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Potential role and therapeutic implications of glutathione peroxidase 4 in the treatment of Alzheimer's disease

Neural Regeneration Research 2025年第3期20卷 613-631页

作者： Yanxin Shen Guimei Zhang Chunxiao wei Panpan Zhao yongchun Wang Mingxi Li Li Sun Department of Neurology and Neuroscience Center The First Hospital of Jilin UniversityJilin UniversityChangchunJilin ProvinceChina Cognitive Impairment Center Department of NeurologyThe First Hospital of Jilin UniversityJilin UniversityChangchunJilin ProvinceChina

Alzheimer's disease is an age-related neurodegenerative disorder with a complex and incompletely understood pathogenesis. Despite extensive research, a cure for Alzheimer's disease has not yet been found. Oxidative stress mediates excessive oxidative responses, and its involvement in Alzheimer's disease pathogenesis as a primary or secondary pathological event is widely accepted. As a member of the selenium-containing antioxidant enzyme family, glutathione peroxidase 4 reduces esterified phospholipid hydroperoxides to maintain cellular redox homeostasis. With the discovery of ferroptosis, the central role of glutathione peroxidase 4 in anti-lipid peroxidation in several diseases, including Alzheimer's disease, has received widespread attention. Increasing evidence suggests that glutathione peroxidase 4 expression is inhibited in the Alzheimer's disease brain, resulting in oxidative stress, inflammation, ferroptosis, and apoptosis, which are closely associated with pathological damage in Alzheimer's disease. Several therapeutic approaches, such as small molecule drugs, natural plant products, and non-pharmacological treatments, ameliorate pathological damage and cognitive function in Alzheimer's disease by promoting glutathione peroxidase 4 expression and enhancing glutathione peroxidase 4 activity. Therefore, glutathione peroxidase 4 upregulation may be a promising strategy for the treatment of Alzheimer's disease. This review provides an overview of the gene structure, biological functions, and regulatory mechanisms of glutathione peroxidase 4, a discussion on the important role of glutathione peroxidase 4 in pathological events closely related to Alzheimer's disease, and a summary of the advances in small-molecule drugs, natural plant products, and non-pharmacological therapies targeting glutathione peroxidase 4 for the treatment of Alzheimer's disease. Most prior studies on this subject used animal models, and relevant clinical studies are lacking. Future clinical trials are required to validate the therapeuti

关键词： apoptosis ferroptosis inflammation lipid peroxidation natural plant products neurodegenerative disorder neuroprotection oxidative stress small-molecule drugs

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Health risks and sources of trace elements and black carbon in PM_(2.5)from 2019 to 2021 in Beijing

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Journal of Environmental Sciences 2024年第8期142卷 69-82页

作者： Chenjie Hua wei Ma Feixue Zheng Yusheng Zhang Jiali Xie Li Ma Boying Song Chao Yan Hongyan Li Zhen Liu Qian Liu Markku Kulmala yongchun Liu Aerosol and Haze Laboratory Advanced Innovation Center for Soft Matter Science and EngineeringBeijing University of Chemical TechnologyBeijing 100029China Institute for Atmospheric and Earth System Research Faculty of ScienceUniversity of HelsinkiHelsinki 00014Finland School of Environment and Safety Taiyuan University of Science and TechnologyTaiyuan 030024China State Key Laboratory of Environmental Chemistry and Ecotoxicology Research Center for Eco-Environmental SciencesChinese Academy of SciencesBeijing 100085China

