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Association of iodized salt with goiter prevalence in Chinese populations: a continuity analysis over time

Military Medical Research 2017年第3期4卷 149-156页

作者： Zhen Liang Chen Xu yong-jun luo Department of Military Medical Geography College of High Altitude Military Medicine Third Military Medical University Battalion 5 of Cadet Brigade Third Military Medical University Key Laboratory of High Altitude Medicine of PLA Third Military Medical University

Background: Iodine deficiency disorders(IDD) refer to diseases that are caused by insufficient iodine intake, and the best strategy to prevent IDD is the addition of iodine to dietary salt. Because iodine deficiency is a common cause of goiter, the prevalence as effectively controlled after the implementation of universal salt iodization(USI) in China. However, there is substantial controversy as to whether the incidence of thyroid disorders is related to iodized salt intake. Therefore, we aimed to clarify whether the risk of goiter can be promoted by ***: A longitudinal continuous study based on the national monitoring results of IDD in China was performed for 3 consecutive years. We recorded the following indicators of IDD from 31 provinces: goiter number, two degrees of goiter(the degree of goiter severity) and cretinism(three endemic diseases), iodized salt intake, median urinary iodine concentration(UIC), soil iodine content and coverage rates of iodized salt. One-way Analysis of Variance(ANOVA) and linear regression analyses examined the differences between the three groups and correlations, respectively. Data were collected from the Chinese national IDD surveillance data in 2011-2013, and the background values of Chinese soil elements were published in ***: A reference male's daily intake of maximum iodine was 378.9μg, 379.2μg and 366.9μg in 2011, 2012, and 2013, respectively. No statistical association between daily iodized salt intake and the three endemic diseases was observed in 2011-2013(P >0.05). No association was observed between daily iodized salt intake and the UIC of children in 2011(P>0.05). Linear regression revealed no significant correlation between the soil iodine content and three endemic diseases. The present study indicated no difference in the daily iodized salt intake in each province during three years(F=0.886, P=0.647). The coverage rate of iodized salt remained above 98.7%, and goiter rates were stable in ***

关键词： Iodine deficiency disorders(IDD) Iodized salt China

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Association between acute mountain sickness(AMS) and age: a meta-analysis

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Military Medical Research 2019年第1期6卷 31-38页

作者： Yu Wu Chi Zhang Yu Chen yong-jun luo Department of Military Medical Geography Army Medical Service Training Base Army Medical University Battalion 5 of Cadet Brigade Army Medical University Key Laboratory of High Altitude Environmental Medicine of PLA Army Medical University

Background: Acute mountain sickness(AMS) is a potentially lethal condition caused by acute hypoxia after ascending to altitudes higher than 2500 m in a short time. The main symptom of AMS is headache. Numerous risk factors of AMS have been examined, including gender, obesity, ascent rate, age and individual susceptibility. In previous studies, age was considered a predisposing factor for AMS. However, different opinions have been raised in recent years. To clarify the association between AMS and age, we conducted this ***: We obtained observational studies that explored risk factors for AMS by searching PubMed, Embase, China National Knowledge Internet(CNKI), the Wanfang database and CQVIP for articles published before March *** studies included were required to provide the mean age and its standard deviation for subjects with and without AMS, the maximum altitude attained and the mode of ascent. The Lake Louse Score(LLS) or the Chinese AMS score(CAS) was used to judge the severity of AMS symptoms and incidence. Studies were pooled for the analysis by using a random effects model in RevMan 5.0. Meta-regression and subgroup analyses were conducted to identify sources of heterogeneity using Stata 14.2 and RevMan ***: In total, 17 studies were included, and the overall number of subjects with and without AMS was 1810 and3014, respectively. The age ranged from 10 to 76 years. Analysis of the 17 included studies showed that age was not associated with AMS(mean difference(MD)=0.10; 95%CI: —0.38-0.58; P=0.69).Conclusions: This meta-analysis suggests that there is no association between age and the risk of AMS. Race, age,and ascent mode are common sources of heterogeneity, which may provide an analytical orientation for future heterogeneity analyses.

