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Mechanism of inflammatory response and therapeutic effects of stem cells in ischemic stroke:current evidence and future perspectives

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Neural Regeneration Research 2025年第1期20卷 67-81页

作者： Yubo Wang Tingli Yuan Tianjie Lyu Ling Zhang Meng Wang Zhiying He yongjun Wang Zixiao Li Vascular Neurology Department of NeurologyBeijing Tiantan HospitalCapital Medical UniversityBeijingChina China National Clinical Research Center for Neurological Diseases Beijing Tiantan HospitalCapital Medical UniversityBeijingChina Shanghai Engineering Research Center of Stem Cells Translational Medicine ShanghaiChina National Center for Healthcare Quality Management in Neurological Diseases Beijing Tiantan HospitalCapital Medical UniversityBeijingChina Institute for Regenerative Medicine Shanghai East HospitalSchool of Life Sciences and TechnologyTongji UniversityShanghaiChina Chinese Institute for Brain Research BeijingChina Research Unit of Artificial Intelligence in Cerebrovascular Disease Chinese Academy of Medical SciencesBeijingChina Beijing Engineering Research Center of Digital Healthcare for Neurological Diseases BeijingChina

Ischemic stroke is a leading cause of death and disability worldwide,with an increasing trend and tendency for onset at a younger ***,in particular,bears a high burden of stroke *** recent years,the inflammatory response after stroke has become a research hotspot:understanding the role of inflammatory response in tissue damage and repair following ischemic stroke is an important direction for its *** review summarizes several major cells involved in the inflammatory response following ischemic stroke,including microglia,neutrophils,monocytes,lymphocytes,and ***,we have also highlighted the recent progress in various treatments for ischemic stroke,particularly in the field of stem cell ***,understanding the complex interactions between inflammation and ischemic stroke can provide valuable insights for developing treatment strategies and improving patient *** cell therapy may potentially become an important component of ischemic stroke treatment.

关键词： cell therapy immune cell inflammatory ischemic stroke stem cell

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毛囊类器官研究:现状、问题与前景

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中国组织工程研究 2025年第31期29卷 6733-6742页

作者：王钊龚琳朴永君大连医科大学附属第一医院皮肤科辽宁省大连市116000

背景:毛囊体外重建依赖于毛乳头细胞及角质形成细胞3D共培养时的自组装行为,该过程与毛囊胚胎发育极为相似,因此,毛囊类器官可作为毛囊再生相关基础研究良好的体外模型,目前,通过仿生系统培养的全人源毛囊类器官已能成功移植到动物体内... 详细信息

背景:毛囊体外重建依赖于毛乳头细胞及角质形成细胞3D共培养时的自组装行为,该过程与毛囊胚胎发育极为相似,因此,毛囊类器官可作为毛囊再生相关基础研究良好的体外模型,目前,通过仿生系统培养的全人源毛囊类器官已能成功移植到动物体内。毛囊类器官研究使毛囊再生成为可能,但构建方法亦无统一定论,仍面临诸多挑战。目的:综述目前毛囊类器官的研究进展,总结毛囊类器官培养方法及表征,阐述应用前景,为后续研究提供可靠依据,以期促进其在组织工程及脱发治疗的临床转化。方法:应用计算机在中国知网(CNKI)及PubMed数据库中,以“毛囊再生,毛发再生,类器官”为中文检索词,“hair growth,hair loss,hair regeneration,hair follicle,dermal papilla cell,organoid”为英文检索词进行检索,查阅国内外关于毛囊类器官的相关文献,共纳入文献67篇进行后续分析。结果与结论:①不同来源的毛乳头细胞与角质形成细胞可在体外构建毛囊类器官,以获得鼠源、人-鼠嵌合及人源毛囊类器官,并成功用于啮齿动物移植模型;②多种重编程方法如电刺激、添加重组蛋白、解离细胞基因过表达等可用于促进毛囊类器官毛胚形成及毛钉伸长,同时,多种3D打印技术的应用已实现大小可控毛囊类器官的批量生产,极大提高了生产效率;③在解离细胞共培养体系中加入黑素细胞时,或可破译新生毛囊的色素缺失难题,而加入人脐静脉血管内皮细胞时,细胞聚集体内的新生血管可改善营养供给,减少中心部位坏死;④随着工程化类毛囊技术逐渐趋于成熟,患者自体细胞构建的毛囊类器官或可用于严重脱发的个体化医疗。

关键词：脱发毛囊再生毛乳头细胞毛囊类器官上皮-间充质交互作用 3D培养类器官组织工程工程化类器官

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Oscillatory squeeze flow through an Oldroyd-B fluid-saturated porous layer

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Applied Mathematics and Mechanics(English Edition) 2024年第11期45卷 2037-2054页

