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Mitochondrial dysfunction:mechanisms and advances in therapy

Signal Transduction and Targeted Therapy 2024年第6期9卷 2362-2390页

作者： Yao Zong Hao Li Peng Liao Long Chen Yao Pan yongqiang zheng Changqing Zhang Delin Liu Minghao zheng Junjie Gao Centre for Orthopaedic Research Medical SchoolThe University of Western AustraliaNedlandsWA 6009Australia Department of Orthopaedics Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai 200233China Institute of Microsurgery on Extremities and Department of Orthopedic SurgeryShanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai 200233China State Key Laboratory of Cell Biology Shanghai Institute of Biochemistry and Cell BiologyCAS Center for Excellence in Molecular Cell ScienceChinese Academy of SciencesUniversity of Chinese Academy of SciencesShanghai 200031China Sixth People’s Hospital Fujian No.16Luoshan SectionJinguang RoadLuoshan StreetJinjiang CityQuanzhouFujianChina

Mitochondria,with their intricate networks of functions and information processing,are pivotal in both health regulation and disease ***,mitochondrial dysfunctions are identified in many common pathologies,including cardiovascular diseases,neurodegeneration,metabolic syndrome,and ***,the multifaceted nature and elusive phenotypic threshold of mitochondrial dysfunction complicate our understanding of their contributions to ***,these complexities do not prevent mitochondria from being among the most important therapeutic *** recent years,strategies targeting mitochondrial dysfunction have continuously emerged and transitioned to clinical *** intervention such as using healthy mitochondria to replenish or replace damaged mitochondria,has shown promise in preclinical trials of various *** components,including mtDNA,mitochondria-located microRNA,and associated proteins can be potential therapeutic agents to augment mitochondrial function in immunometabolic diseases and tissue ***,we review current knowledge of mitochondrial pathophysiology in concrete examples of common *** also summarize current strategies to treat mitochondrial dysfunction from the perspective of dietary supplements and targeted therapies,as well as the clinical translational situation of related pharmacology ***,this review discusses the innovations and potential applications of mitochondrial transplantation as an advanced and promising treatment.

关键词： dysfunction injuries replace

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Prediction of nitrogen and phosphorus contents in citrus leaves based on hyperspectral imaging

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International Journal of Agricultural and Biological Engineering 2015年第2期8卷 80-88页

作者： Liu Yanli Lyu Qiang He Shaolan Yi Shilai Liu Xuefeng Xie Rangjin zheng yongqiang Deng Lie College of Horticulture and Landscape Southwest UniversityBeibeiChongqing 400715China Citrus Research Institute Southwest University-Chinese Academy of Agricultural SciencesBeibeiChongqing 400712China

The nutritional status of citrus leaves is very important to the determining of fertilization *** spectrum technique is a quick,un-injured method and is becoming widely used for plant nutrient *** possibility and method of using spectrum technique to estimate the nutrient of citrus leaf was explored in this study.A total amount of 135 leaves from the mature spring shoots of navel orange trees(*** Osbeck,“Newhall”)were collected and randomly grouped into two sets of samples:100 leaves for the calibration set and 35 leaves for the prediction *** hyperspectral images were scanned upper and lower side of each leaf and then the total nitrogen(N)and phosphorus(P)contents of each leaf were *** raw spectra data were extracted to generate average spectra curves,preprocessed with five different methods,and was used to build N and P content prediction *** performances of the five preprocessing methods,i.e.,Savitzky-Golay smoothing(SGS),standard normal variate(SNV),multiplicative scatter correction(MSC),first-derivative(1-Der)and second-derivative(2-Der),were tested with linear partial least squares(PLS)models and nonlinear least squares-support vector machine(LS-SVM)*** results showed that the SG-PLS and PLS were the best for the N predicting(Rp=0.9049,RMSEP=0.1041)and P(Rp=0.9235,RMSEP=0.0514)in citrus leaves,respectively;the hyperspectral image data from leaf‟s upper side predicting better for the contents of N and *** study suggested that the hyperspectral image data from the upper side of the citrus leaves are suitable for nondestructive estimation of nutrient content.

