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Three-year Follow-up on the Safety and Effectiveness of Rituximab Plus Chemotherapy as First-Line Treatment of Diffuse Large B-Cell Lymphoma and Follicular Lymphoma in Real-World Clinical Settings in China： A Prospective, Multicenter, Noninterventional Study

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Chinese Medical Journal 2018年第15期131卷 1767-1775页

作者： Jian-Qiu Wu yong-ping song Li-ping Su Ming-Zhi Zhang Wei Li Yu Hu Xiao-Hong Zhang Yu-Huan Gao Zuo-Xing Niu Ru FengTM Wei Wang Jie-Wen Peng Xiao-Lin Li Xue-Nong Ouyang Chang-ping Wu Wei-Jing Zhang Yun Zeng Zhen Xiao Ying-Min Liang yong-Zhi Zhuang Ji-Shi Wang Zi-Min Sun Hai Bai Tong-Jian Cui Ji-Feng Feng Department of Oncology Jiangsu Cancer Hospital ＆ Jiangsu Institute of Cancer Research ＆ Nanjing Medical University Affiliated Cancer HospitalNanjing Jiangsu 210008China Department of Hematology Henan Cancer HospitalZhengzhouHenan 450000China Department of Hematology Shanxi Cancer HospitalTaiyuanShanxi 030013China Department of Oncology The First Affiliated Hospital of Zhengzhou UniversityZhengzhouHenan 450000China Department of Oncology Jilin University First Affiliated HospitalChangchunJilin 130000China Department of Hematology Union Hospital Tongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei 430072China Department of Hematology The Second Affiliated Hospital of Zhejiang University School of MedicineHangzhouZhejiang 310009China Department of Hematology Fourth Hospital of Hebei Medical UniversityShijiazhuangHebei 050000China Department of Oncology Affiliated Hospital of Shandong Academy of Medical SciencesJinanShandong 250000China Department of Hematology Medical University Nanfang HospitalGuangzhouGuangdong 510000China Department of Oncology Guangdong Foshan First HospitalFoshanGuangdong 528000China Department of Oncology Guangdong Zhongshan People＇s HospitalZhongshanGuangdong 528403China Department of Hematology Xiangya Hospital Central South UniversityChangshaHunan 410008China Department of Oncology Fuzhou General Hospital of Nanjing Military CommandFuzhouFujian 350001China Department of Oncology Changzhou First People＇s HospitalChangzhouJiangsu 213000China Department of Oncology 307 Hospital of Chinese People＇s Liberation ArmyBeijing 100070China TDepartment of Hematology First Affiliated Hospital of Kunming Medical UniversityKunmingYunnan 650221China Department of Hematology Affiliated Hospital of Neimenggu Medical CollegeHohhotHuhehaoteInner Mongolia 010050China Department of Hematology The Fourth Military Medical University Affiliated Tangdu HospitalXi＇anShaanxi 710038China Department of Oncology Daqing General Hospital Grou

Background： Prospective real-life data on the safety and effectiveness of rituximab in Chinese patients with diffuse large B-cell lymphoma （DLBCL） or follicular lymphoma （FL） are limited. This real-world study aimed to evaluate long-term safety and effectiveness outcomes ofrituximab plus chemotherapy （R-chemo） as first-line treatment in Chinese patients with DLBCL or FL. Hepatitis B virus （HBV） reactivation management was also investigated. Methods： A prospective, multicenter, single-arm, noninterventional study of previously untreated CD20-positive DLBCL or FL patients receiving first-line R-chemo treatment at 24 centers in China was conducted between January 17, 2011 and October 31, 2016. Enrolled patients underwent safety and effectiveness assessments after the last rituximab dose and were followed up for 3 years. Effectiveness endpoints included progression-free survival （PFS） and overall survival （OS）. Safety endpoints were adverse events （AEs）, serious AEs, drug-related AEs, and AEs of special interest. We also reported data on the incidence of HBV reactivation. Results： In total, 283 previously untreated CD20-positive DLBCL and 31 FL patients from 24 centers were enrolled. Three-year PFS was 59% （95% confidence interval [CI]： 50-67%） for DLBCL patients and 46% （95% CI： 20-69%） for FL patients. For DLBCL patients, multivariate analyses showed that PFS was not associated with international prognostic index, tumor maximum diameter, HBV infection status, or number ofrituximab treatment cycles, and OS was only associated with age 〉60 years （P 〈 0.05）. R-chemo was well tolerated. The incidence of HBV reactivation in hepatitis B surface antigen （HBsAg）-positive and HBsAg-negative/hepatitis B core antibody-positive patients was 13% （3/24） and 4% （3/69）, respectively. Conclusions： R-chemo is effective and safe in real-world clinical practice as first-line treatment for DLBCL and FL in China, and that HBV reactivation during R-chemo is manageable with preventive measur

