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Neural Regeneration Research 2016年第8期11卷 1260-1266页

作者： Guo-zhu Sun Fen-fei Gao Zong-mao Zhao Hai Sun Wei Xu Li-wei Wu yong-chang he Department of Neurosurgery Second Hospital of Hebei Medical UniversityShijiazhuangHebei ProvinceChina Department of Pharmacology Shantou University Medical CollegeShantouGuangdong ProvinceChina Division of Neurological Surgery Barrow Neurological InstituteSt Joseph's Hospital and Medical CenterPhoenixAZUSA

Neuronal apoptosis is mediated by intrinsic and extrinsic signaling pathways such as the membrane-mediated,mitochondrial,and endoplasmic reticulum stress *** studies have examined the endoplasmic reticulum-mediated apoptosis pathway in the penumbra after traumatic brain injury,and it remains unclear whether endoplasmic reticulum stress can activate the caspase-12-dependent apoptotic pathway in the traumatic ***,we established rat models of fluid percussion-induced traumatic brain injury and found that protein expression of caspase-12,caspase-3 and the endoplasmic reticulum stress marker 78 k Da glucose-regulated protein increased in the traumatic penumbra 6 hours after injury and peaked at 24 ***,numbers of terminal deoxynucleotidyl transferase-mediated d UTP nick end labeling-positive cells in the traumatic penumbra also reached peak levels 24 hours after *** findings suggest that caspase-12-mediated endoplasmic reticulum-related apoptosis is activated in the traumatic penumbra,and may play an important role in the pathophysiology of secondary brain injury.

关键词： nerve regeneration endoplasmic reticulum stress apoptosis caspase-12 caspase-3 traumatic penumbra traumatic brain injury neural regeneration

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流形方法覆盖系统自动生成算法

同济大学学报（自然科学版） 2004年第5期32卷 585-590页

作者：蔡永昌朱合华夏才初同济大学地下建筑与工程系上海200092

用覆盖所有材料区域但独立于材料实际几何边界的任意形状数学网格和实际的物理网格来建立流形方法的覆盖系统 ,直接从数学覆盖和物理覆盖的定义出发 ,探讨了流形方法覆盖系统的全自动生成技术 ,并用VisioC ++及其标准类库实现了流形单元... 详细信息

用覆盖所有材料区域但独立于材料实际几何边界的任意形状数学网格和实际的物理网格来建立流形方法的覆盖系统 ,直接从数学覆盖和物理覆盖的定义出发 ,探讨了流形方法覆盖系统的全自动生成技术 ,并用VisioC ++及其标准类库实现了流形单元和 2套覆盖的自动形成和编号 .

关键词：流形方法数学覆盖物理覆盖网格

电子皮带秤在高速公路稳定层自动配料系统中的应用

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衡器 2011年第5期40卷 11-14页

作者：常永和南京理工天品自控设备有限公司

本文讨论了电子皮带秤在高速公路稳定层自动配料系统中的应用状况,指出通过该系统的应用,大大改善了高速公路稳定层的自动配料精度、提高了高速公路的施工质量,获得了较好的经济效益。

关键词：电子皮带秤公路稳定层自动配料应用

Recent progress in constructing fluorinated solid-electrolyte interphases for stable lithium metal anodes

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International Journal of Minerals,Metallurgy and Materials 2025年第2期32卷 270-291页

作者： Di Zhang Pengfei Lv Wei Qin Xin he Yuanhua he Civil Aircraft Fire Science and Safety Engineering Key Laboratory of Sichuan Province College of Civil Aviation Safety EngineeringCivil Aviation Flight University of ChinaGuanghan 618307China School of Chemical Engineering Sichuan UniversityChengdu 610065China