关键词： citrus leaves nitrogen phosphorus prediction hyperspectral imaging

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Rapid detection of chlorophyll content and distribution in citrus orchards based on low-altitude remote sensing and bio-sensors

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International Journal of Agricultural and Biological Engineering 2018年第2期11卷 164-169页

作者： Kejian Wang Wentao Li Lie Deng Qiang Lyu yongqiang zheng Shilai Yi Rangjin Xie Yanyan Ma Shaolan He Citrus Research Institute of Chinese Academy of Agricultural Sciences Southwest UniversityBeibeiChongqing 400712China

The accuracy of detecting the chlorophyll content in the canopy and leaves of citrus plants based on sensors with different scales and prediction models was investigated for the establishment of an easy and highly-efficient real-time nutrition diagnosis technology in citrus *** fluorescent values of leaves and canopy based on the Multiplex 3.6 sensor,canopy hyperspectral reflectance data based on the FieldSpec4 radiometer and spectral reflectance based on low-altitude multispectral remote sensing were collected from leaves of Shatang mandarin and then ***,the associations of the leaf SPAD(soil and plant analyzer development)value with the ratio vegetation index(RVI)and normalized differential vegetation index(NDVI)were *** leaf SPAD value predictive model was established by means of univariate and multiple linear regressions and the partial least squares *** distribution maps of the relative canopy chlorophyll content based on spectral reflectance in the orchard were automatically *** results showed that the correlations of the SPAD values obtained from the Multiplex 3.6 sensor,FieldSpec4 radiometer and low-altitude multispectral remote sensing were highly *** measures of goodness of fit of the predictive models were R^(2)=0.7063,RMSECV=3.7892,RE=5.96%,and RMSEP=3.7760 based on RVI_((570/800)) and R^(2)=0.7343,RMSECV=3.6535,RE=5.49%,and RMSEP=3.3578 based on NDVI[(570,800)(570,950)(700,840)].The technique to create spatial distribution maps of the relative canopy chlorophyll content in the orchard was established based on sensor information that directly reflected the chlorophyll content of the plants in different parts of the orchard,which in turn provides evidence for implementation of orchard productivity evaluation and precision in fertilization management.

关键词： citrus remote sensing bio-sensor chlorophyll detection spectrum ratio vegetation index(RVI) normalized differential vegetation index(NDVI) spatial distribution map

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Estimation of carbon and nitrogen contents in citrus canopy by low-altitude remote sensing

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International Journal of Agricultural and Biological Engineering 2016年第5期9卷 149-157页

作者： Liu Xuefeng Lyu Qiang He Shaolan Yi Shilai Hu Deyu Wang Zhitao Xie Rangjin zheng yongqiang Deng Lie Citrus Research Institute Southwest University-Chinese Academy of Agricultural SciencesChongqing 400712China Institute of Optics-Mechanics-Electronics Technology and Application East China Jiaotong UniversityNanchang 330013China College of Horticulture and Landscape Southwest UniversityChongqing 400715China

The study aimed to investigate the fast and nondestructive method for detecting carbon and nitrogen content in citrus *** multispectral imagery of Tarocco blood orange(Citrus sinensis ***)plant canopy was obtained by a multispectral camera array mounted at an eight-rotor unmanned aerial vehicle(UAV)flying at an altitude of 100 m above the canopy in Wanzhou District of Chongqing Municipality,*** spectral reflectance data of the whole canopy,mature leaf areas and young leaves areas were extracted from the *** spectral pre-processing methods,multiplicative scatter correction(MSC)and standard normal variable(SNV),and two modeling methods,the partial least squares(PLS)and the least squares support vector machine(LS-SVM),were adopted and compared for their prediction accuracy of total content of nitrogen,soluble sugar and starch in the *** results showed that,based on the spectral data extracted from the mature leaves in the multispectral imagery,the PLS model based on the original spectrum obtained a Rp(correlation coefficient)of 0.6469 and RMSEP(root mean squares error of prediction)of 0.1296,suggested that it was the best for the prediction of total nitrogen content;the PLS model based on MSC(multiplicative scatter correction)spectrum pre-processing was the best for predicting total soluble sugar content(Rp=0.6398 and RMSEP=8.8891);and the LS-SVM model based on MSC was the best for the starch content prediction(Rp=0.6822 and RMSEP=14.9303).The prediction accuracy for carbon and nitrogen contents based on the spectral data extracted from the whole canopy and the young leaves were lower than that from the mature *** results indicate that it is feasible to estimate the carbon and nitrogen contents by low-altitude airborne multispectral images.

