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Rare Metals 2024年第5期43卷 2241-2250页

作者： Pei-Sen Wang Zi-Tong Wang Ya-Ya Tan Peng Chen Xue-Cheng Zhang Lu-Nan Zhang yong-ge wei Lu-Bin Ni School of Chemistry and Chemical Engineering Yangzhou UniversityYangzhou 225002China Key Lab of Organic Optoelectronics and Molecular Engineering of Ministry of Education Department of ChemistryTsinghua UniversityBeijing 100084China State Key Laboratory of Natural and Biomimetic Drugs Peking UniversityBeijing100191China

An inorganicDorganic hybrid crystalline material(SiMo_(12)O_(40))[Cu(2,2'-bipy)_(2)]_(2)·2H_(2)O(Complex 1,2,2'-bipy=2,2'-bipyridine)was synthesized for the first time by using 2,2'-bipy and transition metal copper to convert Waugh-type polyoxometalate[MnMo_(9)O_(3)_(2)]_(6-)into a Keggin polyoxometalate structure[SiMo_(12)O_(40)]^(4-)under hydrothermal conditions in glass *** crystal tests and a series of characterizations were carried out on Complex *** structure of Complex 1 is composed of[SiMo_(12)O_(40)]^(4-)and[Cu^(Ⅱ)(2,2'-bipy)_(2)]^(2+).The five-coordinated Cu is connected to two 2,2'-bipy through CuDN bonds,forming an approximately square ***,Complex 1 exhibited good photocatalytic performance for methylene blue degradation and electrocatalytic nitrite reduction properties simultaneously.

关键词： Polyoxometalates Inorganic-organic hybrid materials Photocatalytic Electrocatalytic

Peptide Inhibitors of HIV-1 Virus Infection Based on Cullin-5

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Chemical Research in Chinese Universities 2008年第3期24卷 338-343页

作者： ZHU Ke-tong ZHANG Xi-zhen LOU Chao-ping GUO Bo DU Juan WANG Xiao-dan WU yong-ge KONG wei YU Xiang-hui College of Life Science Jilin University Changchun 130012 P. R. China

Virion infectivity factor（Vif） is one of the six accessory proteins of HIV-1 and is necessary for viral infectivity. Human Apolipoprotein B editing complex protein 3G（h-APOBEC3G） is a cytidine deaminase only expressed in ＂nonpermissive＂ cells and exhibits virus suppressive activity. With the aid of a Cullin-5 E3 ligase, Vif induces h-APOBEC3G degradation and with the destruction of this ligase, Vif is functionally inactive. Therefore, it is expected that blocking this E3 pathway would be a new therapeutic strategy against HIV-1 infection. In this article, the authors＇ took sequence alignment of the N-termini of Cullin-5 and three other members of the Cullin protein family, respectively. A set of small peptides has been synthesized based on the sequence comparison results and possible Vif-Cullin-5 interaction domains. Moreover, it has been demonstrated that several peptides can reduce virus infectivity in ＂nonpermissive＂ cells with a dose-responsive manner, but not in ＂permissive＂ cells. The results also indicate that the loss of viral infectivity may be because of the increase of APOBEC3G amount in the peptide-treated cells. It is concluded that peptides derived from Cullin-5 can block the APOBEC3G degradation induced by Vif and suppress HIV-1 infectivity. Therefore this study starts a novel strategy for the development of a new HIV-1 inhibitor.

