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Identification of hub genes and their novel diagnostic and prognostic significance in pancreatic adenocarcinoma

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Cancer Biology & Medicine 2022年第7期19卷 1029-1046页

作者： Duo Zuo yongzi chen Xinwei Zhang Zhuozhi Wang Wenna Jiang Fan Tang Runfen cheng Yi Sun Lu Sun Li Ren Rui Liu Department of Clinical Laboratory Department of Tumor Cell Biology Tianjin Medical University Cancer Institute and HospitalNational Clinical Research Center for CancerKey Laboratory of Cancer Prevention and TherapyTianjinTianjin’s Clinical Research Center for CancerTianjin 300060China School of Biomedical Engineering Tianjin Medical UniversityTianjin 300070China Department of Pathology Tianjin Huanhu HospitalTianjin 300350China Department of Pathology Tianjin Medical University Cancer Institute and HospitalNational Clinical Research Center for CancerKey Laboratory of Cancer Prevention and TherapyTianjinTianjin’s Clinical Research Center for CancerTianjin 300060China School of Pharmacy Tianjin Medical UniversityTianjin 300070China Department of Gastrointestinal Medical Oncology Tianjin Medical University Cancer Institute and HospitalNational Clinical Research Center for CancerKey Laboratory of Cancer Prevention and TherapyTianjinTianjin’s Clinical Research Center for CancerTianjin 300060China

Objective:The main reasons for the poor prognoses of pancreatic adenocarcinoma(PA)patients are rapid early-stage progression,advanced stage metastasis,and chemotherapy *** of novel diagnostic and prognostic biomarkers of PA is therefore urgently ***:Three mRNA microarray datasets were obtained from the Gene Expression Omnibus database to select differentially expressed genes(DEGs).Gene Ontology(GO)and Kyoto Encyclopedia of Genes and Genomes pathway enrichment analyses for hub genes were performed using *** between expression levels of hub genes and cancer-infiltrating immune cells were investigated by *** proportional hazard regression analyses were also *** hub genes were screened using the HPA platform and verified for diagnostic value using ***:We identified 59 hub genes among 752 *** analysis indicated that these 59 hub genes were mainly involved in the defense response to viruses and the type I interferon signaling *** also discovered that RSAD2 and SMC4 were associated with immune cell infiltration in the PA ***,DLGAP5 mRNA might be used as an independent risk factor for the prognoses of PA ***,the protein encoded by ISG15,which exists in peripheral blood,was validated as a potential diagnostic biomarker that distinguished PA patients from healthy controls(area under the curve:0.902,95%confidence interval:0.819–0.961).Conclusions:Our study suggested that RSAD2 and SMC4 were associated with immune cell infiltration in the PA microenvironment,while DLGAP5 mRNA expression might be an independent risk factor for the survival prognoses of PA ***,ELISAs indicated that serum ISG15 could be a potential novel diagnostic biomarker for PA.

关键词： RSAD2 SMC4 DLGAP5 ISG15 pancreatic adenocarcinoma

基因表达谱芯片及核酸测序技术在癌症研究中的应用现状

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生物信息学 2019年第1期17卷 18-23页

作者：陈永孜天津医科大学肿瘤医院肿瘤细胞生物学实验室天津市肿瘤防治重点实验室国家肿瘤临床医学研究中心天津市恶性肿瘤临床医学研究中心天津300060

基因表达谱芯片和核酸序列数据在癌症研究中占有很重要的地位。基因表达谱芯片被广泛的应用在医学研究中,它的主要优势在于灵敏快速成本低,缺点只能对现有基因进行研究,无法进行新基因发现以及变异等方面的研究;而核酸序列数据在这方面... 详细信息

基因表达谱芯片和核酸序列数据在癌症研究中占有很重要的地位。基因表达谱芯片被广泛的应用在医学研究中,它的主要优势在于灵敏快速成本低,缺点只能对现有基因进行研究,无法进行新基因发现以及变异等方面的研究;而核酸序列数据在这方面则具有很大优势。总体来说,二者在癌症研究中都发挥着巨大的作用。随着精准医学的不断发展,对这些高通量数据的深入研究可以有助于人们进一步了解癌症的分子机制,从而加速个体化治疗的进程。

关键词：芯片高通量测序癌症生物信息学

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Profile of *** chen

Science China(Life Sciences) 2024年第10期67卷 2062-2063页

作者： chen, Songlin Yellow Sea Fisheries Res Inst Qingdao Peoples R China

For decades,*** has been engaged in fish germplasm preservation,sex control and research focusing on molecular breeding for disease *** discovered the first sex-specific molecular marker of fish(chen et al.,2007),deciphered the first fish genome(Chinese tongue sole)in China,revealed the sex determination mechanism in fish(chen et al.,2014),and created molecular sex control *** also discovered the molecular mechanism of metamorphosis in flatfish(Shao et al.,2017)and developed China's first fish disease-resistant breeding gene chip,“YUXIN No.1”.

