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Acta Mathematica Sinica,English Series 2025年

作者： yong Tao LIU School of Mathematics and Statistics Ningxia University

Under the assumption of integral m-Bakry-émery Ricci curvature, we give an Escobar-LichnerowiczReilly type eigenvalue estimate for the weighted p-Laplacian on compact smooth metric measure spaces with or without boundaries. This conclusion is a generalization and improvement of Wang-Li’s result in the case of integral Bakry-émery Ricci curvature, and of Seto-Wei’s one to the compact metric measure space setting. Our main tools are the weighted p-Bochner formula and the weighted p-Reilly formula.

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Viscosity and structure relationship with equimolar substitution of CaO with MgO in the CaO–MgO–Al_(2)O_(3)–SiO_(2)slag melts

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International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 70-79页

作者： yong Hou Shuo Zhang Jie Dang Jia Guo Hanghang Zhou Xuewei Lü College of Materials Science and Engineering Chongqing UniversityChongqing 400044China Chongqing Key Laboratory of Vanadium-Titanium Metallurgy and New Materials Chongqing UniversityChongqing 400044China

Currently,the Al_(2)O_(3)content in the high-alumina slag systems within blast furnaces is generally limited to 16wt%–18.5wt%,making it challenging to overcome this *** most studies that concentrated on managing the MgO/Al_(2)O_(3)ratio or basicity,this paper explored the effect of equimolar substitution of MgO for CaO on the viscosity and structure of a high-alumina CaO-MgO-Al_(2)O_(3)-SiO_(2)slag system,providing theoretical guidance and data to facilitate the application of high-alumina *** results revealed that the viscosity first decreased and then increased with higher MgO substitution,reaching a minimum at 15mol%MgO *** transform infrared spectroscopy(FTIR)results found that the depths of the troughs representing[SiO_(4)]tetrahedra,[AlO_(4)]tetrahedra,and Si-O-Al bending became progressively deeper with increased MgO *** of the Raman spectra showed that the average number of bridging oxygens per Si atom and the X_(Q^(3))/X_(Q^(2))(X_(Q^(i))is the molar fraction of Q^(i) unit,and i is the number of bridging oxygens in a[SiO_(4)]tetrahedral unit)ratio increased from 2.30 and 1.02 to 2.52 and 2.14,respectively,indicating a progressive polymerization of the silicate structure.X-ray photoelectron spectroscopy(XPS)results highlighted that non-bridging oxygen content decreased from 77.97mol% to 63.41mol% with increasing MgO concentration,whereas bridging oxygen and free oxygen contents *** analysis demonstrated a gradual increase in the polymerization degree of the tetrahedral structure with the increase in MgO ***,bond strength is another important factor affecting the slag *** occurrence of a viscosity minimum can be attributed to the complex evolution of bond strengths of non-bridging oxygens generated during depolymerization of the[SiO_(4)]and[AlO_(4)]tetrahedral structures by CaO and MgO.

关键词： aluminosilicate viscosity structure spectroscopy

Daclatasvir plus asunaprevir in treatment-na?ve patients with hepatitis C virus genotype 1b infection

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World Journal of Gastroenterology 2018年第12期24卷 1361-1372页

作者： Lai Wei Fu-Sheng Wang Ming-Xiang Zhang Ji-Dong Jia Alexey A Yakovlev Wen Xie Eduard Burnevich Jun-Qi Niu yong Jin jung Xiang-Jun Jiang Min Xu Xin-Yue Chen Qing Xie Jun Li Jin-Lin Hou Hong Tang Xiao-guang Dou Yash Gandhi Wen-Hua Hu Fiona McPhee Stephanie Noviello Michelle Treitel Ling Mo Jun Deng Peking University People’s Hospital and Peking University Hepatology Institute Beijing 100044China Qingdao Municipal Hospital Qingdao 266011Shandong ProvinceChina Guangzhou No.8 People’s Hospital Guangzhou 510060Guangdong ProvinceChina Beijing Youan Hospital Capital Medical UniversityBeijing 100069China Shanghai Ruijin Hospital Jiaotong University School of MedicineShenyang 200025Liaoning ProvinceChina TheFirst Affiliated Hospital with Nanjing Medical University Nanjing 210029Jiangsu ProvinceChina Hepatology Unit Nanfang HospitalSouthern Medical UniversityGuangzhou 510515Guangdong ProvinceChina West China Hospital Sichuan UniversityChengdu 610041Sichuan ProvinceChina China Medical University Shengjing HospitalShenyang 110004Liaoning ProvinceChina Bristol-Myers Squibb PrincetonNJ 08540United States Bristol-Myers Squibb WallingfordCT 06492United States 302 Military Hospital of China Beijing 100039China Bristol-Myers Squibb Shanghai 200040China the Sixth People’s Hospital of Shenyang Shenyang 110006Liaoning ProvinceChina Beijing Friendship Hospital Capital Medical UniversityBeijing 100050China Saint-Petersburg State Healthcare Institution'Clinical Infectious Hospital n.a.S.P.Botkin’ Saint-Petersburg 191167Russia Beijing Ditan Hospital Capital Medical UniversityBeijing 100015China I.M.Sechenov First Moscow State Medical University Moscow 119991Russia The First Hospital of Jilin University Jilin 1300021Jilin ProvinceChina SMG-SNU Boramae Medical Center Seoul 07061South Korea

