检索结果-南通市图书馆

Activatable chemiluminescence probe based on four-arm PEGconjugated-pyropheophorbide-a for in vivo autofluorescence-free imaging of peroxynitrite

在线全文

学校读者我要写书评

暂无评论

Science China Chemistry 2025年

作者： Jianmei Ke Lei Ding Ronggui Lian Cheng Zheng Wenjun Li Aixian Zheng Yupeng Sun ming Wu yongyi Zeng Xiaolong Liu Maochun Hong Xiaolong zhang The United Innovation of Mengchao Hepatobiliary Technology Key Laboratory of Fujian Province Mengchao Hepatobiliary Hospital of Fujian Medical University Ganjiang Innovation Academy Chinese Academy of Sciences School of Rare Earths University of Science and Technology of China College of Chemistry Fuzhou University State Key Laboratory of Structure Chemistry Fujian Institute of Research on the Structure of Matter Chinese Academy of Sciences

Peroxynitrite（ONOO-） is a highly reactive nitrogen species that plays pivotal roles in cell signal transduction and physiological or pathological progresses. However, commonly used ONOO-optical imaging probes are still hampered by high background/autofluorescence（fluorescence probe）, short emission wavelength, or poor selectivity in the case of chemiluminescence. Herein,we report a facile method to prepare an activatable chemiluminescence probe（PPA-PEG） with good biocompatibility and functionality for in vivo autofluorescence-free imaging of ONOO-. The PPA-PEG consists of pyropheophorbide-a（PPA）, a typical deep red photosensitizer that acts as both the recognition and signaling element, and 4-arm poly（ethylene glycol）(4-arm PEG), which improves the biosafety and water solubility of probe. These components can self-assemble into nanoparticles（namely PPA-PEG nanoprobe） in aqueous solution. The PPA-PEG nanoprobe showed an ultra-low chemiluminescence signal before interacting with ONOO-, but exhibited good selectivity, high sensitivity and a fast response toward ONOO-. The PPAPEG was successfully applied to image cellular ONOO-changes, as well as the endogenous ONOO-changes in inflammation models and subcutaneous or orthotopic hepatocellular carcinoma（HCC） tumors models in living mice. In vitro and in vivo studies verified the good detection and imaging capabilities of PPA-PEG for peroxynitrite, demonstrating suitable tissue penetration and a high signal-to-background ratio（SBR）. Thus, our nanoprobe can serve as a valuable activatable chemiluminescence imaging tool for studying important peroxynitrite-related chemical and biological applications.

关键词：

早期非小细胞肺癌前哨淋巴结微转移检测的应用研究

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

中华肿瘤防治杂志 2016年第24期23卷 1623-1627页

作者：宋平平贾慧李广旭刘希斌郝少雨张为迪张永明张百江山东大学附属山东省肿瘤医院胸外科山东省医学科学院山东济南250117 山东大学附属山东省肿瘤医院内科山东省医学科学院山东济南250117 德州市第二人民医院胸外科山东德州253000

目的目前,尚无检测技术可准确判断肺癌前哨淋巴结（sentinel lymph node,SLN）微转移。本研究探讨CK19和MAGE-A3表达与非小细胞肺癌（non-small cell lung cancer,NSCLC）SLN微转移的相关性及临床价值。方法选择山东大学附属山东省肿瘤... 详细信息

