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Effect of surface acidity and pore size of Al-substituted plugs-containing SBA-15 and MCM-41 silicas on the polymerization of THF

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Chinese Chemical Letters 2011年第1期22卷 105-108页

作者： Zhi Qi Jia Ming zhao Chun Guang Gao yong xiang zhao School of Chemistry and Chemical Engineering Shanxi University Engineering Research Center for Fine Chemicals of Ministry of Education Taiyuan 030006 China

We reported here the simultaneous influence of surface acidity and pore size of M-substituted hexagonal mesoporous silicas （Al- doped plugs-containing SBA-15 and M-doped MCM-41） on polymerization of THE These materials were directly synthesized by introduced aluminum isopropoxide into reaction mixture including surfactant and siliceous precursor. Al-doped plugs-containing SBA-15 （denotes as PAS） samples not only possess typical two-step desorption isotherms, which implied PAS materials generated plugs in their mesochannel, but also exhibit larger pore size and thicker wall than that of Al-doped MCM-41 （denotes as ACM）, which implied PAS would have a great advantage on catalytic reaction involving large molecular （e.g. polymer of THF） in industrial point＇of view. To investigate catalytic activity of PAS and ACM with moderate acidic sites the polymerization of THF in the presence of acetic anhydride was carried out. The results showed PAS exhibiting good performance on polymerization of THF. Such result could be related to the large pore size and moderate acidic sites.

关键词： Hexagonal mesostructure Polymerization THF Acidity Pore size

The Park-and-Ride Behavior in a Cumulative Prospect Theory-Based Model

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Journal of the Operations Research Society of China 2017年第3期5卷 363-376页

作者： Li-Jun Tian Cheng-Rui Lyu yong-xiang zhao School of Economics and Management Fuzhou UniversityFuzhou 350116China

As an effective travel demand management means,park-and-ride(P&R)mode is an important part of urban *** a traffic corridor with P&R service,suppose that the travel time on highway is uncertain,a cumulative prospect theory(CPT)-based travel decision-making model is established with two travel modes of driving all the way and(P&R).With this setting,the effect of various factors such as the transit fare rate,the parking fee and the total travel demand on the CPT-based and expected utility theory(EUT)-based equilibrium results are *** addition,the sensitivity analysis focus on CPT-related parameters are also *** numerical results in our case show that the equilibrium flow on P&R mode is always underestimated in an EUT-based model,especially for a low total travel ***,it is found that reducing the transit fare rate or parking fee for P&R station and raising the parking fee for CBD has the same effect on promoting more commuters transfer to P&R mode,whatever CPT-based or EUT-based model is ***,commuter’s reference dependence characteristic is also observed in a CPT-based model,and it is especially noticeable when the road uncertainty is large.

关键词： Urban traffic Park-and-ride Cumulative prospect theory Commute behavior Equilibrium model

Application of Newcastle disease virus in the treatment of colorectal cancer

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World Journal of Clinical Cases 2019年第16期7卷 2143-2154页

作者： Hui Song Li-Ping Zhong Jian He yong Huang yong-xiang zhao National Center for International Research of Bio-targeting Theranostics Guangxi Key Laboratory of Biotargeting Theranostics Collaborative Innovation Center for Targeting Tumor Diagnosis and Therapy Guangxi Medical University

Colorectal cancer (CRC) is one of the main reasons of tumor-related deaths *** present,the main treatment is surgery,but the results are unsatisfactory,and the prognosis is *** majority of patients die due to liver or lung metastasis or *** recent years,great progress has been made in the field of tumor gene therapy,providing a new treatment for combating *** oncolytic viruses selectively replicate almost exclusively in the cytoplasm of tumor cells and do not require integration into the host genome,they are safer,more effective and more attractive as oncolytic *** disease virus (NDV) is a natural RNA oncolytic *** NDV selectively infects tumor cells,the immune response induced by NDV’s envelope protein and intracellular factors can effectively kill the tumor without affecting normal *** genetic techniques make NDV a vector for gene *** the virus by inserting various exogenous genes or using NDV in combination with immunotherapy can also improve the anti-CRC capacity of NDV,and good results have been achieved in animal models and clinical treatment *** article reviews the molecular biological characteristics and oncolytic mechanism of NDV and discusses in vitro and in vivo experiments on NDV anti-CRC capacity and clinical *** conclusion,NDV is an excellent candidate for cancer treatment,but more preclinical studies and clinical trials are needed to ensure its safety and efficacy.