AIM To assess daclatasvir plus asunaprevir(d UAL) in treatment-na?ve patients from China's Mainland, Russia and South Korea with hepatitis C virus(HCV) genotype 1 b infection. METHODS Patients were randomly assigned(3:1) to receive 24 wk of treatment with d UAL(daclatasvir 60 mg once daily and asunaprevir 100 mg twice daily) beginning on day 1 of the treatment period(immediate treatment arm) or following 12 wk of matching placebo(placebodeferred treatment arm). The primary endpoint was a comparison of sustained virologic response at posttreatment week 12(SVR12) compared with the historical SVR rate for peg-interferon plus ribavirin(70%) among patients in the immediate treatment arm. The first 12 wk of the study were blinded. Safety was assessed in d UAL-treated patients compared with placebo patients during the first 12 wk(doubleblind phase), and during 24 wk of d UAL in both arms *** In total, 207 patients were randomly assigned to immediate(n = 155) or placebo-deferred(n = 52) treatment. Most patients were Asian(86%), female(59%) and aged < 65 years(90%). Among them, 13% had cirrhosis, 32% had IL28 B non-CC genotypes and 53% had baseline HCV RNA levels of ≥ 6 million IU/m L. Among patients in the immediate treatment arm, SVR12 was achieved by 92%(95% confidence interval: 87.2-96.0), which was significantly higher than the historical comparator rate(70%). SVR12 was largely unaffected by cirrhosis(89%), age ≥ 65 years(92%), male sex(90%), baseline HCV RNA ≥ 6 million(89%) or IL28 B non-CC genotypes(96%), although SVR12 was higher among patients without(96%) than among those with(53%) baseline NS5 A resistanceassociated polymorphisms(at L31 or Y93 H). during the double-blind phase, aminotransferase elevations were more common among placebo recipients than among patients receiving d UAL. during 24 wk of d UAL therapy(combined arms), the most common adverse events(≥ 10%) were elevated alanine aminotransferase and upper respiratory tract infection; emergent

关键词： Asunaprevir Daclatasvir Direct-acting antiviral Chronic hepatitis C Liver disease NS3 NS5A Genotype 1b

猪源干扰素刺激基因PPBP荧光定量PCR检测方法的建立及初步应用

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中国动物传染病学报 2018年第3期26卷 28-33页

作者：王飞飞刘珂郇贝丽魏建超邵东华李蓓蓓邱亚峰石元元钱莺娟马志永 jung yong-Sam 南京农业大学动物医学院教育部动物健康与食品安全国际合作联合实验室南京210095 中国农业科学院上海兽医研究所上海200241

根据猪源干扰素刺激基因PPBP(pro-platelet basic protein)基因全长序列,使用引物设计软件Primer Premier5.0设计合成特异性引物,经过PCR扩增,将基因扩增的片段连接到相应的载体上,成功构建重组质粒p3XFLAG-CMV-7.1-PPBP。重组质粒经过... 详细信息

