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World Journal of Gastrointestinal Surgery 2024年第7期16卷 2096-2105页

作者： Yu-Hang diao Xin-peng Shu Can Tan Li-Juan Wang yong Cheng Department of Gastrointestinal Surgery The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400016China

BACKGROUND The albumin-bilirubin(ALBI)score is a serum biochemical indicator of liver function and has been proven to have prognostic value in a variety of *** colorectal cancer(CRC),a high ALBI score tends to be associated with poorer *** To investigate the correlation between the preoperative ALBI score and outcomes in CRC patients who underwent radical *** Patients who underwent radical CRC surgery between January 2011 and January 2020 at a single clinical center were *** ALBI score was calculated by the formula(log10 bilirubin×0.66)+(albumin×-0.085),and the cutoff value for grouping patients *** short-term outcomes,overall survival(OS),and disease-free survival(DFS)were *** A total of 4025 CRC patients who underwent radical surgery were enrolled in this study,and there were 1908 patients in the low ALBI group and 2117 patients in the high ALBI *** regression analysis revealed that age,tumor size,tumor stage,ALBI score,and overall complications were independent risk factors for OS;age,tumor stage,ALBI score,and overall complications were identified as independent risk factors for *** A high preoperative ALBI score is correlated with adverse short-term outcomes,and the ALBI score is an independent risk factor for OS and DFS in patients with CRC undergoing radical surgery.

关键词： Colorectal cancer Albumin-bilirubin score Overall survival Disease-free survival Outcomes

Prognostic prediction model of colorectal cancer based on preoperative serum tumor markers

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World Journal of Gastrointestinal Surgery 2024年第5期16卷 1344-1353页

作者： Yu-Hang diao Si-Qi Rao Xin-peng Shu yong Cheng Can Tan Li-Juan Wang Dong peng Department of Gastrointestinal Surgery The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400016China

BACKGROUND Preoperative serum tumor markers not only play a role in the auxiliary diagnosis and postoperative monitoring in colorectal cancer(CRC),but also have been found to have potential prognostic *** To analyze whether preoperative serum tumor markers,including carcinoembryonic antigen(CEA)and carbohydrate antigen 19-9(CA19-9),affect the prognosis of *** This was a retrospective study conducted in a single *** with nonmetastatic CRC who underwent initial surgery between January 2011 and January 2020 were enrolled and divided into development site and validation site groups at a ratio of 7:*** independent prognostic factors were screened by Cox regression analysis,and finally,a prognostic nomogram model was *** newly developed model was tested by internal *** Eventually,3526 postoperative patients with nonmetastatic CRC were included in the *** were 2473 patients at the development site and 1056 patients at the validation ***(P<0.01,HR=1.042,95%CI=1.033-1.051),tumor node metastasis(TNM)classification(P<0.01,HR=1.938,95%CI=1.665-2.255),preoperative CEA(P=0.001,HR=1.393,95%CI=1.137-1.707)and CA19-9(P<0.01,HR=1.948,95%CI=1.614-2.438)levels were considered independent prognostic factors for patients with nonmetastatic CRC and were used as variables in the nomogram *** areas under the curve of the development and validation sites were 0.655 and 0.658,*** calibration plot also showed the significant performance of the newly established *** We successfully constructed a nomogram model based on age,TNM stage,preoperative CEA,and CA19-9 levels to evaluate the overall survival of patients with nonmetastatic CRC.