关键词： Asian Hematopoietic Malignancy Hepatitis B Virus Observational Study Rituximab

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Recent Advances in Fibrous Materials for Hydroelectricity Generation

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Nano-Micro Letters 2025年第2期17卷 109-133页

作者： Can Ge Duo Xu Xiao Feng Xing Yang Zheheng song Yuhang song Jingyu Chen Yingcun Liu Chong Gao yong Du Zhe Sun Weilin Xu Jian Fang College of Textile and Clothing Engineering Soochow UniversitySuzhou 215123People’s Republic of China National Engineering Laboratory for Modern Silk Soochow UniversitySuzhou 215123People’s Republic of China State Key Laboratory of New Textile Materials and Advanced Processing Technologies Wuhan Textile UniversityWuhan 430200People’s Republic of China Institute of Functional Nano&Soft Materials(FUNSOM) Soochow UniversitySuzhou 215123People’s Republic of China Department of Electrical and Computer Engineering University of MassachusettsAmherstMA 01003USA Department of Materials Imperial College LondonSouth Kensington CampusLondon SW72AZUK College of Textile Science and Engineering Zhejiang Sci-Tech UniversityHangzhou 310018People’s Republic of China School of Materials Science and Engineering Shanghai Institute of Technology100 Haiquan RoadShanghai 201418People’s Republic of China

Depleting fossil energy sources and conventional polluting power generation pose a threat to sustainable *** generation from ubiquitous and spontaneous phase transitions between liquid and gaseous water has been considered a promising strategy for mitigating the energy *** materials with unique flexibility,processability,multifunctionality,and practicability have been widely applied for fibrous materials-based hydroelectricity generation(FHG).In this review,the power generation mechanisms,design principles,and electricity enhancement factors of FHG are first ***,the fabrication strategies and characteristics of varied constructions including 1D fiber,1D yarn,2D fabric,2D membrane,3D fibrous framework,and 3D fibrous gel are ***,the advanced functions of FHG during water harvesting,proton dissociation,ion separation,and charge accumulation processes are analyzed in ***,the potential applications including power supply,energy storage,electrical sensor,and information expression are also ***,some existing challenges are considered and prospects for future development are sincerely proposed.

关键词： Hydroelectricity Fibrous material Streaming potential Ion diffusion

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大学生感恩与道德判断能力关系研究

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河北大学成人教育学院学报 2017年第1期19卷 110-116页

作者：李勇平宋广文广东财经大学艺术与设计学院华南理工大学马克思主义学院广东广州510000

采用大学生感恩品质调查问卷和道德判断测验量表对广州地区五所院校1,200名本科生进行感恩水平与道德判断能力研究,结果表明:整体感恩处于中等偏上水平,道德判断能力处于中等水平;感恩与道德判断能力存在显著的正相关,道德判断能力得分... 详细信息

采用大学生感恩品质调查问卷和道德判断测验量表对广州地区五所院校1,200名本科生进行感恩水平与道德判断能力研究,结果表明:整体感恩处于中等偏上水平,道德判断能力处于中等水平;感恩与道德判断能力存在显著的正相关,道德判断能力得分最高的是高感恩组,得分最低的是低感恩组,在一定程度上,感恩对道德判断能力具有显著的预测作用。

关键词：大学生感恩道德判断能力

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De novo synthesis of atropisomeric benzofurans via Cu/SPDO complex catalyzed asymmetric formal [3 + 2] annulation

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Science China Chemistry 2025年第01期 174-180页

作者： Fan-Xiao Meng Xing-Yu Wang Ka Lu Ju-song Yang Fu-Min Zhang Ai-Jun Ma Bao Du yong-Qiang Tu State Key Laboratory of Applied Organic Chemistry College of Chemistry and Chemical Engineering Lanzhou University School of Chemistry and Chemical Engineering Shanghai Jiao Tong University School of Biotechnology and Health Sciences Wuyi University

Herein, the de novo synthesis of atropisomeric benzofurans through the Cu/spirocyclic-pyrrolidine-oxazoline(SPDO) complex catalyze asymmetric formal [3 + 2] cycloaddition between quinones and ynamides is explored, producing a range of structurally diverse axially chiral benzofurans in satisfactory yields with good to excellent enantioselectivities. Furthermore, density functional theory calculations were applied to explain the possible reaction mechanism.