关键词： Meta-analysis Age Acute mountain sickness Individual susceptibility

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Association between medical resources and the proportion of oldest-old in the Chinese population

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Military Medical Research 2021年第4期8卷 587-589页

作者： Chao Tan Cai-Zhi Tang Xing-Shu Chen yong-jun luo Department of Military Medical Geography Army Medical Service Training BaseArmy Medical UniversityChongqing 400038China

The potential association between medical resources and the proportion of oldest-old(90 years of age and above)in the Chinese population was examined,and we found that the higher proportion of oldest-old was associate... 详细信息

关键词： Longevity Gross domestic product Medical resource Air pollution index Oldest-old

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Sex-based differences in the prevalence of acute mountain sickness: a meta-analysis

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Military Medical Research 2020年第2期7卷 228-238页

作者： Yun-Peng Hou Jia-Lin Wu Chao Tan Yu Chen Rui Guo yong-jun luo Department of Military Medical Geography Army Medical Service Training BaseArmy Medical UniversityChongqing 400038China

Background:When lowlanders rapidly ascend to altitudes>2500 m,they may develop acute mountain sickness(AMS).The individual susceptibility,ascending velocity,time spent at altitude,activity levels and altitude reached are considered risk factors for ***,it is not clear whether sex is a risk *** results have been *** conducted a meta-analysis to test whether there were sex-based differences in the prevalence of AMS using Lake Louise Scoring ***:Systematic searches were performed in August 2019 in EMBASE,PubMed,and Web of Science for prospective studies with AMS data for men and *** titles and abstracts were independently checked in the primary screening step,and the selected full-text articles were independently assessed in the secondary screening step by the two authors(YPH and JLW)based on pre-defined inclusion *** meta-analysis was performed using by the STATA 14.1 software program.A random-effects model was ***:Eighteen eligible prospective studies were included.A total of 7669 participants(2639[34.4%]women)were *** results showed that there was a statistically significant higher prevalence rate of AMS in women than in men(RR=1.24,95%CI 1.09–1.41),regardless of age or ***,the heterogeneity was significant in the analysis(Tau2=0.0403,Chi2=50.15,df=17;I2=66.1%,P=0.000),it was main caused by different numbers of subjects among the studies(coefficient=–2.17,P=0.049).Besides,the results showed that there was no evidence of significant publication bias in the combined studies on the basis of Egger’s test(bias coefficient=1.48,P=0.052)and Begg’s test(P=0.130).Conclusions:According to this study,the statistically significant finding emerging from this study was that women have a higher prevalence of ***,the authors could not exclude studies where patients were on *** analysis provided a direction for future studies of the relationship of sex and the risk of AMS,such as

关键词： Prevalence Sex differences Acute mountain sickness Risk factors

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Association between endothelial nitric oxide synthase(ENOS) G894T polymorphism and high altitude(HA) adaptation： a meta-analysis

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中国应用生理学杂志 2015年第6期31卷 517-523页

作者： Hong-xiang LU Yu-xiao WANG Yu CHEN yong-jun luo Department of Military Medical Geography College of High Altitude Military Medicine the Third Military Medical University Chongqing 400038 China Battalion 5 of Cadet Brigade the Third Military Medical University Chongqing 400038 China Key Laboratory of High Altitude Medicine (Ministry of Education) the Third Military Medical University Chongqing 400038 China

Objective: Highland natives adapt well to the hypoxic environment at high altitude(HA). Several genes have been reported to be linked to HA adaptation. Previous studies showed that the endothelial nitric oxide synthase(ENOS) G894 T polymorphism contributed to the physiology and pathophysiology of humans at HA by regulating the production of NO. In this meta-analysis, we evaluate the association between the ENOS G894 T polymorphism and HA adaptation through analyzing the published data. Methods: We searched all relevant literature about the ENOS G894 T polymorphism and HA adaptation in Pub Med, Medline, and Embase before Step 2015. A random-effects model was applied(Revman 5.0), and study quality was assessed in duplicate. Six studies with 634 HA native cases and 621 low-altitude controls were included in this meta-analysis. Results: From the results, we observed that the wild-type allele G was significantly overrepresented in the HA groups(OR=1.85; 95% CI, 1.47–2.33; P<0.0001). In addition, the GG genotype was significantly associated with HA adaptation(OR=1.99; 95% CI, 1.54–2.57; P<0.0001). Conclusion: Our results showed that in 894 G allele carriers, the GG genotype might be a beneficial factor for HA adaptation through enhancing the level of NO. However, more studies were needed to confirm our findings due to the limited sample size.

关键词：内皮型一氧化氮合酶 eNOS 多态性 HA 高海拔高原低氧环境 MEDLINE 病理生理学

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Mutual regulation between microRNA-373 and methyl-CpGbinding domain protein 2 in hilar cholangiocarcinoma

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World Journal of Gastroenterology 2012年第29期18卷 3849-3861页

作者： yong-jun Chen Jian luo Guang-Yao Yang Kang Yang Song-Qi Wen Sheng-Quan Zou Department of Biliary-pancreatic Surgery Tongji Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan 430030 Hubei Province China

