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Comparison of Ex‑PRESS implantation versus trabeculectomy combined with phacoemulsification in primary open‑angle glaucoma:a retrospective in vivo confocal microscopy study

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Eye and Vision 2024年第2期10卷 1-11页

作者： Yuqiao Zhang Beiting He Yulin Zhang Jin Zeng Yanlei Chen yongyi Niu Honghua Yu Yongjie Qin Hongyang Zhang Department of Ophthalmology Guangdong Eye InstituteGuangdong Academy of Medical SciencesGuangdong Provincial People’s HospitalNo.106 Zhongshan Er RoadGuangzhou 510080China Shantou University Medical College ShantouChina The Second School of Clinical Medicine Southern Medical UniversityGuangzhouChina Department of Ophthalmology School of MedicineSouth China University of TechnologyGuangzhouChina

Background:To compare the efficacy of Ex-PRESS implantation versus trabeculectomy combined with ***:A retrospective 12-month study on patients with coincident primary open-angle glaucoma(POAG)and *** patients underwent combined phacoemulsification and Ex-PRESS implant(Phaco-ExPRESS,n=35)or phacotrabeculectomy(Phaco-Trab,n=35).The morphological structures of the filtering bleb were examined by slitlamp,anterior segment optical coherence tomography(AS-OCT)and in vivo confocal microscopy(IVCM).Complete success was defined as postoperative intraocular pressure(IOP)<18 mmHg without the use of anti-glaucoma *** success was defined as postoperative IOP<18 mmHg with or without anti-glaucoma *** data were collected preoperatively and postoperatively at 2 weeks,1 month,3 months,6 months,and 12 ***:No significant difference in the variables such as age,IOP and perimetry was found between the groups of Phaco-ExPRESS and *** the one-year postoperative visit for filtering blebs,Phaco-ExPRESS increased the mean area of epithelial microcysts significantly from 0.10±0.05 to 0.20±0.09μm^(2)perμm^(2),while Phaco-Trab decreased the mean area significantly from 0.08±0.04 to 0.04±0.06μm^(2)perμm^(2).Notably,the hyperreflective dots detected by IVCM decreased by 84.9%in Phaco-ExPRESS but increased by 36.3%in *** hyperreflective dots were further identified as neutrophil-and monocyte-like *** number of these cells were negatively correlated with the microcysts area(r=−0.7,P<0.01)but positively associated with the grade of connective tissue(r=0.5,P<0.01).By creating different microstructural changes in the filtering blebs,Phaco-ExPRESS produced a higher complete success rate(84.9%vs.41.2%,P<0.01)and significant decrease in the number of anti-glaucoma medications(P<0.01)when compared with those in ***,the qualified success showed no significant difference between the two groups(

关键词： POAG Ex-PRESS Phacoemulsification Confocal microscopy

Direct Analysis of Whole Blood by a Disposable Monolithic Column Mass Spectrometry Analysis Kit

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Chinese Journal of Chemistry 2024年第10期42卷 1073-1078页

作者： Wenxin Wang Jin Han Yutong Zheng Haijie Wang Chengbiao Zhu yongyi Li Yuqi Feng Zhenwei Wei Xiangyu Wang College of Chemistry and Molecular Science Wuhan UniversityWuhanHubei 430072China School of Public Health Wuhan UniversityWuhanHubei 430072China Schoolof Bioengineering and Health Wuhan Textile UniversityWuhanHubei 430200China

A monolithic column-based mass spectrometry(MS)analysis kit was prepared for whole blood analysis with *** kit is disposable and can be used for purification,storage,transportation and direct analysis of whole *** kit mainly consists of a capillary for quantitative microsampling,a cation exchange monolithic column for purification and storage,and a syringe for loading *** kit is very friendly to various users that one can easily siphon the blood in the kit followed by rapid *** established a quantitative method using the kit with a limit detection as low as 0.33 nmol/L,and achieved more than five orders of magnitude enhancement in sensitivity compared to direct nanoelectrospray ionization MS *** column can avoid analyte exposure to environment,which helps the storage of the sample for laboratory *** relative standard deviation of immediate blood analysis and storage blood analysis within 10 d was less than 10%.This method has been successfully applied to the quantitative analysis of procainamide hydrochloride in 2μL rat *** results indicate that this disposable kit does have the potential to achieve highly sensitive quantitative MS analysis in biological samples,which is expected to become a cost-effective and powerful tool for in vitro diagnostics.