关键词： Newcastle disease virus Exogenous gene Armed virus Oncolytic therapy Colorectal cancer

Ultrafine Ru nanoparticles anchored on core-shell structured zeolite-carbon for efficient catalysis of hydrogen generation

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Rare Metals 2023年第7期42卷 2324-2334页

作者： Yue-Wei Wei Guang Yang Xi-Xi Xu Yan-Yan Liu Nai-Xin Kang Bao-Jun Li yong-zhao Wang yong-xiang zhao School of Chemistry and Chemical Engineering Shanxi UniversityTaiyuan030006China Engineering Research Center of Ministry of Education for Fine Chemicals Shanxi UniversityTaiyuan030006China Tobacco College of Henan Agricultural University Zhengzhou450002China College of Science Henan Agricultural UniversityZhengzhou450002China ISM UMR CNRS Nº5255Univ.BordeauxTalence Cedex33405France Research Center of Green Catalysis College of ChemistryZhengzhou UniversityZhengzhou450001China

As a promising route to hydrogen production,hydrolysis of ammonia borane(AB)aqueous solution requires efficient and stable *** this paper,a carbon-coated zeolite is prepared by high temperature calcination using glucose as carbon *** Ru nanoparticles are anchored on the composite support with core-shell structure using a simple in situ reduction *** prepared catalyst expressed outstanding catalytic activity in the hydrolytic dehydrogenation of *** effects of support prepared by different synthesis parameters on the performance of catalyst are *** Ru/S-1@C(RSC-2)catalyst exhibited the highest catalytic activity for hydrolytic dehydrogenation of AB with a turnover frequency of 892 min^(-1)at room *** performance is superior to that of many catalysts previously *** excellent catalytic activity is attributed to the carbon layer on catalyst surface effectively limiting the aggregation of Ru nanoparticles in the hydrolysis *** zeolite also plays a role in preactivation of *** pre-activation accelerates the ratelimiting step of water dissociation in the *** kinetic studies for determining the activation energy(E_(a)=36.8 kJ·mol^(-1))were based on reaction *** effects of catalyst concentration,AB concentration and NaOH concentration on hydrolysis rate of AB were further *** high-performance catalysts and the preparation method in this study have wide application prospects in the field of clean energy.

关键词： Ammonia borane Ruthenium Hydrogen generation Carbon Zeolite

A New Method for Preparing Ti-Si Mixed Oxides

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Chinese Chemical Letters 2003年第11期14卷 1159-1162页

作者： Lin Ping XU yong xiang zhao Zhi Gang WU Dian Sheng LIU School of Chemistry and Chemical Engineering Shanxi UniversityTaiyuan 030006

Ti-Si mixed oxides with different TiO2 content were prepared by sol-gel one step hydrolysis, using TiCl4 as the precursor. The samples were characterized by BET, FT-IR and XRD. The results indicated that titanium is in fourfold coordination with oxygen in the SiO44- in mixed oxides, form the bond of Ti-O-Si, and the low titania materials are mixed on an atomic scale. The phase of anatase appeared when TiO2 content is up to 80%. The mixed oxides had high specific surface areas up to 681.5 m2/g. 10TiSi is a better support than SiO2 in the reaction of CO oxidation.

关键词： Ti-Si mixed oxide sol-gel one step hydrolysis TiCl4.

