,the risk of CRC in IBD increases with longer duration,extent of colitis,a familial history of CRC,coexistent primary sclerosing cholangitis,and the degree of *** pathogenesis of CRC in IBD is poorly *** to sporadic CRC,IBD-associated CRC is a consequence of sequential episodes of genomic *** inter-related pathways,including immune response by mucosal inflammatory mediators,oxidative stress,and intestinal microbiota,are also involved the pathogenesis of IBD-associated *** colonic inflammation appears to be a factor in the development of CRC;therefore,anti-inflammatory agents such as5-aminosalicylate compounds and immune modulators have been considered as potential chemopreventive *** surveillance is widely accepted as being effective in reducing the risk of IBD-associated CRC,although no clear evidence has confirmed that surveillance colonoscopy prolongs survival in patients with extensive *** traditional recommendation has been quadrantic random biopsies throughout the entire colon;however,several guidelines now have endorsed chromoendoscopy with a target biopsy because of increasing diagnostic yields and reduced workloads for endoscopists and *** technologies such as narrow band imaging,confocal endomicroscopy,and autofluorescence imaging have not yet been confirmed as surveillance strategies in IBD.

关键词： Inflammatory bowel disease Colorectal cancer Pathogenesis Chemoprevention Surveillance

Relationship between early structural changes at cornea incision sites and surgical outcomes after phacoemulsification

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International Journal of Ophthalmology(English edition) 2019年第7期12卷 1139-1145页

作者： kyung Hyun Jin Tae Gi kim Department of Ophthalmology Kyung Hee University Medical Center Kyung Hee University Seoul 02447 Korea Department of Ophthalmology Kyung Hee University Hospital at Gangdong Kyung Hee University Seoul 05278 Korea

AIM: To assess the early structural changes at clear corneal cataract incision sites and surgical outcomes using anterior segment optical coherence tomography(AS-OCT).METHODS: We evaluated 80 eyes of 59 patients who underwent phacoemulsification with a clear corneal incision. All incisions were evaluated 1 wk, 1, and 3 mo postoperatively using AS-OCT and analyzed regarding angle, length of the incision, maximal corneal thickness at the incision, and if present, corneal endothelial gap length and incision gap area. The patients were divided into two groups according to whether or not an endothelial gap was present at 1 wk postoperatively(endothelial gap, group 1;no endothelial gap, group 2). We analyzed the difference in patient and surgical factors between the two groups, and compared the surgical outcome and the refractive ***: An endothelial gap was observed in 56(70.0%) of 80 eyes at 1 wk postoperatively but not at 3 mo postoperatively. The mean patient age was significantly higher in group 1 than in group 2. The longer the length of the corneal incision and the steeper the incision angle, the greater the length and area of the endothelial gap. In group 1, the mean change in mean keratometry of the anterior cornea was significantly greater than in group 2, and the spherical equivalent(SE) and mean numerical error indicated significant myopic changes at 1 wk postoperatively. CONCLUSION: The risk of an endothelial gap increases with patient age and a long corneal incision and steep incision angle. The presence of an endothelial gap aftersurgery may affect the early postoperative corneal curvature and SE.

关键词： corneal incision structure phacoemulsification corneal curvature corneal endothelial gap anterior segment optical coherence tomography

An Advanced Probabilistic Neural Network for the Design of Breakwater Armor Blocks

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China Ocean Engineering 2007年第4期21卷 597-610页

作者： Dookie kim Dong Hyawn kim Seongkyu CHANG Gil Lim yoon Department of Civil and Environmental Engineering Kunsan National UniversityKunsanJeonbukKorea Department of Ocean System Engineering Kunsan National UniversityKunsanJeonbukKorea Coastal Engineering Research Department KORDIAnsanGyeonggiKorea

In this study, an advanced probabilistic neural network （APNN） method is proposed to reflect the global probability density function （PDF） by summing up the heterogeneous local PDF which is automatically determined in the individual standard deviation of variables. The APNN is applied to predict the stability number of armor blocks of breakwaters using the experimental data of＇ van der Meet, and the estimated results of the APNN are compared with those of an empirical formula and a previous artificial neural network （ANN） model. The APNN shows better results in predicting the stability number of armor bilks of breakwater and it provided the promising probabilistic viewpoints by using the individual standard deviation in a variable.

