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Berber.ne Enhances Intestinal Mucosal Barrier Function by Promoting Vitamin D receptor Activity

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Chinese Journal of Integrative Medicine 2024年第2期30卷 143-151页

作者： HUAnG yong-quan LIU Jia-lin CHEn Geng-xin SHEn Dan-ting ZHU Wang CHEn Xin-lin LIU Feng-bin HOU Qiu-ke Graduate School Guangzhou University of Chinese MedicineGuangzhou(510405)China Department of Orthopedics the Second Affiliated Hospital of Guangzhou University of Chinese MedicineGuangzhou(510006)China Department of Preventive Medicine and Health Statistics Guangzhou University of Chinese MedicineGuangzhou(510006)China Department of Gastroenterology the First Affiliated Hospital of Guangzhou University of Chinese MedicineGuangzhou(510405)China

Objective:To evaluate if berber.ne can act on vitamin D receptors(VDr)and thereby regulate the expression of tight junction proteins(TJPs)in irritable bowel syndrome-diarrhea-predominant(IBS-D)***:The newborn rats were induced into IBS-D rat model via neonatal maternal separation combined with acetic acid chemical *** modeling,the model was evaluated and rats were divided into the control group and berber.ne treatment groups(0.85,1.7 and 3.4 mg/kg,once a day for 2 weeks).The distal colon was obtained and colonic epithelial cells(CECs)were isolated and cultured after IBS-D model *** vitamin D receptor response element(VDrE)reporter gene was determined in the CECs of IBS-D rats to analyze the effect of berber.ne on the VDrE *** overexpression or silencing technology was used to analyze whether VDr plays a role in promoting intestinal barrier repair,and to determine which region of VDr plays a role in berber.ne-regulated intestinal ***:The IBS-D rat model was successfully constructed and the symptoms were improved by berber.ne in a dose-dependent manner(PrE promoter was also effectively promoted by berber.ne(Prber.ne increased the expression of TJPs in IBS-D CECs(Pr expression was significantly increased after tr.nsfection of differ.nt domains of VDr when compared to normal control and basic plasmid groups(all PrT-qPCr and Western blot results showed that compared with the blank group,expressions of occludin and zonula occludens-1 were significantly higher in VDr containing groups(all Prber.ne plus pCMV-Myc-VDr.n group exerted the highest expression levels of occludin and zonula occludens-1(Pnclusion:Berber.ne enhances intestinal mucosal barrier function of IBS-D rats by promoting VDr activity,and the main site of action is the n-terminal region of VDr.

关键词： berber.ne Chinese medicine irritable bowel syndrome-diarrhea-predominant vitamin D receptors intestinal mucosal barrier tight junction proteins

A homopolymolybdate-supported plate-like 2D cobalt network constructed from a new pyrazole-amide-pyridyl ligand: highly electrochemical activity in both capacitive performance and the detection of Cr(Ⅵ)

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Tungsten 2024年第2期6卷 422-427页

作者： Xiu-Li Wang yong-Zhen Chen Zhi-Han Chang Yu-Chun lin Jing-Yi Ma College of Chemistry and Materials Engineer.ng Bohai UniversityJinzhou 121013China Professional Technology Innovation Center of Liaoning Province for Conversion Materials of Solar Cell Jinzhou 121013China

By employing a new semi-rigid pyrazole-amide-derived bis(pyridyl)ligand[n,n'-bis(4-picolylamine)-1-hydropyrazole(4-dpap)],a new homopolymolybdate-based two-dimensional(2D)plate-like complex[Co(4-dpap)(H_(2)O)(β-Mo_(8)O_(2)6)1/2](1)has been prepared under solvothermal condition and structurally ***β-Mo_(8)anions are fi xed between the 2D metal–organic networks[Co(4-dpap)(H_(2)O)]n 2n+via hydrogen-bonding *** 1 possesses satisfactory specifi c capacitance of 1512.4 F·g^(−1)(curr.nt density:1 A·g^(−1))and good cycling stability(90.8%after 1000 cycles).Moreover,1 represents a promising amperometric sensor for measurement of Cr(Ⅵ)with low detection limit(0.042μmol·L^(−1))and high *** insertion ofβ-Mo_(8)anions between the unique 2D metal−organic networks improves the active area of polyoxometalates,which further promotes electrochemical performance.