AIM:To investigate the reciprocal modulation between microRNA(miRNA) and DNA methylation via exploring the correlation between miR-373 and methyl-CpGbinding domain protein(MBD)***:MiR-373 expression was examined using the TaqMan miRNA *** of miR-373 was investigated using methylation-specific polymerase chain reaction,and recruitment of methyl binding proteins was studied using the chromatin immunoprecipitation *** analysis was conducted using the QuikChange Site-Directed Mutagenesis *** activity of miR-373 gene promoter constructs and targeting at MBD2-three prime untranslated region(3'UTR) by miR-373 were evaluated by a dual-luciferase reporter gene ***:In hilar cholangiocarcinoma,miR-373 decreased and was closely associated with poor cell differentiation,advanced clinical stage,and shorter *** promoter-associated CpG island of miR-373 gene was hypermethylated and inhibited expression of ***2 was up-regulated and enriched at the promoter-associated CpG island of ***-mediated suppression of miR-373 required MBD2 enrichment at the promoter-associated CpG island,and miR-373 negatively regulated MBD2 expression through targeting the 3'***:MiR-373 behaves as a direct transcriptional target and negative regulator of MBD2 activity through a feedback loop of CpG island methylation.

关键词： MicroRNA-373 Methyl-CpG binding domain proteins 2 Methylation Hilar cholangiocarcinoma Three prime untranslated region

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Microstructure evolution of Ti_(48)Zr_(27)Cu_(6)Nb_(5)Be_(14)amorphous alloy after semi-solid isothermal treatment

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China Foundry 2024年第3期21卷 287-294页

作者： Xin-hua Huang Jing-wen Pu yong-xin luo Yue-jun Ouyang School of Material Electricity and Intelligent ManufacturingHuaihua UniversityHuaihua 330031HunanChina Hunan Renewable Aluminum Innovation Research Center Huaihua UniversityHuaihua 330031HunanChina

The as-cast amorphous Ti_(48)Zr_(27)Cu_(6)Nb_(5)Be_(14)composites,comprising in situ formedβ-Ti ductile crystalline precipitates,were prepared by water cooled copper mold suction ***,the semi-solid composites were obtained after the as-cast composites were treated by semi-solid isothermal *** microstructure evolution and kinetics of the composites were *** show that the microstructures of both the as-cast and semi-solid composites comprise ofβ-Ti crystal phases and amorphous matrix *** and after treatment,the crystals evolve from fine granular or fine dendritic crystals to coarse *** the treatment temperature increasing or the time prolonging,the average crystal size gradually increases and the surface morphology of the crystals gradually becomes *** studying the microstructural evolution and dynamics during the isothermal treatment process,it is found that the final morphology ofβ-Ti crystals is influenced by the isothermal treatment temperature and time(t),and theβ-Ti evolution rate increases with an increase in treatment *** addition,a linear relationship was observed between the size of cubicβ-Ti crystals(D^(3))and t;the growth kinetics factor K is 3.8μm^(3)·s^(-1).As the K value closes to 4μm^(3)·s^(-1),it is inferred the morphology evolution ofβ-Ti crystals is a coarsening behavior controlled by the diffusion of solute elements.

关键词： Ti_(48)Zr_(27)Cu_(6)Nb_(5)Be_(14) amorphous matrix composites semi-solid as-cast microstructure

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Over-starvation aggravates intestinal injury and promotes bacterial and endotoxin translocation under high-altitude hypoxic environment

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World Journal of Gastroenterology 2011年第12期17卷 1584-1593页

作者： Qi-Quan Zhou Ding-Zhou Yang yong-jun luo Su-Zhi Li Fu-Yu Liu Guan-Song Wang Department of High Altitude Disease College of High Altitude Military MedicineThird Military Medical UniversityChongqing 400038China Key Laboratory of High Altitude Medicine Ministry of EducationThird Military Medical universityChongqing 400038China Research Center of Mountain Sickness General Hospital of Tibetan Military Area CommandLhasa 850007Tibet Autonomous RegionChina Institute of Respiratory Diseases Xinqiao HospitalThird Military Medical UniversityChongqing 400037China

AIM:To study whether over-starvation aggravates intestinal mucosal injury and promotes bacterial and endotoxin translocation in a high-altitude hypoxic ***:Sprague-Dawley rats were exposed to hy-pobaric hypoxia at a simulated altitude of 7000 m for 72 *** nitrate was used as a tracer to detect intestinal *** apoptosis was observed with terminal deoxynucleotidyl transferase dUTP nick end labeling *** levels of diamino oxidase(DAO),malondialdehyde(MDA),glutamine(Gln),superoxide dismutase(SOD) and endotoxin were measured in intestinal *** translocation was detected in blood culture and intestinal *** addition,rats were given Gln intragastrically to observe its protective effect on intestinal ***:Apoptotic epithelial cells,exfoliated villi and inflammatory cells in intestine were increased with edema in the lamina propria accompanying effusion of red blood *** particles were found in the intercellular space and intracellular *** translocation to mesenteric lymph nodes(MLN) and spleen was *** serum endotoxin,DAO and MDA levels were significantly higher while the serum SOD,DAO and Gln levels were lower in intestine(P< 0.05).The bacterial translocation number was lower in the high altitude hypoxic group than in the high altitude starvation group(0.47±0.83 vs 2.38±1.45,P<0.05).The bacterial translocation was found in each organ,especially in MLN and spleen but not in peripheral *** bacterial and endotoxin translocations were both markedly improved in rats after treatment with ***:High-altitude hypoxia and starvation cause severe intestinal mucosal injury and increase bacterial and endotoxin translocation,which can be treated with Gln.