关键词： breakwater armor block stability number multivariate gaussian distribution classigication artificial neural network (ANN) advanced probabilistic neural network (APNN)

Deposition and Characterization of (Ba, Sr)RuO3 Oxide Electrode Using TMHD-Based Single Cocktail Source

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Journal of Rare Earths 2004年第z2期22卷 8-12页

作者： Hyun Chul kim kyung Il Hong Young Bae kim Duck Kyun Choi Department of Ceramic Engineering Hanyang University17 Haengdang-dongSeongdong-kuSeoul 133-791Korea Department of Ceramic EngineeringHanyang University17 Haengdang-dongSeongdong-kuSeoul 133-791Korea Department of Ceramic EngineeringHanyang University17 Haengdang-dongSeongdong-kuSeoul 133-791Korea Department of Ceramic EngineeringHanyang University17 Haengdang-dongSeongdong-kuSeoul 133-791Korea

(Ba, Sr)RuO3 has been paid an attention as a promising electrode for (Ba, Sr)TiO3 dielectric material due to its similarity in structure and chemical composition with BST. In this study, (Ba, Sr)RuO3 conductive oxide film was deposited on a 4 inch p-type Si wafer by metal organic chemical vapor deposition (MOCVD) using single cocktail source for the practical device application. Ba(TMHD)2, Sr(TMHD)2, Ru(TMHD)3 precursors and solvent [1-EtylePiPerdine (C7H15 N) ] as starting materials were mixed together for single cocktail source. A liquid delivery system (LDS) and a vaporization cell were utilized for the delivery and vaporization of single cocktail source, respectively. The source feeding rate was controlled by a liquid mass flow controller (LMFC). Deposition parameters, such as the oxygen flow and the source flow rate,were sensitive to phase formation, resistivity and the composition ratio of (Ba, Sr)RuO3 films. Highly (110)-textured (Ba,Sr)RuO3 film was obtained vhen the Ar/O2 ratio was 200/140 sccm at a source flow rate of 0.05 sccm. The process window of stoichiometric composition of BSR film was observed with varying the source flow rate from 0.05 sccm to 0.1 sccm.

关键词： (Ba, Sr)RuO3 (Ba, Sr)TiO3 MOCVD liquid delivery system(LDS) nozzle type injector

Endoscopic retrograde cholangiopancreatography in pancreatic and biliary tract disease in Korean children

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World Journal of Gastroenterology 2010年第4期16卷 490-495页

作者： Joo Young Jang Chong Hyun yoon kyung Mo kim Department of Pediatrics Asan Medical Center Children's HospitalUniversity of Ulsan College of MedicineSeoul 138-736South Korea Department of Pediatrics Ajou University School of MedicineSuwon 443-721South Korea Department of Pediatric Radiology Asan Medical Center Children's HospitalUniversity of Ulsan College of MedicineSeoul 138-736South Korea Department of Pediatrics Asan Medical Center Children’s HospitalUniversity of Ulsan College of MedicineSeoul 138-736South Korea

AIM:To assess the indications,findings,therapeutic procedures,safety,and complications of endoscopic retrograde cholangiopancreatography(ERCP) performed in Korean ***:The demographic characteristics,indications for ERCP,findings,therapeutic procedures,and complications of 122 pediatric patients who underwent 245 ERCPs in the Asan Medical Center between June 1994 and March 2008 were ***:The mean age of the 122 patients was 8.0 ± 4.2 *** were biliary pathology in 78(64.0%),pancreatic pathology in 43(35.2%),and chronic abdominal pain in *** indications included choledochal cysts in 40,choledocholithiasis in 24,suspected sclerosing cholangitis in 8,trauma in 2,and other conditions in *** indications includedacute pancreatitis in 7,acute recurrent pancreatitis in 11,chronic pancreatitis in 20,trauma in 3,and pancreatic mass in *** the 245 ERCPs,success rate was 98.4% and 190(77.6%) were for therapeutic purposes,including endoscopic nasal drainage(51.8%),biliary sphincterotomy(38.0%),pancreatic sphincterotomy(23.3%),stent insertion(15.1%),stone extraction(18.8%),and balloon dilatation(11.0%).Complications were postERCP pancreatitis in 16(6.5%),ileus in 23(9.4%),hemorrhage in 2(0.8%),perforation in 2(0.8%),sepsis in 1(0.4%),and impacted basket in 1(0.4%).There were no procedure-related deaths,and most complications improved under supportive ***:This study showed that there is a high incidence of choledochal cyst and diagnostic and therapeutic ERCP for the management of various biliary and pancreatic diseases was safe and effective in Korean children.

关键词： Endoscopic retrograde cholangiopancreatography Pancreatic diseases Biliary tract diseases Choledochal cyst Pancreatitis Pediatrics

NIR-Ⅱ thiopyrylium dyads guided photodynamic inactivation of coronavirus

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Science China Chemistry 2023年第7期66卷 1877-1878页

作者： Yunjie Xu Changyu yoon Jong Seung kim Department of Chemistry Korea UniversitySeoul 02841Korea

COVID-19,a highly contagious respiratory infection caused by the SARS-Co V-2 virus,was first identified in December 2019 and has rapidly expanded to become a global pandemic[1].From then on,millions of people were infected,while the exact number of infections is difficult to determine,as not all people who are infected with the virus get tested,and some may not show any symptoms,and the number is rising as the pandemic *** sickness is characterized by fever,cough.

关键词： respiratory infected infection