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Efficacy and influencing factors of allogeneic hematopoietic stem cell transplantation in treatment of 71 children with leukemia

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Chinese Medical Journal 2019年第7期132卷 860-864页

作者： Bing-Lei Zhang Jian Zhou Tian-Xi Lyu Rui-Rui Gui Ying-Ling Zu Feng-Kuan Yu Hui-Fang Zhao Zhen Li Juan Wang Yan-Li Zhang Wen-Lin Zhang Yue-Wen Fu Xu-Dong Wei Bai-Jun Fang Yu-Fu Li Ke-Shu Zhou yong-ping song Department of Hematology Tumor Hospital Affiliated to Zhengzhou UniversityHenan Cancer HospitalZhengzhouHenan 450003China

To the Editor:Leukemia is a malignant proliferative disease that has become the most common malignancy in children,accounting for 40.5%of malignant cancers children.[1]Although chemotherapy can effectively treat children,some patients with high-risk and relapsed acute lymphoblastic leukemia(ALL)and acute myelocytic leukemia(AML)failed to achieve long-term *** these patients,allogeneic hematopoietic stem cell transplantation(allo-HSCT)is the best ***,many factors may impact the efficacy of *** retrospectively analyzed the clinical data of 71 children with leukemia treated using allo-HSCT to observe the clinical efficacy and analyze the possible influencing factors.

关键词： allogeneic hematopoietic stem cell transplantation leukemia malignant cancers children

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Constraints on holographic QCD phase transitions from PTA observations

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 71-78页

作者： song He Li Li Sai Wang Shao-Jiang Wang Center for Theoretical Physics and College of Physics Jilin University School of Physical Science and Technology Ningbo University Max Planck Institute for Gravitational Physics (Albert Einstein Institute) CAS Key Laboratory of Theoretical Physics Institute of Theoretical Physics Chinese Academy of Sciences School of Fundamental Physics and Mathematical Sciences Hangzhou Institute for Advanced StudyUniversity of Chinese Academy of Sciences (UCAS) School of Physical Sciences University of Chinese Academy of Sciences (UCAS) Theoretical Physics Division Institute of High Energy Physics Chinese Academy of Sciences

The underlying physics of QCD phase transition in the early Universe remains largely unknown due to its strong-coupling nature during the quark-gluon plasma/hadron gas transition, yet a holographic model has been proposed to quantitatively fit the lattice QCD data while with its duration of the first-order phase transition(FoPT) left undetermined. At specific baryon chemical potential, the first-order QCD phase transition agrees with the observational constraint of baryon asymmetry. It, therefore, provides a scenario for phase transition gravitational waves(GWs) within the standard model of particle physics. If these background GWs could contribute dominantly to the recently claimed common-spectrum red noise from pulsar timing array(PTA) observations, the duration of this FoPT can be well constrained, and the associated primordial black holes are still allowed by current observations.

关键词： pulsar timing array QCD phase transition gravitational waves primordial black holes

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Dunkl's Theory and Best Approximation by Entire Functions of Exponential Type in L_2-metric with Power Weight

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Acta Mathematica Sinica,English Series 2014年第10期30卷 1748-1762页

作者： yong ping LIU Chun Yuan song School of Mathematical Sciences Beijing Normal University Laboratory of Mathematics and Complex Systems Ministry of Education

In this paper, we study the sharp Jackson inequality for the best approximation of f ∈L2,k（Rd） by a subspace Ek2（σ）（SEk2（σ））, which is a subspace of entire functions of exponential type （spherical exponential type） at most σ. Here L2,k（Rd） denotes the space of all d-variate functions f endowed with the L2-norm with the weight vk（x）=Пζ∈R＋}（ζ,x）}2k（ζ）,which is defined by a positive subsystem R＋ of a finite root system R Rd and a function k（ζ）：R→R＋ invariant under the reflection group G（R） generated by R. In the case G（R） = Z2d, we get some exact results. Moreover, the deviation of best approximation by the subspace Ek2（σ）（SE2（σ）） of some class of the smooth functions in the space L2,k（Rd） is obtained.