Lithium metal batteries(LMBs)are emerging as a promising energy storage solution owing to their high energy density and specific ***,the non-uniform plating of lithium and the potential rupture of the solid-electrolyte interphase(SEI)during extended cycling use may result in dendrite growth,which can penetrate the separator and pose significant short-circuit *** a stable SEI is essential for the long-term operation of the ***-rich SEI has garnered significant attention for its ability to effectively passivate electrodes,regulate lithium deposition,and inhibit electrolyte *** the structural components and preparation methods of existing fluorinated SEI is crucial for optimizing lithium metal anode *** paper reviews the research on optimizing LiF passivation interfaces to protect lithium metal *** focuses on four types of compositions in fluorinated SEI that work synergistically to enhance SEI *** instance,combining compounds with LiF can further enhance the mechanical strength and ionic conductivity of the *** metals with LiF significantly improves electrochemical performance at the SEI/anode interface,with a necessary focus on reducing electron tunneling ***,incorporating polymers with LiF offers balanced improvements in interfacial toughness and ionic conductivity,though maintaining structural stability over long cycles remains a critical area for future *** alloys combined with LiF increase surface energy and lithium affinity,challenges such as dendrite growth and volume expansion *** summary,this paper emphasizes the crucial role of interfacial structures in LMBs and offers comprehensive guidance for future design and development efforts in battery technology.

关键词： LiF lithium metal anodes solid-electrolyte interphase interface cycling stability

Deciphering the molecular mechanisms of Simiaowan in the treatment of hyperuricemia: in vivo and in silico approaches

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Traditional Medicine Research 2025年第2期10卷 37-54页

作者： yong-chang Zeng Jun-Hong Wu Dan-Dan Xu Kang he chang-Qing Liu Li-Fei Song Zheng-Zhi Wu Qian-Qian Jiang Shao-Yu Liang Department of Neurology The First Affiliated Hospital of Shenzhen UniversityShenzhen 518020China Pharmaceutical Department The Affiliated TCM Hospital of Guangzhou Medical UniversityGuangzhou 510000China School of Pharmacy Guizhou University of Traditional Chinese MedicineGuiyang 550025China Guangzhou Zeli Medical Technology Co. Ltd.Guangzhou 510700China

Background:Simiaowan(SMW),a well-known traditional Chinese medicine,has been employed to treat hyperuricemia(HUA)and gout for ***,the bioactive components and underlying mechanisms have not been *** objective of this study was to identify the active components and potential mechanisms of SMW by integrating pharmacological experimentation,serum pharmacochemistry,network pharmacology and molecular ***:HUA rats modelling by high-fat/high-sugar diet and potassium oxonate/adenine oral administration were used to evaluate the pharmacodynamic effects of ***-Q-Exactive-MS/MS was employed to detect the bioactive components present in SMW-containing *** pharmacology and molecular docking were utilized to elucidate the potential targets and underlying ***:SMW effectively ameliorated HUA rats via the inhibition of uric acid(UA)production,promotion of UA excretion,improvement of lipid and glucose metabolic abnormalities,antioxidant,anti-inflammatory and anti-insulin resistance effects.A total of 73 compounds detected in SMW-containing serum were identified as potential active components,with alkaloids,flavonoids,organic acids,and terpenoids emerging as the primary active *** 203 corresponding targets were obtained as SMW anti-HUA/gout targets,which mainly participated in apoptosis,insulin resistance,TNF,PI3K-Akt,HIF-1,NF-κB,MAPK,IL-17 and TLR signaling *** docking indicated that active compounds(***,phellodendrine,quercetin,formononetin,ferulic acid)had superior binding abilities to the key targets(*** carrier family 22 member 12(URAT1),solute carrier family 22 member 6(OAT1),ATP-binding cassette sub-family G member 2(ABCG2),solute carrier family 2,facilitated glucose transporter member 9(GLUT9),xanthine dehydrogenase/oxidase(XDH),transcription factor p65(RELA),toll-like receptor 4(TLR4),prostaglandin G/H synthase 2(PTGS2),caspase-3(CASP3),insulin(INS)).Conclusion:S

关键词： hyperuricemia network pharmacology serum pharmacochemistry Simiaowan UPLC-Q-Exactive-MS/MS

3D Printing of Tough Hydrogel Scaffolds with Functional Surface Structures for Tissue Regeneration

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Nano-Micro Letters 2025年第2期17卷 18-45页