关键词： technology breeding

Effect of Reclamation on the Groundwater-Lake Water Interaction in chen Lake

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Journal of Earth Science 2024年第3期35卷 1083-1086页

作者： Kun Lei Teng Ma Liuzhu chen Zhenxing Li Yu chen School of Environmental Studies State Key Laboratory of Biogeology and Environmental GeologyChina University of GeosciencesWuhan 430078China

0 INTRODUCTION To relieve the short supply of suitable land for residing,cultivating,and commerce,it is accepted to reclaim land from lakes,river estuaries,and coastal regions in many countries(Mancini et al.,2020).The large-scale reclamation activities have an irreversible effect on the mico-geomorphology and hydrodynamic system of seasonally flooded areas(Zhang et al.,2019;Yu et al.,2018).For example,coastal regions reclaimed extended the groundwater flow paths,as well as created groundwater level rise,resulting in water-logging in the reclaimed area(Hu et al.,2008).Similar changes in groundwater flow systems may alter groundwater-lake water interactions,and it can ultimately affect the water cycle in the lake ***,such detailed studies are presently *** addition,natural exchanges between the lake and groundwater systems can be strongly affected by physical hydrological processes(Javadzadeh et al.,2020),chemical properties(Kamtchueng et al.,2015),and bioto behavior(Hancock et al.,2005).

关键词： groundwater coastal logging

石化工程建设中的仪表专业项目全过程管理要点

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建设监理 2021年第8期 13-16页

作者：乔妹莉陈永资青岛华鹏工程咨询集团有限公司山东青岛266000 中海油石化工程有限公司山东济南250101

石化工程建设项目具有技术难度高、工程投资大、建设周期长、影响因素多等特点,项目建设的各参与方在熟悉项目各阶段管理要点后,才能够更好地沟通协调,才能更有助于项目的进展。从石化工程项目建设全过程分析了仪表专业管理要点,既有理... 详细信息

石化工程建设项目具有技术难度高、工程投资大、建设周期长、影响因素多等特点,项目建设的各参与方在熟悉项目各阶段管理要点后,才能够更好地沟通协调,才能更有助于项目的进展。从石化工程项目建设全过程分析了仪表专业管理要点,既有理论依据又有实践经验。以期对石化工程仪表专业项目管理起到借鉴作用。

关键词：石化工程仪表项目全过程管理安全管理成本控制

Meridional deflection of global eddy propagation derived from tandem altimetry: Mechanism and implication

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Science China Earth Sciences 2024年第3期67卷 811-825页

作者： Ge chen Xiaoyan chen Frontiers Science Center for Deep Ocean Multispheres and Earth System School of Marine TechnologyOcean University of ChinaQindao 266100China Laboratory for Regional Oceanography and Numerical Modeling Laoshan LaboratoryQindao 266237China

A common view on meridional deflection of eddy propagation is poleward for cyclones and equatorward for anticyclones. This widely accepted polarity-sensitive pattern has been increasingly undermined given that it is systematically violated on both zonal and regional scales as recently reported. Here, we approach the problem by exploring these violations in terms of eddy effects of spatiotemporal geostrophy, thermal fading, and flow dragging, yielding the following main conclusions.(1) The polarity-dependent deflection discrepancy is a pseudo feature resulting from a biased fit to the normalized eddy tracks which are spatially asymmetric(though azimuthally symmetric) between the two signs;Instead, the primary pattern of eddy deflection appears to be geographically correlated and polarity independent.(2) Geostrophic adjustment plays a critical role in defining the meridional movement of an eddy. Specifically, a consistent poleward(equatorward) trajectory bending of spatially(temporally) ageostrophic eddies is observed irrespective of their polarity.(3) The mechanism of eddy deflection is also determined by its zonal propagation direction. Westward propagating eddies are substantially affected by thermal fading, while opposite ones by flow dragging. A realistic and comprehensive understanding of eddy deflection mechanisms serves as a significant contribution to the prediction of eddy trajectory, and the protection of ocean environment.

关键词： Mesoscale eddies Eddy propagation Eddy meridional deflection Satellite observation Geostrophic adjustment

A refined representation method of the particle size distribution curve based on grading entropy

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Particuology 2024年第5期88卷 302-311页

作者： Xing Li Qun chen Zhaozhao Liu cheng Zhou chen Wang chen chen State Key Laboratory of Hydraulics and Mountain River Engineering College of Water Resource and HydropowerSichuan UniversityChengdu610065China

The particle size distribution(PSD)curve is an important expression of the basic properties of the *** characteristic parameters such as median particle size D_(50),effective particle size D_(10),and some combinations of characteristic parameters can only represent some points of the PSD curve,failing to represent all information of the PSD *** this paper,a fraction characteristic parameter F that could reflect the fraction size variation of the PSD curve was introduced based on grading *** a new presentation method of the A-B-F three parameters was proposed for a refined representation of the PSD *** was found that the newly constructed model not only better represents the differences in the width of PSD curves but also has a higher sensitivity than the A-B two-parameter model proposed by Lő*** PSD curves with similar distributions,the new presentation method has a higher degree of discrimination than that of the D_(50)-C_(u)-C_(c) three-parameter or the four-parameter combination G_(c) proposed by ***,the application of this new method in describing the spatial nonuniformity distribution of depositions and predicting the soil hydraulic conductivity was *** research results can provide a reference for the refined representation of PSD curves.