关键词： Homopolymolybdate Metal–organic network Pyrazole-amide-derived bis(pyridyl)ligand Supercapacitor Electrochemical sensor

Optimizing theπ-Bridge of non-fuller.ne Acceptors to Suppress Dark Curr.nt in nIr Organic Photodetectors

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Chemical research in Chinese Universities 2024年第4期40卷 712-721页

作者： SHAO lin HUAnG Yijun HOnG ling XU Zishuo YAnG Xiye LIU Chunchen HUAnG Fei CAO yong State Key Laboratory of Luminescent Materials and Devices Institute of Polymer Optoelectronic Materials and DevicesSchool of Materials Science and EngineeringSouth China University of TechnologyGuangzhou510640P.R.China Lumidar Technology Co. Ltd.Guangzhou510530P.R.China

recently,the rapid development of non-fuller.ne acceptors(nFAs)has laid the foundation for performance improvements in near-infrared(nIr)organic photodetectors(OPDs).However,reducing the bandgap of nFAs to achieve str.ng absorption in the shorter-wave region usually leads to increased dark curr.nt density(J_(d))and decreased responsivity(r),severely limiting the detectivity(D*)of *** date,it remains challenging to manipulate the J_(d) of nIr-OPDs through rational structure engineer.ng of ***,three nIr.nFAs,namely bis(2-decyltetradecyl)4,4′-(2′,7′-di-tert-butylspiro[cyclopenta[2,1-b:3,4-b′]dithiophene-4,9′-fluor.ne]-2,6-diyl)bis(6-(((Z)-1-(dicyanomethylene)-5,6-difluoro-3-oxo-1,3-dihydro-2H-inden-2-ylidene)methyl)thieno[3,4-b]thiophene-2-carboxylate)(TSIC-4F),bis(2-decyltetradecyl)6,6′-(2′,7′-di-tert-butylspiro[cyclopenta[2,1-b:3,4-b′]dithiophene-4,9′-fluor.ne]-2,6-diyl)bis(4-(((Z)-1-(dicyanomethylene)-5,6-difluoro-3-oxo-1,3-dihydro-2H-inden-2-ylidene)methyl)thieno[3,4-b]thiophene-2-carboxylate)(STIC-4F),and 2,2′-((2Z,2′Z)-(((2′,7′-di-tert-butylspiro[cyclopenta[2,1-b:3,4-b′]dithiophene-4,9′-fluor.ne]-2,6-diyl)bis(2,3-bis(5-(2-butyloctyl)thiophen-2-yl)thieno[3,4-b]pyrazine-7,5-diyl))bis(metha-neylylidene))bis(5,6-difluoro-3-oxo-2,3-dihydro-1H-indene-2,1-diylidene))dimalononitrile(TPIC-4F),were designed using the thieno[3,4-b]thiophene(TT)and thieno[3,4-b]pyrazine(TPy)derivatives as theπ-*** to the intramolecular S-S and S-n interactions,STIC-4F and TPIC-4F exhibited smaller backbone distortions than TSIC-4F.A significantly red-shifted absorption with a peak at 1015 nm was observed in TPIC-4F film,larger than that(ca.960 nm)for TSIC-4F and STIC-4F ***,OPDs operating in a photovoltaic mode were successfully fabricated,and TPIC-4F-based OPDs achieved the lowest J_(d) of 3.18×10^(-8) A/cm^(2) at-0.1 ***,although TPIC-4F-based OPDs exhibited the lowest r,higher shot-noise-limited specific detectivity(D_(sh)*)in 1000-1200 nm co

关键词： π-Bridge near-infrared non-fuller.ne acceptor Dark curr.nt Organic photodetector

Differ.nt mechanisms underlie similar species-area relationships in two tropical archipelagoes

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Plant Diversity 2024年第2期46卷 238-246页

作者： Shengchun Li Tieyao Tu Shaopeng Li Xian Yang yong Zheng Liang-Dong Guo Dianxiang Zhang lin Jiang Key Laboratory of Plant resources Conservation and Sustainable Utilization South China Botanical GardenChinese Academy of SciencesGuangzhou 510650China ECnU-Alberta Joint Lab for Biodiversity Study Tiantong Forest Ecosystem National Observation and Research StationSchool of Ecological and Environmental SciencesEast China Normal UniversityShanghai 200241China School of Biological Sciences Georgia Institute of TechnologyAtlantaGA 30332USA Jiangxi Academy of Forestry Nanchang 330032China Institute of Eco-Chongming(IEC) Shanghai 202162China State Key Laboratory of Biocontrol School of EcologySun Yat-sen UniversityGuangzhou 510275China School of Geographical Sciences Fujian Normal UniversityFuzhou 350007China State Key Laboratory of Mycology Institute of MicrobiologyChinese Academy of SciencesBeijing 100101China