关键词： Clinical Ms Whole blood analysis Porous polymers Matrix isolation Trace analysis

Perfluoropentane-based oxygen-loaded nanodroplets reduce microglial activation through metabolic reprogramming

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Neural Regeneration Research 2025年第4期20卷 1178-1191页

作者： Wanxian Luo Chuanhui Xu Linxi Li Yunxiang Ji Yezhong Wang Yingjia Li yongyi Ye Department of Medicine Ultrasonics Nanfang HospitalSouthern Medical UniversityGuangzhouGuangdong ProvinceChina Institute of Neuroscience Department of NeurosurgeryThe Second Affiliated Hospital of Guangzhou Medical UniversityGuangzhouGuangdong ProvinceChina

Microglia,the primary immune cells within the brain,have gained recognition as a promising therapeutic target for managing neurodegenerative diseases within the central nervous system,including Parkinson’s *** perfluorocarbon droplets have been reported to not only possess a high oxygen-carrying capacity,but also exhibit remarkable anti-inflammatory ***,the role of perfluoropentane in microglia-mediated central inflammatory reactions remains poorly *** this study,we developed perfluoropentane-based oxygen-loaded nanodroplets(PFP-OLNDs)and found that pretreatment with these droplets suppressed the lipopolysaccharide-induced activation of M1-type microglia in vitro and in vivo,and suppressed microglial activation in a mouse model of Parkinson’s *** suppression led to a reduction in the inflammatory response,oxidative stress,and cell migration capacity in ***,the neurotoxic effects were mitigated,which alleviated neuronal ***,ultrahigh-performance liquid chromatography–tandem mass spectrometry showed that the anti-inflammatory effects of PFP-OLNDs mainly resulted from the modulation of microglial metabolic *** further showed that PFP-OLNDs regulated microglial metabolic reprogramming through the AKT-mTOR-HIF-1α***,our findings suggest that the novel PFP-OLNDs constructed in this study alleviate microglia-mediated central inflammatory reactions through metabolic reprogramming.

关键词： metabolic reprogramming microglia microglial migration nanotherapy neurodegenerative diseases neuroinflammation oxygen-loaded nanodroplets Parkinson’s disease perfluoropentane ultra-performance liquid chromatography–mass spectrometry

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Inversion of maize leaf nitrogen using UAV hyperspectral imagery in breeding fields

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International Journal of Agricultural and Biological Engineering 2024年第3期17卷 144-155页

作者： Qiwen Cheng Bingsun Wu Huichun Ye yongyi Liang Yingpu Che Anting Guo Zixuan Wang Zhiqiang Tao Wenwei Li Jingjing Wang School of Tropical Agriculture and Forestry Hainan UniversityHaikou 570228China Rubber Research Institute Chinese Academy of Tropical Agricultural SciencesHaikou 571101China Key Laboratory of Earth Observation of Hainan Province Hainan Aerospace Information Research InstituteSanya 572029HainanChina Key Laboratory of Digital Earth Science Aerospace Information Research InstituteChinese Academy of SciencesBeijing 100094China Institute of Crop Science Chinese Academy of Agricultural SciencesBeijing 100081China

Nitrogen(N)as a pivotal factor in influencing the growth,development,and yield of *** the N status of maize rapidly and non-destructive and real-time is meaningful in fertilization management of agriculture,based on unmanned aerial vehicle(UAV)remote sensing *** this study,the hyperspectral images were acquired by UAV and the leaf nitrogen content(LNC)and leaf nitrogen accumulation(LNA)were measured to estimate the N nutrition status of maize.24 vegetation indices(VIs)were constructed using hyperspectral images,and four prediction models were used to estimate the LNC and LNA of *** models include a single linear regression model,multivariable linear regression(MLR)model,random forest regression(RFR)model,and support vector regression(SVR)***,the model with the highest prediction accuracy was applied to invert the LNC and LNA of maize in breeding *** results of the single linear regression model with 24 VIs showed that normalized difference chlorophyll(NDchl)had the highest prediction accuracy for LNC(R^(2),RMSE,and RE were 0.72,0.21,and 12.19%,respectively)and LNA(R^(2),RMSE,and RE were 0.77,0.26,and 14.34%,respectively).And then,24 VIs were divided into 13 important VIs and 11 unimportant *** prediction models for LNC and LNA were constructed using 13 important VIs,and the results showed that RFR and SVR models significantly enhanced the prediction accuracy of LNC and LNA compared to the multivariable linear regression model,in which RFR model had the highest prediction accuracy for the validation dataset of LNC(R^(2),RMSE,and RE were 0.78,0.16,and 8.83%,respectively)and LNA(R^(2),RMSE,and RE were 0.85,0.19,and 9.88%,respectively).This study provides a theoretical basis for N diagnosis and precise management of crop production based on hyperspectral remote sensing in precision agriculture.

