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Distinguished biological adaptation architecture aggravated population differentiation of Tibeto-Burman-speaking people

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Journal of Genetics and Genomics 2024年第5期51卷 517-530页

作者： Yuntao Sun Mengge Wang Qiuxia Sun Yan Liu Shuhan Duan Zhiyong Wang Yunyu Zhou jun Zhong Yuguo huang Xinyu huang Qingxin Yang Xiangping Li Haoran Su Yan Cai Xiucheng Jiang Jing chen Jiangwei Yan Shengjie nie Liping hu junbao Yang Renkuan Tang Chuan-Chao Wang Chao Liu Xiaohui Deng Libing Yun Guanglin He West China School of Basic Science&Forensic Medicine Sichuan UniversityChengduSichuan 610041China Institute of Rare Diseases West China Hospital of Sichuan UniversitySichuan UniversityChengduSichuan 610000China Center for Archaeological Science Sichuan UniversityChengduSichuan 610000China Faculty of Forensic Medicine Zhongshan School of MedicineSun Yat-sen UniversityGuangzhouGuangdong 510275China Guangzhou Forensic Science Institute GuangzhouGuangdong 510055China Department of Forensic Medicine College of Basic MedicineChongqing Medical UniversityChongqing 400331China School of Clinical Medical Sciences North Sichuan Medical CollegeNanchongSichuan 637100China School of Basic Medical Sciences North Sichuan Medical CollegeNanchongSichuan 637100China School of Forensic Medicine Kunming Medical UniversityKunmingYunnan 650500China School of Stomatology North Sichuan Medical CollegeNanchongSichuan 637100China Department of Medical Laboratory North Sichuan Medical CollegeNanchongSichuan 637007China School of Life Sciences Xiamen UniversityXiamenFujian 361005China Anti-Drug Technology Center of Guangdong Province GuangzhouGuangdong 510230China School of Forensic Medicine Shanxi Medical UniversityJinzhongShanxi030600China

Tibeto-Burman(TB)people have endeavored to adapt to the hypoxic,cold,and high-UV high-altitude environments in the Tibetan Plateau and complex disease exposures in lowland rainforests since the late Paleolithic ***,the full landscape of genetic history and biological adaptation of geographically diverse TB-speaking people,as well as their interaction mechanism,remain ***,we generate a whole-genome meta-database of 500 individuals from 39 TB-speaking populations and present a comprehensive landscape of genetic diversity,admixture history,and differentiated adaptative features of geographically different TB-speaking *** identify genetic differentiation related to geography and language among TB-speaking people,consistent with their differentiated admixture process with incoming or indigenous ancestral source populations.A robust genetic connection between the Tibetan-Yi corridor and the ancient Yellow River people supports their Northern China origin *** finally report substructure-related differentiated biological adaptative signatures between highland Tibetans and Loloish *** signatures associated with the physical pigmentation(EDAR and SLC24A5)and metabolism(ALDH9A1)are identified in Loloish people,which differed from the high-altitude adaptative genetic architecture in ***-related genomic resources provide new insights into the genetic basis of biological adaptation and better reference for the anthropologically informed sampling design in biomedical and genomic cohort research.

关键词： Tibeto-Burman people Genetic profile Natural selection Genetic diversity Biological adaptation

Development of a High-throughput Sequencing Platform for Detection of Viral Encephalitis Pathogens Based on Amplicon Sequencing

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Biomedical and Environmental Sciences 2024年第3期37卷 294-302页

作者： ZHANG Ya Li SU Wen Zhe WANG Rui chen LI Yan ZHANG jun Feng LIU Sheng hui hu Dan He XU Chong Xiao YIN Jia Yu YIN Qi Kai HE Ying LI Fan FU Shi Hong nie Kai LIANG Guo Dong TAO Yong XU Song Tao MA Chao Feng WANG huan Yu Shaanxi University of Chinese Medicine Xianyang 712000ShaanxiChina National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases National Institute for Viral Disease Control and PreventionChinese Center for Disease Control and PreventionBeijing 102206China Guangzhou Center for Disease Control and Prevention Guangzhou 510000GuangdongChina Shandong Center for Disease Control and Prevention Jinan 250000ShandongChina Department of Ophthalmology Beijing Chaoyang HospitalCapital Medical UniversityBeijing 100020China Xi'an Center for Disease Control and Prevention Xi’an 710054ShaanxiChina