根据猪源干扰素刺激基因PPBP(pro-platelet basic protein)基因全长序列,使用引物设计软件Primer Premier5.0设计合成特异性引物,经过PCR扩增,将基因扩增的片段连接到相应的载体上,成功构建重组质粒p3XFLAG-CMV-7.1-PPBP。重组质粒经过筛选、鉴定以及纯化后,经10倍系列稀释作为质控样品,用于实时荧光定量PCR中PPBP标准曲线的构建,并检测重复性、灵敏性和特异性。结果显示标准曲线线性关系R2>0.99;特异性试验中也能检测到PPBP扩增曲线;组间和组内变异系数均小于5%。使用建立的SYBR GreenⅠ荧光定量RT-PCR检测PRRSV感染组织和未感染组织中PPBP的表达情况,能够检测出组织中PPBP的含量存在差异。本研究初步建立了检测猪PPBP基因的SYBR GreenⅠ荧光定量RT-PCR的方法,为后续猪传染性疾病和猪PPBP之间相互关系的研究提供一个特异灵敏的检测和手段。

关键词：促血小板碱性蛋白 SYBR GreenⅠ 实时荧光定量PCR

Neddylation蛋白修饰通路激活与流感病毒致病性关系研究

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Neddylation蛋白修饰通路激活与流感病毒致病性关系研究

Structural designs and mechanism insights into electrocatalytic oxidation of 5-hydroxymethylfurfural

中国畜牧兽医学会兽医公共卫生学分会第六次学术研讨会

作者：孙海伟钱莺娟 yong-Sam jung 陈鸿军中国农业科学院上海兽医研究所南京农业大学动物医学院

为了明确流感病毒感染宿主细胞后Neddylation蛋白修饰通路的变化,本研究利用流感病毒A/swine/Jiangsu/C1/08 (H9N2)(简称:H9C1)、A/California/04/09 (H1N1)小鼠适应株(简称:maCa04)病毒感染A549细胞,研究结果揭示:H9N2和H1N1亚型流感病毒在感染早期(4h～6h)激活了Neddylation蛋白修饰通路,修饰后的Neddylated-Cullin-1含量升高1.6～2.1倍,并引起IL-1β、IL-6和TNF-α显著升高(P<0.01)。为了探明Neddylation蛋白修饰对流感病毒的复制及致病性影响,利用活化酶(NAE1)特异性抑制剂MLN4924预处理A549细胞12hr,分别感染不同流感病毒,在感染后9h、12h分别收获感染细胞和培养液,结果表明:MLN4924抑制剂阻断Neddylation修饰后,流感病毒在细胞中的复制能力明显降低,炎性反应明显降低。为了验证MLN4924在体内同样具有抑制病毒作用,将20μg MLN4924经鼻腔给药预处理Balb/C小鼠,利用10TCID的maCa04、10 TCID的H9C1和5×10TCID的A/PuertoRico/8/34(PR8)(H1N1)(简写:PR8)病毒感染小鼠,结果显示:弱毒株H9C1株感染组,经MLN4924治疗后,肺脏中病毒载量明显降低,强毒株(maCa04,PR8)感染组有20%小鼠得以存活,肺脏中病毒载量明显降低,肺部IL-1β、IL-6和TNF-α等炎性因子表达量明显降低。进一步阐明流感病毒蛋白与Neddylation通路之间的互作关系,本研究利用慢病毒shRNA表达系统敲低Neddylation通路相关因子,构建成Cullin-1敲低(KD)细胞系。感染流感病毒后,Cullin-1敲低细胞系的病毒滴度明显升高。这说明该通路负调控流感病毒感染。进一步通过免疫共沉淀技术,结果发现:Cullin-1与流感病毒蛋白NS1存在互作,而与PB2、PB1、PA、NP等病毒蛋白无互作。Cullin-1介导NS1通过蛋白酶体途径降解,而NS1通过RNA结合区与Cullin-1直接互作,NS1极有可能劫持Cullin-1-RING E3连接酶复合体(CRL1),负调控CRL1对其他病毒蛋白的降解作用。

关键词：流感病毒 Neddylation修饰 MLN4924 Cullin-1

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Journal of Energy Chemistry 2025年第1期100卷 792-814页

作者： Jing Lei Huijie Zhang Jian Yang Jia Ran Jiqiang Ning Haiyan Wang yong Hu Key Laboratory of the Ministry of Education for Advanced Catalysis Materials Department of Chemistry Zhejiang Normal University Jinhua Advanced Research Institute Department of Optical Science and Engineering Fudan University College of Chemistry and Materials Engineering Zhejiang A&F University

