检索结果-南通市图书馆

Overexpression of MiR-633 Suppresses the Tumorigenicity of Gastric Cancer Cells and Induces Apoptosis by Targeting MAPK1

引用

Current Medical Science 2022年第5期42卷 1033-1045页

作者： Hai-long LI Yao-hui SONG Zheng-ping DU yong-hua HU Zhuan-xiong WANG Xi CHEN Xing-mei LU Ying-xia CHEN yong-qiang duan Xiang-dong ZHU Department of Geriatrics Affiliated Hospital of Gansu University of Traditional Chinese MedicineLanzhou730000China Department of Internal Medicine The First Clinical Medical CollegeGansu University of Chinese MedicineLanzhou730000China Provincial-Level Key Laboratory for Molecular Medicine of Major Diseases and The Prevention and Treatment with Traditional Chinese Medicine in Gansu Colleges and Universities Gansu University of Chinese MedicineLanzhou730000China School of Basic Medicine Gansu Vocational College of HealthLanzhou730300China College of Traditional Chinese Medicine Ningxia Medical UniversityYinchuan750004China

Objective MicroRNA(miRNA/miR)-633 is dysregulated in several types of cancers and is involved in ***,the function and role of this miRNA in gastric cancer(GC)are not fully *** aim of the present study was to evaluate miR-633 expression in GC cell lines and in GC tissue *** normal tissue,and to determine its association with clinicopathological *** work was extended to investigate the effects of miR-633 overexpression on tumor cells in *** Reverse transcription-quantitative PCR(RT-qPCR)was used to detect and compare the expression level of miR-633 in GC cells,as well as in GC and normal adjacent tissue *** clinical significance of miR-633 was also ***-633 lentivirus(LV-miR-633)and negative control lentivirus(LV-NC)were generated and used to transduce SGC-7901 and HGC-27 GC cells in order to analyze the effect of miR-633 on their *** effects of miR-633 overexpression on GC cell proliferation,apoptosis,migration and invasion were *** target gene of miR-633 was predicted,then confirmed using a dual luciferase reporter gene assay,RT-qPCR and Western *** MiR-633 was significantly downregulated in GC cell lines,as well as in GC tissue compared with adjacent normal ***,miR-633 expression was associated with the tumor/node/metastasis(TNM)stage,invasion depth,Borrmann classification and lymph node metastasis(P<0.05).Compared with the LV-NC group,transduction with LV-miR-633 reduced the proliferation,the number of clones,the wound healing rate,the number of invading cells and the number of cells in the G1 phase of the cell cycle(P<0.01).LV-miR-633 also increased the apoptosis rate(P<0.01).The expression level of mitogen-activated protein kinase(MAPK)1,high-mobility group box 3(HMGB3),claudin 1(CLDN1)and MAPK13 were downregulated in LV-miR-633-transduced cells(P<0.01).The dual luciferase reporter assay confirmed that the 3′-untranslated region of MAPK1 was the t

关键词： miR-633 gastric cancer apoptosis metastasis mitogen-activated protein kinase 1

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

De novo synthesis of atropisomeric benzofurans via Cu/SPDO complex catalyzed asymmetric formal [3 + 2] annulation

引用

Science China Chemistry 2025年第1期 174-180页

作者： Fan-Xiao Meng Xing-Yu Wang Ka Lu Ju-Song Yang Fu-Min Zhang Ai-Jun Ma Bao Du yong-qiang Tu State Key Laboratory of Applied Organic Chemistry College of Chemistry and Chemical Engineering Lanzhou University School of Chemistry and Chemical Engineering Shanghai Jiao Tong University School of Biotechnology and Health Sciences Wuyi University

Herein, the de novo synthesis of atropisomeric benzofurans through the Cu/spirocyclic-pyrrolidine-oxazoline(SPDO) complex catalyze asymmetric formal [3 + 2] cycloaddition between quinones and ynamides is explored, producing a range of structurally diverse axially chiral benzofurans in satisfactory yields with good to excellent enantioselectivities. Furthermore, density functional theory calculations were applied to explain the possible reaction mechanism.