Screening of aptamers and their potential application in targeted diagnosis and therapy of liver cancer

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World Journal of Gastroenterology 2019年第26期25卷 3359-3369页

作者： Guo-Qing Zhang Li-Ping Zhong Nuo Yang yong-xiang zhao National Center for International Research of Biological Targeting Diagnosis and Therapy Guangxi Key Laboratory of Biological Targeting Diagnosis and Therapy Research Collaborative Innovation Center for Targeting Tumor Diagnosis and Therapy Guangxi Medical University

Aptamers are a class of single oligonucleotide molecules(DNA or RNA)that are screened from random DNA or RNA oligonucleotide chain libraries by the systemic evolution of ligands by exponential enrichment *** selected aptamers are capable of specifically binding to different targeting molecules,which is achieved by the three-dimensional structure of *** are similar in function to monoclonal antibodies,and therefore,they are also referred to as"chemical antibodies".Due to their high affinity and specificity and low immunogenicity,aptamers are topics of intense interest in today's biological targeting research especially in tumor *** not only have high potential for clinical advances in tumor targeting detection but also are highly promising as targeted tumor drug carriers for use in tumor *** experimental studies have shown that aptamer-based diagnostic and therapeutic methods for liver cancer have great potential for *** paper summarizes the structure,characteristics,and screening methods of aptamers and reviews the recent research progress on nucleic acid aptamers in the targeted diagnosis and treatment of liver cancer.

关键词： Aptamer Systemic evolution of ligands by exponential enrichment Liver cancer Outlook

Preoperative application of combination of portal venous injection of donor spleen cells and intraperitoneal injection of rapamycin prolongs the survival of cardiac allografts in mice

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Asian Pacific Journal of Tropical Medicine 2017年第5期10卷 433-439页

作者： Wen-lin Gong Chuang Sha Gang Du Zhong-gui Shan Zhong-quan Qi Su-fang Zhou Nuo Yang yong-xiang zhao National Center for International Research of Biological Targeting Diagnosis and Therapy Guangxi Key Laboratory of Biological Targeting Diagnosis and Therapy ResearchCollaborative Innovation Center for Targeting Tumor Diagnosis and TherapyGuangxi Medical University Department of Cardiac Surgery Zhongshan HospitalXiamen University Organ Transplantation Institute Xiamen University Department of Cardio-Thoracic Surgery The First Affiliated Hospital of Guang Xi Medical University

Objective:To investigate the effects of preoperative portal venous injection of donor spleen cells(PVIDSC) and intraperitoneal injection of rapamycin in the acute rejection of cardiac allograft in mice and the underlying mechanisms. Methods:Homogenous female B6 mice and BALB/c mice were used as recipients and donors of heart transplantation. These mice were randomly divided into different groups and received PVIDSC alone,rapamycin alone,or PVIDSC and rapamycin combined therapy. In addition,the underlying mechanism was studied by measuring a number of cytokines. Results:Preoperative combination of PVIDSC and intraperitoneal injection of rapamycin significantly prolonged the survival of heterotopic cardiac allograft in mice,but had no effects on the survival time of cardiac allografts in mice pre-sensitized by skin grafting. Preoperative combination of PVIDSC and intraperitoneal injection of rapamycin increased the expression of IL-10 and Foxp3 and reduced the expression of INF-γ. Short-term preoperative administration of rapamycin promotes the expression of CD4^+CD25^+Foxp3^+ regulator T cells. However,preoperative using alone of rapamycin,or combination of PVIDSC and rapamycin had no effects on the inhibition of proliferation of memory T cells. Conclusions:Preoperative application of combination of PVIDSC and rapamycin significantly prolonged the survival time of cardiac allografts in mice but not in mice pre-sensitized by skin grafting. This may be explained by the fact that combination of PVIDSC and rapamycin inhibited the cellular immune response and induced the expression of IL-10 from Tr1 cells and CD4^+CD25^+FoxP3^+ regulatory T cells.