关键词： Colorectal cancer Prognosis Carcinoembryonic antigen Carbohydrate antigen 19-9 Nomogram

Nerve Growth Factor Promotes Angiogenesis and Skeletal Muscle Fiber Remodeling in a Murine Model of Hindlimb Ischemia

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Chinese Medical Journal 2016年第3期129卷 313-319页

作者： yong-peng diao Feng-Kui Cui Sheng Yan Zuo-Guan Chen Li-Shan Lian Li-Long Guo yong-Jun Li Department of Vascular Surgery Beijing Shijitan Hospital Capital Medical University Beijing 100038 China Department of Vascular Surgery Peking Union Medical College Hospital Peking Union Medical College Chinese Academy of Medical Science Beijing 100730 China Department of Vascular Surgery Daqing Oilfield General Hospital Heilongjiang 163001 China

Background： Therapeutic angiogenesis has been shown to promote blood vessel growth and improve tissue *** growth factor （NGF） has been reported to play an important role in both physiological and pathological *** study aimed to investigate the effects of NGF on angiogenesis and skeletal muscle fiber remodeling in a murine model of hindlimb ischemia and study the relationship between NGF and vascular endothelial growth factor （VEGF） in ***： Twenty-four mice were randomly allocated to normal control group （n =6）, blank control group （n =6）, VEGF gene transfection group （n =6）, and NGF gene transfection group （n =6）.The model of left hindlimb ischemia model was established by ligating the femoral ***165 plasmid （125 μg） and NGF plasmid （125 μg） was injected into the ischemic gastrocnemius of mice from VEGF group and NGF group, *** hindlimb function and ischemic damage were assessed with terminal points at 21th day postischemia *** gastrocnemius of four groups was tested by hematoxylin-eosin staining, proliferating cell nuclear antigen and CD34 immunohistochemistry staining, and myosin ATPase *** and VEGF protein expression was detected by enzyme-linked immunosorbent ***： On the 21th day after surgery, the functional assessment score and skeletal muscle atrophy degree of VEGF group and NGF group were significantly lower than those of normal control group and blank control *** endothelial cell proliferation index and the capillary density of VEGF group and NGF group were significantly increased compared with normal control group and blank control group （P 〈 0.05）.The NGF and VEGF protein expression of NGF group showed a significant rise when compared with blank control group （P 〈 0.05）.Similarly, the VEGF protein expression of VEGF group was significantly higher than that of blank control group （P 〈 0.05）, but there was no significant difference of the NGF protein expressi

关键词： Angiogenesis Limb lschemia Muscle Fiber Type Nerve Growth Factor Vascular Endothelial Growth Factor

Outcomes of Chimney and/or Periscope Techniques in the Endovascular Management of Complex Aortic Pathologies

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Chinese Medical Journal 2017年第17期130卷 2095-2100页

作者： Zhi-Yuan Wu Zuo-Guan Chen Li Ma yong-peng diao Yue-Xin Chen Chang-Wei Liu Yue-Hong Zheng Bao Liu yong-Jun Li Department of Vascular Surgery Beijing Hospital Peking Union Medical College and Chinese Academy of Medical Sciences Beijing 100730 China Department of Vascular Surgery Peking Union Medical College Hospital Peking Union Medical College and Chinese Academy of Medical SciencesBeijing 100730 China

Background：The chimney/periscope technique has been used to address complex aortic *** study aimed to report the outcomes and experiences of chimney and/or periscope grafts （CPGs） used in the endovascular management of complex aortic ***：Twenty-two patients with complex aortic pathologies were retrospectively studied from January 2013 to August 2016 in two vascular centers of teaching *** patients were diagnosed using computed tomography angiography （CTA）.The patients were followed up at postoperative 1,3,6,and 12 months and yearly thereafter with X-ray,ultrasound,and/or ***：Twenty-two cases （17 males;mean age 60.7 ＆#177; 16.3 years） with complex aortic pathologies were *** patients underwent CPGs only,and the other three cases underwent the simultaneous implantation of chimney/periscope and fenestrated/scallop ***-six arteries were managed with forty CPGs during the *** angiographies revealed two Type Ⅰ endoleaks,one Type Ⅲ endoleak,and one Type Ⅳ *** intraoperative complications included brachial thrombosis,external iliac artery rupture,and left renal *** 30-day mortality was *** mean follow-up was 26.1 ＆#177; 10.1 months with a range of 2-39 *** the follow-up,two Type Ⅰ endoleaks and one Type Ⅳ endoleak were *** right renal stent occlusion occurred in the 5th month and turned patent after *** patients died during the follow-up,one due to an aneurysm rupture as a Type Ⅰ endoleak,and two due to myocardial *** instant technical success was 96%.The primary and secondary patencies were 92%and 96%,*** overall survival rates were 95%,84%,and 84% at 12,24,and 36 months,*** migration was not observed in any ***：Chimney/periscope techniques could be used to tackle complex aortic pathologies,but the indications must be strictly controlled,and additional experiences are required