Despite much research in the field of island biogeography,mechanisms regulating insular diversity remain ***,we aim to explore mechanisms underlying plant species-area relationships in two tropical archipelagoes in the South China *** found positive plant species-area relationships for both coral and continental ***,our results showed that differ.nt mechanisms contributed to similar plant species-area relationships between the two *** coral islands,soil nutrients and spatial distance among communities played major roles in shaping plant community structure and species *** contrast,the direct effect of island area,and to a lesser extent,soil nutrients determined plant species richness on continental ***,increasing soil nutrients availability(n,P,K)had opposite effects on plant diversity between the two *** summary,the habitat quality effect and dispersal limitation are important for regulating plant diversity on coral islands,whereas the passive sampling effect,and to a lesser extent,the habitat quality effect are important for regulating plant diversity on continental *** generally,our findings indicate that island plant species-area relationships are outcomes of the interplay of both niche and neutral processes,but the driving mechanisms behind these relationships depends on the type of islands.

关键词： Coral and continental islands Plant diversity Soil nutrients Species-area relationships The sampling effect

Decipher.ng the high-carbonization-temperature triggered enzymatic activity of wool-derived n,S-co-doped carbon nanosheets

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Chinese Chemical Letters 2024年第3期35卷 182-188页

作者： Jiachen Zhao Deshuai Yu Jianmin Chen Shihao lin yonghua Tang Chaoyu Fan Dongfang Zhou Youhui lin Department of Physics Research Institute for Biomimetics and Soft MatterFujian Provincial Key Laboratory for Soft Functional Materials ResearchXiamen UniversityXiamen 361005China School of Pharmacy and Medical Technology Putian UniversityPutian 351100China Key Laboratory of Mental Health of the Ministry of Education NMPA Key Laboratory for Research and Evaluation of Drug Metabolism&Guangdong Provincial Key Laboratory of New Drug ScreeningSchool of Pharmaceutical SciencesSouthern Medical UniversityGuangzhou 510515China Key Laboratory of Pharmaceutical Analysis and Laboratory Medicine(Putian University) Fujian Province UniversityPutian 351100China

It is well-established that high carbonization temperature will trigger the enzyme-like activity of carbon-based ***,the catalytic mechanism is still ambiguous,which hinders the further rational design of nanomaterials as enzyme ***,n,S-rich carbonized wool nanosheets(CWs)were synthesized at differ.nt pyrolysis *** expected,only CWs treated with high-temperature possess intr.nsic oxidase-and peroxidase-like ***,density functional theory(DFT)calculations demonstrate that graphitic nitrogen and the co-existence of nitrogen and sulfur in the carbon matrix serve as the active sites for the enzyme-like *** importantly,combining theoretical calculations and experimental observations,the high-temperature triggered catalytic mechanism can be ascribed to the fact that an appropriate high-temperature maximizes the graphitization degree to a certain extent,at which most of the catalytic active sites are well retained rather than ***,coupling with excellent photothermal conversion efficiency and catalytic performance,CWs can be applied to photothermal-catalytic cancer therapy under.near-infrared region(nIr)light *** believe this work will contribute to understanding the catalytic mechanism of carbon-based nanozymes and promote the development of new biomedical and pharmaceutical applications.

关键词： Carbon-based nanozyme Catalytic mechanism Density functional theory High-temperature carbonization

Asymmetric copolyimide membr.nes fabricated by nonsolvent-induced phase separation for He/CH_(4) and He/n_(2) separation

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Fr.ntiers of Chemical Science and Engineer.ng 2024年第4期18卷 97-106页

作者： Ying Li Lu Wang Junyan Xie yong Dai Xuehong Gu Xuerui Wang State Key Laboratory of Materials-Oriented Chemical Engineer.ng College of Chemical EngineeringNanjing Tech UniversityNanjing 211816China Quzhou Membr.ne Material Innovation Institute Quzhou 324000China