关键词： HIV-1 inhibitor Peptide Vif Cullin-5 APOBEC3G

Hetero-bimetallic transition metal-substituted Krebs-type polyoxometalate with N-chelating ligand as anticancer agents

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Tungsten 2023年第2期5卷 225-234页

作者： Han-Zhi Zhang Hong-Xia Zhao Wen-Hui Chang Xin-Yuan Liu Peng Chen Ai-Qin Yu Aadil Nabi Chishti Yu-Zhen Zhang Lu-Bin Ni Xi-Qing Wang yong-ge wei School of Chemistry and Chemical Engineering Yangzhou UniversityYangzhou 225002China College of Bioscience and Biotechnology Yangzhou UniversityYangzhou 225009China School of Chemistry and Chemical Engineering Guangxi Minzu UniversityNo.158Daxue West RoadNanning 530006China Key Lab of Organic Optoelectronics and Molecular Engineering of Ministry of Education Department of ChemistryTsinghua UniversityBeijing 100084China

A novel hetero-bimetallic transition metal(Sb^(Ⅴ)/Mn^(Ⅱ))-substituted Krebs-type polyoxometalate(POM)with N-chelating ligand H_(4)Na_(4)[Mn_(4)(H_(2)O)_(4)(trz)_(2)(SbO_(2))_(2)(SbW_(9)O_(33))_(2)]-20H_(2)O(Sb_(2)Mn_(2))(1)(trz=1,2,4-triazole)built from trilacunary Keggin POM unitα-B-[SbW_(9)O_(33)]^(9-){SbW_(9)]has been synthesized and characterized by single-crystal/powder X-ray diffraction and a wide range of analytical methods,including powder X-ray diffraction,Fourier transform infrared spectroscopy,Raman,ultraviolet-visible spectroscopy,electrospray ionization-mass spectroscopy,and thermogravimetric *** further investigate the antitumor activity of the(Sb_(2)Mn_(2))(1)in human gastric cancer Human Gastric Adenocarcinoma Cells and Human Gastric Cancer Cell lines,in vitro cytotoxicity assay and flow cytometry analysis was *** results indicated that the IC_(50) values of(Sb_(2)Mn_(2))(1)on Human Gastric Adenocarcinoma(AGS)and Human Gastric Cancer(BGC-823)Cell Lines were 1.86±0.05μmol·L^(-1) and 14.61±0.55μmol·L^(-1),respectively.(Sb_(2)Mn_(2))(1)also exhibited high cytotoxicity on Human Gastric Cancer Cells and could induce cell apoptosis by inhibiting S and G_(2)/M cell ***,the result not only shows that this new POM-based inorganic-organic hybrid compound has high selectivity and low toxicity,but also provides an effective method for the development of potential transition metal-substituted POMs based antitumor drugs.

关键词： Polyoxometalate Inorganic-organic hybrid material-In vitro cytotoxicity Anticancer agent

The Multi-level Recovery of Main-memory Real-time Database Systems with ECBH

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The Journal of China Universities of Posts and Telecommunications 2003年第1期10卷 15-24页

作者： ZOU yong-gui, ge Jun-wei (College of Computer Science and Technology, Chonqqing University of Posts and Telecommunications, Chongqing 400065, P.R. China) College of Computer Science and Technology Chonqqing University of Posts and Telecommunications 重庆 400065

Storing the whole database in the main-memory is a common method to processreal-time transaction in real-time database systems. The recovery mechanism of Main-memory Real-timeDatabase Systems (MMRTDBS) should reflect the characteristics of the main-memory database andreal-time database because their structures are quite different from other conventional databasesystems. In this paper, therefore, we propose a multi-level recovery mechanism for main-memoryreal-time database systems with Extendable Chained Bucket Hashing (ECBH). Owing to the occurrence ofreal-time data in real-time systems, we should also consider it in our recovery mechanism .According to our performance test, this mechanism can improve the transaction concurrency, reducingtransactions ' deadline missing rate.

关键词： DBMS multi-level recovery hash main- memory database real-time

Network pharmacology:Changes the treatment mode of"one disease-one target"in cancer treatment

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World Journal of Gastrointestinal Oncology 2025年第1期17卷 268-271页

作者： Shuai Liu yong-wei Yu Department of Cardiology The First People’s Hospital of JiashanJiaxing 314100Zhejiang ProvinceChina Department of Critical Care Medicine The First Affiliated Hospital of Zhejiang University School of MedicineHangzhou 310000Zhejiang ProvinceChina

The article concluded that network pharmacology provides new ideas and insights into the molecular mechanism of traditional Chinese medicine(TCM)treatment of *** is a new choice and hot spot in the field of cancer *** have also previously published studies on TCM and network *** this letter,we summarize the new paradigm of network pharmacology in cancer treatment mechanisms.