目的目前,尚无检测技术可准确判断肺癌前哨淋巴结（sentinel lymph node,SLN）微转移。本研究探讨CK19和MAGE-A3表达与非小细胞肺癌（non-small cell lung cancer,NSCLC）SLN微转移的相关性及临床价值。方法选择山东大学附属山东省肿瘤医院胸外科32例接受手术治疗的临床Ⅰ~ⅡA期NSCLC患者,术中联合应用染色法（异舒泛蓝溶液）和放射同位素法（99 Tc硫胶体检测）找寻SLN,并采用免疫组化技术检测SLN及非前哨淋巴结（non-sentinel lymph node,non-SLN）中CK19和MAGE-A3抗体的表达。结果 32例患者均检测出SLN,共清除淋巴结598枚,其中SLN 103枚,non-SLN 495枚。平均每例患者清除淋巴结（18.69±8.13）枚,清除SLN（3.22±1.74）枚。免疫组化法检测到20例患者44枚SLN中CK19表达阳性,19例患者31枚SLN中MAGE-A3抗体表达阳性。SLN免疫组化检查阳性率为42.72%,明显高于常规HE染色的阳性率（25.24%）,P=0.01。SLN的阳性表达率与临床病理分期有关,P〈0.05;而与性别、年龄、肿瘤部位、分化程度、肿瘤大小和肿瘤类型无关,P〉0.05。结论 CK19和MAGE-A3是判断淋巴结微转移较好的分子标志物,通过免疫组化技术检测SLN中CK19和MAGE-A3表达有助于评估区域淋巴结微转移状况。

关键词：肺肿瘤前哨淋巴结微转移细胞角蛋白19片段黑色素瘤抗原基因A3

Electro-optic tuning in ferroelectric capacitor with photonic crystal nanobeam cavity

在线全文

学校读者我要写书评

暂无评论

Science China(Information Sciences) 2025年

作者： Tongtong WANG yong zhang Danyang YAO Zhi JIANG Dongxin TAN Jie WEN Qiyu YANG Xuetao GAN Yan LIU Yue HAO Genquan HAN State Key Discipline Laboratory of Wide Band Gap Semiconductor Technology School of MicroelectronicsXidian University Key Laboratory of Light Field Manipulation and Information Acquisition Ministry of Industry and Information TechnologyShaanxi Key Laboratory of Optical Information Technology School of Physical Science and TechnologyNorthwestern Polytechnical University Hangzhou Institute of Technology Xidian University

Silicon photonics has provided a platform for the convergency of photonic devices and electronic circuits, facilitating the development of optical telecommunications and optical interconnects on chip[1]. As the basic building block of optical communication systems, electro-optic tuning is expected to be more compact, high bandwidth, energy efficient, and allow for CMOS-compatible fabrication in the future[2]. Resonator-based electro-optic tuning has attracted more and more interest due to the small footprint, enhanced light-matter interactions and high energy efficiency. Compared with microring and microdisk resonators, photonic crystal nanobeam cavities （PCNBCs） realize higher quality factors, stronger light-matter interactions, ultrasmall mode volume and a much larger free spectral range （FSR）[3].

关键词：

STUDY AND APPLICATION OF STEADY FLOW AND UNSTEADY FLOW MATHEMATICAL MODEL FOR CHANNEL NETWORKS

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Journal of Hydrodynamics 2007年第5期19卷 572-578页

作者： zhang ming-liang SHEN yong-ming State Key Laboratory of Coastal and Offshore Engineering Dalian University of Technology Dalian 116024 China

Based on the Preissmann implicit scheme for the one-dimensional Saint-Venant equation, the mathematical model for one-dimensional fiver networks and canal networks was developed and the key issues on the model were expatiated particularly in this article. This model applies the method of three-steps solution for chaunel-junction-channel to simulate the river networks, and the Gauss elimination method was used to calculate the sparse matrix. This model was applied to simulate the tree-type irrigation canal networks, complex looped channel networks and the Lower Columbia Slough networks. The results of water level and discharge agree with the data from the Adlul and field data. The model is proved to be robust for simulating unsteady flows in river networks with various degrees of complex structure. The calculated results show that this model is useful for engineering applications in complicated river networks. Future research was recommended to focus on setting up ecological numerical model of water quality in river networks and canal networks.