关键词： Anetlrysm Chimney/Periscope Technique Complex Aortic Pathologies Dissection Endovascular Aortic Repair

Associations between the use of red yeast rice preparations and adverse health outcomes:An umbrella review of meta-analyses of randomized controlled trials

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Journal of Integrative Medicine 2024年第2期22卷 126-136页

作者： Zhen-yu Ma Shu-ping Yang Ying Li Tian-tian Xu Ya-lin Yang Hui-yong Yang Heng-bing Li Le-jin Zhou yong diao Su-yun Li School of Medicine Huaqiao UniversityQuanzhou 362021Fujian ProvinceChina College of Traditional Chinese Medicine Shandong University of Traditional Chinese MedicineJinan 250355Shandong ProvinceChina Second Clinical Medical College Nanjing Medical UniversityNanjing 211166Jiangsu ProvinceChina

Background:Red yeast rice(RYR),a natural lipid-lowering agent,is widely used in clinical ***,the existing meta-analyses concerning the safety of RYR preparations have yielded inconsistent results,and the credibility of the evidence has not been ***:This study was designed to evaluate the existing evidence and offer a comprehensive understanding of the associations between the use of RYR preparations and various adverse health *** strategy:Seven literature databases were searched from inception to May 5,2023,using medical subject headings and free-text terms(e.g.,“red yeast rice,”“Xuezhikang,”and“Zhibitai”).Inclusion criteria:Meta-analyses that investigated and quantitatively estimated associations between the use of RYR preparations and adverse health outcomes were included in this *** extraction and analysis:Two researchers independently extracted data using a standardized data collection table;any disagreements were resolved by consulting a third *** on the participant,intervention,comparator and outcome(PICO)framework in each eligible meta-analysis,a series of unique associations between the use of RYR preparations and adverse health outcomes were *** associations’effect estimates were re-evaluated using random-effect ***:Fifteen meta-analyses,comprising 186(164 unique)randomized controlled trials,were *** on A Mea Surement Tool to Assess Systematic Reviews version 2,3(20%)and 12(80%)of these meta-analyses had low and critically low confidence,respectively.A total of 61 unique associations between the use of RYR preparations and adverse health outcomes were extracted from eligible *** on the random-effect models,10(16.4%)associations indicated a significant protective effect of RYR preparations against adverse health outcomes,while 5(8.2%)indicated an increased risk of adverse health outcomes related to uric acid,alanine transaminase and aspartate trans

关键词： Red yeast rice Safety Adverse health outcomes Umbrella review Meta-analysis Systematic review

Tannic acid and silicate-functionalized polyvinyl alcohol-hyaluronic acid hydrogel for infected diabetic wound healing

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Regenerative Biomaterials 2024年第4期3卷 125-137页

作者： Zhentian diao Longkang Li Huan Zhou Lei Yang School of Materials Science and Engineering Hebei University of TechnologyTianjin 300131China Center for Health Science and Engineering Hebei Key Laboratory of Biomaterials and Smart TheranosticsSchool of Health Sciences and Biomedical EngineeringHebei University of TechnologyTianjin 300131China

