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World Journal of Gastroenterology 2004年第16期10卷 2311-2317页

作者： Chang-TaiXu Shu-yongmeng Bo-RongPan DepartmentofThoracicandOncologySurgery ShaanxiProvincialTextileHospitalXi'an710038ShaanxiProvinceChina DepartmentofOncology XijingHospitalFourthMilitaryMedicalUniversityXi'an710032ShaanxiProvinceChinaSupportedbytheScienceFoundationofHealthBureauofShaanxiprovinceNo.04D26 EditorialDepartment JournalofFourthMilitaryMedicalUniversityFourthMilitaryMedicalUniversityXi'an710032ShaanxiProvinceChina

Ulcerative colitis (UC) is an inflammatory destructive disease of the large intestine occurred usually in the rectum and lower part of the colon as well as the entire colon. Drug therapy is not the only choice for UC treatment and medical management should be as a comprehensive ***, Asacol, Pentasa, Dipentum, and Rowasa all contain 5-aminosalicylic acid (5-ASA), which is the topical anti-inflammatory ingredient. Pentasa is more commonly used in treating Crohn's ileitis because Pentasa capsules release more 5-ASA into the small intestine than Asacol tablets. Pentasa can also be used for treating mild to moderate UC. Rowasa enemas are safe and effective in treating ulcerative proctitis and proctosigmoiditis. The sulfafree 5-ASA agents (Asacol, Pentasa, Dipentum and Rowasa) have fewer side effects than sulfa-containing Azulfidine. In UC patients with moderate to severe disease and in patients who failed to respond to 5-ASA compounds,systemic (oral) corticosteroids should be used. Systemic corticosteroids (prednisone, prednisolone, cortisone, etc.)are potent and fast-acting drugs for treating UC, Crohn's ileitis and ileocolitis. Systemic corticosteroids are not effective in maintaining remission in patients with *** side effects can result from prolonged corticosteroid treatment. To minimize side effects, corticosteroids should be gradually reduced as soon as the disease remission is achieved. In patients with corticosteroid-dependent or unresponsive to corticosteroid treatment, surgery or immunomodulator is considered. Immunomodulators used for treating severe UC include azathioprine/6-MP,methotrexate, and cyclosporine. Integrated traditional Chinese and Western medicine is safe and effective in maintaining remission in patients with UC.

关键词：麻醉药治疗方法大肠溃疡 5-ASA 糖皮质激素

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Modeling and Analysis of Mechanical Quality Factor of the Resonator for Cylinder Vibratory Gyroscope

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Chinese Journal of Mechanical Engineering 2017年第1期30卷 180-189页

作者： XI Xiang WU Xuezhong WU Yulie ZHANG yongmeng College of Mechatronics Engineering and Automation National University of Defense TechnologyChangsha 410073China

Mechanical Quality factor（Q factor） of the resonator is an important parameter for the cylinder vibratory gyroscope（CVG）. Traditional analytical methods mainly focus on a partial energy loss during the vibration process of the CVG resonator, thus are not accurate for the mechanical Q factor prediction. Therefore an integrated model including air damping loss, surface defect loss, support loss, thermoelastic damping loss and internal friction loss is proposed to obtain the mechanical Q factor of the CVG resonator. Based on structural dynamics and energy dissipation analysis, the contribution of each energy loss to the total mechanical Q factor is quantificationally analyzed. For the resonator with radius ranging from 10 mm to 20 mm, its mechanical Q factor is mainly related to the support loss, thermoelastic damping loss and internal friction loss, which are fundamentally determined by the geometric sizes and material properties of the resonator. In addition, resonators made of alloy 3J53 （Ni42CrTiA1）, with different sizes, were experimentally fabricated to test the mechanical Q factor. The theoretical model is well verified by the experimental data, thus provides an effective theoretical method to design and predict the mechanical Q factor of the CVG resonator.

关键词： mechanical Quality factor cylinder vibratory gyroscope energy loss

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Effect of resveratrol on microcirculation disorder and lung injury following severe acute pancreatitis in rats

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World Journal of Gastroenterology 2005年第3期11卷 433-435页

作者： yongmeng MeiZhang JunXu Xue-MinLiu Qing-YongMa DepartmentofHepatobiliarySurgery FirstHospitalXi'anJiaotongUniversityXi'an710061ShaanxiProvinceChina DepartmentofHepatobiliarySurgery FirstHospitalXi'anJiaotongUniversityXi'an710061ShaanxiProvinceChina

