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Journal of Geriatric Cardiology 2024年第6期21卷 589-630页

作者： Hypertension Branch of Chinese Geriatrics Society,beijing Hypertension Association,National Clinical Research Center of the Geriatric Diseases qi HUA Li FAN Zeng-Wu WANG Jing LI 不详 Xuanwu Hospital Capital Medical UniversityBeijingChina Chinese PLA General Hospital BeijingChina Fuwai Hospital Chinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina

Preamble Hypertension is one of the most common chronic diseases and the primary risk factor for stroke,myocardial infarction and even cardiovascular *** than half of the elderly population has high blood *** people are a unique group,and strategies for the prevention,diagnosis,evaluation,and treatment of hypertension in elderly individuals differ significantly from those in the general population.

关键词： hypertension prevention diagnosis

Problems in wavelet analysis of hydrologic series and some suggestions on improvement

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Progress in Natural Science:Materials International 2007年第1期17卷 80-86页

作者： WANG Hongrui, YE Letian, LIU Changming, YANG Chi and LIU Peng ( college of water sciences, beijing normal university, beijing 100875, China Key Laboratory for water and Sediment sciences, Ministry of Education, beijing 100875, China School of Mathematical sciences, Peking university, beijing 100089, China college of Engineering sciences, university of Region, Canada) [a]college of water sciences Beijing Normal University Beijing China [b]Key Laboratory for water and Sediment sciences Ministry of Education Beijing China [c]School of Mathematical sciences Peking University Beijing China [d]college of Engineering sciences University of Region Canada

Applying the wavelet theory and methods to investigate the hydrologic processes such as precipitation and runoff is a hot field. However, several aspects in research are usually ignored: the effect of admissible condition of wavelet functions and the disturbance of noises for the detection of periods, the effect of the length of a hydrologic time-series on the final result, and the choice between the anomaly and the original time series for wavelet analysis. In this paper, these issues are fully discussed. Precipitation data from Lanzhou Precipitation Station are taken for case study. The result indicates that in the wavelet analysis of hydrologic series, denoise methods should be used to eliminate the influence of noises. The MexHat wavelet function satisfies the admissible condition, which ensures that the periodic properties of hydrologic processes can be well represented by using the MexHat wavelet for decomposition. The affected range of hydro-logic series which should be discarded before analysis is given. It is also suggested that the anomaly series should be used to highlight the actual undulation of the hydrologic series.

关键词： wavelet analysis hydrologic process admissible condition noise period.

Development and application of ergodicity model with FRCM and FLAR for hydrological process

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Science China(Technological sciences) 2009年第2期52卷 379-386页

作者： WANG HongRui1, FENG qiLei2, LIN Xin3 & ZENG WenYi4 1 college of water Science, Key Laboratory for water and Sediment sciences of the Ministry of Education, beijing normal university, beijing 100875, China 2 School of Science, beijing Institute of Education, beijing 100011, China 3 School of Mathematical sciences, beijing normal university, beijing 100875, China 4 college of Information Science and Technology, beijing normal university, beijing 100875, China 1. college of water Science Key Laboratory for Water and Sediment Sciences of the Ministry of Education Beijing Normal University Beijing 100875 China 2. School of Science Beijing Institute of Education Beijing 100011 China 3. School of Mathematical sciences Beijing Normal University Beijing 100875 China 4. college of Information Science and Technology Beijing Normal University Beijing 100875 China

In this paper, a new ergodic property analysis model of hydrological process is proposed based on fuzzy-rough c-means clustering (FRCM), autocorrelogram, and fuzzy least absolute regression (FLAR). A precipitation time series (1951―2004) from Shanghai Hydrology Station is then analyzed with the model. The results show that the precipitation time series of April, May, June, and September has er-godic property. We conclude that in the long run, the precipitation of April, May, June, and September will not keep decreasing; it will converge to its mean value in some period.

关键词： hydrological process ergodic autocorrelogram fuzzy-rough c-means clustering fuzzy least absolute regression

An ecological hydraulic radius approach to estimate the instream ecological water requirement

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Progress in Natural Science:Materials International 2007年第3期17卷 320-327页

作者： LIU Changming and MEN Baohui ( Key Laboratory of water Cycle and Related Land Surface Process, Institute of Geographical sciences and Natural Resources Research, Chinese Academy of sciences, beijing 100101, China Key Laboratory of water and Sediment sciences, Ministry of Education & water sciences college, beijing normal university, beijing 100875, China Department of Hydraulic and Hydropower Engineering, North China Electric Power university, beijing 102206, China) [a]Key Laboratory of water Cycle and Related Land Surface Process Institute of Geographical Sciences and Natural Resources Research Chinese Academy of Sciences Beijing China [b]Key Laboratory of water and Sediment sciences Ministry of Education & Water Sciences Gllege Beijing Noirnal University Beijing China [c]Departhent of Hydraulic and Hydropower Engineering North China Elecfric Power University Beijing China