关键词： Preissmann implicit scheme canal networks and river networks unsteady flow ecological numerical model

Selective Deoxygenation of Nitrones Mediated by Sm/CoCl_26H_2O Reductive System

在线全文

学校读者我要写书评

暂无评论

Chinese Chemical Letters 2001年第11期12卷 945-946页

作者： Ji ming zhang yong Min zhang Department of Chemistry Zhejiang University(Xixi Campus)Hangzhou 310028 State Key Laboratory of Organometallic Chemistry Shanghai Institute of Organic ChemistryChinese Academy of SciencesShanghai 200032

In the presence of metallic samariumcobalt (II) chloride hexahydrate, the nitrones can be reduced to the corresponding imines in moderate to high yields under mild and neutral conditions.

关键词： Nitrone samarium cobalt (II) chloride hexahydrate.

在线全文

学校读者我要写书评

暂无评论

侵犯商业秘密罪评价标准的修正与规范解读

海南大学学报（人文社会科学版） 2025年第1期43卷 185-194页

作者：冯明昱张勇南京师范大学法学院江苏南京210023 华东政法大学刑事法学院上海200042

《刑法修正案(十一)》完成了侵犯商业秘密罪由数额犯到情节犯的全面转型,但未跟进更新的司法解释易使得司法实务将情节犯作数额犯化处理,仅关注数额要素对于犯罪评价的影响。侵犯商业秘密罪所保护的是复合法益:一是商业秘密权利人对商... 详细信息

《刑法修正案(十一)》完成了侵犯商业秘密罪由数额犯到情节犯的全面转型,但未跟进更新的司法解释易使得司法实务将情节犯作数额犯化处理,仅关注数额要素对于犯罪评价的影响。侵犯商业秘密罪所保护的是复合法益:一是商业秘密权利人对商业秘密享有的私权利,二是市场竞争秩序,后者又可还原为具体的个人法益——商业秘密权。以此为逻辑起点,侵犯商业秘密罪的评价体系应当坚持区分性、形式与实质相统一、强保护的原则,建构综合评价体系。各要素不可单独作为入罪标准,而应综合考量,建构起以数额要素为主,非数额要素为辅的“情节严重”解释体系。

关键词：侵犯商业秘密罪情节犯数额犯

Heterointerface Engineering-Induced Oxygen Defects for the Manganese Dissolution Inhibition in Aqueous Zinc Ion Batteries

同方期刊数据库博看期刊评论

在线全文

学校读者我要写书评

暂无评论

Energy & Environmental Materials 2024年第3期7卷 112-122页

作者： Wentao Qu yong Cai Baohui Chen ming zhang Hunan Provincial Key Laboratory of Low-Dimensional Structural Physics&Devices School of Physics and ElectronicsHunan UniversityChangsha 410082China Engineering Research Center of Advanced Semiconductor Technology and Application of Ministry of Education&Key Laboratory for Micro-/Nano-Optoelectronic Devices of Ministry of Education College of Semiconductors(College of Integrated Circuits)Hunan UniversityChangsha 410082China Changsha Semiconductor Technology and Application Innovation Research Institute College of Semiconductors(College of Integrated Circuits)Hunan UniversityChangsha 410082China State Key Laboratory of Disaster Prevention&Reduction for Power Grid Transmission and Distribution Equipment(Hunan Electric Power Corporation Disaster Prevention and Reduction Center) Changsha 410007China