关键词：

来源：

同方期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

肺癌患者胆碱激酶(Chok)及胆碱磷酸胞苷转移酶(PCYT)基因的表达水平研究

引用

临床肺科杂志 2017年第1期22卷 1-3页

作者：宋华勇张帆历永强段永建修雁河南大学第一附属医院肿瘤科河南开封475000 河南大学第一附属医院影像中心河南开封475000 河南大学生化教研室河南开封475000 复旦大学中山医院核医学科上海200032

目的探讨肺癌患者胆碱激酶及胆碱磷酸胞苷转移酶基因的表达水平。方法选取2014年2月至2016年2月就诊于我院接受11C-胆碱PET/CT显像的可疑肺癌患者共68例,术后选取病变组织作为观察组,同时选取每例患者病变组织周围≥5cm处的正常组织作... 详细信息

目的探讨肺癌患者胆碱激酶及胆碱磷酸胞苷转移酶基因的表达水平。方法选取2014年2月至2016年2月就诊于我院接受11C-胆碱PET/CT显像的可疑肺癌患者共68例,术后选取病变组织作为观察组,同时选取每例患者病变组织周围≥5cm处的正常组织作为自身对照组,将两组的组织分别进行病理检查和RT-PCR检测,分析两组患者病变组织胆碱激酶及胆碱磷酸胞苷转移酶基因的表达水平。结果经RTPCR检测,50例放射性高摄取的肺癌组织中Chok(0.75±0.13)和PCYT(0.73±0.21)基因的表达水平均显著高于对照组(0.34±0.11)、(0.35±0.05),差异均有统计学意义(P0.05)。结论大部分肺癌患者存在胆碱激酶及胆碱磷酸胞苷转移酶基因表达水平的升高。

关键词：肺癌胆碱激酶胆碱磷酸胞苷转移酶表达水平

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

新型上胸椎椎弓根钉内固定系统的设计及其生物力学分析

引用

中国骨与关节损伤杂志 2017年第9期32卷 905-908页

作者：陈雍君华强段少银林永祥赵慧毅厦门大学附属中山医院脊柱外科福建厦门361004 厦门大学附属中山医院影像科福建厦门361004

目的测试新型上胸椎椎弓根钉内固定系统的生物力学性能。方法采用国际通用标准ASTM F543-2013及ASTM F1717-2013测试新型上胸椎椎弓根钉内固定系统的生物力学性能,进行单轴钉置入及拔出试验,万向钉压缩试验。并与常用颈胸椎椎弓根钉棒系... 详细信息

目的测试新型上胸椎椎弓根钉内固定系统的生物力学性能。方法采用国际通用标准ASTM F543-2013及ASTM F1717-2013测试新型上胸椎椎弓根钉内固定系统的生物力学性能,进行单轴钉置入及拔出试验,万向钉压缩试验。并与常用颈胸椎椎弓根钉棒系统(常用组)及强生椎弓根钉棒系统(强生组)进行比较。结果试验组置入力矩低于常用组,拔出力小于常用组,差异有统计学意义(P0.05)。试验组动态试验加载力最大值81 N为强生组的屈服力,反复加载后未损坏,故动态测试结果优于强生组。常用组动态试验加载力最大值110.9 N为试验组的屈服力,试验组与常用组反复加载后均未损坏,故动态试验结果接近。结论若上胸椎不稳但胸廓完整,新型上胸椎椎弓根钉内固定系统的生物力学性能可以满足临床的需要,提供即刻稳定性。

关键词：上胸椎新型椎弓根钉胸廓内固定生物力学

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Experimental and numerical study of hypervelocity impact damage on composite overwrapped pressure vessels

引用

Defence Technology（防务技术） 2024年第1期31卷 58-72页

作者： yong-Pan duan Run-qiang Chi Bao-Jun Pang Yuan Cai Hypervelocity Impact Research Center Harbin Institute of TechnologyHarbin150080China College of Science Heilongjiang University of Science and TechnologyHarbin 150022China