A comprehensive health risk assessment of PM_(2.5)is meaningful to understand the current status and directions regarding further improving air quality from the perspective of human health.In this study,we evaluated the health risks of PM_(2.5)as well as highly toxic inorganic components,including heavy metals(HMs)and black carbon(BC)based on longterm observations in Beijing from 2019 to 2021.Our results showed that the relative risks of chronic obstructive pulmonary disease,lung cancer,acute lower respiratory tract infection,ischemic heart disease,and stroke decreased by 4.07%-9.30%in 2020 and 2.12%-6.70%in2021 compared with 2019.However,they were still at high levels ranging from 1.26 to 1.77,in particular,stroke showed the highest value in 2021.Mn had the highest hazard quotient(HQ,from 2.18 to 2.56)for adults from 2019 to 2021,while Ni,Cr,Pb,As,and BC showed high carcinogenic risks(CR>1.0×10^(-6))for adults.The HQ values of Mn and As and the CR values of Pb and As showed constant or slight upwards trends during our observations,which is in contrast to the downward trends of other HMs and PM_(2.5).Mn,Cr,and BC are crucial toxicants in PM_(2.5).A significant shrink of southern region sourcesof HMs and BCshrank suggests the increased importance of local sources.Industry,dust,and biomass burning are the major contributors to the non-carcinogenic risks,while traffic emissions and industry are the dominant contributors to the carcinogenic risks in Beijing.

关键词： PM_(2.5) Heavy metals Black carbon Health risk Source apportionment

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Super-resolution imaging reveals the subcellular distribution of dextran at the nanoscale in living cells

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Chinese Chemical Letters 2022年第4期33卷 1865-1869页

作者： Huimin Chen Han Wang yongchun wei Maomao Hu Bo Dong Hongbao Fang Qixin Chen Institute of Materia Medica Shandong First Medical University&Shandong Academy of Medical SciencesJi’nan 250062China Department of Cardiology Shandong Provincial Hospital Affiliated to Shandong UniversityJi’nan 250012China State Key Laboratory of Coordination Chemistry Chemistry and Biomedicine Innovation Center(ChemBIC)School of Chemistry and Chemical EngineeringNanjing UniversityNanjing 210023China

Theranostic visualization of dextran at the nanoscale is beneficial for understanding the bioregulatory mechanisms of this molecule. In this study, we applied structured illumination microscopy(SIM) to capture the distribution of Cy5-Dextran at different incubation periods in living cells. The results showed that Cy5-Dextran could be absorbed by He La cells. In addition, we clarified that Cy5-Dextran exhibited differential organelle distribution(lysosomal or mitochondrial) in a time-dependent manner. Moreover,lysosomal Cy5-Dextran localization was found to be independent of the autophagy process, while Cy5-Dextran localized to the mitochondria triggered a pro-apoptotic event, upregulating the levels of reactive oxygen species(ROS) to accelerate mitochondrial fragmentation. This work uses a visualized strategy to reveal the anti-tumor bioactivity of dextran, which was achieved by regulating apoptosis and autophagy.

关键词： Dextran Subcellular distribution Super-resolution imaging Structured illumination microscopy

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Technical operation specification for cupping therapy

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Journal of Integrative Nursing 2023年第2期5卷 155-160页

作者： yongchun wei Yali WANG Haiyan E Kaiye ZHANG Ling TANG Department of Anorectal Medicine Dongfang Hospital of Beijing University of Chinese MedicineBeijingChina Department of Nursing Dongfang Hospital of Beijing University of Chinese MedicineBeijingChina

Cupping,as one of the characteristic therapies of traditional Chinese medicine,has been applied for more than 2000 years and has a unique curative effect in clinic.With the evolution of the times,the types and operation techniques of cupping method are also iterating.In the process of its inheritance and development,cupping technology is also known by more and more people.Starting from the development and efficacy of cupping method,this paper introduces the clinical operation steps and precautions of cupping method in detail,and lists the representative diseases such as lumbar muscle strain,herpes zoster,and ankylosing spondylitis,to provide reference for clinical application.