关键词： High altitude Hypoxia Starvation Intestinal mucosal injury Bacterial translocation Endotoxin Glutamine

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Glucose-sensitive Membrane with PBA-based Contraction-type Linear Polymer as Chemical Valves Prepared by Surface Grafting

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Chinese Journal of Polymer Science 2024年第8期42卷 1067-1076页

作者： Chun-Peng Zhang Si-Jia Gao Ying luo Lei Zou yong-jun Zhang State Key Laboratory of Separation Membranes and Membrane Processes School of Material Science and EngineeringTiangong UniversityTianjin 300387China State Key Laboratory of Separation Membranes and Membrane Processes School of Pharmaceutical SciencesTiangong UniversityTianjin 300387China Tianjin Key Laboratory of Extracorporeal Life Support for Critical Diseases Institute of Hepatobiliary DiseaseNankai University Affiliated Third Center HospitalTianjin 300170China Cangzhou Institute of Tiangong University Cangzhou 061000China

Glucose-sensitive membrane has potential application in self-regulating insulin *** acid(PBA)is a well-known glucose ***,most PBA-based glucose-sensitive materials are expansion-type,which are not suitable as chemical valves in membrane pores for self-regulating insulin *** to a new glucose-sensitive mechanism,we synthesized PBA-based contraction-type glucose-sensitive liner polymer and ***,a glucose-sensitive membrane was prepared by grafting PBA-based contraction-type glucose-sensitive linear polymer on the membrane *** adjusting the chain length and chain density,the glucose-sensitivity of the membrane was *** membrane can reversibly regulate insulin release at physiologically relevant glucose concentrations in simulates body fluids and fetal bovine *** membrane also has good stability,anti-fouling and biocom *** has potential application in selfregulating insulin release.

关键词： Phenylboronic acid Glucose-sensitive Membrane Surface grafting Insulin

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Structural engineering of hard carbon through spark plasma sintering for enhanced sodium-ion storage

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Rare Metals 2024年第9期43卷 4274-4285页

作者： Hao-Ming Xiao Heng Zheng Ping Yuan jun-Hui luo Lin-Lin Shen Jie-Feng Tan Xian-You luo De Li yong Chen Guangdong Key Laboratory for Hydrogen Energy Technologies School of Materials Science and Hydrogen EnergyFoshan UniversityFoshan 528000China State Key Laboratory of Marine Resource Utilization in South China Sea Hainan Provincial Key Laboratory of Research on Utilization of Si-Zr-Ti ResourcesHainan UniversityHaikou 570228China

Hard carbon(HC)has emerged as one of the superior anode materials for sodium-ion batteries(SIBs),with its electrochemical performance significantly influenced by the presence of oxygen functional groups and its closed pore ***,current research on the structural adjustment of these oxygen functional groups and the closed pore architecture within HC remains ***,energy-efficient and contamination-free spark plasma sintering technology was employed to tune the structure of coconut-shell HC,resulting in significant adjustments to the content of carboxyl(decreasing from 5.71 at%to 2.12 at%)and hydroxyl groups(decreasing from 7.73 at%to 6.26 at%).Crucially,these modifications reduced the irreversible reaction of oxygen functional groups with Na^(+).Simultaneously,a substantial number of closed pores with an average diameter of 1.22 nm were generated within the HC,offering an ideal environment for efficient Na^(+)*** structural changes resulted in a remarkable improvement in the electrochemical performance of the modified *** reversible specific capacity of the modified HC surged from 73.89 mAh·g^(-1)to an impressive 251.97 m Ah·g^(-1)at a current density of 50 mA·g^(-1).Even at 400 mA·g^(-1),the reversible specific capacity increased significantly from 14.55 to 85.44 mAh·g^(-1).Hence,this study provides a novel perspective for designing tailored HC materials with the potential to develop high-performance SIBs.

关键词： Hard carbon Spark plasma sintering Sodiumion batteries Closed pores Oxygen functional groups

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