关键词： citrus canopy low-altitude remote sensing carbon and nitrogen contents soluble sugar starch estimation

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Detection of Huanglongbing(citrus greening) based on hyperspectral image analysis and PCR

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Frontiers of Agricultural Science and Engineering 2019年第2期6卷 172-180页

作者： Kejian WANG Dongmei GUO Yao ZHANG Lie DENG Rangjin XIE Qiang LV Shilai YI yongqiang zheng Yanyan MA Shaolan HE Southwest University/Citrus Research Institute of Chinese Academy of Agricultural Sciences Chongqing 400712 China National Agricultural Technology Extension and Service Center Beijing 100125 China Chengdu Plant Quarantine Station Chengdu 610000 China Key Laboratory of Modern Precision Agriculture System Integration Research China Agricultural University Beijing 100083 China

Huanglongbing (HLB, citrus greening) is one of the most serious quarantine diseases of citrus worldwide. To monitor in real-time, recognize diseased trees, and efficiently prevent and control HLB disease in citrus, it is necessary to develop a rapid diagnostic method to detect HLB infected plants without symptoms. This study used Newhall navel orange plants as the research subject, and collected normal color leaf samples and chlorotic leaf samples from a healthy orchard and an HLB-infected orchard, respectively. First, hyperspectral data of the upper and lower leaf surfaces were obtained, and then the polymerase chain reaction (PCR) was used to detect the HLB bacterium in each leaf. The PCR test results showed that all samples from the healthy orchard were negative, and a portion of the samples from the infected orchard were positive. According to these results, the leaf samples from the orchards were divided into disease-free leaves and HLB-positive leaves, and the least squares support vector machine recognition model was established based on the leaf hyperspectral reflectance. The effect on the model of the spectra obtained from the upper and lower leaf surfaces was investigated and different pretreatment methods were compared and analyzed. It was observed that the HLB recognition rate values of the calibration and validation sets based on upper leaf surface spectra under 9-point smoothing pretreatment were 100% and 92.5%, respectively. The recognition rate values based on lower leaf surface spectra under the second-order derivative pretreatment were also 100% and 92.5%, respectively. Both upper and lower leaf surface spectra were available for recognition of HLB-infected leaves, and the HLB PCR-positive leaves could be distinguished from the healthy by the hyperspectral modeling analysis. The results of this study show that early and nondestructive detection of HLBinfected leaves without symptoms is possible, which provides a basis for the hyperspectral diagnosi

关键词： citrus HLB hyperspectral identification PCR

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Prevalence and outcomes of focal ablation versus prostatectomy for elderly patients with prostate cancer:a population-based study

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Journal of the National Cancer Center 2022年第1期2卷 25-32页

作者： yongqiang zheng Yuzhong Ye Lezong Chen Zikun Ma Lei Liu Gong Cheng Wen Xiao Yuenan Liu Jingchong Liu Qi Miao Zhihao Wei Hailong Ruan Xiaoping Zhang State Key Laboratory of Oncology in South China Sun Yat-sen University Cancer CenterSun Yat-sen UniversityGuangzhou 510060China Department of Urology Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China

Background:Despite rapid advances in the treatment of prostate cancer(PCa),the optimal treatment for elderly patients with PCa remains unclear due to a lack of high-quality *** study aimed to evaluate whether surgical procedures are beneficial for PCa patients aged 75 years and older and compare the effects of focal ablation and ***:Male patients aged 75 years and older who were diagnosed with Tis-T2/N0/M0 PCa between 2000 and 2017 were retrospectively identified from the Surveillance,Epidemiology,and End Results program *** regression models were used to test for statistical differences between the overall survival(OS)and disease-specific survival(DSS).Results:A total of 114,506 patients aged 75 years and older with PCa were included in this study,among which 60,131 died during the study *** most prevalent surgical procedure for these patients was focal *** local excision rate increased with advancing age,while the prostatectomy rate decreased sharply with *** proportion of the elderly patients who underwent a focal ablation also increased with the age at *** survival rate of patients aged 75 years and older who underwent a focal ablation was significantly worse than that for those who did not undergo any surgical procedures(OS:HR,1.32,P<0.001;DSS:HR,1.58,P<0.001).Although only a few of the patients underwent prostatectomy,the procedure was still related to improved OS and DSS(OS:HR,0.60,P<0.001;DSS:HR,0.37,P<0.001)***:Focal ablation has gradually replaced prostatectomy as the most common surgical procedure for elderly patients with PCa in the United ***,our results revealed that the procedure might not provide benefits for elderly patients with PCa;instead,we found that focal ablation resulted in increased negative effects on patient *** patients should have the same opportunity to be treated with standard surgical interventions as younger patients.

