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Down-staging depth score to predict outcomes in locally advanced rectal cancer achieving ypl stage after neoadjuvant chemo-radiotherapy versus de novo stage pl cohort:A propensity score-matched analysis

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Chinese Journal of Cancer Research 2018年第3期30卷 373-381页

作者： Ning Li Jing Jin Jing Yu Shuai Li Yuan Tang Hua Ren Wenyang Liu Shulian Wang Yueping Liu yongwen song Hui Fang Zihao Yu Yexiong Li Department of Radiation Oncology National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical SciencesPeking Union Medical College

Objective：Prognosis of patients with locally advanced rectal cancer（LARC）but achieving yp T1–2N0 stage after neoadjuvant concurrent chemo-radiotherapy（CRT）has been shown to be *** study aims to determine whether the long-term outcome of yp T1–2N0 cases can be comparable to that of p T1–2N0 cohort that received definitive surgery for early ***：From January 2008 to December 2013,449 consecutive patients with rectal cancer were treated and their outcome maintained in a *** with LARC underwent total mesorectal excision（TME）surgery at4–8 weeks after completion of CRT,and those achieving stage yp I were identified as a *** a comparison,stage p I group pertains to patients whose initially limited disease was not upstaged after TME surgery *** propensity score matching（PSM）,comparisons of local regional control（LC）,distant metastasis-free survival（DMFS）,disease-free survival（DFS）and overall survival（OS）were performed using Kaplan-Meier analysis and log-rank test between yp I and p I ***-staging depth score（DDS）,a novel method of evaluating CRT response,was used for subset ***：Of the 449 patients,168 matched cases were generated for ***-year LC,DMFS,DFS and OS for stage p I *** I groups were 96.7%vs.96.4%（P=0.796）,92.7%vs.73.6%（P=0.025）,91.2%vs.73.6%（P=0.080）and 93.1%vs.72.3%（P=0.040）,*** the DDS-favorable subset of the yp I group,LC,DMFS,DFS and OS resulted in no significant differences in comparison with the p I group（P=0.384,0.368,0.277 and0.458,respectively）.Conclusions：LC was comparable in both groups;however,distant metastasis developed more frequently in down-staged LARC than de novo early stage cases,reflecting the need to improve the efficacy of systemic treatment despite excellent pathologic *** can be an indicator to identify a subset of the yp I group whose longterm oncologic outcomes are as good as those of stage p I cohort.

关键词： Rectal neoplasms neoadjuvant chemo-radiotherapy down-staging propensity score-matched analysis

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Genetic polymorphisms in genes regulating cell death and prognosis of patients with rectal cancer receiving postoperative chemoradiotherapy

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Cancer Biology & Medicine 2023年第4期20卷 297-316页

作者： Hongxia Chen Luxi Yin Jie Yang Ningxin Ren Jinna Chen Qixuan Lu Ying Huang Yanru Feng Weihu Wang Shulian Wang Yueping Liu yongwen song Yexiong Li Jing Jin Wen Tan Dongxin Lin State Key Laboratory of Molecular Oncology Department of Etiology and CarcinogenesisBeijing Key Laboratory for Carcinogenesis and Cancer PreventionNational Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China Department of Radiation Oncology National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China Sun Yat-sen University Cancer Center State Key Laboratory of Oncology in South ChinaGuangzhou 510060China

Objective:The identification of biomarkers for predicting chemoradiotherapy efficacy is essential to optimize personalized *** study determined the effects of genetic variations in genes involved in apoptosis,pyroptosis,and ferroptosis on the prognosis of patients with locally advanced rectal cancer receiving postoperative chemoradiotherapy(CRT).Methods:The Sequenom MassARRAY was used to detect 217 genetic variations in 40 genes from 300 patients with rectal cancer who received postoperative *** associations between genetic variations and overall survival(OS)were evaluated using hazard ratios(HRs)and 95%confidence intervals(CIs)computed using a Cox proportional regression *** experiments were performed to determine the functions of the arachidonate 5-lipoxygenase(ALOX5)gene and the ALOX5 rs702365 ***:We detected 16 genetic polymorphisms in CASP3,CASP7,TRAILR2,GSDME,CASP4,HO-1,ALOX5,GPX4,and NRF2 that were significantly associated with OS in the additive model(P[C]represses ALOX5 transcription and corollary experiments suggested that ALOX5 may promote colon cancer cell growth by mediating an inflammatory ***:Polymorphisms in genes regulating cell death may play essential roles in the prognosis of patients with rectal cancer who are treated with postoperative CRT and may serve as potential genetic biomarkers for individualized treatment.