关键词： Cupping nursing technology operating procedures traditional Chinese medicine

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Operating procedures of moxibustion technology

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中西医结合护理杂志(英文) 2023年第3期5卷 228-233页

作者： Yali WANG Ling TANG E.HAIYAN yongchun wei Jing JIANG Yuxia DONG Department of Anorectal Medicine Dongfang Hospital of Beijing University of Chinese MedicineBeijingChina Department of Nursing Dongfang Hospital of Beijing University of Chinese MedicineBeijingChina

Moxibustion therapy is a treatment and health-care method that originated from China.It is a kind of therapy for preventing and treating diseases by stimulating meridians and acupoints using heat to regulate the viscera and enhance immunity.This article introduces the definition and mechanism of moxibustion technology,clinical operation technics,and precautions of moxibustion in practice,and demonstrates plenty of iconic cases of application of moxibustion in the treatment of insomnia,dysmenorrhea,urinary retention,knee arthritis,chronic eczema,etc.,so as to provide a reference for the wide application of moxibustion technology.

关键词： Chronic eczema dysmenorrhea insomnia knee osteoarthritis moxibustion traditional Chinese medicine nursing technology urinary retention

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输电线路雷电绕击风险评估多源数据融合可视化方法

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高电压技术 2024年第5期50卷 1877-1888,I0006,I0007页

作者：杜勇黄良灿沈小军辛巍金哲翁永春国网湖北省电力有限公司超高压公司武汉430072 同济大学电气工程系上海200092

直观描述超/特高压输电线路的绕击风险分布,展现线路结构、地形地貌、雷电活动等复杂因素的交互关系具有重要的价值,相关研究亟待深化。该文开展了绕击风险评估多源数据融合可视化方法研究。基于输电通道点云数据、EGM模型参数、绕击闪... 详细信息

直观描述超/特高压输电线路的绕击风险分布,展现线路结构、地形地貌、雷电活动等复杂因素的交互关系具有重要的价值,相关研究亟待深化。该文开展了绕击风险评估多源数据融合可视化方法研究。基于输电通道点云数据、EGM模型参数、绕击闪络率等多源数据特征分析,借鉴“以数生智”认知过程,提出了一种数据融合3维可视化框架及关键技术。该方法采用“档距-导线-断面-计算点-暴露弧”层级数据结构,按层级关联整合不同维度表达需求的数据,基于输电通道激光雷达点云空间开展以暴露弧为载体的绕击风险机理可视化,实现绕击闪络率、屏蔽机理、雷电流幅值等多源信息的综合立体展示,通过支持对限定条件的响应,实现了绕击故障分析应用。某500 kV线路档距案例应用结果表明:融合可视化能够发挥3维视图多尺度、多视角的优势,通过暴露弧与点云数据的信息互补,从机理层面揭示避雷线、地面对导线的屏蔽作用,提升数据展示的全面性、直观性。

关键词：输电线路雷电绕击多源数据信息融合 3维可视化

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改性磁珠吸附剂脱汞及脱附再生动力学研究

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煤炭转化 2024年第1期47卷 91-99页

作者：谢占军魏书洲杨威赵永椿常林张军营国能三河发电有限责任公司河北三河065201 河北省燃煤电站污染防治技术创新中心河北三河065201 华中科技大学煤燃烧与低碳利用全国重点实验室武汉430074 国家能源集团新能源技术研究院有限公司北京102209

为了有效控制燃煤烟气中的汞排放和有效解决燃煤飞灰的资源化利用问题,制备出一种新型的氯化铜改性磁珠脱汞吸附剂(Cu-MF)。在固定床吸附系统中,系统研究了反应温度(100℃~180℃)、烟气流量(0.8 L/min~1.5 L/min)、吸附剂用量(0.2 g~1.0... 详细信息