Ground-based tests are important for studying hypervelocity impact(HVI)damage to spacecraft pressure vessels in the orbital debris *** analyzed the damage to composite overwrapped pressure vessels(COPVs)in the HVI tests and classified the damage into non-catastrophic damage and catastrophic *** proposed a numerical simulation method to further study non-catastrophic damage and revealed the characteristics and mechanisms of non-catastrophic damage affected by impact conditions and internal *** fragments of the catastrophically damaged COPVs were collected after the *** crack distribution and propagation process of the catastrophic ruptures of the COPVs were *** findings contribute to understanding the damage characteristics and mechanisms of COPVs by HVIs.

关键词： Orbital debris Hypervelocity impact Composite overwrapped pressure vessels Damage mechanisms

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Fermionic Zero Modes in Self-dual Vortex Background on a Torus

引用

Communications in Theoretical Physics 2007年第4X期48卷 675-679页

作者： LIU Yu-Xiao WANG yong-qiang duan Yi-Shi Institute of Theoretical Physics Lanzhou University Lanzhou 730000 China Zhejiang Institute of Modern Physics Department of Physics Zhejiang University Hangzhou 310027 China

We study fermionic zero modes in the self-dual vortex background on an extra two-dimensional Riemann surface in （5＋1） dimensions. Using the generalized Abelian-Higgs model, we obtain the inner topological structure of the self-dual vortex and establish the exact self-duality equation with topological term. Then we analyze the Dirac operator on an extra torus and the effective Lagrangian of four-dimensional fermions with the self-dual vortex background. Solving the Dirac equation, the fermionic zero modes on a torus with the self-dual vortex background in two simple cases are obtained.

关键词： fermionic zero modes large extra dimensions self-dual vortex

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Robust Attitude Control for Reusable Launch Vehicles Based on Fractional Calculus and Pigeon-inspired Optimization

引用

IEEE/CAA Journal of Automatica Sinica 2017年第1期4卷 89-97页

作者： qiang Xue Haibin duan Bio-inspired Autonomous Flight Systems(BAFS) Research Group the Science and Technology on Aircraft Control Laboratory School of Automation Science and Electrical Engineering Beihang University (BUAA) IEEE

In this paper, a robust attitude control system based on fractional order sliding mode control and dynamic inversion approach is presented for the reusable launch vehicle RLV during the reentry phase. By introducing the fractional order sliding surface to replace the integer order one, we design robust outer loop controller to compensate the error introduced by inner loop controller designed by dynamic inversion approach. To take the uncertainties of aerodynamic parameters into account, stochastic robustness design approach based on the Monte Carlo simulation and Pigeon-inspired optimization is established to increase the robustness of the controller. Some simulation results are given out which indicate the reliability and effectiveness of the attitude control system. © 2014 Chinese Association of Automation.

关键词： Attitude control Calculations Communication satellites Control systems Intelligent systems Launch vehicles Launching Monte Carlo methods Nonlinear control systems Reusability Reusable rockets Robustness (control systems) Sliding mode control Stochastic systems Vehicles

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

定向电场下W_(6)C_(6)团簇的超卤素调制及非线性光学特性

引用

原子与分子物理学报 2025年第3期42卷 72-76页

作者：蔡璧钧段宇静魏强重庆理工大学理学院重庆400050

本文采用密度泛函(DFT)方法研究了定向外电场(OEEF)对W_(6)C_(6)团簇几何结构、电子性质以及非线性光学响应(NLO)的影响.计算结果表明W_(6)C_(6)的结构在一定OEEF强度下可以保持稳定.OEEF可以增大W_(6)C_(6)团簇的电子亲和能(EA值),且... 详细信息