关键词： Grading entropy Particle size distribution curve Refined representation

肝细胞肝癌NTS的表达与炎症微环境形成和肿瘤上皮间质转化及预后的相关性研究

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中国肿瘤临床 2013年第19期40卷 1150-1154页

作者：刘芃芃陈永孜任秀宝李慧应国光陈可欣于津浦天津医科大学肿瘤医院强生联合实验室国家肿瘤临床医学研究中心天津医科大学肿瘤医院天津市肿瘤防治重点实验室天津市肿瘤免疫与生物治疗重点实验室天津市075000 天津医科大学肿瘤医院生物技术研究室天津市075000 天津医科大学肿瘤医院肿瘤细胞生物学实验室天津市075000 天津医科大学肿瘤医院流行病学研究室天津市075000

目的:利用免疫组织化学染色法(IHC)检测肝细胞肝癌(HCC)中神经降压素(NTS)的表达,并探讨HCC中NTS/IL-8通路的激活与炎性微环境形成和肿瘤上皮间质转化(EMT)及临床预后的关系。方法:收集本院2007年11月至2009年7月期间进行部分肝切除术... 详细信息

目的:利用免疫组织化学染色法(IHC)检测肝细胞肝癌(HCC)中神经降压素(NTS)的表达,并探讨HCC中NTS/IL-8通路的激活与炎性微环境形成和肿瘤上皮间质转化(EMT)及临床预后的关系。方法:收集本院2007年11月至2009年7月期间进行部分肝切除术后确诊为肝细胞癌(HCC)、随访资料完整的肝癌患者64例。采用IHC法检测肝癌及相应癌旁正常组织中NTS,多种炎症因子和EMT相关蛋白的表达情况,包括IL-8、VEGF、MMP-9、CD68、E-cadherin,β-Catenin和Vimentin的表达水平,并比较不同NTS表达对HCC患者总生存时间(OS)的影响。结果:NTS在HCC中表达率为17.19%(11/64),NTS阳性HCC标本中IL-8阳性率较NTS阴性标本明显增加(90.91%vs.41.17%),二者表达呈正相关(R2=0.298,P=0.006)。NTS和IL-8双阳性(NTS+IL-8+)HCC标本中,VEGF和MMP-9表达显著增加。同时,NTS+IL-8+HCC细胞EMT特征明显,表现为E-Cadherin表达降低和Vi mentin表达升高。在肿瘤中NTS和IL-8共表达与患者的临床疗效呈正相关,术后NTS+IL-8+HCC患者的死亡率比非NTS和IL-8共表达的患者高2.5倍(P=0.022)。NTS+IL-8+HCC患者的OS显著缩短[(24.65±4.45)个月vs.(75.79±16.32)个月,P=0.013)],而死亡风险明显升高,其预期危险比(HR)为3.457。结论:在部分HCC中存在NTS/IL-8炎症通路的异常活化,NTS的高表达与炎症微环境形成和肿瘤EMT与肝癌患者预后较差密切相关。

关键词： HCC NTS 炎症微环境 EMT 预后

Track correlation algorithm based on CNN-LSTM for swarm targets

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Journal of Systems Engineering and Electronics 2024年第2期35卷 417-429页

作者： chen Jinyang WANG Xuhua chen Xian Research Institute for National Defense Engineering Academy of Military SciencesLuoyang 471023China Information Engineering University Zhengzhou 450001China School of Computer Science and Technology Xidian UniversityXi’an 710071China

The rapid development of unmanned aerial vehicle(UAV) swarm, a new type of aerial threat target, has brought great pressure to the air defense early warning system. At present, most of the track correlation algorithms only use part of the target location, speed, and other information for *** this paper, the artificial neural network method is used to establish the corresponding intelligent track correlation model and method according to the characteristics of swarm ***, a route correlation method based on convolutional neural networks (CNN) and long short-term memory (LSTM)Neural network is designed. In this model, the CNN is used to extract the formation characteristics of UAV swarm and the spatial position characteristics of single UAV track in the formation,while the LSTM is used to extract the time characteristics of UAV swarm. Experimental results show that compared with the traditional algorithms, the algorithm based on CNN-LSTM neural network can make full use of multiple feature information of the target, and has better robustness and accuracy for swarm targets.

关键词： track correlation correlation accuracy rate swarm target convolutional neural network(CNN) long short-term memory(LSTM)neural network