为了有效控制燃煤烟气中的汞排放和有效解决燃煤飞灰的资源化利用问题,制备出一种新型的氯化铜改性磁珠脱汞吸附剂(Cu-MF)。在固定床吸附系统中,系统研究了反应温度(100℃~180℃)、烟气流量(0.8 L/min~1.5 L/min)、吸附剂用量(0.2 g~1.0 g)、SO_(2)体积分数(800×10^(-6)~1200×10^(-6))和NO体积分数(100×10^(-6)~300×10^(-6))对改性磁珠吸附剂汞吸附性能的影响。分别采用准一级和准二级动力学模型分析了改性磁珠吸附剂的汞吸附机制和控制过程,通过程序升温脱附(temperature programmed desorption,TPD)的方法探讨了改性磁珠吸附剂的汞脱附再生过程。结果表明:改性磁珠吸附剂在120℃~150℃区间内具有较高的汞脱除能力,吸附剂用量的增加有利于汞的脱除,而烟气流量和烟气组分(SO_(2),NO)对改性磁珠吸附剂汞吸附性能的影响较小。在不同反应温度和不同烟气流量下,改性磁珠吸附剂的脱汞过程可以通过准一级和准二级动力学模型描述。当吸附剂用量大于0.5 g时,改性磁珠吸附剂的吸附行为受物理吸附及化学吸附行为双重因素控制,可以分别用准一级和准二级动力学模型来描述改性磁珠吸附剂在SO_(2)和NO存在时的汞吸附过程。改性磁珠吸附剂的汞脱附行为更符合准一级动力学模型。

关键词：烟气单质汞磁珠吸附动力学脱附再生

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基于改进A^(*)算法的地下自动驾驶铲运机路径规划

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矿业研究与开发 2024年第5期44卷 185-193页

作者：崔冰赵辉军段景文魏威谭丽龙刘永春北方矿业有限责任公司北京100053 长沙迪迈科技股份有限公司湖南长沙410205 长沙施玛特迈科技有限公司湖南长沙410012 智能软硬件(嵌入式)长沙市新一代人工智能开放创新平台湖南长沙410012

为解决自动驾驶铲运机路径规划的安全和效率问题,提出一种基于改进A^(*)算法的地下自动驾驶铲运机路径规划方法.该方法通过将A^(*)节点扩展限制在巷道骨架范围内,使得规划路径分布于巷道中央区域,并采用矿山的真实地图数据进行了对比试... 详细信息

为解决自动驾驶铲运机路径规划的安全和效率问题,提出一种基于改进A^(*)算法的地下自动驾驶铲运机路径规划方法.该方法通过将A^(*)节点扩展限制在巷道骨架范围内,使得规划路径分布于巷道中央区域,并采用矿山的真实地图数据进行了对比试验和路径跟踪应用.结果表明,使用曼哈顿距离作为算法的启发函数表现最优,且相较于传统A^(*)算法,改进A^(*)算法的规划路径更接近巷道中央、平均耗时减少约76.0%,在安全性和规划速度方面具有优越性.现场应用中,自动驾驶铲运机的平均跟踪偏差为0.26m,能够根据规划路径安全抵达终点.研究结果可为地下矿无人驾驶系统的建设提供参考.

关键词：自动驾驶路径规划铲运机改进A^(*)算法启发函数

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煤电基地CO_(2)和CH_4遥感监测及时空特征分析

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煤田地质与勘探 2024年第6期52卷 79-90页

作者：徐燕飞陈永春李静刘晓舟苗伟赵得荣芮成奇深部煤炭安全开采与环境保护全国重点实验室安徽淮南232001 中国矿业大学环境与测绘学院江苏徐州221116 安徽省煤矿绿色低碳发展工程研究中心安徽淮南232001 淮南大气科学研究院安徽淮南232001

【目的】CO_(2)和CH_(4)是煤电基地能源生产活动中的主要温室气体排放种类,其监测与时空分布是研究区碳监测体系建设的重要内容。【方法】以安徽淮南市为例,利用GOSAT、OCO-2和Sentinel-5P这3种卫星数据进行研究区CO_(2)和CH_(4)浓度监... 详细信息