作者： Ke Yao Gaoying Hong Ximin Yuan Weicheng Kong Pengcheng Xia Yuanrong Li Yuewei Chen Nian Liu Jing he Jue Shi Zihe Hu Yanyan Zhou Zhijian Xie yong he State Key Laboratory of Fluid Power and Mechatronic Systems School of Mechanical EngineeringZhejiang UniversityHangzhou 310027People’s Republic of China Liangzhu Laboratory Zhejiang UniversityHangzhou 310027People’s Republic of China Key Laboratory of 3D Printing Process and Equipment of Zhejiang Province College of Mechanical EngineeringZhejiang UniversityHangzhou 310027People’s Republic of China Stomatology Hospital School of StomatologyZhejiang University School of MedicineHangzhou 310027People’s Republic of China State Key Laboratory of Advanced Welding and Joining Harbin Institute of TechnologyHarbin 150001People’s Republic of China Institute of Digital Medicine Nanjing First HospitalNanjing Medical UniversityNanjing 210006People’s Republic of China

Hydrogel scaffolds have numerous potential applications in the tissue engineering ***,tough hydrogel scaffolds implanted in vivo are seldom reported because it is difficult to balance biocompatibility and high mechanical *** by Chinese ramen,we propose a universal fabricating method(printing-P,training-T,cross-linking-C,PTC&PCT)for tough hydrogel scaffolds to fill this ***,3D printing fabricates a hydrogel scaffold with desired structures(P).Then,the scaffold could have extraordinarily high mechanical properties and functional surface structure by cycle mechanical training with salting-out assistance(T).Finally,the training results are fixed by photo-cross-linking processing(C).The tough gelatin hydrogel scaffolds exhibit excellent tensile strength of 6.66 MPa(622-fold untreated)and have excellent ***,this scaffold possesses functional surface structures from nanometer to micron to millimeter,which can efficiently induce directional cell ***,this strategy can produce bionic human tissue with mechanical properties of 10 kPa-10 MPa by changing the type of salt,and many hydrogels,such as gelatin and silk,could be improved with PTC or PCT *** experiments show that this scaffold can effectively promote the new generation of muscle fibers,blood vessels,and nerves within 4 weeks,prompting the rapid regeneration of large-volume muscle loss injuries.

关键词： 3D printing Tough hydrogel scaffold Functional surface structure Tissue regeneration Biomaterials

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火灾后混凝土桥梁检测评估分析

消防科学与技术 2016年第10期35卷 1470-1474页

作者：许肇峰陈映贞王勇平鲁昌河广东华路交通科技有限公司广东广州510550 公路交通安全与应急保障技术及装备行业研发中心广东广州510550 广东省交通集团有限公司广东广州510101

介绍火灾后混凝土桥梁检测评估体系,包括火场踏勘、结构损伤详细调查、详细检测以及检测结果的综合性评估等多个阶段。重点说明该体系中各阶段的检测方法,包括经典升温曲线火灾温度推定分析法、火灾现场物质形态调查推定法、混凝土表观... 详细信息

介绍火灾后混凝土桥梁检测评估体系,包括火场踏勘、结构损伤详细调查、详细检测以及检测结果的综合性评估等多个阶段。重点说明该体系中各阶段的检测方法,包括经典升温曲线火灾温度推定分析法、火灾现场物质形态调查推定法、混凝土表观损伤推定分析法、芯样抗压强度推定分析法等。工程实例应用结果表明:该体系对火灾后混凝土桥梁温度分布、损伤范围、深度等多个方面进行了分析,内容详实,且各方面相互论证,具有较高的可靠性。

关键词：火灾混凝土桥梁桥梁检测评估体系

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湖南省国家湿地公园分类分区管理探讨

中南林业科技大学学报 2016年第11期36卷 144-150页

作者：吴后建但新球刘世好舒勇陈红长何见国家林业局中南林业调查规划设计院湖南长沙410014 湖南省林业厅湖南长沙410004

经过十多年的快速发展,我国国家湿地公园已经由数量快速增加阶段向质量稳步提升阶段发展。在国家湿地公园质量稳步提升阶段,从宏观尺度对其进行分类分区管理至关重要。本文以湖南省为例,选择自然地理条件、本底资源条件、社会经济条件... 详细信息