关键词： maize nitrogen hyperspectral imagery vegetation index UAV random forest regression support vector regression

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风土:文史演绎与地景再造的新史学研究

思想战线 2024年第1期50卷 60-74页

作者：岳永逸中国人民大学社会与人口学院、社会学理论与方法研究中心、北京社会建设研究基地北京100872

在其生前身后海量的诗、文、史、画中反复出现的杨贵妃,首先是一个常人,是姿质丰艳、善歌舞、通音律的杰出艺人,其次才是身不由己、动移上意的贵妃。无论叹惋还是诅咒,作为一个文化符号的杨贵妃,更多指向的是人人挥之不去又向往的“情... 详细信息

在其生前身后海量的诗、文、史、画中反复出现的杨贵妃,首先是一个常人,是姿质丰艳、善歌舞、通音律的杰出艺人,其次才是身不由己、动移上意的贵妃。无论叹惋还是诅咒,作为一个文化符号的杨贵妃,更多指向的是人人挥之不去又向往的“情”。抛离爱恨夹杂的贵妃情结所支配的文史叙事诗学的层层陷阱,杨贵妃的常人和艺人面相就呼之欲出。作为一个雅俗共享的消费对象,贵妃的遗物也脱离唐明皇的专利属性。其故冢和传闻遗失在马嵬并引过客争相观瞻的锦靿,犹如显圣物将马嵬圣地化,也支撑了贵妃落户海外的“野野史”。悖谬的是,在旅游成为一种生活方式的今天,马嵬已成为一个不再具有归属感、关系性和历史性的“非地点”。由此观之,文化就是在时空连续体中不同心性行动主体情与理的对撞、交融和辩证,抽象与具象的互生互促。

关键词：新史学常人文化非地点顾颉刚

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Characterization of SH3GLB1 in the Checkfor auditory system and its potential role in updates mitophagy

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Genes & Diseases 2024年第4期11卷 61-64页

作者： Xue Gao Weiqian Wang Jincao Xu Shasha Huang Kun Yang Jinyuan Yang Yijin Chen Guojian Wang Mingyu Han Zhendong Wang Dongyang Kang yongyi Yuan Pu Dai College of Otolaryngology Head and Neck Surgery Chinese PLA General HospitalChinese PLA Medical SchoolBeijing 100853China National Clinical Research Center for Otolaryngologic Diseases State Key Lab of Hearing ScienceMinistry of EducationBeijing 100853China Beijing Key Lab of Hearing Impairment Prevention and Treatment Chinese PLA Medical SchoolBeijing 100853China Department of Otolaryngology PLA Rocket Force Characteristic Medical CenterBeijing 100088China

Mitochondria energize the inner ear to maintain the cochlear potential createdbythe striavascularis,assist the motility of outer hair cells,perform synaptic processes,and maintain the spontaneous and sound-driven discharges of the spiral ganglion neurons(SGNs).Mitophagy deficiencies induce the accumulation of damaged organelles and mitochondria in cells and are a primary cause of drug-induced hearing loss.

关键词： auditory maintain potential

Multifunctional solar-blind ultraviolet photodetectors based on p-PCDTBT/n-Ga_(2)O_(3)heterojunction with high photoresponse

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InfoMat 2024年第2期6卷 118-130页

作者： Yifei Wang Zhenhua Lin Jingli Ma yongyi Wu Haidong Yuan Dongsheng Cui Mengyang Kang XingGuo Jie Su Jinshui Miao Zhifeng Shi Tao Li Jincheng Zhang Yue Hao Jingjing Chang State Key Discipline Laboratory of Wide Band Gap Semiconductor Technology School of MicroelectronicsXidian UniversityXi'anthe People's Republic of China School of Physics and Microelectronics Key Laboratory of Material PhysicsMinistry of EducationZhengzhou UniversityZhengzhouthe People's Republic of China Center for Spintronics and Quantum Systems State Key Laboratory for Mechanical Behavior of MaterialsDepartment of Materials Science and EngineeringXi'an Jiaotong UniversityXi'anthe People's Republic of China Advanced Interdisciplinary Research Center for Flexible Electronics Xidian UniversityXi'anthe People's Republic of China State Key Laboratory of Infrared Physics Shanghai Institute of Technical PhysicsChinese Academy of SciencesShanghaithe People's Republic of China