关键词： Rectal neoplasms genetic variation regulated cell death overall survival ALOX5

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Clinical features and outcomes of diffuse large B-cell lymphoma based on nodal or extranodal primary sites of origin:Analysis of 1,085 WHO classified cases in a single institution in China

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Chinese Journal of Cancer Research 2019年第1期31卷 152-161页

作者： Yuankai Shi Ying Han Jianliang Yang Peng Liu Xiaohui He Changgong Zhang Shengyu Zhou Liqiang Zhou Yan Qin yongwen song Yueping Liu Shulian Wang Jing Jin Lin Gui Yan Sun Department of Medical Oncology Beijing Key Laboratory of Clinical Study on Anticancer Molecular Targeted DrugsNational Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China Departement of Radiation Oncology National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China

Objective: To explore the clinicobiologic features and outcomes of diffuse large B-cell lymphoma(DLBCL)patients in China according to the primary ***: A total of 1,085 patients diagnosed with DLBCL in National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College during a 6-year period were enrolled. Their clinical characteristics and outcomes were analyzed according to the primary ***: In the 1,085 patients, 679(62.6%) cases were nodal DLBCL(N-DLBCL) and 406 cases(37.4%) were extranodal DLBCL(EN-DLBCL). The most common sites of N-DLBCL were lymphonodus(64.8%), Waldeyer's ring(19.7%), mediastinum(12.8%) and spleen(2.7%), while in EN-DLBCL, stomach(22.4%), intestine(16.0%),nose and sinuses(8.9%), testis(8.4%), skin(7.9%), thyroid(6.9%), central nervous system(CNS)(6.4%), breast(5.7%), bone(3.4%), and salivary gland(2.7%) were most common. N-DLBCL patients tend to present B symptoms, bulky disease, and elevated LDH more often, while age >60 years, extranodal sites >1, Ann Arbor stage I or II, bone marrow involvement, and Ki-67 index >90% were usually seen in EN-DLBCL. The 5-year overall survival(OS) rate and progression-free survival(PFS) rate for all patients were 62.5% and 54.2%. The 5-year OS rate for patients with N-DLBCL and EN-DLBCL were 65.5% and 56.9%(P=0.008), and the 5-year PFS were57.0% and 49.0%(P=0.020). Waldeyer's ring originated DLBCL possessed the highest 5-year OS rate(83.6%) and PFS rate(76.9%) in N-DLBCL. The top five EN-DLBCL subtypes with favorable prognosis were stomach,breast, nose and sinuses, lung, salivary gland, with 5-year OS rate: 70.3%, 69.6%, 69.4%, 66.7% and 63.6%,respectively. While CNS, testis, oral cavity and kidney originated EN-DLBCL faced miserable prognosis, with 5-year OS rate of 26.9%, 38.2%, and 42.9%.Conclusions: In our study, primary sites were associated with clinical characteristics and outcomes. Compared with EN-DLBCL, N-DLBCL had better prognosis.