This essay defines the concepts of ecological flow velocity as well as ecological hydraulic radius (EHR) and proposes an ecological hydraulic radius approach (EHRA) which considers both the watercourse information (including hydraulic radius, roughness coefficient and hydraulic gradient) and the required stream velocity necessary for maintenance of certain ecological functions all together. The key parameter of EHRA is to fix the watercourse cross-sectional flow area corresponding to EHR, by which the relation between parabola shaped cross-sectional flow area and hydraulic radius is deduced. The EHRA not only meets the requirement of flow velocity for adequate fish spawning migration, but also is applicable to the ecological flows in regard with other ecological issues (such as the calculation of the instream flow requirements for transporting sediment and for pollution self-purification, etc.). This essay has illuminated the computational process taking the estimation of ecological water requirement of Zhuba Hydrologyical Station watercourse in Niqu branch of the Yalong River as an example. Additionally, we compare EHRA with Tennant approach. The result shows that the Zhuba Hydrological Station ecological water requirement calculated by EHRA lies between the minimum and favorable ecological water requirement calculated by the Tennant approach. This is due to the fact that the ecological flow velocity (such as the fish spawning migration flow velocity) was taken into consideration, producing results applicable to the practical situation.

关键词： ecological flow flow velocity cross-sectional flow area ecological hydraulic radius (HER) instreamecological water requirement.

Cu(Ⅱ) Potentiation of Alzheimer Aβ1-40 Cytotoxicity and Transition on its Secondary Structure

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Acta Biochimica et Biophysica Sinica 2006年第11期38卷 765-772页

作者： Xue-Ling DAI~1 Ya-Xuan SUN~2 Zhao-Feng JIANG~2* 1 college of Life Science,Capital normal university,beijing 100037,China 2 college of Applied sciences and Humanities,beijing Union university,beijing 100083,China college of Life Science Capital Normal UniversityBeijing 100037 China college of Applied sciences and Humanities Beijing Union UniversityBeijing 100083 China

Mounting evidence has shown that dyshomeostasis of the redox-active biometals such as Cuand Fe can lead to oxidative stress,which plays a key role in the neuropathology of Alzheimer's disease（AD）.Here we demonstrate that with the formation of Cu（Ⅱ）·Aβ1-40 complexes,copper markedly potentiatesthe neurotoxicity exhibited by β-amyloid peptide （Aβ）.A greater amount of hydrogen peroxide was releasedwhen Cu（Ⅱ）·Aβ1-40 complexes was added to the xanthine oxidase/xanthine system detected by potassiumiodide *** bound to Aβ1-40 was observed by electron paramagnetic resonance（EPR） *** dichroism （CD） studies indicated that copper chelation could cause a structuraltransition of Aβ.The addition of copper to Aβ introduced an increase on β-sheet as well as α-helix,whichmay be responsible for the aggregation of Aβ.We hypothesized that Aβ aggregation induced by copper maybe responsible for local injury in *** interaction between Cu2+and Aβ also provides a possible mechanismfor the enrichment of metal ions in amyloid plaques in the AD brain.

关键词： Alzheimer’s disease Cu(Ⅱ)·Aβ1-40 complex neuron injury Aβ secondary structure

Plausible impact of global climate change on water resources in the Tarim River Basin

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Science China Earth sciences 2005年第1期48卷 65-73页

作者： CHEN Yaning & XU Zongxue Xinjiang Institute of Ecology & Geography, Chinese Academy of sciences, Urumqi 830011, China college of Environmental sciences, beijing normal university, beijing 100875, China 1. Xinjiang Institute of Ecology & Geography Chinese Academy of Sciences 830011 Urumqi China 2. college of Environmental sciences Beijing Normal University 100875 Beijing China

Combining the temperature and precipitation data from 77 climatological stations and the climatic and hydrological change data from three headstreams of the Tarim River: Hotan, Yarkant, and Aksu in the study area, the plausible association between climate change and the variability of water resources in the Tarim River Basin in recent years was investigated, the long-term trend of the hydrological time series including temperature, precipitation, and streamflow was detected, and the possible association between the El Ni(n)o/Southern Oscillation (ENSO) and these three kinds of time series was tested. The results obtained in this study show that during the past years, the temperature experienced a significant monotonic increase at the speed of 5%, nearly 1℃ rise; the precipitation showed a significant decrease in the 1970s, and a significant increase in the1980s and 1990s, the average annual precipitation was increased with the magnitude of 6.8 mm per decade. A step change occurred in both temperature and precipitation time series around 1986, which may be influenced by the global climate change. Climate change resulted in the increase of the streamflow at the headwater of the Tarim River, but the anthropogenic activities such as over-depletion of the surface water resulted in the decrease of the streamflow at the lower reaches of the Tarim River. The study result also showed that there is no significant association between the ENSO and the temperature, precipitation and streamflow.