Solar-blind ultraviolet(UV)photodetectors based on p-organic/n-Ga_(2)O_(3) hybrid heterojunctions have attracted extensive attention ***,the multifunctional solar-blind photodetector based on p-type poly[N-90-heptadecanyl-2,7-carbazole-alt-5,5-(40,70-di-2-thienyl-20,10,30-benzothiadiazole)](PCDTBT)/n-type amorphous Ga_(2)O_(3)(a-Ga_(2)O_(3))is fabricated and investigated,which can work in the phototransistor mode coupling with self-powered *** the introduction of PCDTBT,the dark current of such the a-Ga_(2)O_(3)-based photodetector is decreased to 0.48 ***,the photoresponse parameters of the a-Ga_(2)O_(3)-based photodetector in the phototransistor mode to solar-blind UV light are further increased,that is,responsivity(R),photo-detectivity(D*),and external quantum efficiency(EQE)enhanced to 187 A W^(-1),1.3×10^(16) Jones and 9.1×10^(4)% under the weak light intensity of 11μW cm^(-2),*** to the formation of the built-in field in the p-PCDTBT/n-Ga_(2)O_(3) type-Ⅱ heterojunction,the PCDTBT/Ga_(2)O_(3) multifunctional photodetector shows self-powered *** responsivity of p-PCDTBT/n-Ga_(2)O_(3) multifunctional photodetector is 57.5 mA W^(-1) at zero *** multifunctional p-n hybrid heterojunction-based photodetectors set the stage for realizing high-performance amorphous Ga_(2)O_(3) heterojunction-based photodetectors.

关键词： amorphous Ga_(2)O_(3) heterojunction multifunctional PCDTBT solar-blind photodetectors

Expression and characterization of a novel GH128 laminarinase OUC-BsLam26 harboring both hydrolyzing and transferring activities

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Food Science and Human Wellness 2024年

作者： Yueyang Dong yongyi Quan Hong Jiang Hamed I.Hamouda Zewei Lu Yimiao Chen Chengqiang Li Xiangzhao Mao State Key Laboratory of Marine Food Processing and Safety Control， College of Food Science and Engineering， Ocean University of China Qingdao Key Laboratory of Food Biotechnology Sanya Ocean Research Institute， Ocean University of China Processes Design and Development Department， Egyptian Petroleum Research Institute Laboratory for Marine Drugs and Bioproducts of Qingdao National Laboratory for Marine Science and Technology Key Laboratory of Biological Processing of Aquatic Products，China National Light Industry

Laminarin oligosaccharides (LOSs) with a specific degree of polymerization prepared through the laminarin degradation via laminarinase present more significant nutritional functions and application values. Human intestinal bacteria are promising potential producers of novel carbohydrate-active enzymes with unique properties. Here， a novel glycoside hydrolase family 128 (GH128) laminarinase OUC-BsLam26 from the intestinal bacterium Bacteroides sp. CBA7301 was heterologously expressed and characterized. The recombinant OUC-BsLam26 with a molecular mass of 49.86 kDa exhibits highest activity (6.60 U/mg) at 45 ℃ and pH 6.0， which shows noticeable temperature and pH stability. The purified OUC-BsLam26 could degrade laminarin via an endo-type mode with the generation of laminaripentaose， laminaritetraose， laminaritriose， and laminaribiose， among them， laminaritetraose is the principal product， which accounts for 45.25% of the total products， which is significantly different from the reported GH128 laminarinases. The minimum recognition substrate of OUC-BsLam26 is laminarihexaose. Furthermore， OUC-BsLam26 also could catalyze the transglycosylation process with the production of some novel glycosides. Altogether， the intestinal bacterium Bacteroides sp. CBA7301 contains laminarinase with unique product composition and OUC-BsLam26 is a hopeful bio-catalyst with the potential to produce laminaritetraose and some novel glycosides.

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坚守专业精神,谱写智创华章——广东省立中山图书馆“采编图灵”建设述略

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图书馆论坛 2024年第4期44卷 1-9页

作者：潘咏怡广东省立中山图书馆

广东省立中山图书馆研发的“图书采分编全流程智能作业系统‘采编图灵’”是丰富智慧图书馆多场景应用、以技术驱动服务创新的典范。文章概述采编图灵的功能和效能;从需求分析、总体思路、建设内容等角度回顾采编图灵建设历程。文章认为... 详细信息

广东省立中山图书馆研发的“图书采分编全流程智能作业系统‘采编图灵’”是丰富智慧图书馆多场景应用、以技术驱动服务创新的典范。文章概述采编图灵的功能和效能;从需求分析、总体思路、建设内容等角度回顾采编图灵建设历程。文章认为,采编工作是生长的有机体,采编图灵作为智能作业系统,为采编业务创新注入时代的血液,促进了编目员回归专业化发展方向,推动了采编岗位的结构性调整,能够科学开展供应商服务评价,精准对接读者服务需求。

关键词：图书采分编全流程智能作业系统采编图灵智慧图书馆专业化建设图书馆自动化