关键词： Network pharmacology Cancer Multicomponent Multitarget Therapy

CRYSTAL AND MOLECULAR STRUCTURE OF 1-PHENYL-3-METHYL-4-( 3' -PHENYL-1', 3' -ACEDION)-PYRAZOLONE-5

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Chinese Journal of Structural Chemistry 1991年第3期 245-246页

作者： Kong Bi-Xia Yang Yan-Sheng Li Yuan-Ying Chemistry Department,Zhongshan University,Guangzhou,516275 Liu yong-Sheng wei ge-Cheng Jin Zhong-Sheng Changchun Institute of Applied Chemistry Aeademia Sinica,Changchun, 130022

A new 4-acetyl pyrazolone chelating agent CHNOMr=320. 348 has been synthesized. The molecular composition is different from β-Diketon and "Double β-Diketon". There are conjugated metiple bonds composed of three carbonyl groups in the molecule. A single crystal of approximate dimensions 0.1 × 0.2 × 0.5mm was mounted on an NICOLET R3M/E four-circle diffractomcter with graphite monochromated MoKa

关键词： PYRAZOLONE-5 CRYSTAL AND MOLECULAR STRUCTURE OF 1-PHENYL-3-METHYL-4 PHENYL-1 ACEDION

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粉煤灰与钢渣做公路基层试验性能分析

内蒙古公路与运输 2009年第1期 33-36页

作者：葛永卫衡水路桥工程有限公司河北衡水053000

利用钢渣、粉煤灰做路面基层材料可大量利用工业废渣,减少天然石料的开采,是一种生态建筑材料。文章主要研究了钢渣、粉煤灰的路用性能,其中包括配合比、无侧限抗压强度、劈裂抗拉强度、回弹模量等常用性能,通过试验比较,证明钢渣与粉... 详细信息

利用钢渣、粉煤灰做路面基层材料可大量利用工业废渣,减少天然石料的开采,是一种生态建筑材料。文章主要研究了钢渣、粉煤灰的路用性能,其中包括配合比、无侧限抗压强度、劈裂抗拉强度、回弹模量等常用性能,通过试验比较,证明钢渣与粉煤灰组合完全可以做道路基层使用。

关键词：公路基层钢渣粉煤灰应用研究

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设计流量推求中特大值判断方法的改进

水利水运工程学报 2012年第5期 8-12页

作者：黄伟昊左利钦李寿千盖永伟南京水利科学研究院江苏南京210029 河海大学水利水电学院江苏南京210098

设计洪峰流量的推求过程中,特大值判断的正确与否对洪水频率分析的精度有着较大的影响.而在特大值判断的过程中,Ex+kσ常作为水文频率分析中特大值判断的准则,其中k为经验常数,其取值的不同常会给设计流量的计算带来较大的误差.采用数... 详细信息

设计洪峰流量的推求过程中,特大值判断的正确与否对洪水频率分析的精度有着较大的影响.而在特大值判断的过程中,Ex+kσ常作为水文频率分析中特大值判断的准则,其中k为经验常数,其取值的不同常会给设计流量的计算带来较大的误差.采用数值模拟方法,生成符合PⅢ型曲线分布的样本,再通过适线拟合,探讨了k值与样本总量、变差系数及偏态系数之间的相互关系,并在此基础上建立了k值估计公式.最后,通过将该k值的估计公式应用于天然河道设计流量的推求过程中,取得了良好的效果.

关键词：洪水频率特大值设计洪峰流量重现期频率分析