关键词： climate change, hydrological change, temperature, precipitation, streamflow, Tarim River.

Effects of chronic exposure to nonylphenol on locomotor activity and social behavior in zebrafish(Danio rerio)

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Journal of Environmental sciences 2010年第9期22卷 1435-1440页

作者： Jigang Xia,Cuijuan Niu ,Xuejiao Pei Ministry of Education Key Laboratory of Biodiversity Science and Ecological Engineering,college of Life sciences,beijing normal university,100875 beijing,China. [a] Ministry of Education Key Laboratory of Biodiversity Science Ecological Engineering College of Life Sciences Beijing Normal University 100875 Beijing China

Nonylphenol （NP）, a xenoestrogen ubiquitously found in aquatic ecosystems, is of high environmental concern. The present work assessed the effects of exposure to NP on locomotor activity and social behavior in male and female zebrafish （Danio rerio）, to evaluate the possible hazard of NP to fish behavior and to pursue a potential biomarker of NP contamination. Fish were randomly divided into six groups. Five groups were receiving 0.1, 1, 10, 50 and 100 μg/L nominal concentrations of NP for 60 days, respectively. A sixth control group was given the same treatment as the other five groups, but no NP. Locomotor activity, aggressive behavior, group preference and leaving shoal were examined. NP exposure showed marked influence on locomotor activity of the male zebrafish, whereas that of the female was not significantly affected by NP. Aggressive behavior and group preference were significantly affected by NP exposure in both male and female groups. Locomotor activity and aggressive behavior of the male and group preference of both male and female zebrafish were clearly inhibited at 100 μg/L NP. No significant alteration in leaving shoal was observed under NP exposure. The results suggested that changes in locomotor activity and aggressive behavior of the male and group preference of both male and female may be used as an ecologically relevant integrative biomarker of NP contamination.

关键词： chronic toxicity nonylphenol biomarker zebrafish

MAPK signal pathways in the regulation of cell proliferation in mammalian cells

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Cell Research 2002年第1期12卷 9-18页

作者： WEI ZHANG, Hui Tu LIU The Key Laboratory of Cell Proliferation and Regulation Biology of Ministry of Education, college of Life sciences, beijing normal university, beijing 100875, China 1The Key Laboratory of Cell Proliferation and Regulation Biology of Ministry of Education College of Life Sciences Beijing Normal University Beijing 100875 China 1The Key Laboratory of Cell Proliferation and Regulation Biology of Ministry of Education College of Life Sciences Beijing Normal University Beijing 100875 China

MAPK families play an important role in complex cellular programs like proliferation, differentiation, development, transformation, and apoptosis. At least three MAPI(families have been characterized: extracellular signal-regulated kinase (ERK), Jun kinase (JNK/SAPK) and p38 MAPK. The above effects are fulfilled by regulation of cell cycle engine and other cell proliferation related proteins. In this paper we discussed their functions and cooperation with other signal pathways in regulation of cell proliferation.

关键词： MAPK ER.K JNK/SPAK p38 cell proliferation cross-talk.

Research progress in studies on the coalbed gas geochemistry

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Progress in Natural Science:Materials International 2006年第3期16卷 215-220页

作者： TAO Mingxin (college of Resources sciences & Technology, beijing normal university, beijing 100875, China Key Laboratory of Gas Geochemistry, Institute of Geology and Geophysics, Chinese Academy of sciences, Lanzhou 730000, China) [a]college of Resources sciences & Technology Beijing Normal University Beijing China [b]Key Laboratory of Gas Geochemistry Institute of Geology and Geophysics Lanzhou China

The current situation of geochemical studies on coalbed gas is reviewed in this paper. Generally, coalbed gas is composi-tionally dominated by methane with δ13C1 values ranging approximately from - 80‰ to - 10‰. However, few isotopic studies have been carried out on other components of coalbed gas except for hydrogen and carbon dioxide, whose δDCH4 values available for utilization vary from - 333‰ to - 117‰, and δ13CCO2 values from - 29. 4‰ to + 18. 6‰. Two major types of coalbed gas, thermogenic gas and secondary biogenic gas, have been identified, and there are also some other classification criteria. Compared with conventional natural gases, coalbed gas has a wide distribution range of δ13C1 and δ13CCO2 values, especially possessing some extremely heavy values. Current problems that remain unsolved in the coalbed gas geochemistry include the variation mechanism, controlling factors and application of carbon and hydrogen isotopes of methane, the relation between the values of δ13C1 and Ro, the systematic classification scheme and criterion of genetic types, and the application of the coalbed gas geochemistry in evaluating target districts of the coalbed gas exploration.

关键词： coalbed gas geochemistry isotopic composition genetic type novel resource.