关键词： Heart transplantation tolerance Portal venous injection of donor spleen cells Rapamycin

Targeting neuropilin-1 interactions is a promising anti-tumor strategy

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Chinese Medical Journal 2021年第5期134卷 508-517页

作者： Shao-Dan Liu Li-Ping Zhong Jian He yong-xiang zhao National Center for International Research of Bio-targeting Theranostics Guangxi Key Laboratory of Bio-targeting TheranosticsCollaborative Innovation Center for Targeting Tumor Diagnosis and TherapyGuangxi Medical UniversityNanningGuangxi 530021China

Neuropilins(NRP1 and NRP2)are multifunctional receptor proteins that are involved in nerve,blood vessel,and tumor ***1 was first found to be expressed in neurons,but subsequent studies have demonstrated its surface expression in cells from the endothelium and lymph ***1 has been demonstrated to be involved in the occurrence and development of a variety of ***1 interacts with various cytokines,such as vascular endothelial growth factor family and its receptor and transforming growth factor p i and its receptor,to affect tumor angiogenesis,tumor proliferation,and *** addition,NRP1+regulatory T cells(Tregs)play an inhibitory role in tumor *** numbers of NRP1+Tregs were associated with cancer *** NRP1 has shown promise,and antagonists against NRP1 have had therapeutic efficacy in preliminary clinical ***1 treatment modalities using nanomaterials,targeted drugs,oncolytic viruses,and radio-chemotherapy have gradually been ***,we reviewed the use of NRP1 in the context of tumorigenesis,progression,and treatment.

关键词： Neuropilin-1 Anti-tumor Immunotherapy Tumor targeting

Targeting of AUF1 to vascular endothelial cells as a novel anti-aging therapy

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Journal of Geriatric Cardiology 2017年第8期14卷 515-523页

作者： Jian HE Ya-Feng JIANG Liu LIANG Du-jin WANG Wen-Xin WEI Pan-Pan JI Yao-Chan HUANG Hui SONG Xiao-Ling LU yong-xiang zhao National Center for International Research of Biological Targeting Diagnosis and Therapy Guangxi Key Laboratory of Biological Targeting Diagnosis andTherapy Research 'Collaborative lnnovatton Center for Targeting Tumor Diagnosis and TherapyGuangxi Medical UniversityNanningGuangxiChina

Background Inhibition of aging of vascular endothelial cells （VECs） may delay aging and prolong life. The goal of this study was to prepare anti-CD31 monoclonal antibody conjugated PEG-modified liposomes containing the AU-rich region connecting factor 1 （AUF1） gene （CD31-PILs-AUF1） and to explore the effects of targeting CD31-PILs-AUF1 to aging VECs. Methods The mean particle sizes of various PEGylated immunoliposomes （PILs） were measured using a Zetasizer Nano ZS. Gel retardation assay was used to confirm whether PILs had encapsulated the AUF1 plasmid successfully. Fluorescence microscopy and flow cytometry were used to quantify binding of CD31-PILs-AUF1 to target cells. Flow cytometry was also used to analyze the cell cycles of aging bEnd3 cells treated with CD31-PILs-AUF1. We also developed an aging mouse model by treating mice with D-galactose. Enzyme-linked immunosorbent assay （ELISA） was used to evaluate the levels of interleuldn-6 （IL-6） and tumor necrosis factor-or （TNF-ct）. The malondialdehyde （MDA） and the superoxide dismutase （SOD） levels were detected by commercial kits. Hematoxylin-eosin （HE） staining was used to determine whether treatment with CD31-PILs-AUF 1 was toxic to the mice. Results CD31-PILs-AUF 1 specifically could targeted bEnd3 VECs and increased the percentage of cells in the S and G2/M phases of aging bEnd3 cells. ELISA showed that content of the IL-6 and TNF-ct decreased in CD31-PILs-AUF1 group. The level of SOD increased, whereas MDA decreased in the CD31-PILs-AUF1 group. Additionally, CD31-PILs-AUF 1 was not toxic to the mice. Conclusion CD31-PILs-AUF 1 targets VECs and may delay their senescence.

关键词： Aging AU-rich region connecting factor 1 PEGylated immunoliposomes Vascular endothelial ceils