本文采用密度泛函(DFT)方法研究了定向外电场(OEEF)对W_(6)C_(6)团簇几何结构、电子性质以及非线性光学响应(NLO)的影响.计算结果表明W_(6)C_(6)的结构在一定OEEF强度下可以保持稳定.OEEF可以增大W_(6)C_(6)团簇的电子亲和能(EA值),且在特定强度下,OEEF可以将W_(6)C_(6)团簇转变为超卤素.通过对EA值的非线性拟合可以实现对W_(6)C_(6)团簇的连续调制.进一步对不同外电场下W_(6)C_(6)团簇的最高占据分子轨道(HOMO)和最低未占据分子轨道(LUMO)能级进行分析,发现OEEF降低了W_(6)C_(6)团簇LUMO能级是其EA值增大的主因.此外,OEEF可以显著增大W_(6)C_(6)团簇的平均极化率和第一超极化率,尤其是第一超极化率,改变其非线性光学性质.

关键词：定向外电场超原子密度泛函理论 NLO W_(6)C_(6)团簇

来源：

维普期刊数据库博看期刊

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Cloud service performance evaluation： status, challenges, and opportunities - a survey from the system modeling perspective

引用

Digital Communications and Networks 2017年第2期3卷 101-111页

作者： qiang duan Information Sciences & Technology Department The Pennsylvania State University Abington College USA

With rapid advancement of Cloud computing and networking technologies, a wide spectrum of Cloud services have been developed by various providers and utilized by numerous organizations as indispensable ingredients of their information systems. Cloud service performance has a significant impact on performance of the future information infrastructure. Thorough evaluation on Cloud service performance is crucial and beneficial to both service providers and consumers; thus forming an active research area. Some key technologies for Cloud computing, such as virtualization and the Service-Oriented Architecture （SOA）, bring in special challenges to service performance evaluation. A tremendous amount of effort has been put by the research community to address these challenges and exciting progress has been made. Among the work on Cloud performance analysis, evaluation approaches developed with a system modeling perspective play an important role. However, related works have been reported in different sections of the literature; thus lacking a big picture that shows the latest status of this area. The objectives of this article is to present a survey that reflects the state of the art of Cloud service performance evaluation from the system modeling perspective. This articles also examines open issues and challenges to the surveyed evaluation approaches and identifies possible opportunities for future research in this important field.

关键词： Cloud computing Cloud services Quality of Service Performance evaluation

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

The coexistence of hermaphroditic and dioecious plants is associated with polyploidy and gender dimorphism in Dasiphora fruticosa

引用

Plant Diversity 2019年第5期41卷 323-329页

作者： Lin-Lin Wang Zhi-qiang Zhang yong-Ping Yang Yuan-Wen duan Key Laboratory for Plant Diversity and Biogeography of East Asia Germplasm Bank of Wild SpeciesInstitute of Tibetan Plateau Research at KunmingKunming Institute of BotanyChinese Academy of SciencesKunmingYunnan650201China University of the Chinese Academy of Sciences Beijing100049China Laboratory of Ecology and Evolutionary Biology Yunnan UniversityKunmingYunnan650091China

Dasiphora fruticosa comprises male,female and hermaphrodite plants,which are distributed sympatrically in some populations on the Qinghai-Tibet *** explore what governs the coexistence of these three sexual phenotypes,we investigated the DNA contents,pollen and ovule production,pollen deposition,and performed hand-pollination in both hermaphroditic and dioecious individuals of *** cytometry confirmed that the DNA content of males and females were almost twice as much as that of the *** and female flowers produced more pollen grains and ovules than hermaphroditic ***-pollinated treatments showed that unisexual flowers were sterile in one sexual function and bisexual flowers were fertile for both functions,but no sterile seeds were produced between unisexual and bisexual *** findings imply that polyploidy is related to gender dimorphism,and both are likely to play a strong role in the coexistence of two cryptic biological species of ***(low ploidy hermaphroditic species and high ploidy dioecious species)in the Qinghai-Tibet Plateau.

关键词： Gender polymorphism Dioecy Dasiphora fruticosa Polyploidy Reproductive isolation

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：