经过十多年的快速发展,我国国家湿地公园已经由数量快速增加阶段向质量稳步提升阶段发展。在国家湿地公园质量稳步提升阶段,从宏观尺度对其进行分类分区管理至关重要。本文以湖南省为例,选择自然地理条件、本底资源条件、社会经济条件和交通条件4个方面的11个指标,运用聚类分析方法,并借鉴其它空间分区成果,对湖南省国家湿地公园的分类分区管理进行了初步探讨。结果表明:1现阶段湖南省60个国家湿地公园可以归类为保护利用型、利用保护型、水源涵养型、利用宣教型和重点保护型5类,其中保护利用型湿地公园数量最多。2从管理的角度出发,在空间上把湖南省国家湿地公园划分为环洞庭湖区、湘东山地区、湘南山地区、湘西山地区、相中丘陵山地区和长株潭城市群区6个区,其中环洞庭湖区国家湿地公园数量最多。3根据不同类型、不同分区国家湿地公园的现状和特点,有针对性地提出了相应的分类管理和分区管理对策,希望能对现阶段湖南省国家湿地公园的宏观管理有一定的指导作用,也希望为国家层面开展国家湿地公园的分类分区管理提供思路。

关键词：国家湿地公园分类管理分区管理聚类分析湖南省

Constraints on holographic QCD phase transitions from PTA observations

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 71-78页

作者： Song he Li Li Sai Wang Shao-Jiang Wang Center for Theoretical Physics and College of Physics Jilin University School of Physical Science and Technology Ningbo University Max Planck Institute for Gravitational Physics (Albert Einstein Institute) CAS Key Laboratory of Theoretical Physics Institute of Theoretical Physics Chinese Academy of Sciences School of Fundamental Physics and Mathematical Sciences Hangzhou Institute for Advanced StudyUniversity of Chinese Academy of Sciences (UCAS) School of Physical Sciences University of Chinese Academy of Sciences (UCAS) Theoretical Physics Division Institute of High Energy Physics Chinese Academy of Sciences

The underlying physics of QCD phase transition in the early Universe remains largely unknown due to its strong-coupling nature during the quark-gluon plasma/hadron gas transition, yet a holographic model has been proposed to quantitatively fit the lattice QCD data while with its duration of the first-order phase transition(FoPT) left undetermined. At specific baryon chemical potential, the first-order QCD phase transition agrees with the observational constraint of baryon asymmetry. It, therefore, provides a scenario for phase transition gravitational waves(GWs) within the standard model of particle physics. If these background GWs could contribute dominantly to the recently claimed common-spectrum red noise from pulsar timing array(PTA) observations, the duration of this FoPT can be well constrained, and the associated primordial black holes are still allowed by current observations.

关键词： pulsar timing array QCD phase transition gravitational waves primordial black holes

Impact of ocean data assimilation on the seasonal forecast of the 2014/15 marine heatwave in the Northeast Pacific Ocean

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Atmospheric and Oceanic Science Letters 2025年第1期18卷 24-31页

作者： Tiantian Tang Jiaying he Huihang Sun Jingjia Luo Institute for Climate and Application Research(ICAR)/Key Laboratory of Meteorological Disaster Nanjing University of Information Science and TechnologyNanjingChina

A remarkable marine heatwave,known as the“Blob”,occurred in the Northeast Pacific Ocean from late 2013 to early 2016,which displayed strong warm anomalies extending from the surface to a depth of 300 *** study employed two assimilation schemes based on the global Climate Forecast System of Nanjing University of Information Science(NUIST-CFS 1.0)to investigate the impact of ocean data assimilation on the seasonal prediction of this extreme marine *** sea surface temperature(SST)nudging scheme assimilates SST only,while the deterministic ensemble Kalman filter(EnKF)scheme assimilates observations from the surface to the deep *** latter notably improves the forecasting skill for subsurface temperature anomalies,especially at the depth of 100-300 m(the lower layer),outperforming the SST nudging *** excels in predicting both horizontal and vertical heat transport in the lower layer,contributing to improved forecasts of the lower-layer warming during the *** improvements stem from the assimilation of subsurface observational data,which are important in predicting the upper-ocean *** results suggest that assimilating ocean data with the EnKF scheme significantly enhances the accuracy in predicting subsurface temperature anomalies during the Blob and offers better understanding of its underlying mechanisms.

关键词： Seasonal forecast Ocean data assimilation Marine heatwave Subsurface temperature