Healing of chronic diabetic wounds is challenging due to complications of severe inflammatory microenvironment,bacterial infection and poor vascular ***,a novel injectable polyvinyl alcohol-hyaluronic acid-based composite hydrogel was developed,with tannic acid(TA)and silicate functionalization to fabricate an‘all-in-one’hydrogel *** one hand,after being locally injected into the wound site,the hydrogel underwent a gradual sol-gel transition in situ,forming an adhesive and protective dressing for the *** of rheological characteristics,mechanical properties and swelling ability of PTKH could be performed via regulating TA and silicate content in *** the other hand,PTKH was capable of eliminating reactive oxygen species overexpression,combating infection and generating a cell-favored microenvironment for wound healing acceleration in *** animal studies demonstrated that PTKH could greatly stimulate angiogenesis and epithelization,accompanied with inflammation and infection risk ***,in consideration of its impressive in vitro and in vivo outcomes,this‘all-in-one’multifunctional hydrogel may hold promise for chronic diabetic wound treatment.

关键词： diabetic wound healing ROS overexpression combating infection stimulate angiogenesis

Preweaning period is a critical window for rumen microbial regulation of average daily gain in Holstein heifer calves

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Journal of Animal Science and Biotechnology 2024年第1期15卷 396-411页

作者： Shengyang Xu Chong Jiao Qiyu diao Yan Tu Beijing Key Laboratory for Dairy Cow Nutrition Institute of Feed ResearchChinese Academy of Agricultural SciencesBeijing 100081People’s Republic of China

Background Rumen bacterial groups can affect growth performance,such as average daily gain(ADG),feed intake,and *** study aimed to investigate the inter-relationship of rumen bacterial composition,rumen fermentation indicators,serum indicators,and growth performance of Holstein heifer calves with different *** calves were chosen from a trail with 60 calves and divided into higher ADG(HADG,high pre-and post-weaning ADG,n=6)and lower ADG(LADG,low pre-and post-weaning ADG,n=6)groups to investigate differences in bacterial composition and functions and host *** During the preweaning period,the relative abundances of propionate producers,including g_norank_f_Butyricicoccaceae,g_Pyramidobacter,and g_norank_f_norank_o_Clostridia_vadin BB60_group,were higher in HADG calves(LDA>2,P<0.05).Enrichment of these bacteria resulted in increased levels of propionate,a gluconeogenic precursor,in preweaning HADG calves(adjusted P<0.05),which consequently raised serum glucose concentrations(adjusted P<0.05).In contrast,the relative abundances of rumen bacteria in post-weaning HADG calves did not exert this ***,no significant differences were observed in rumen fermentation parameters and serum indices between the two *** The findings of this study revealed that the preweaning period is the window of opportunity for rumen bacteria to regulate the ADG of calves.

关键词： Average daily gain Calves Preweaning period Rumen microbiota

Core and variable antimicrobial resistance genes in the gut microbiomes of Chinese and European pigs

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Zoological Research 2024年第1期45卷 189-200页

作者： Cui-Hong Tong Zhi-peng Huo Lu diao Dan-Yu Xiao Ruo-Nan Zhao Zhen-Ling Zeng Wen-Guang Xiong Guangdong Provincial Key Laboratory of Veterinary Pharmaceutics Development and Safety Evaluation South China Agricultural UniversityGuangzhouGuangdong 510642China National Risk Assessment Laboratory for Antimicrobial Resistance of Animal Original Bacteria College of Veterinary MedicineSouth China Agricultural UniversityGuangzhouGuangdong 510642China National Laboratory of Safety Evaluation(Environmental Assessment)of Veterinary Drugs South China Agricultural UniversityGuangzhouGuangdong 510642China National Reference Laboratory of Veterinary Drug Residues South China Agricultural UniversityGuangzhouGuangdong 510642China