Objective Viral encephalitis is an infectious disease severely affecting human *** is caused by a wide variety of viral pathogens,including herpes viruses,flaviviruses,enteroviruses,and other *** laboratory diagnosis of viral encephalitis is a worldwide ***,high-throughput sequencing technology has provided new tools for diagnosing central nervous system ***,In this study,we established a multipathogen detection platform for viral encephalitis based on amplicon *** We designed nine pairs of specific polymerase chain reaction(PCR)primers for the 12 viruses by reviewing the relevant *** detection ability of the primers was verified by software simulation and the detection of known positive *** sequencing was used to validate the samples,and consistency was compared with Sanger *** The results showed that the target sequences of various pathogens were obtained at a coverage depth level greater than 20×,and the sequence lengths were consistent with the sizes of the predicted *** sequences were verified using the National Center for Biotechnology Information BLAST,and all results were consistent with the results of Sanger *** Amplicon-based high-throughput sequencing technology is feasible as a supplementary method for the pathogenic detection of viral *** is also a useful tool for the high-volume screening of clinical samples.

关键词： Viral encephalitis Amplicon sequencing High-throughput sequencing Multipathogen detection

Preconditioned Multilevel Fast Inhomogeneous Plane Wave Algorithm for Solving Electromagnetic Scattering Problems

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Preconditioned Multilevel Fast Inhomogeneous Plane Wave Algo...

Quantitative tracing of bioprobes by simultaneously monitoring radiative and nonradiative relaxations

2006 7th International Symposium on Antennas, Propagation and EM Theory

作者： yongpin chen jun hu zaiping nie Min Meng College of Electronic Engineering University of Electronic Science and Technology of China

A mesh-neighbor preconditioner is implemented into the multilevel fast inhomogeneous plane wave algorithm （MLFIPWA）,to solve three dimensional electromagnetic scattering problems more *** spectrum integration of the Green's function and grouping technique are used in FIPWA to translate the direct source and field interaction into aggregation,translation and disaggregation,to accelerate the matrix-vector *** computation complexity of this algorithm is O(N).By applying a multilevel strategy, this complexity can be reduced to O（N log N）.To further speed up the solution process,a mesh-neighbor preconditioner is applied into this fast algorithm. Numerical results show the accuracy and efficiency of this algorithm.

关键词： RCS Preconditioned Multilevel Fast Inhomogeneous Plane Wave Algorithm for Solving Electromagnetic Scattering Problems

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创新光学健康科学杂志(英文) 2023年第4期16卷 40-47页

作者： Hongjiang chen Xiaoyu Tang Guangshuai nie Zhen Wang Jia hu jun hu huan Qin Department of Orthopaedics The First Affiliated Hospital of Shantou University Medical College Shantou 515041Guangdong ProvinceP.R.China MOE Key Laboratory of Laser Life Science&Institute of Laser Life Science College of Biophotonics South China Normal University Guangzhou 510631P.R.China Guangdong Provincial Key Laboratory of Laser Life Science College of Biophotonics South China Normal University Guangzhou 510631P.R.China Guangzhou Key Lab of Spectral Analysis and Functional Probes College of Biophotonics South China Normal University Guangzhou 510631P.R.China

Bioprobe based on fluorescence is widely used in biological and medical research due to its high sensitivity and ***,its quantification in vivo is complicated and often compromised by the interaction between the fluorophore with the environmental factors,as well as the optical scattering and absorption by the tissue.A high florescence quantum yield and minimal interference by the environment are key requirements for designing an effective bioprobe,and the prerequisitions severely limit the available *** propose that a comprehensive evaluation of potential bioprobe can be achieved by simultaneously measuring both radiative and nonradiative transitions,the two fundamental and complementary pathways for the energy *** approach will not only improve the accuracy of the quantification by catching the information from a broader spectrum of the energy,but also provide additional information of the probe environment that often impacts the balance between the two forms of the energy *** work first analyzes the underlying mechanism of the *** practical feasibility is then tested by means of simultaneous measurements of photoacoustic signal for the non-radiative and fluorescence for the radiative energy processes,*** is demonstrated that the systematic evaluation of the probe energy de-excitation results in an improved quantitative tracing of a bioprobe in complex environment.