【目的】CO_(2)和CH_(4)是煤电基地能源生产活动中的主要温室气体排放种类,其监测与时空分布是研究区碳监测体系建设的重要内容。【方法】以安徽淮南市为例,利用GOSAT、OCO-2和Sentinel-5P这3种卫星数据进行研究区CO_(2)和CH_(4)浓度监测,得到CO_(2)、CH_(4)柱浓度(XCO_(2)和XCH_(4))变化和分布情况,采用源清单法分析CO_(2)行业和区域排放特征,同时采用Pearson相关系数和多元回归方法分析影响研究区XCO_(2)和XCH_(4)浓度的主控因素。【结果和结论】结果表明:(1)基于GOSAT和OCO-2卫星融合数据分析显示,淮南市2016-2020年XCO_(2)和XCH_(4)浓度整体呈增长趋势,期间XCO_(2)浓度增加12×10^(-6)、XCH_(4)浓度增加23×10^(-9);XCO_(2)浓度和累计发电量的Pearson相关系数为0.98,XCH_(4)浓度和累计煤炭产量的Pearson相关系数为0.99,均呈极强相关。(2)利用Sentinel-5P卫星搭载的对流层观测仪(TROPOMI)高分辨产品数据分析淮南市各区域XCH_(4)浓度分布时空特征发现,研究区秋季XCH_(4)浓度高于夏季,XCH_(4)浓度受能源生产和农业生产两方面的影响。(3)源清单法得出淮南市一级源分类CO_(2)排放最多的为化石燃料固定燃烧源,占全市CO_(2)总排放量的89.59%,化石燃料固定燃烧源中电力供热占比99%以上;主要为淮南市潘集区和凤台县燃煤电厂CO_(2)排放;源识别显示集中分布在淮南市北部的火力发电厂为研究区CO_(2)最主要排放源。(4)影响研究区XCO_(2)浓度的主控因素为地区生产总值、累计发电量和第二产业产值,影响XCH_(4)浓度的主控因素为累计煤炭产量、第一产业产值、播种面积。研究结果对我国“双碳”目标下煤电基地碳监测体系构建与完善具有重要的参考意义。

关键词：碳排放遥感监测 XCO_(2) XCH_4 主控因素多元回归分析煤电基地安徽淮南市

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Heterogeneous kinetics of the OH-initiated degradation of fenthion and parathion

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Journal of Environmental Sciences 2023年第11期133卷 161-170页

作者： Yuanhong Shang yongchun Liu Jinfeng Tian Changgeng Liu Xuejun Zhu Jun Wang Dandan Chen wei Tao School of Biological and Chemical Engineering Panzhihua UniversityPanzhihua 617000China Beijing Advanced Innovation Center for Soft Matter Science and Engineering Beijing University of Chemical TechnologyBeijing 100029China Medical College Panzhihua UniversityPanzhihua 617000China Key Laboratory of Green Chemistry of Sichuan Institutes of Higher Education Sichuan University of Science&EngineeringZigong 643000China

Fenthion and parathion are two representative kinds of organophosphorus pesticides and widely used in agriculture.They are directly or indirectly released into the atmosphere by spraying or volatilization processes.However,their heterogeneous reactivity toward OH radicals has not yet been well understood.Therefore,this work investigated the heterogeneous kinetics of the OH-initiated degradation of surface-bound fenthion and parathion using a flow reactor.The results showed that OH radicals played an important role in the atmospheric degradation of fenthion and parathion.Their average rate constants were(7.20±0.77)×10^(-12) and(10.40±0.60)×10^(−12) cm^(3)/(mol·sec)at a relative humidity(RH)and temperature of 35% and 20℃,respectively,suggesting that they have relatively short lifetimes in the atmosphere.In addition,a negative RH dependence and a positive temperature dependence of the rate constants were observed.The Arrhenius expressions of fenthion and parathion were k_(2)=(1.34±0.48)×10^(-9) exp[-(1432.59±105.29)/T]and k_(2)=(1.96±1.38)×10^(-9) exp[-(1619.98±222.02)/T],respectively,and their overall activation energy was estimated to be(11.88±0.87)and(13.48±1.83)kJ/mol.The experimental results will update the kinetic data of fenthion and parathion in the atmosphere and be helpful to further understand their atmospheric transportation processes.

关键词： Organophosphorus pesticide Heterogeneous kinetics Fenthion Parathion OH radicals

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