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All-Fabric Bi-directional Actuators for Multi-joint Assistance of Upper Limb

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Journal of Bionic Engineering 2023年第6期20卷 2661-2669页

作者： Junlin Ma Diansheng Chen Zhe Liu Jie Wei Xianglin Zhang Zihan Zeng yongkang jiang Institute of Robotics Beihang UniversityBeijing100191China Department of Control Science and Engineering Tongji UniversityShanghai201804China Frontiers Science Center for Intelligent Autonomous Systems Shanghai201210China

According to clinical studies,upper limb robotic suits are vital to reduce therapist fatigue and accelerate patient *** pneumatic actuators have drawn increasing attention for the development of wearable robots due to their low weight,flexibility,and high power-to-weight ***,most of current actuators were designed for the flexion assistance of a specific joint,and that for joint extension requires further ***,designing an actuator for diverse working scenarios remains a *** this paper,we propose an all-fabric bi-directional actuator to assist the flexion and extension of the elbow,wrist,and fingers.A mathematical model is presented that predicts the deformation and guides the design of the proposed bi-directional *** further validate the applicability and adaptability of the proposed actuator for different joints,we developed a 3-DOF soft robotic *** results show that the robotic suit can assist the motion of the elbow,wrist,and finger of the subject.

关键词： Soft robotic suits Fabric-based actuators Multi-DOF motion Upper limb rehabilitation

Full sexual maturity-cycle exposure to environmentally relevant concentrations of 17β-estradiol decreases reproductive capacity of zebrafish

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Journal of Environmental Sciences 2024年第3期137卷 580-592页

作者： yongkang Zhang Yuanjun jiang Qian Sun Meng Li Sheng Chen Jingyu Liang Chunsheng Liu College of Fisheries Huazhong Agricultural UniversityWuhan 430070China School of Environmental Studies China University of GeosciencesWuhan 430074China

17β-Estradiol(E2)has been widely detected in natural water and treatment with E2 induces potential endocrine disrupting effects in ***,effects on fish fecundity and steroid system after treatment with environmentally relevant concentrations of E2 for the full sexual maturation cycle remain *** this study,zebrafish were treatment with 0,10 or100 ng/L E2 from embryo to adult stage,and effects on gonadal development and differentiation,steroid hormone levels,transcription of genes associated with the hypothalamic-pituitary-gonadal-liver(HPG)axis in adults and fertilization rate of offspring were *** results showed that treatment with E2 lead to increased number of feminization in *** females,E2 decreased cumulative amount of spawning and inhibited the maturation of *** males,E2 inhibited the maturation and motility of sperm,as well as decreased the movement speed of *** adverse effects on sperm might be responsible for the reduced fertilization observed in *** addition,treatment with E2 changed the levels of steroid hormones in zebrafish gonad and altered the transcriptional levels of genes associated with HPG axis,which is responsible for the regulation of germ cells maturation and gonadal development in ***,these results suggested that treatment with environmentally relevant concentrations of E2 for the full sexual maturity cycle resulted in adverse effects on reproduction in zebrafish.

关键词： Environmental estrogen Zebrafish Fecundity Gonadal development Endocrine disruption

High-strength and thermally stable TiB_(2)-modified Al-Mn-Mg-Er-Zr alloy fabricated via selective laser melting

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International Journal of Minerals,Metallurgy and Materials 2024年第10期31卷 2221-2232页

作者： jiang Yu Yaoxiang Geng yongkang Chen Xiao Wang Zhijie Zhang Hao Tang Junhua Xu Hongbo Ju Dongpeng Wang School of Materials Science and Engineering Jiangsu University of Science and TechnologyZhenjiang 212003China Beijing Advanced Innovation Center for Materials Genome Engineering Institute for Advanced Materials and TechnologyUniversity of Science and Technology BeijingBeijing 100083China National Engineering Research Center of Near-Net Shape Forming for Metallic Materials Guangdong Provincial Key Laboratory for Processing and Forming of Advanced Metallic MaterialsSouth China University of TechnologyGuangzhou 510640China CEMMPRE-Centre for Mechanical Engineering Materials and Processes Department of Mechanical EngineeringUniversity of CoimbraRua Luís Reis SantosCoimbra 3030-788Portugal

To increase the processability and plasticity of the selective laser melting(SLM)fabricated Al-Mn-Mg-Er-Zr alloys,a novel TiB_(2)-modified Al-Mn-Mg-Er-Zr alloy with a mixture of Al-Mn-Mg-Er-Zr and nano-TiB_(2) powders was fabricated by *** pro-cessability,microstructure,and mechanical properties of the alloy were systematically investigated by density measurement,microstruc-ture characterization,and mechanical properties *** alloys fabricated at 250 W displayed higher relative densities due to a uni-formly smooth top surface and appropriate laser energy *** maximum relative density value of the alloy reached(99.7±0.1)%,demonstrating good *** alloy exhibited a duplex grain microstructure consisting of columnar regions primarily and equiaxed regions with TiB_(2),Al6Mn,and Al3Er phases distributed along the grain *** directly aging treatment at a high tem-perature of 400℃,the strength of the SLM-fabricated TiB_(2)/Al-Mn-Mg-Er-Zr alloy increased due to the precipitation of the secondary Al6Mn *** maximum yield strength and ultimate tensile strength of the aging alloy were measured to be(374±1)and(512±13)MPa,*** SLM-fabricated TiB_(2)/Al-Mn-Mg-Er-Zr alloy demonstrates exceptional strength and thermal stability due to the synergistic effects of the inhibition of grain growth,the incorporation of TiB_(2) nanoparticles,and the precipitation of secondary Al6Mn nanoparticles.