关键词： Bioprobe fluorescence photoacoustic

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基于积分方程区域分解算法的研究进展

电波科学学报 2020年第2期35卷 169-177页

作者：江明胡俊陈涌频聂在平电子科技大学成都611731

介绍了近年来用于电磁建模的积分方程区域分解算法(domain decomposition method,DDM).DDM是一种基于“分而治之”策略的框架性算法,为复杂电磁问题的求解提供了一种灵活的技术途径.结合国内外研究动态详细介绍了三类积分方程DDM,即重... 详细信息

介绍了近年来用于电磁建模的积分方程区域分解算法(domain decomposition method,DDM).DDM是一种基于“分而治之”策略的框架性算法,为复杂电磁问题的求解提供了一种灵活的技术途径.结合国内外研究动态详细介绍了三类积分方程DDM,即重叠型积分方程DDM,非共形、非重叠型积分方程DDM以及基于等效原理的积分方程DDM,并通过数值算例说明了这些算法的优缺点.最后总结了积分方程DDM的主要挑战以及展望.

关键词：积分方程方法区域分解算法(DDM) 电磁散射快速算法

Two-dimensional tin diselenide nanosheets pretreated with an alkaloid for near-and mid-infrared ultrafast photonics

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Photonics Research 2020年第11期8卷 1687-1696页

作者： Zhenhong Wang Bin Zhang Bing hu Zhongjun Li Chunyang Ma Yu chen Yufeng Song Han Zhang jun Liu Guohui nie Shenzhen Engineering Laboratory of Phosphorene and Optoelectronics Institute of Translational MedicineDepartment of OtolaryngologyShenzhen Second People's HospitalThe First Affiliated Hospital of Shenzhen UniversityHealth Science CenterInternational Collaborative Laboratory of 2D Materials for Optoelectronics Science and Technology of Ministry of EducationCollege of Physics and Optoelectronic EngineeringShenzhen UniversityShenzhen 518060China

Two-dimensional(2D)tin diselenide(SnSe2),a novel layered material with excellent optical and electronic properties,has been extensively investigated in various promising applications,including photodetectors,optical switching,and ultrafast *** this work,SnSe2 nanosheets have been obtained after pretreatment in an alkaloid,exhibiting high optical absorption and electron-enriched ***,the performances of the prepared SnSe2 in near-infrared(NIR)and mid-infrared(MIR)ultrafast photonics are ***,by employing the SnSe2-deposited microfiber device as a saturable absorber(SA)exhibiting typical nonlinear optical absorption properties,stable ultrashort pulses and rogue waves are realized in an erbium-doped fiber ***,the SnSe2-deposited SA device is also applied to a thulium-doped fiber laser to achieve stable ultrashort *** study indicates that SnSe2 is expected to be a suitable candidate for ultrafast fiber lasers in the NIR and MIR regions.

关键词： SnSe2 fiber ultrashort

Exponential distance distribution of connected neurons in simulations of two-dimensional in vitro neural network development

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Frontiers of physics 2017年第3期12卷 133-138页

作者： Zhi-Song Lv chen-Ping Zhu Pei nie Jing Zhao hui-Jie Yang Yan-jun Wang Chin-Kun hu Department of Physics in Science College Nanjing University of Aeronautics and Astronautics Nanjing 210016 Research Center of Complex Systems Science University of Shanghai for Science and Technology Shanghai 200093 Department of Mathematics College-of Logistic-Engineering of PLANanjing 210016 College of Civil Aviation Nanjing University of Aeronautics and Astronautics Nanjing 210016 Institute of Physics Academia Sinica Nankang Taipei 11529 National Center for Theoretical Sciences Tsing Hua University Hsinchu 30013

The distribution of the geometric distances of connected neurons is a practical factor underlying neural networks in the brain. It can affect the brain＇s dynamic properties at the ground level. Karbowski derived a power-law decay distribution that has not yet been verified by experiment. In this work, we check its validity using simulations with a phenomenological model. Based on the in vitro two- dimensional development of neural networks in culture vessels by Ito, we match the synapse number saturation time to obtain suitable parameters for the development process, then determine the distri-bution of distances between connected neurons under such conditions. Our simulations obtain a clear exponential distribution instead of a power-law one, which indicates that Karbowski＇s conclusion is invalid, at least for the case of in vitro neural network development in two-dimensional culture vessels.