关键词： Diffuse large B-cell lymphoma(DLBCL) distribution nodal extranodal

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Down-staging depth score could be a survival predictor for locally advanced gastric cancer patients after preoperative chemoradiotherapy

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Chinese Journal of Cancer Research 2021年第4期33卷 447-456页

作者： Ning Li Xin Wang Yuan Tang Dongbin Zhao Yihebali Chi Lin Yang Liming Jiang Jun Jiang Jinming Shi Wenyang Liu Hua Ren Hui Fang Yu Tang Bo Chen Ningning Lu Hao Jing Shunan Qi Shulian Wang Yueping Liu yongwen song Yexiong Li Jing Jin State Key Laboratory of Molecular Oncology Department of Radiation OncologyNational Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical SciencesPeking Union Medical CollegeBeijing 100021China Department of Abdominal Surgical Oncology National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China Department of Medical Oncology National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China Department of Radiology National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China

Objective:The predictive effect of preoperative chemoradiotherapy(CRT)is low and difficult in guiding individualized *** examined a surrogate endpoint for long-term outcomes in locally advanced gastric cancer patients after preoperative ***:From April 2012 to April 2019,95 patients with locally advanced gastric cancer who received preoperative concurrent CRT and who were enrolled in three prospective studies were *** patients were stage T_(3/4) N_(+).Local control,distant metastasis-free survival(DMFS),disease-free survival(DFS)and overall survival(OS)were *** factors related to long-term prognosis were analyzed using univariate and multivariate *** down-staging depth score(DDS),which is a novel method of evaluating CRT response,was used to predict long-term ***:The median follow-up period for survivors was 30 *** area under the curve(AUC)of the receiver operating characteristic(ROC)curve predicted by the DDS was 0.728,which was better than the pathological complete response(pCR),histological response and *** curve analysis further affirmed that DDS had the largest net *** DDS cut-off value was *** and ypN0 were associated with OS(P=0.026 and 0.049).Surgery and DDS are correlated with DMFS,DFS and OS(surgery:P=0.001,<0.001 and<0.001,respectively;and DDS:P=0.009,0.013 and 0.032,respectively).Multivariate analysis showed that DDS was an independent prognostic factor of DFS(P=0.021).Conclusions:DDS is a simple,short-term indicator that was a better surrogate endpoint than pCR,histological response and ypN0 for DFS.

关键词： Gastric cancer preoperative chemoradiotherapy prediction long-term outcomes

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Postoperative chemoradiotherapy with capecitabine and oxaliplatin *** for pathological stage N2 rectal cancer

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Chinese Journal of Cancer Research 2024年第5期36卷 577-586页

作者： Ning Li Yuan Zhu Luying Liu Yanru Feng Wenling Wang Jun Wang Hao Wang Gaofeng Li Yuan Tang Chen Hu Wenyang Liu Hua Ren Shulian Wang Weihu Wang yongwen song Yueping Liu Hui Fang Yu Tang Ningning Lu Bo Chen Shunan Qi Yexiong Li Jing Jin State Key Laboratory of Molecular Oncology Department of Radiation OncologyNational Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China Department of Radiation Oncology Cancer Hospital of the University of Chinese Academy of SciencesZhejiang Cancer HospitalInstitute of Cancer and Basic MedicineChinese Academy of SciencesHangzhou 310022China Department of Radiation Oncology Guizhou Cancer HospitalGuiyang 550001China Department of Radiation Oncology Tumor Hospital of Hebei ProvinceShijiazhuang 050011China Department of Radiation Oncology Peking University Third HospitalBeijing 100034China Department of Radiation Oncology Beijing HospitalBeijing 100730China Division of Biostatistics and Bioinformatics Sidney Kimmel Comprehensive Cancer CenterJohns Hopkins University School of MedicineBaltimoreMD 21205USA Department of Radiation Oncology United Family HealthcareShenzhen 518038China Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education/Beijing) Department of Radiation OncologyPeking University Cancer Hospital&InstituteBeijing 100142China Department of Radiation Oncology National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital&Shenzhen HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeShenzhen 518116China