关键词： Reflection group Dunkl transform Bessel function Jackson inequality continuous modulus

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Electrochemical dissolution behavior of gold and its main coexistent sulfide minerals in acid thiocyanate solutions

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Rare Metals 2022年第1期41卷 254-261页

作者： Guan Le Wen-Juan Li Kun song yong-Sheng song yong Chen An-ping Bai Yu Cheng National Engineering Laboratory of Biohydrometallurgy GRINM Group Co.Ltd.Beijing 100088China GRINM Resources and Environment Tech.Co. Ltd.Beijing 101407China General Research Institute for Nonferrous Metals Beijing 100088China School of Chemical and Environmental Engineering China University of Mining and TechnologyBeijing 100083China GRIMAT Engineering Institute Co. Ltd.(GRIMAT)Beijing 101407China Jiangxi Copper Technology Research Institute Co. LtdNanchang 330096China Beijing Vocational College of Labour and Social Security Beijing 102200China Jiangsu East China Mineral Exploration and Development Bureau Nanjing 210007China

Electrochemical tests were developed to investigate the electrochemical dissolution behavior of gold and its main coexistent sulfide minerals in acid thiocyanate *** optimal leaching conditions for gold in acidic thiocyanate system were pH 2,0.15 mol·L^(-1) thiocyanate and 0.2 g·L^(-1)Fe^(3+).Fe^(3+) addition to the acidic thiocyanate system promoted gold dissolution significantly,arsenopyrite dissolution was inhibited,chalcopyrite dissolution was increased,and the dissolution behavior of other associated minerals remained mostly *** made gold and associated mineral leaching *** galvanic corrosion effect of gold and its main coexistent sulfide minerals in an acidic thiocyanate-free system was that the chalcocite,arsenopyrite and pyrite acted as a cathode to reduce anodic gold dissolution;galena as an anode undergoes oxidation to inhibit anodic gold *** was almost no galvanic corrosion behavior between stibnite,yellow sphalerite and black sphalerite and *** addition changed the galvanic corrosion behavior of stibnite and yellow sphalerite in the thiocyanate system,which inhibited anodic gold *** the acidic thiocyanate system in the presence of ferric iron,the arsenopyrite promoted anodic gold dissolution,the chalcocite and gold were mostly free of galvanic corrosion,and the remaining minerals inhibited anodic gold dissolution.

关键词： Acid thiocyanate Ferric iron Electrochemical adsorption Associated mineral

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Constitutive Modeling for Thixoforming of 9Cr18 Semi-solid Alloy and 3D Forecast Mapping

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Journal of Iron and Steel Research International 2016年第12期23卷 1309-1315页

作者： Ya-ping LI Ren-bo song yong-jin WANG School of Materials Science and Engineering University of Science and Technology Beijing

Thixotropic Compression tests were carried out on 9Cr18 semi-solid alloy through Gleeble-1500 thermal simulation machine. According to the experiment analysis, macro separation occurred during thixoforming. The liquid film was extruded outside to the surface and solidified to form eutectic structure. The solid particles were connected with each other and underwent plastic deformation. According to the comparison between Zhou-Guan model and modified Zhou-Guan model, it could be observed that the adding of thixotropic factor played an important role in the regression and the latter one was more credible. The modified Zhou-Guan model could well describe the thixoforming behavior. 3D forecast mapping was built for 9Cr18 semi solid alloy in thixoforming temperature range. It would provide valuable information for selecting process parameters during thixoforming in the manufacture process.

关键词： thixoforming constitutive model liquid fraction thixotropic factor 3D forecast

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Inspires effective alternatives to backpropagation:predictive coding helps understand and build learning

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Neural Regeneration Research 2025年第11期20卷 3215-3216页

作者： Zhenghua Xu Miao Yu Yuhang song School of Health Sciences and Biomedical Engineering Hebei University of TechnologyTianjinChina Department of Computer Science University of OxfordOxfordUK

Artificial neural networks are capable of machine learning by simulating the hiera rchical structure of the human *** enable learning by brain and machine,it is essential to accurately identify and correct the prediction errors,referred to as credit assignment(Lillicrap et al.,2020).It is critical to develop artificial intelligence by understanding how the brain deals with credit assignment in neuroscience.

关键词： assignment learning enable

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