关键词： selective laser melting aluminum alloy processability mechanical properties thermal stability

Robust Genetic Diagnosis of Split Hand–Foot Malformation by Exome Sequencing

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Chinese Journal of Plastic and Reconstructive Surgery 2020年第1期2卷 18-24页

作者： Hengqing CUI Zhengsheng CHEN Li CHEN Shengbo ZHOU yongkang jiang Xinyi DAI Bin WANG Department of Plastic and Reconstructive Surgery Shanghai 9th People’s HospitalShanghai Jiaotong University School of MedicineShanghaiChina Shanghai Jiaotong University School of Medicine ShanghaiChina

Purpose The present study aimed to evaluate the genetic diagnostic yield and accuracy of exome sequencing in Chinese patients with split hand–foot malformation(SHFM),a severe heterogeneous congenital anomaly characterized by hypodevelopment of the central ray of the hands and *** A cohort of seven families and five sporadic patients with SHFM was *** DNA was prepared from the peripheral blood of affected as well as unaffected *** exome sequencing(WES)was performed to identify the pathogenic ***-based comparative genomic hybridization(aCGH),CytoScan,quantitative polymerase chain reaction(qPCR),and Sanger sequencing were performed to validate the findings of *** data of an additional cohort of 24 patients with non-SHFM congenital hand anomalies were analyzed as the *** Pathogenic variants of TP63,c.G956A p.R319H,and c.T602A:p.L201H,were identified in two families by *** the remaining patients,copy number analysis of the WES data by XHMM software identified pathogenic 10q 24 duplication in five individuals from three families,which was further validated via CytoScan and qPCR;however,WES could not detect duplication in 10q24 in an additional cohort of 24 individuals with non-SHFM congenital hand ***,qPCR analysis of the 10q24 region copy number revealed a definite consistency with WES data in all ***–phenotype analysis did not present any unique feature that could differentiate between the families with TP63 mutation and 10q24 *** Our study demonstrated that WES is an accurate and sensitive method to detect the pathogenic 10q24 ***,with TP63 mutation,a single WES testing could yield a diagnosis rate of about 40%(5/12)for the SHFM patients,at least in our *** the genotype–phenotype correlation remains unclear,WES could be used as a cost-effective method for the genetic diagnosis of SHFM.

关键词： Hand-foot malformation Genetic diagnosis Exome sequencing

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基于生成对抗网络的僵尸网络检测

通信学报 2021年第7期42卷 95-106页

作者：邹福泰谭越王林蒋永康上海交通大学网络空间安全学院上海200240

为了解决僵尸网络隐蔽性强、难以识别等问题,提高僵尸网络检测精度,提出了基于生成对抗网络的僵尸网络检测方法。首先,通过将僵尸网络流量中的数据包重组为流,分别提取时间维度的流量统计特征和空间维度的流量图像特征;然后,基于生成对... 详细信息

为了解决僵尸网络隐蔽性强、难以识别等问题,提高僵尸网络检测精度,提出了基于生成对抗网络的僵尸网络检测方法。首先,通过将僵尸网络流量中的数据包重组为流,分别提取时间维度的流量统计特征和空间维度的流量图像特征;然后,基于生成对抗网络的僵尸网络流量特征生成算法,在2个维度生产僵尸网络特征样本;最后,结合深度学习在僵尸网络检测场景下的应用,提出了基于DCGAN的僵尸网络检测模型和基于BiLSTM-GAN的僵尸网络检测模型。实验表明,所提模型提高了僵尸网络检测能力和泛化能力。

关键词：僵尸网络深度学习流量分析机器学习生成对抗网络

基于鱼骨图和层次分析法的知识转移粘滞影响因素研究

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科技管理研究 2021年第10期41卷 169-177页

作者：蒋永康梅强江苏大学管理学院江苏镇江212013 镇江高等专科学校财经商贸学院江苏镇江212028

对知识转移粘滞影响因素进行系统分析和定量研究。首先提出知识转移三阶段模型,包括发送者知识编码度、接受者知识吸收度和交互情景3个知识转移粘滞直接影响因素和1个间接影响因素社会资本网络,采用鱼骨图法确定各因素及其层次关系,然... 详细信息