Objective:Several studies have been conducted on the effects and toxicity of adding oxaliplatin to fluorouracilbased or capecitabine-based chemoradiotherapy(CRT)regimens as significantly increasing the toxic response without benefit to *** this study,we further explored the role of these two postoperative CRT regimens in patients with pathological stage N2 rectal ***:This study was a subgroup analysis of a randomized clinical trial.A total of 180 patients with pathological stage N2 rectal cancer were eligible,85 received capecitabine with radiotherapy(RT),and 95 received capecitabine and oxaliplatin with *** in both groups received adjuvant chemotherapy[capecitabine and oxaliplatin(XELOX);or fluorouracil,leucovorin,and oxaliplatin(FOLFOX)]after ***:At a median follow-up of 59.2[interquartile range(IQR),34.0−96.8]months,the three-year diseasefree survival(DFS)was 53.3%and 64.9%in the control group and the experimental group,respectively[hazard ratio(HR),0.63;95%confidence interval(95%CI),0.41−0.98;P=0.04].There was no significant difference between the groups in overall survival(OS)(HR,0.62;95%CI,0.37−1.05;P=0.07),the incidence of locoregional recurrence(HR,0.62;95%CI,0.24−1.64;P=0.33),the incidence of distant metastasis(HR,0.67;95%CI,0.42−1.06;P=0.09)and grade 3−4 acute toxicities(P=0.78).For patients with survival longer than 3 years,the conditional overall survival(COS)was significantly better in the experimental group(HR,0.39;95%CI,0.16−0.96;P=0.03).Conclusions:Our results indicated that adding oxaliplatin to capecitabine-based postoperative CRT is safe and effective in patients with pathological stage N2 rectal cancer.

关键词： Chemoradiotherapy oxaliplatin capecitabine rectal neoplasms drug therapy radiotherapy treatment outcome

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新汶矿区翟镇井田2~#煤层小断层发育规律研究

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中国煤炭 2015年第7期41卷 34-37页

作者：施龙青宋忠航吕大炜宋永文山东科技大学地球科学与工程学院山东省沉积成矿作用与沉积矿产重点实验室山东省青岛市266590 枣庄矿业集团蒋庄煤矿山东省枣庄市277500

以翟镇煤矿2#煤层开采过程中获得的断层资料为依据,结合区域构造背景,分析了井田内小断层的成因特征及分布特征。研究发现,井田经历不同时期的构造应力场后形成了4组方向的断层构造,后期形成的NE向断层切割较早发育的NW向断层,井田内断... 详细信息

以翟镇煤矿2#煤层开采过程中获得的断层资料为依据,结合区域构造背景,分析了井田内小断层的成因特征及分布特征。研究发现,井田经历不同时期的构造应力场后形成了4组方向的断层构造,后期形成的NE向断层切割较早发育的NW向断层,井田内断层密度分布不均,其中,高密度区主要分布在井田东部。通过断层特征分析总结出井田内小断层具有方向性、分区性、分级控制性和成带性等发育规律。

关键词：翟镇井田小断层发育规律地质构造

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Association of overall survival benefit of radiotherapy with progression-free survival after chemotherapy for diffuse large B-cell lymphoma:A systematic review and meta-analysis

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Journal of the National Cancer Center 2024年第3期4卷 249-259页

作者： Jingnan Wang Xin Liu Yunpeng Wu Qiuzi Zhong Tao Wu Yong Yang Bo Chen Hao Jing Yuan Tang Jing Jin Yueping Liu yongwen song Hui Fang Ningning Lu Ning Li Yirui Zhai Wenwen Zhang Min Deng Shulian Wang Fan Chen Lin Yin Chen Hu Shunan Qi Yexiong Li Department of Radiation Oncology National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeCollaborative Innovation Center for Cancer MedicineBeijingChina Beijing Hospital National Geriatric Medical CenterBeijingChina Affiliated Hospital of Guizhou Medical University Guizhou Cancer HospitalGuiyangGuizhouChina Department of Radiation Oncology Fujian Medical University Union HospitalFuzhouChina Department of Radiation Oncology National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital&Shenzhen HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeShenzhenChina Department of Radiation Oncology Affiliated Hospital of Qinghai UniversityQinghaiChina Division of Biostatistics and Bioinformatics Sidney Kimmel Comprehensive Cancer CenterJohns Hopkins University School of MedicineBaltimoreUnited States