作者： yongjun JIAN School of Mathematics and Statistics Donghua UniversityShanghai201620China Institute for Nonlinear Science Donghua UniversityShanghai201620China

This study deals with the analytical investigation of oscillatory squeeze film flow through a Brinkman viscoelastic Oldroyd-B fluid-saturated porous layer subject to two vertically harmonically oscillatory *** validity of the present proposed analytical solutions is first demonstrated for the Newtonian fluids when bothΛ_(1)andΛ_(2)tend to zero by comparison with the previous *** demonstrate that an increase in the elasticity parameterΛ_(1)correlates with a rise in axial velocities,indicating that the relaxation timeΛ_(1)facilitates enhanced squeeze *** the case of squeeze film flow in porous layers,low oscillating frequencies exert minimal effects on axial velocities,independent of variations in the viscoelasticity parameterΛ_(1).However,at higher oscillating frequencies,axial velocities escalate with increasing the viscoelasticity parameterΛ_(1).Furthermore,the retardation timeΛ_(2)of the viscoelastic fluid shows no significant effect on the axial velocity,regardless of oscillating frequency changes in both pure fluids and porous layers.

关键词： Oldroyd-B fluid squeeze flow porous media oscillating boundary

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PIMOL:A New Semi-analytical Method Based on the Finite Difference Method of Lines and the Precise Integration Method

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Acta Mechanica Solida Sinica 2020年第3期33卷 381-391页

作者： yongjun Xu Key Laboratory for Mechanics in Fluid Solid Coupling Systems Institute of MechanicsChinese Academy of SciencesBeijing 100190China

The aim of this paper is to introduce a new semi-analytical method,namely PIMOL(precise integration method of lines,the parametric finite difference method of lines based on the precise integration method),which is developed and used to solve the ordinary differential equation(ODEs)systems based on the finite difference method of lines and the precise integration method(PIM).Two examples of Poisson^equation problems are given:a boundary value problem and an ODE eigenvalue *** PIMOL can effectively reduce a semi-discrete ODE problem to a linear algebraic matrix *** results show that the PIMOL is a powerful method.

关键词： PIMOL ODE FDMOL PIM Poisson’s equation Semi-analytical Semi-discrete

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PIMOL: The Finite Difference Method of Lines Based on the Precise Integration Method for an Arbitrary Irregular Domain

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Acta Mechanica Solida Sinica 2020年第6期33卷 823-835页

作者： yongjun Xu Key Laboratory for Mechanics in Fluid Solid Coupling Systems Institute of MechanicsChinese Academy of SciencesBeijing 100190China

The aim of this paper is to introduce a new semi-analytical method named precise integration method of lines(PIMOL),which is developed and used to solve the ordinary differential equation(ODE)systems based on the finite difference method of lines and the precise integration *** irregular domain problem is mainly discussed in this *** classical examples of Poisson^equation problems are given,including one regular and two irregular domain *** PIMOL reduces a semi-discrete ODE problem to a linear algebraic matrix equation and does not require domain mapping for treating the irregular domain *** results show that the PIMOL is a powerful method.

关键词： PIMOL ODEs FDMOL PIM Poisson’s equation problems Semi-analytical(discrete) Irregular domain

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Science China Materials 2018年第1期61卷 127-128页

作者： yongjun Tian State Key Laboratory of Metastable Materials Science and Technology Yanshan University

When a metal is subject to cyclic loading with cyclic stress values much lower than its tensile strength,fatigue occurs due to accumulative and irreversible damages developed in the microstructure,causing service failure of the metal workpiece or even fatal disaster in the worst *** develop materials with higher fatigue limit and longer fatigue life relies on reducing or suppressing

关键词： Rise of correlated dislocations in nanotwinned metals against fatigue

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Recent advancements and manipulation strategies of colloidal Cs_(2)B^(I)B^(III)X_(6)lead-free halide double perovskite nanocrystals

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Nano Research 2023年第4期16卷 5572-5591页

作者： Shufang Wu yongjun Liu College of Chemical Engineering Huaqiao UniversityXiamen 361021China

Double-metallic lead-free halide perovskites,Cs_(2)B^(I)B^(III)X_(6),sharing three-dimensional crystal structure,have been under the spotlight as the promising alternatives for the toxic and instable lead-based *** in Cs_(2)B^(I)B^(III)X_(6)motivates intense research into their colloidal nanocrystals(NCs).Recently,Cs_(2)B^(I)B^(III)X_(6)NCs have made great progress in the optical performance via alloying or doping,but there are still great challenges for optoelectronic *** this review,the latest advances of Cs_(2)B^(I)B^(III)X_(6)NCs in synthesis approaches,bandgap engineering,photoluminescence(PL)optimization,and applications are *** focus is put upon the composition-property relationships of Cs_(2)B^(I)B^(III)X_(6)NCs,which is approached by discussing the influences of composition variation on the electronic states,carrier dynamics,and optical *** challenges and the corresponding improving strategies in the development of high-effective and stable Cs_(2)B^(I)B^(III)X_(6)NCs for device applications are also *** is believed that this review can deepen the understanding on this burgeoning material system and shed light on their future research directions.