Manganese-based material is a prospective cathode material for aqueous zinc ion batteries(ZIBs)by virtue of its high theoretical capacity,high operating voltage,and low ***,the manganese dissolution during the electrochemical reaction causes its electrochemical cycling stability to be *** this work,heterointerface engineering-induced oxygen defects are introduced into heterostructure MnO_(2)(δa-MnO_(2))by in situ electrochemical activation to inhibit manganese dissolution for aqueous zinc ion ***,the heterointerface between the disordered amorphous and the crystalline MnO_(2)ofδa-MnO_(2)is decisive for the formation of oxygen *** the experimental results indicate that the manganese dissolution ofδa-MnO_(2)is considerably inhibited during the charge/discharge *** analysis indicates that the oxygen defect regulates the electronic and band structure and the Mn-O bonding state of the electrode material,thereby promoting electron transport kinetics as well as inhibiting Mn ***,the capacity ofδa-MnO_(2)does not degrade after 100 cycles at a current density of 0.5 Ag^(-1)and also 91%capacity retention after 500cycles at 1 Ag^(-1).This study provides a promising insight into the development of high-performance manganese-based cathode materials through a facile and low-cost strategy.

关键词： electrochemical activation heterointerface manganese dissolution inhibition oxygen defects zinc ion batteries

Material removal mechanisms and characteristics of potassium dihydrogen phosphate crystals under nanoscratching

在线全文

学校读者我要写书评

暂无评论

Advances in Manufacturing 2021年第4期9卷 558-567页

作者： Ning Hou yong zhang Liang-Chi zhang ming-Hai Wang School of Mechatronics Engineering Shenyang Aerospace UniversityShenyang 110136People’s Republic of China Key Laboratory of Fundamental Science for National Defense of Aeronautical Digital Manufacturing Process Shenyang Aerospace UniversityShenyang 110136People’s Republic of China School of Mechatronics Engineering Harbin Institute of TechnologyHarbin 150001People’s Republic of China Department of Mechanics and Aerospace Engineering Southern University of Science and TechnologyShenzhen 518055GuangdongPeople’s Republic of China

Potassium dihydrogen phosphate(KDP)crystals are important materials in high-energy laser ***,because these crystals are brittle and soft,machining-induced defects often emerge in KDP *** study aimed to investigate the material removal mechanisms and characteristics of KDP during nanoscratching using Berkovich,spherical,and conical *** found that KDP surface layers could be removed in a ductile mode at the micro/nanoscale and that dislocation motion was one of the main removal *** characteristics are related to the stress fields generated by indenter *** spherical indenter achieved a ductile removal mode more *** lateral force of nanoscratching increased with an increase in the normal *** coefficient of friction(COF)followed the same trend as the lateral force when spherical and conical indenters were ***,the COF was independent of the normal force when using a Berkovich *** found that these COF variations could be accurately described by friction models.

关键词： Potassium dihydrogen phosphate(KDP)crystals Removal mechanism Nanoscratching Indenter geometry

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

文明叙事:习近平文化思想的方法论审视

新疆师范大学学报（哲学社会科学版） 2025年第1期46卷 34-42页

作者：张明谷生秀南京大学马克思主义学院江苏南京210023

文明是中国共产党百余年推进马克思主义中国化时代化的核心线索,文明叙事是中国共产党历史叙事的重要维度,也是习近平文化思想的重要方法论。习近平文化思想的深厚文明意蕴体现在四个方面:一是从历史纵深出发把握“走自己的路”的文明基... 详细信息

文明是中国共产党百余年推进马克思主义中国化时代化的核心线索,文明叙事是中国共产党历史叙事的重要维度,也是习近平文化思想的重要方法论。习近平文化思想的深厚文明意蕴体现在四个方面:一是从历史纵深出发把握“走自己的路”的文明基因,即从中华5000多年文明的历史传承中把握中国道路的来龙去脉及其内在逻辑必然;二是以“第二个结合”为根本方法,重塑发展中华文明的使命担当,不断推动建设中华民族现代文明实现传统文明的现代新生;三是坚守文明超越理念,将新文明的建构与中国式现代化的现实实践相互关联,以中国式现代化创造人类文明新形态,打破西方以资本逻辑为核心的形而上学抽象文明观的历史困境;四是坚持文明交流互鉴,推动落实全球文明倡议,构建人类文明交往新范式。

关键词：习近平文化思想文明叙事 “走自己的路” “第二个结合” 文明交流互鉴