Objective:To evaluate whether improved progression-free survival(PFS)from radiotherapy(RT)translates into an overall survival(OS)benefit for diffuse large B-cell lymphoma(DLBCL).Methods:A systematic literature search identified randomized controlled trials(RCTs)and retrospective studies that compared combined-modality therapy(CMT)with chemotherapy(CT)*** regression analyses were used to estimate the correlation between OS and PFS ***’s kappa statistic assessed the consis-tency between DLBCL risk-models and PFS ***,the benefit trend of RT was analyzed by fitting a linear regression model to the pooled hazard ratio(HR)according to the PFS ***:For both 7 RCTs and 52 retrospective studies,correlations were found between PFS HR(HRPFS)and OS HR(HROS)at trial level(r=0.639-0.876),and between PFS and OS rates at treatment-arm level,regardless of CT regimens(r=0.882-0.964).Incorporating RT into CT increased about 18%of PFS,and revealed a different OS benefit *** were stratified into four CT-generated PFS patterns(>80%,>60-80%,>40-60%,and≤40%),which was consistent with risk-stratified subgroups(kappa>0.6).Absolute gain in OS from RT ranged from≤5%at PFS>80%to about 21%at PFS≤40%,with pooled HROS from 0.70(95%CI,0.51-0.97)to 0.48(95%CI,0.36-0.63)after rituximab-based *** OS benefit of RT was predominant in intermediate-and high-risk patients with PFS≤80%.Conclusion:We demonstrated a varied OS benefit profile of RT to inform treatment decisions and clinical trial design.

关键词： Diffuse large B-cell lymphoma Chemotherapy Radiotherapy Risk-benefit

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Adaptive ultra-hypofractionated whole-pelvic radiotherapy in high-risk and very high-risk prostate cancer on 1.5-Tesla MR-Linac:Estimated delivered dose and early toxicity results

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Chronic Diseases and Translational Medicine 2024年第1期10卷 51-61页

作者： Linrui Gao Ran Wei Shirui Qin Yuan Tian Wenlong Xia yongwen song Shulian Wang Hui Fang Yu Tang Hao Jing Yueping Liu Yuan Tang Shunan Qi Bo Chen Yexiong Li Nianzeng Xing Ningning Lu Department of Radiation Oncology National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina GCP Center/Clinical Research Center National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina Department of Urology State Key Laboratory of Molecular OncologyNational Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina

Background: Magnetic resonance(MR)-guided ultra-hypofractionated radiotherapy with whole-pelvic irradiation(UHF-WPRT)is a novel approach to radiotherapy for patients with high-risk(HR)and very high-risk(VHR)prostate cancer(PCa).However,the inherent complexity of adaptive UHF-WPRT might inevitably result in longer on-couch *** aimed to estimate the delivered dose,study the feasibility and safety of adaptive UHF-WPRT on a 1.5-Tesla ***: Ten patients with clinical stage T3a-4N0-1M0-1c PCa,who consecutively received UHF-WPRT,were enrolled *** contours of the target and organ-at-risks on the position verification-MR(PV-MR),beam-on 3D-MR(Bn-MR),and post-MR(after radiotherapy delivery)were derived from the pre-MR data by deformable image *** physician then manually adjusted them,and dose recalculation was performed *** Prism 9(GraphPad Prism Software Inc.)was utilized for conducting statistical ***: In total,we collected 188 MR scans(50 pre-MR,50 PV-MR,44 Bn-MR,and 44 post-MR scans).With median 59 min,the mean prostate clinical target volume(CTV)-V_(100%)was 98.59%±2.74%,and the mean pelvic CTVp-V_(100%)relative percentages of all scans was 99.60%±1.18%.The median V29 Gy change in the rectal wall was−2%(−18%to 20%).With a median follow-up of 9 months,no patient had acute Common Terminology Criteria for Adverse Events(CTCAE)grade 2 or more severe genitourinary(GU)or gastrointestinal(GI)toxicities(0%).Conclusion: UHF-RT to the prostate and the whole pelvis with concomitant boost to positive nodes using an Adapt-To-Shape(ATS)workflow was technically feasible for patients with HR and VHR PCa,presenting only mild GU and GI *** estimated target dose during the beam-on phase was clinically acceptable based on the 3D-MR-based dosimetry *** trial registration Chinese Clinical Trial Registry ChiCTR2000033382.