Membr.ne gas separation is considered an energy-saving technique to extract He from natural gas due to no phase change and room temperature ***,the membr.ne performance was str.ngly limited by the trade-off between permeance and ***,novel 4,4′-(hexafluoroisopropylidene)diphthalic anhydride(6FDA)-2,2′-bis(3-amino-4-hydroxyphenyl)hexafluoropropane(APAF)-5-amino-2-(4-aminobenzene)benzimidazole(BIA)asymmetric membr.nes with a thickness of 300 nm were successfully prepared by the non-solvent induced phase separation *** membr.ne performance was modulated by regulating dope solution compositions(e.g.,tetrahydrofur.n and polymer concentration).The ideal He/CH_(4) selectivity was 124 and the optimized He permeance reached 87 GPU,beyond the curr.nt upper ***/CH_(4) selectivity was 75 and He permeance was 73 GPU for the binary mixture feed containing 0.2 mol%*** membr.ne showed good resistance to CO_(2) and C_(2)H_(6),which are the typical impurities in natural *** 6FDA-APAF-BIA membr.nes have good stability(>160 h),which can provide great potential in He extraction from natural gas.

关键词： He separation membr.ne natural gas copolyimide

Associations between the use of red yeast rice preparations and adverse health outcomes:An umbrella review of meta-analyses of r.ndomized controlled trials

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Journal of Integrative Medicine 2024年第2期22卷 126-136页

作者： Zhen-yu Ma Shu-ping Yang Ying Li Tian-tian Xu Ya-lin Yang Hui-yong Yang Heng-bing Li Le-jin Zhou yong Diao Su-yun Li School of Medicine Huaqiao UniversityQuanzhou 362021Fujian ProvinceChina College of Traditional Chinese Medicine Shandong University of Traditional Chinese MedicineJinan 250355Shandong ProvinceChina Second Clinical Medical College Nanjing Medical UniversityNanjing 211166Jiangsu ProvinceChina

Background:red yeast rice(rYr),a natural lipid-lower.ng agent,is widely used in clinical ***,the existing meta-analyses concerning the safety of rYr preparations have yielded inconsistent results,and the credibility of the evidence has not been ***:This study was designed to evaluate the existing evidence and offer a comprehensive understanding of the associations between the use of rYr preparations and various adverse health *** strategy:Seven literature databases were searched from inception to May 5,2023,using medical subject headings and free-text terms(e.g.,“red yeast rice,”“Xuezhikang,”and“Zhibitai”).Inclusion criteria:Meta-analyses that investigated and quantitatively estimated associations between the use of rYr preparations and adverse health outcomes were included in this *** extraction and analysis:Two researchers independently extracted data using a standardized data collection table;any disagreements were resolved by consulting a third *** on the participant,intervention,comparator and outcome(PICO)framework in each eligible meta-analysis,a series of unique associations between the use of rYr preparations and adverse health outcomes were *** associations’effect estimates were re-evaluated using r.ndom-effect ***:Fifteen meta-analyses,comprising 186(164 unique)r.ndomized controlled trials,were *** on A Mea Surement Tool to Assess Systematic reviews version 2,3(20%)and 12(80%)of these meta-analyses had low and critically low confidence,respectively.A total of 61 unique associations between the use of rYr preparations and adverse health outcomes were extracted from eligible *** on the r.ndom-effect models,10(16.4%)associations indicated a significant protective effect of rYr preparations against adverse health outcomes,while 5(8.2%)indicated an increased risk of adverse health outcomes related to uric acid,alanine tr.nsaminase and aspartate tr.ns

关键词： red yeast rice Safety Adverse health outcomes Umbrella review Meta-analysis Systematic review

Cross section determination of^(27)Al(n,2n)^(26)Al reaction induced by 14-MeV neutr.ns uniting with D-T neutr.n activation and AMS techniques

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nuclear Science and Techniques 2024年第6期35卷 78-89页

作者： Xian-lin Yang Chang-lin Lan Yu-Ting Wei Yi Zhang Gong Jiang Bo Xie Yu Liu Hong-Tao Shen Xiao-Jun Sun School of nuclear Science and Technology Lanzhou UniversityLanzhou 730000China MOE Fr.ntiers Science Center for rare Isotopes Lanzhou UniversityLanzhou 730000China State Key Laboratory of Envir.nmental Geochemistry Institute of GeochemistryChinese Academy of SciencesGuiyang 550081China Guangxi Key Laboratory of nuclear Physics and nuclear Technology Guangxi Normal UniversityGuilin 541004China