关键词： distance distribution connected neurons development exponential power-law neuralnetworks complex systems

三维重建及3D打印技术在精准胸腔镜肺段切除术中的应用

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影像科学与光化学 2024年第3期42卷 239-246页

作者：莫靓韦兵聂军梁任技胡敏杰陈贤俊刘超南华大学附属第一医院胸外科湖南衡阳421001

目的:探讨三维重建及3D打印技术在精准胸腔镜肺段切除术中的应用。方法:选取2020年1月至2022年12月在我院行精准胸腔镜肺段切除术患者105例,用随机数表法分为2组,对照组(53例)和研究组(52例),对照组给予三维重建制定术前计划,研究组给... 详细信息

目的:探讨三维重建及3D打印技术在精准胸腔镜肺段切除术中的应用。方法:选取2020年1月至2022年12月在我院行精准胸腔镜肺段切除术患者105例,用随机数表法分为2组,对照组(53例)和研究组(52例),对照组给予三维重建制定术前计划,研究组给予三维重建及3D打印技术制定术前计划。比较两组围术期相关指标,术前、术后3 d、术后3个月的肺功能指标,临床治疗疗效以及并发症发生情况。结果:研究组术中出血量、住院费用与对照组比较,差异均无统计学意义(P>0.05),研究组手术时间、拔管时间、住院时间明显短于对照组(P0.05)。结论:三维重建及3D打印技术应用在精准胸腔镜肺段切除术中,可有效缩短手术时间,促进患者康复,改善肺功能,提高临床治疗疗效,且安全性较好。

关键词：三维重建 3D打印技术精准治疗胸腔镜肺段切除术肺功能术前计划

Association between Vitamin D Insufficiency and the Risk for Gestational Diabetes Mellitus in Pregnant Chinese Women

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Biomedical and Environmental Sciences 2012年第4期25卷 399-406页

作者： WANG Ou nie Min hu Ying Ying ZHANG Kui LI Wei PING Fan LIU jun Tao chen Li Meng XING Xiao Ping Department of Endocrinology Peking Union Medical College Hospital Peking Union Medical College Chinese Academy of Medical Sciences Key Laboratory of Endocrinology Ministry of Health Beijing 100730 China Department of Obstetrics& Gynecology Peking Union Medical College Hospital Peking Union Medical College Chinese Academy of Medical Sciences Beijing 100730 China Department of Nephrology Peking Union Medical College Hospital Peking Union Medical College Chinese Academy of Medical Sciences Beijing 100730 China

Objective To investigate the association between vitamin D deficiency and risk of gestational diabetes rnellitus （GDM） in pregnant Chinese women. Methods A nested case-control study was conducted. Clinical and biochemical data were analyzed for 200 subjects with GDM and 200 subjects with normal glucose tolerance （NGT）. Results The median （interquartile range） serum 25-hydroxyvitamin D （25OHD） levels were 22.39 （17.67, 29.38） and 25.86 （19.09, 34.88） nmol/L in the GDM and NGT groups, respectively. Rates of 25OHD deficiency or insufficiency were significantly higher in the GDM group than in the NGT group. Subjects with 25OHD levels 〈25 nmol/L had a 1.g-fold higher risk of GDM compared with subjects with higher vitamin D levels. In the GDM group, serum 25OHD was independently associated with HbAlc and insulin resistance after adjusting for confounding factors. In the NGT group, serum 25OHD was independently associated with fasting plasma glucose and systolic blood pressure after adjusting for maternal age and other confounding factors. Conclusion 2SOHD insufficiency is very common in Chinese women. Low 25OHD status may be associated with insulin resistance and act as a risk factor for GDM.

关键词： Gestational diabetes mellitus Vitamin D insufficiency Chinese women