关键词： Prostate cancer Focal ablation Prostatectomy

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桥式起重机主梁结构的可靠性拓扑优化

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现代制造工程 2023年第2期 122-127,147页

作者：郑勇强程文明西南交通大学机械工程学院成都610031 轨道交通运维技术与装备四川省重点实验室成都610031

为了在降低设计难度和提高设计效率前提下实现起重机主梁结构的可靠性优化设计,首先基于变密度方法和概率方法分别构建以起重机主梁结构体积最小作为目标函数的确定性拓扑优化模型和可靠性拓扑优化模型;其次,将可靠性拓扑优化模型中的... 详细信息

为了在降低设计难度和提高设计效率前提下实现起重机主梁结构的可靠性优化设计,首先基于变密度方法和概率方法分别构建以起重机主梁结构体积最小作为目标函数的确定性拓扑优化模型和可靠性拓扑优化模型;其次,将可靠性拓扑优化模型中的优化问题经混合法解耦处理后,分解为可靠性分析和当量确定性拓扑优化2个独立子问题;再次,在优化设计过程中使用灰色关联系数法分配各工况的权重系数;最后,再对经过可靠性拓扑优化设计后所得的新型主梁结构进行二次设计。结果表明,同确定性拓扑优化比较,可靠性拓扑优化的迭代次数较少,计算速度较快;经二次设计后,起重机主梁结构的刚度、强度与固有频率均得到了提高;设计结果可为起重机金属结构优化设计提供新思路。

关键词：起重机可靠性拓扑优化密度法灰色关联系数法

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风光-储电-抽水蓄能系统多目标优化设计

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化学工程 2023年第10期51卷 24-29,35页

作者：李征李剑峰王文宾郑永强范曾国网邢台供电公司河北邢台0540011

大规模、高比例的可再生能源和储能的结合是实现碳中和的有效途径,因此,可再生能源和储能的合理配置显得尤为重要。首先,提出包含风光-储电-抽水蓄能的混合能源系统,建模时考虑了设备实际运行的约束。其次,构建多目标优化模型,采用NSGA... 详细信息

大规模、高比例的可再生能源和储能的结合是实现碳中和的有效途径,因此,可再生能源和储能的合理配置显得尤为重要。首先,提出包含风光-储电-抽水蓄能的混合能源系统,建模时考虑了设备实际运行的约束。其次,构建多目标优化模型,采用NSGA-Ⅱ算法和TOPSIS方法求解,旨在提高系统的环保性、经济性、稳定性。最后,对此系统和光-储电-抽水蓄能、风-储电-抽水蓄能、风光-抽水蓄能、风光-储电4个系统展开了关于性能、配置和运行特性的对比。结果表明:风光-储电-抽水蓄能系统促进了可再生能源的消纳,减少了单类型储能的配置需求,碳排放、年值成本、电网交互相对于其他4个系统分别最多减少了55.7%,6.3%,50.0%,并且负荷损失概率最低,为28.7%。

关键词：可再生能源抽水蓄能多目标优化碳排放

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基于提高冷却温度的机车柴油机部件可靠性研究

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铁道机车车辆 2020年第4期40卷 80-84页

作者：郑永强薛良君张强中车戚墅堰机车有限公司产品设计部江苏常州213011

基于提高柴油机高温冷却水、机油出口温度,可降低内燃机车冷却单节的体积及质量,利于机车的总体设计,对燃油经济性及热效率有一定改善。通过热平衡试验研究确定了冷却温度提高的范围,采用有限元法分析了气缸盖温度场分布及热应力水平;... 详细信息

基于提高柴油机高温冷却水、机油出口温度,可降低内燃机车冷却单节的体积及质量,利于机车的总体设计,对燃油经济性及热效率有一定改善。通过热平衡试验研究确定了冷却温度提高的范围,采用有限元法分析了气缸盖温度场分布及热应力水平;进行了滑动轴承NHD分析,明确了该型柴油机滑动轴承的使用温度范围;测试并对比了活塞温度场在温升前、后的变化,确保了承受热负荷部件的使用可靠性,为干线机车用柴油机的设计提供数据支撑。

关键词：内燃机车柴油机温度场热应力 NHD分析

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针灸配合中药治疗坐骨神经痛120例

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现代医院 2006年第6期6卷 93-94页

作者：郑永强潮州市潮州医院广东潮州521021

目的探讨针灸配合中药治疗坐骨神经痛的疗效。方法对120例坐骨神经痛患者随机分成2组,治疗组采用针灸配合中药;对照组用消炎痛口服进行治疗。结果治疗效果治疗组明显优于对照组,差异有显著性;治疗组对原发性坐骨神经痛和继发性坐骨神经... 详细信息

目的探讨针灸配合中药治疗坐骨神经痛的疗效。方法对120例坐骨神经痛患者随机分成2组,治疗组采用针灸配合中药;对照组用消炎痛口服进行治疗。结果治疗效果治疗组明显优于对照组,差异有显著性;治疗组对原发性坐骨神经痛和继发性坐骨神经痛无显著性差异。结论针灸配合中药治疗坐骨神经痛效果良好,值得推广。

关键词：针灸中药坐骨神经痛

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