Aluminum is the primary structural material in nuclear engineer.ng,and its cross section induced by 14-MeV neutr.ns is of great *** address the issue of insufficient accuracy for the^(27)Al(n,2n)^(26)Al reaction cross section,the activation method and accelerator mass spectrometry(AMS)technique were used to determine the^(27)Al(n,2n)^(26)Al cross section,which could be used as a D-T plasma ion temperature monitor in fusion *** the China Academy of Engineer.ng Physics,neutr.n activation was performed using a K-400 neutr.n generator produced by the T(d,n)4He ***^(26)Al∕^(27)Al isotope ratios were measured using the newly installed GYIG 1 MV AMS at the Institute of Geochemistry,Chinese Academy of *** neutr.n flux was monitored by measur.ng the activity of 92mnb produced by the 93nb(n,2n)92mnb *** measured results were compared with available data in the experimental nuclear reaction database,and the measured values showed a reasonable degree of consistency with partially available literature *** newly acquired cross-sectional data at 12 neutr.n energy points through systematic measurements clarified the divergence,which has two differ.nt growth tr.nds from the existing experimental *** obtained results are also compared with the corresponding evaluated database,and the newly calculated excitation functions with TALYS−1.95 and EMPIrE−3.2 codes,the agreement with CEnDL−3.2,TEnDL-2021 and EMPIrE−3.2 results are generally acceptable.A substantial improvement in the knowledge of the^(27)Al(n,2n)^(26)Al reaction excitation function was obtained in the present work,which will lay the foundation for the diagnosis of the fusion ion temperature,testing of the nuclear physics model,evaluation of nuclear data,etc.

关键词： 14-MeV neutr.n ^(27)Al(n,2n)^(26)Al Cross section AMS

Astrophysical S-factor and reaction rate for 15n(p,γ)16O within the modified potential cluster model

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Chinese Physics C 2024年第4期48卷 130-145页

作者： S.B.Dubovichenko A.S.Tkachenko r.Ya.Kezerashvili n.A.Burkova B.M.Yeleusheva Fesenkov Astrophysical Institute 050020 AlmatyKazakhstan new York City College of Technology City University of New YorkBrooklyn11201 New YorkUSA Graduate School and University Center City University of New York10016 New YorkUSA al-Farabi Kazakh national University 050040 AlmatyKazakhstan

We study radiative p^(15)n capture on the ground state of ^(16)O at stellar energies within the framework of a modified potential cluster model(MPCM)with forbidden states,including low-lying *** investigation of the ^(15)n(p,γ0)^(16)O reaction includes the consideration of ^(3)S_(1) resonances due to E1 tr.nsitions and the contribution of the ^(3)P_(1) scatter.ng wave in the p+^(15)n channel due to the ^(3)P_(1)→^(3)P_(0)M1 *** calculated the astrophysical low-energy S-factor,and the extrapolated S(0)turned out to be within 34.7−40.4 keV·*** important role of the asymptotic constant(AC)for the ^(15)n(p,γ0)16O process with interfer.ng ^(3)S_(1)(312)and ^(3)S_(1)(962)resonances is elucidated.A comparison of our calculation for the S-factor with existing experimental and theoretical data is addressed,and a reasonable agreement is *** reaction rate is calculated and compared with the existing *** has negligible dependence on the variation of AC but shows a str.ng impact of the interfer.nce of ^(3)S_(1)(312)and ^(3)S_(1)(962)resonances in refer.nce to the CnO Gamow windows,especially at low *** estimate the contribution of cascade tr.nsitions to the reaction rate based on the exclusive experimental data from ***.C.85,065810(2012).The reaction rate enhancement due to the cascade tr.nsitions is observed from T_(9)>0.3 and reaches the maximum factor~1.3 at T_(9)=*** present the Gamow energy window and a comparison of rates for radiative proton capture reactions ^(12)n(p,γ)^(13)O,^(13)n(p,γ)^(14)O,^(14)n(p,γ)^(15)O,and ^(15)n(p,γ)^(16)O obtained in the framework of the MPCM and provide the temperature windows,prevalence,and significance of each process.

关键词： low and astrophysical energies p^(15)n system thermonuclear reaction rate potential cluster model CnO-cycle