AIM: To investigate the mechanism of resveratrol underlying the microcirculation disorder and lung injury following severe acute pancreatitis (SAP). METHODS: Twenty-four rats were divided into 3 groups (SAP, sham and resveratrol groups) randomly. SAP model was established by injecting 4% sodium taurocholate l mL/kg through puncturing pancreatic ducts. Sham (control) group (8 rats) was established by turning over the duodenum. Resveratrol was given at 0.1 mg/kg b.m. intraperitoneally. Rats were sacrificed 9 h after SAP was induced. Blood samples were obtained for hemorrheological examination. Lung tissues were used for pathological observation, and examination of microvascular permeability, dry/wet ratio and myeloperoxidase (MPO) activity. Gene expression of intercellular adhesion molecule-1 (ICAM-1) was detected by RT-PCR. RESULTS: Compared with SAP group, resveratrol relieved the edema and infiltration of leukocytes in the lungs. Resveratrol improved markers of hemorrheology: high VTB (5.77±1.18 mPas vs9.49±1.34 mPas), low VTB (16.12±3.20 mPas vs30.91±7.28 mPas), PV (4.69±1.68 mPas vs 8.00±1.34 mPas), BSR (1.25±0.42 mm/h vs50.03±0.03 mm/h), VPC (54.67±3.08% vs 62.17±3.39%), fibrinogen (203.2?7.8 g/ L vs 51.3±19.1 g/L), original hemolysis (0.45±0.02 vs 0.49±0.02), and complete hemolysis (0.41±0.02 vs 0.43±0.02) (P<0.05). Resveratrol decreased the OD ratio of ICAM-1 gene (0.800±0.03 vs 1.188±0.10), dry/wet ratio (0.74±0.02 vs 0.77±0.03), microvascular permeability (0.079±0.006 vs 0.112±0.004) and MPO activity (4.42±0.32 vs 5.03±0.51) significantly (P<0.05). CONCLUSION: Resveratrol can improve the microcirculation disorder of the lung by decreasing leukocyte-endothelial interaction, reducing blood viscosity, improving the decrease of blood flow, and stabilizing erythrocytes in SAP rats. It may be a potential candidate to treat SAP and its severe complications (ALI).

关键词： Severe acute pancreatitis Resveratrol Lung injury Micro-circulation disorder

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Effect of resveratrol on activation of nuclear factor kappa-B and inflammatory factors in rat model of acute pancreatitis

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World Journal of Gastroenterology 2005年第4期11卷 525-528页

作者： yongmeng Qing-YongMa Xiao-PingKou JunXu DepartmentofHepatobiliarySurgery FirstHospitalofXi'anJiaotongUniversityXi'an710061ShaanxiProvinceChina DepartmentofHepatobiliarySurgery FirstHospitalofXi'anJiaotongUniversityXi'an710061ShaanxiProvinceChina

AIM: To observe the effect of resveratrol on nuclear factor Kappa-B (NF-κB) activation and the inflammatory response in sodium taurocholate-induced pancreatitis in rats. METHODS: Seventy-two male SD rats were randomly divided into three groups: sham operation group (control), severe acute pancreatitis (SAP) group, and severe acute pancreatitis group treated with resveratrol (RES). A SAP model was established by injecting 4% sodium taurocholate 1 mL/kg through puncturing the pancreatic duct. In Res group, Res was given at 30 mg/kg b.m. intraperitoneally after the SAP model was successfully established. Eight animals from each group were sacrificed at 3, 6 and 12 h after modeling. The expression of NF-κB activation of pancreas was detected by irnmunohistochemical staining, whereas the levels of TNF-α and IL-8 in pancreatic tissues were estimated by radioimrnunoassay. The pathological changes of pancreas and lungs were examined microscopically. RESULTS: Much less hyperemia, edema, dust-colored necrotic focus and soaps were noticed in pancreas in RES group than in SAP group. In RES group, hemorrhage, exudates and infiltration of inflammatory cells in pancreas and interstitial edema, destruction of alveolar wall in lung were significantly less than in SAP group. In the SAP group, the activation of NF-κB in pancreatic tissues was enhanced significantly at any measure point compared with control group (64.23±10.72% vs 2.56±0.65%, 55.86±11.34% vs 2.32±0.42%, 36.23±2.30% vs 2.40±0.36%,P<0.01), TNF-α, IL-8 were also increased and reached their peak at 6 h and then declined. The activation of NF-κB and the levels of TNF-α and IL-8 in RES group were significantly lower than those in SAP group (P<0.01): activation (52.63±9.45% vs 64.23±10.72%, 40.52±8.40% vs 55.86±11.34%, 29.83±5.37% vs 36.23±2.30%), TNF-α (132.76±15.68 pg/mL vs 158.36±12.58 pg/mL, 220.32±23.57 pg/mL vs 247.67± 11.62 pg/mL, 175.68±18.43 pg/mL vs 197.35±12.57 pg/mL) and IL-8 (0.62±0.21 μg/L vs 0.83±0.10 μg/L, 1.1