关键词： dosimetry hypofractionation magnetic resonance imaging prostate cancer radiation dose radiotherapy

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23例原发气管癌的放射治疗

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中华放射肿瘤学杂志 1999年第3期8卷 152-154页

作者：肖泽芬宋永文苗延俊李伟雄冯宁远殷蔚伯中国医学科学院中国协和医科大学肿瘤医院放射治疗科北京100021

目的　评价原发气管癌放射治疗的意义及加腔内放射治疗后能否提高肿瘤局部控制率。方法　原发气管癌２３例，其中单纯放射治疗１３例，术后复发或残留行放射治疗１０例。结果　（１）全组１，５，１０年生存率分别为６５．２％... 详细信息

目的　评价原发气管癌放射治疗的意义及加腔内放射治疗后能否提高肿瘤局部控制率。方法　原发气管癌２３例，其中单纯放射治疗１３例，术后复发或残留行放射治疗１０例。结果　（１）全组１，５，１０年生存率分别为６５．２％，２６．１％，５．９％，中位生存时间为２５个月。术后复发或肿瘤残留再放射治疗与单纯放射治疗的中位生存时间分别为５２个月与２３个月。根治放射治疗组与姑息放射治疗组的１，３，５年生存率分别为７６．９％，４６．２％，４６．２％与３０．０％，２０．０％，１０．０％。肿瘤局部控制率为３０．４％（７／２３），其中单纯外照射１例，加腔内放射治疗４例，术后＋放射治疗２例。（２）病理类型对生存率无明显影响。（３）第１程放射治疗后局部未控复发再放射治疗７例，未治７例，其１，３，５年生存情况前者分别为６／７，３／７，１／７，后者１年为２／７，无２年以上生存者。结论　（１）对不能手术、术后复发或肿瘤残留的患者，放射治疗是主要的、有效的治疗手段之一。（２）加用腔内放射治疗可提高肿瘤局部控制率。（３）复发后再程放射治疗仍可缓解症状延长部分患者寿命。

关键词：气管肿瘤放射疗法腔内放射疗法

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2001-2013年中国煤矿瓦斯事故分析

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煤矿安全 2015年第6期46卷 231-234页

作者：冯阳施龙青牛超许磊潘超宋永文山东科技大学山东省沉积成矿作用与沉积矿产重点实验室山东青岛266590 山东科技大学地球科学与工程学院山东青岛266590 新汶矿业集团福城煤矿内蒙古鄂尔多斯017000 山东新巨龙能源有限责任公司山东菏泽274918 枣庄矿业集团蒋庄煤矿山东枣庄277500

利用国家煤矿安全监察局煤矿事故查询系统公布的数据,对2001-2013年我国发生的矿井瓦斯事故进行统计,通过分析瓦斯事故类型、发生区域、发生时间等信息与煤矿瓦斯事故之间的相关性,总结我国煤矿瓦斯事故的频发规律;分析我国煤矿法律法... 详细信息

利用国家煤矿安全监察局煤矿事故查询系统公布的数据,对2001-2013年我国发生的矿井瓦斯事故进行统计,通过分析瓦斯事故类型、发生区域、发生时间等信息与煤矿瓦斯事故之间的相关性,总结我国煤矿瓦斯事故的频发规律;分析我国煤矿法律法规、小煤矿政策对煤矿瓦斯事故的影响。分析表明,瓦斯事故是我国煤矿第1大事故,其中瓦斯爆炸事故危害性最大,乡镇小煤矿是我国瓦斯事故的重灾区。

关键词：煤矿生产瓦斯事故统计分析频发规律煤矿安全

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