关键词： Cs_(2)B^(I)B^(III)X_(6)nanocrystals alloying/doping composition-property relationships improving strategies device applications

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Electromagnetohydrodynamic flows and mass transport in curved rectangular microchannels

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Applied Mathematics and Mechanics(English Edition) 2020年第9期41卷 1431-1446页

作者： Yongbo LIU yongjun JIAN School of Mathematical Science Inner Mongolia UniversityHohhot 010021China

Curved microchannels are often encountered in lab-on-chip systems because the effective axial channel lengths of such channels are often larger than those of straight microchannels for a given per unit chip *** this paper,the effective diffusivity of a neutral solute in an oscillating electromagnetohydrodynamic(EMHD)flow through a curved rectangular microchannel is investigated *** flow is assumed as a creeping flow due to the extremely low Reynolds number in such microflow *** the theoretical analysis,we find that the effective diffusivity primarily depends on five dimensionless parameters,i.e.,the curvature ratio of the curved channel,the Schmidt number,the tidal displacement,the angular Reynolds number,and the dimensionless electric field strength *** on the obtained results,we can precisely control the mass transfer characteristics of the EMHD flow in a curved rectangular microchannel by appropriately altering the corresponding parameter values.

关键词： electromagnetohydrodynamic(EMHD)flow curved rectangular microchannel mass transfer characteristic effective diffusivity

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Robust resource allocation for NOMA-assisted heterogeneous networks

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Digital Communications and Networks 2022年第2期8卷 208-214页

作者： Hao Xie yongjun Xu School of Communication and Information Engineering Chongqing University of Posts and TelecommunicationsChongqing400065China

As a promising technology to improve spectrum efficiency and transmission coverage,Heterogeneous Network(HetNet)has attracted the attention of many scholars in recent ***,with the introduction of the Non-Orthogonal Multiple Access(NOMA)technology,the NOMA-assisted HetNet cannot only improve the system capacity but also allow more users to utilize the same frequency band resource,which makes the NOMA-assisted HetNet a hot ***,traditional resource allocation schemes assume that base stations can exactly estimate direct link gains and cross-tier link gains,which is impractical for practical HetNets due to the impact of channel delays and random *** further improve energy utilization and system robustness,in this paper,we investigate a robust resource allocation problem to maximize the total Energy Efficiency(EE)of Small-Cell Users(SCUs)in NOMA-assisted HetNets under imperfect channel state *** considering bounded channel uncertainties,the robust resource optimization problem is formulated as a mixed-integer and nonlinear programming problem under the constraints of the cross-tier interference power of macrocell users,the maximum transmit power of small base station,the Resource Block(RB)assignment,and the quality of service requirement of each *** original problem is converted into an equivalent convex optimization problem by using Dinkelbach's method and the successive convex approximation method.A robust Dinkelbach-based iteration algorithm is designed by jointly optimizing the transmit power and the RB *** results verify that the proposed algorithm has better EE and robustness than the existing algorithms.

关键词： Heterogeneous network Imperfect channel state information Non-orthogonal multiple access Robust resource allocation Energy efficiency maximization

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Electroviscous effect on electromagnetohydrodynamic flows of Maxwell fluids in parallel plate microchannels

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Applied Mathematics and Mechanics(English Edition) 2019年第10期40卷 1457-1470页

作者： Yongbo LIU yongjun JIAN School of Mathematical Science Inner Mongolia University

Considering the influence of the streaming potential and electroviscous effects, the analytical solutions for electromagnetohydrodynamic (EMHD) flows in parallel plate microchannels are obtained. The electrolyte solutions in the microchannels are taken as generalized Maxwell fluids, and slip boundary conditions are adopted. To accurately analyze the EMHD flow characteristics, the variation trends of the electroviscous effects with the corresponding parameters must be understood. The results show that the electroviscous effects increase with the increase in the relaxation time De, the slip coefficient , and the wall zeta potential 0. However, the increase in the inverse of the electrical double-layer (EDL) thickness K, the electrical oscillating Reynolds number Re, and the ionic P'eclet number Pe can decrease the electroviscous effects. We also demonstrate that the electroviscous effect on the EMHD flows of generalized Maxwell fluids is larger than that of Newtonian fluids. This work will be useful in designing EMHD flows in parallel plate microchannels.

关键词： electroviscous e ect electromagnetohydrodynamic (EMHD) ow generalized Maxwell uid

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