关键词： Acute pancreatitis Resveratrol NF-κB Inflammatory factors

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Electrocatalytic construction of the C–N bond from the derivates of CO_(2) and N_(2)

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Science China Chemistry 2022年第2期65卷 204-206页

作者： Yanmei Huang Yuting Wang yongmeng Wu Yifu Yu Bin Zhang Institute of Molecular Plus Department of ChemistrySchool of ScienceTianjin UniversityTianjin 300072China

Electrochemical synthesis of C-N bond-containing compounds(e.g.,urea,amino acid,amide,amine,and their derivates)from CO_(2)/N_(2)and their derivates is emerging as a promising sustainable strategy[1-7].CO_(2)and its derived products,CO,HCOOH,(COOH)_(2),etc.,could serve as carbon sources(Figure 1)[8].N_(2),making up 80%of air,is an appealing nitrogen ***,the low solubility of N2 and the high dissociation energy for the N≡N bond limit its application.

关键词： bond Figure solubility

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Effect of lamellar structural parameters on the bending fracture behavior of AA1100/AA7075 laminated metal composites

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Journal of Materials Science & Technology 2022年第4期99卷 28-38页

作者： Taiqian Mo Zejun Chen Dayu Zhou Guangming Lu yongmeng Huang Qing Liu Joint International Research Laboratory for Light Alloys Ministry of EducationCollege of Materials Science and EngineeringChongqing UniversityChongqing 400044China Key Laboratory for Light-weight Materials Nanjing Tech UniversityNanjing 210009China

The lamellar structure has an important impact on the mechanical properties of dissimilar laminated metal composites(LMCs),including the thickness ratio of dissimilar metal constituent layers and the number of ***1100 and AA7075 with thickness ratios of 1:4 and 3:4 were fabricated for multilayer AA1100/AA7075 LMCs by hot accumulative roll bonding(ARB)*** bending fracture characteristics of AA1100/AA7075 LMCs with different thickness ratios and numbers of constituent layers were *** research results indicated that AA1100/AA7075 LMCs with a low thickness ratio exhibited better bending ductility and toughness than those with a high thickness ratio,which was attributed to the crack growth resistance caused by the thickness of the soft AA1100 *** toughening mechanism introduced by crack deflection or arresting contributed to the enhancement in the toughness of the LMCs compared with that of the single 7075 Al *** bonding interfaces of AA1100/AA7075 LMCs with different numbers of layers are continuous and straight due to the high ARB temperature.A decrease in bending toughness was observed as the number of layers *** LMCs with a low number of layers,crack deflection or interface delamination is also considered a main toughening mechanism in dissimilar LMCs in addition to the thickness effect.

关键词： Laminated metal composite Mechanical properties Bending Fracture behavior Toughening mechanism

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Evaluation of measurement uncertainty based on grey system theory for small samples from an unknown distribution

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Science China(Technological Sciences) 2013年第6期56卷 1517-1524页

作者： HAN LianFu TANG WenYan LIU yongmeng WANG Jun FU ChangFeng Institute of Precision Instrument Harbin Institute of Technology School of Electronic Science Northeast Petroleum University

To evaluate measurement uncertainty for small sample size and measurement data from an unknown distribution, we propose a grey evaluation method of measurement uncertainty based on the grey relation coefficient. The uncertainty of measurement is analyzed using grey system theory, and the defects of the grey evaluation model of measurement uncertainty (GEMU) are studied. We then establish an improved grey evaluation model of measurement uncertainty (IGEMU). Simulations show that the precision of IGEMU is greater than that of GEMU, and that sample size has only a small effect on the precision of IGEVU. In particular, IGEMU is applied to evaluating measurement uncertainty for small sample size and measurement data from an unknown distribution. The measurement uncertainty of total profile deviation, which is measured by the CNC gear measuring center, can be evaluated by a combination of IGEMU and the Monte Carlo method.

关键词： grey system theory grey relational coefficient measurement uncertainty tooth profile gear measuring center

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Prediction of peritoneal free cancer cells in gastric cancer patients by golden-angle radial sampling dynamic contrast-enhanced magnetic resonance imaging

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2024年第7期25卷 617-627页

作者： Xueqing YIN Xinzhong RUAN yongmeng ZHU Yongfang YIN Rui HUANG Chao LIANG The First Affiliated Hospital of Ningbo University Ningbo 315000China Ningbo Medical Center Lihuili Hospital Ningbo 315000China