对知识转移粘滞影响因素进行系统分析和定量研究。首先提出知识转移三阶段模型,包括发送者知识编码度、接受者知识吸收度和交互情景3个知识转移粘滞直接影响因素和1个间接影响因素社会资本网络,采用鱼骨图法确定各因素及其层次关系,然后导入层次分析模型进行一致性评价,计算各层次因素的权重并进行排序,得到排名前4位的是转移意愿、接受意愿、转移能力和吸收能力,社会资本网络的中心性排名第5位、结构洞排名第9位。基于研究结果提出通过激励机制、市场机制等措施提高知识发送方的知识转移意愿是降低知识转移粘滞的关键,设计和优化知识接受者的激励机制非常重要,同时应注重通过多开展培训、讲座和现场指导等手段来提高双方的知识转移能力;此外,要充分利用知识转移双方、科技中介的社会资本网络来降低知识转移粘滞度。

关键词：知识转移粘滞知识转移模型鱼骨图层次分析法(AHP)

ASF1A-dependent P300-mediated histone H3 lysine 18 lactylation promotes atherosclerosis by regulating EndMT

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Acta Pharmaceutica Sinica B 2024年第7期14卷 3027-3048页

作者： Mengdie Dong Yunjia Zhang Minghong Chen yongkang Tan Jiao Min Xian He Fuhao Liu Jiaming Gu Hong jiang Longbin Zheng Jiajing Chen Quanwen Yin Xuesong Li Xiang Chen Yongfeng Shao Yong Ji Hongshan Chen Department of Cardiovascular Surgery the First Affiliated Hospital of Nanjing Medical Universityand Key Laboratory of Cardiovascular and Cerebrovascular MedicineSchool of PharmacyNational Vaccine Innovation PlatformNanjing Medical UniversityNanjing 211166China Key Laboratory of Cardiovascular and Cerebrovascular Medicine School of PharmacyNanjing Medical UniversityNanjing 211166China Department of Clinical Medicine Nanjing Medical University TIANYUAN Honors SchoolNanjing Medical UniversityNanjing 211166China Department of Anesthesiology Sir Run Run HospitalNanjing Medical UniversityNanjing 211166China Department of Cardiovascular Surgery the First Affiliated Hospital of Nanjing Medical UniversityNanjing 211166China Key Laboratory of Cardiovascular and Cerebrovascular Medicine Key Laboratory of Targeted Intervention of Cardiovascular DiseaseCollaborative Innovation Center for Cardiovascular Disease Translational MedicineState Key Laboratory of Reproductive MedicineSchool of Pharmacythe Affiliated Suzhou Hospital of Nanjing Medical UniversityGusu SchoolNanjing Medical UniversityNanjing 211166China National Key Laboratory of Frigid Zone Cardiovascular Diseases(NKLFZCD) Department of Pharmacology(State-Province Key Laboratories of Biomedicine-Pharmaceutics of China)College of PharmacyKey Laboratory of Cardiovascular Medicine Research and Key Laboratory of Myocardial IschemiaChinese Ministry of EducationNHC Key Laboratory of Cell Transplantationthe Central Laboratory of the First Affiliated HospitalHarbin Medical UniversityHarbin 150081China Key Laboratory of Targeted Intervention of Cardiovascular Disease Collaborative Innovation Center for Cardiovascular Disease Translational MedicineNanjing Medical UniversityNanjing 211166China Department of Cardiology Huai’an First People’s Hospital Affiliated with Nanjing Medical UniversityHuai’an 223399China

Endothelial-to-mesenchymal transition(EndMT)is a key driver of *** glycolysis is increased in the endothelium of atheroprone areas,accompanied by elevated lactate *** lactylation,mediated by lactate,can regulate gene expression and participate in disease ***,whether histone lactylation is involved in atherosclerosis remains ***,we report that lipid peroxidation could lead to EndMT-induced atherosclerosis by increasing lactatedependent histone H3 lysine 18 lactylation(H3K18la)in vitro and in vivo,as well as in atherosclerotic patients’***,the histone chaperone ASF1A was first identified as a cofactor of P300,which precisely regulated the enrichment of H3K18la at the promoter of SNAI1,thereby activating SNAI1 transcription and promoting *** found that deletion of ASF1A inhibited EndMT and improved endothelial *** analysis based on Apoe^(KO)Asf1a^(ECKO) mice in the atherosclerosis model confirmed the involvement of H3K18la in atherosclerosis and found that endotheliumspecific ASF1A deficiency inhibited EndMT and alleviated atherosclerosis *** of glycolysis by pharmacologic inhibition and advanced PROTAC attenuated H3K18la,SNAI1 transcription,and EndMT-induced *** study illustrates precise crosstalk between metabolism and epigenetics via H3K18la by the P300/ASF1A molecular complex during EndMT-induced atherogenesis,which provides emerging therapies for atherosclerosis.

关键词： Histone lactylation Atherosclerosis Endothelial-tomesenchymal transition ASF1A SNAI1 Endothelial dysfunction Lactate Epigenetic