Monitoring the prevalence of antimicrobial resistance genes(ARGs)is vital for addressing the global crisis of antibiotic-resistant bacterial *** its importance,the characterization of ARGs and microbiome structures,as well as the identification of indicators for routine ARG monitoring in pig farms,are still lacking,particularly concerning variations in antimicrobial exposure in different countries or ***,metagenomics and random forest machine learning were used to elucidate the ARG profiles,microbiome structures,and ARG contamination indicators in pig manure under different antimicrobial pressures between China and *** showed that Chinese pigs exposed to high-level antimicrobials exhibited higher total and plasmid-mediated ARG abundances compared to those in European pigs(P<0.05).ANT(6)-Ib,APH(3')-IIIa,and tet(40)were identified as shared core ARGs between the two pig ***,the core ARGs identified in pig populations were correlated with those found in human populations within the same geographical *** and Prevotella were identified as the dominant genera in the core microbiomes of Chinese and European pigs,*** ARG markers and 43 biomarkers were able to differentiate between the Chinese and European pig manure samples with accuracies of 100%and 98.7%,*** for assessing ARG contamination in Chinese and European pigs also achieved high accuracy(r=0.72-0.88).Escherichia flexneri in both Chinese and European pig populations carried between 21 and 37 *** results of this study emphasize the importance of global collaboration in reducing antimicrobial resistance risk and provide validated indicators for evaluating the risk of ARG contamination in pig farms.

关键词： Metagenomic Pig manure Antimicrobial pressure Antimicrobial resistance genes Microbiome

Molecular mechanisms of stress resistance in sorghum: Implications for crop improvement strategies

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Journal of Integrative Agriculture 2024年第3期23卷 741-768页

作者： Hongxiang Zheng Yingying Dang Xianmin diao Na Sui Shandong Provincial Key Laboratory of Plant Stress/College of life Sciences Shandong Normal UniversityJinan 250014China Institute of Crop Sciences Chinese Academy of Agricultural SciencesBeijing 100081China

Abiotic stresses, such as drought, salt, extreme temperatures, and heavy metal pollution, are the main environmental factors that limit crop growth and yield. Sorghum, a C4 grass plant with high photosynthetic efficiency, can grow in adverse environmental conditions due to its excellent stress resistance characteristics. Therefore, unraveling the stress-resistance mechanism of sorghum could provide a theoretical basis for developing and cultivating various stress-resistant crops. This understanding could also help to create a conducive environment for using marginal soil in agriculture and ensuring food security. In this review, we discuss the adaptation mechanisms of sorghum under drought, salinity, temperature, and soil heavy metal stresses, the specific response to stress, the screening of sorghum-resistant germplasm, and the identification and functional analysis of the relevant genes and quantitative trait loci(QTL). In addition, we discuss the application potential of different stress-tolerant sorghum germplasms reported to date and emphasize the feasibility and potential use in developing and promoting highly stress-tolerant sorghum in marginal soil.

关键词： abiotic stress C4 plants QTL sorghum stress resistance yield stability

Graph neural network based method for robot path planning

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Biomimetic Intelligence & Robotics 2024年第1期4卷 80-87页

作者： Xingrong diao Wenzheng Chi Jiankun Wang Shenzhen Key Laboratory of Robotics Perception and Intelligence Department of Electronic and Electrical EngineeringSouthern University of Science and TechnologyShenzhen 518055China Robotics and Microsystems Center School of Mechanical and Electric EngineeringSoochow UniversitySuzhou 215021China Jiaxing Research Institute Southern University of Science and TechnologyJiaxing 314000China

Sampling-based path planning is widely used in robotics,particularly in high-dimensional state *** the path planning process,collision detection is the most time-consuming ***,we propose a learning-based path planning method that reduces the number of collision *** develop an efficient neural network model based on graph neural *** model outputs weights for each neighbor based on the obstacle,searched path,and random geometric graph,which are used to guide the planner in avoiding *** evaluate the efficiency of the proposed path planning method through simulated random worlds and real-world *** results demonstrate that the proposed method significantly reduces the number of collision checks and improves the path planning speed in high-dimensional environments.

关键词： Graph Neural Network(GNN) Collision detection Sampling-based path planning