Objectiveperitoneal free cancer cells can negatively impact disease progression and patient outcomes in gastric cancer. This study aimed to investigate the feasibility of using golden-angle radial sampling dynamic contrast-enhanced magnetic resonance imaging (GRASP DCE-MRI) to predict the presence of peritoneal free cancer cells in gastric cancer *** enrolled patients were consecutively divided into analysis and validation groups. Preoperative magnetic resonance imaging (MRI) scans and perfusion were performed in patients with gastric cancer undergoing surgery, and peritoneal lavage specimens were collected for examination. Based on the peritoneal lavage cytology (PLC) results, patients were divided into negative and positive lavage fluid groups. The data collected included clinical and MR information. A nomogram prediction model was constructed to predict the positive rate of peritoneal lavage fluid, and the validity of the model was verified based on data from the verification *** was no statistical difference between the proportion of PLC-positive cases predicted by GRASP DCE-MR and the actual PLC test. MR tumor stage, tumor thickness, and perfusion parameter Tofts-Ketty model volume transfer constant (Ktrans) were independent predictors of positive peritoneal lavage fluid. The nomogram model featured a concordance index (C-index) of 0.785 and 0.742 for the modeling and validation groups, *** DCE-MR could effectively predict peritoneal free cancer cells in gastric cancer patients. The nomogram model constructed using these predictors may help clinicians to better predict the risk of peritoneal free cancer cells being present in gastric cancer patients.

关键词： Gastric cancer Magnetic resonance Golden-angle radial sampling Nomogram model Peritoneal free cancer cells

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Electrosynthesis of ^(15)N-labeled amino acids from ^(15)N-nitrite and ketonic acids

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Science China Chemistry 2023年第6期66卷 1854-1859页

作者： yongmeng Wu Mengyang Li Tieliang Li Jinghui Zhao Ziyang Song Bin Zhang Department of Chemistry School of ScienceInstitute of Molecular PlusTianjin UniversityTianjin 300072China Tianjin Key Laboratory of Molecular Optoelectronic Science Key Laboratory of Systems Bioengineering(Ministry of Education)Tianjin UniversityTianjin 300072China

^(15)N isotope-labeled amino acids(^(15)N-amino acids)are crucial in the fields of biology,medicine,and chemistry.^(15)N-amino acids are conventionally synthesized through microbial fermentation and chemical reductive amination of ketonic acids methodologies,which usually require complicated procedures,high temperatures,or toxic cyanide usage,causing energy and environmental ***,we report a sustainable pathway to synthesize ^(15)N-amino acids from readily available ^(15)N-nitrite(^(15)NO_(2)-)and biomass-derived ketonic acids under ambient conditions driven by renewable electricity.A mechanistic study demonstrates a ^(15)N-nitrite→^(15)NH_(2)OH→^(15)N-pyruvate oxime→^(15)N-alanine reaction pathway for ^(15)N-alanine ***,this electrochemical strategy can synthesize six ^(15)N-amino acids with 68%–95%***,a ^(15)N-labeled drug of ^(15)N-tiopronin,the most commonly used hepatitis treatment drug,is fabricated using ^(15)N-glycine as the building ***,^(15)N sources can be recycled by the electrooxidation of ^(15)NH4^(+) to ^(15)NO_(2)-with a method *** work opens an avenue for the green synthesis of ^(15)N-labeled compounds or drugs.

关键词： green synthesis ^(15)N-labeled amino acids electrosynthesis C-N bond isotope labeling

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0.79 ppm scale-factor nonlinearity whole-angle microshell gyroscope realized by real-time calibration of capacitive displacement detection

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Microsystems & Nanoengineering 2021年第5期7卷 129-139页

作者： Jiangkun Sun Sheng Yu yongmeng Zhang Qingsong Li Xiang Xi Kun Lu Xuezhong Wu Dingbang Xiao National University of Defense Technology Changsha 410073China

Whole-angle gyroscopes have broad prospects for development with inherent advantages of excellent scale factor,wide bandwidth and measurement range,which are restrictions on rate *** studies on the whole-angle mode are based mostly on the linear model of Lynch,and the essential nonlinearity of capacitive displacement detection is always neglected,which has significant negative effects on the *** this paper,a novel realtime calibration method of capacitive displacement detection is proposed to eliminate these nonlinear *** novel method innovatively takes advantage of the relationship between the first and third harmonic components of detective signals for *** on this method,the real-time calibration of capacitive displacement detection is achieved and solves the problems of traditional methods,which are usually related to the vibration amplitude,environmental variations and other ***,this novel calibration method is embedded into a whole-angle control system to restore the linear capacitive response in real time and then combined with a microshell resonator for the first time to exploit the enormous potential of an ultrahigh Q factor and symmetric *** effectiveness is proven because the angle drift is reduced significantly to improve the scale-factor nonlinearity by 14 times to 0.79 ppm with 0.0673/h bias instability and a 0.0017s rate threshold,which is the best reported performance of the MEMS whole-angle gyroscope thus *** importantly,this novel calibration method can be applied for all kinds of resonators with the requirement of a linear capacitive response even under a large resonant amplitude.

关键词： structure nonlinearity displacement

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