Endoplasmic reticulum stress-induced apoptosis in the penumbra aggravates secondary damage in rats with traumatic brain injury

作     者：Guo-zhu Sun Fen-fei Gao Zong-mao Zhao Hai Sun Wei Xu Li-wei Wu Yong-chang He 无

作者机构：Department of NeurosurgerySecond Hospital of Hebei Medical UniversityShijiazhuangHebei ProvinceChina Department of PharmacologyShantou University Medical CollegeShantouGuangdong ProvinceChina Division of Neurological SurgeryBarrow Neurological InstituteSt Joseph's Hospital and Medical CenterPhoenixAZUSA 

出 版 物：《Neural Regeneration Research》 (中国神经再生研究（英文版）)

年 卷 期：2016年第11卷第8期

页      面：1260-1266页

核心收录：

学科分类：0710[理学-生物学] 1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 100210[医学-外科学(含：普外、骨外、泌尿外、胸心外、神外、整形、烧伤、野战外)] 10[医学] 

基　　金：supported by the Natural Science Foundation of Hebei Province of China,No.H2014206383 Foundation for High-Level Personnel Projects in Hebei Province of China,No.A201401041 

主　　题：nerve regeneration endoplasmic reticulum stress apoptosis caspase-12 caspase-3 traumatic penumbra traumatic brain injury neural regeneration 

摘      要：Neuronal apoptosis is mediated by intrinsic and extrinsic signaling pathways such as the membrane-mediated,mitochondrial,and endoplasmic reticulum stress *** studies have examined the endoplasmic reticulum-mediated apoptosis pathway in the penumbra after traumatic brain injury,and it remains unclear whether endoplasmic reticulum stress can activate the caspase-12-dependent apoptotic pathway in the traumatic ***,we established rat models of fluid percussion-induced traumatic brain injury and found that protein expression of caspase-12,caspase-3 and the endoplasmic reticulum stress marker 78 k Da glucose-regulated protein increased in the traumatic penumbra 6 hours after injury and peaked at 24 ***,numbers of terminal deoxynucleotidyl transferase-mediated d UTP nick end labeling-positive cells in the traumatic penumbra also reached peak levels 24 hours after *** findings suggest that caspase-12-mediated endoplasmic reticulum-related apoptosis is activated in the traumatic penumbra,and may play an important role in the pathophysiology of secondary brain injury.