Biomass conversion offers an efficient approach to alleviate the energy and environmental *** oxidation of 5-hydroxymethylfurfural(HMF) has attracted tremendous attention in the latest few years for the mild synthesis conditions and high conversion efficiency to obtain 2,5-furan dicarboxylic acid(FDCA), but there still remain problems such as limited yield, short cycle life,and ambiguous reaction mechanism. Despite many reviews highlighting a variety of electrocatalysts for electrochemical oxidation of HMF, a detailed discussion of the structural modulation of catalyst and the underlying catalytic mechanism is still lacking. We herein provide a comprehensive summary of the recent development of electrochemical oxidation of HMF to FDCA, particularly focusing on the mechanism studies as well as the advanced strategies developed to regulate the structure and optimize the performance of the electrocatalysts, including heterointerface construction, defect engineering,single-atom engineering, and in situ reconstruction. Experimental characterization techniques and theoretical calculation methods for mechanism and active site studies are elaborated, and challenges and future directions of electrochemical oxidation of HMF are also prospected. This review will provide guidance for designing advanced catalysts and deepening the understanding of the reaction mechanism beneath electrochemical oxidation of HMF to FDCA.

关键词： Structural design

Weak KAM theory for two classes of almost periodic Hamiltonian systems

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Science China Mathematics 2025年

作者： Xun Niu Kaizhi Wang yong Li School of Mathematics and Statistics Center for Mathematics and Interdisciplinary SciencesNortheast Normal University School of Mathematical Sciences Shanghai Frontier Science Center of Modern Analysis (CMA-Shanghai)Shanghai Jiao Tong University Institute of Mathematics Jilin University

The purpose of this paper is to investigate the dynamics of Bohr almost periodic and Levitan almost periodic Hamiltonian systems via the weak KAM theory. We obtain minimal measures and weak KAM solutions in both cases. The weak KAM solution is a weak solution to the Hamilton-Jacobi equation, which formally transforms the original Hamiltonian systems into an integrable one. Consequently, we get the existence of an invariant torus in the aforementioned weak sense.

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ATP5J促进猪繁殖与呼吸综合征病毒复制研究

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畜牧与兽医 2018年第8期50卷 54-58页

作者：王飞飞刘珂郇贝丽欧安妮魏建超李蓓蓓邵东华邱亚峰钱莺娟 jung yong-Sam 马志永南京农业大学动物医学院/教育部动物健康与食品安全国际合作联合实验室江苏南京210095 中国农业科学院上海兽医研究所上海200241

为了研究猪繁殖与呼吸综合征病毒（porcine reproductive and respiratory syndrome virus,PRRSV）复制与细胞调控酶ATP5J的关系,本研究首先对猪源ATP5J基因进行了抗原表位分析,选取并合成了3段抗原小肽,制备ATP5J的多克隆的抗体。用制... 详细信息

为了研究猪繁殖与呼吸综合征病毒（porcine reproductive and respiratory syndrome virus,PRRSV）复制与细胞调控酶ATP5J的关系,本研究首先对猪源ATP5J基因进行了抗原表位分析,选取并合成了3段抗原小肽,制备ATP5J的多克隆的抗体。用制备的多抗检测了ATP5J质粒在293T细胞中过表达的情况。然后,用PRRSV感染猪肺泡巨噬细胞（PAMs）,利用qPCR和Western blot检测PRRSV感染对PAM细胞中ATP5J表达的影响。最后,我们通过小RNA干扰以及过表达ATP5J,使用qPCR和Western blot技术,在PAM和Marc-145细胞上检测ATP5J变化对PRRSV复制增殖的影响。结果显示：PRRSV感染能够导致宿主细胞ATP5J蛋白表达下调;ATP5J下调时,PRRSV复制减弱;ATP5J过表达时,PRRSV复制增强,说明ATP5J能够促进PRRSV复制增殖。进一步分析证明：ATP5J促进PRRSV复制功能没有剂量依赖性。综上,PRRSV感染能够导致宿主细胞ATP5J蛋白表达下调,而ATP5J具有促进PRRSV复制的作用。该研究为阐明PRRSV与宿主相互作用提供了新思路,为解析PRRSV免疫抑制和免疫逃逸机制奠定了基础。

关键词：猪繁殖与呼吸综合征病毒 ATP5J 基因调节病毒复制

情绪劳动和工作压力对中国养老院护理人员离职意愿的影响

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中阿科技论坛（中英文） 2021年第6期 205-207页

作者：孔晨丁起荣韩国世翰大学当津31746 韩国世翰大学木浦58447

本研究旨在防止护理人员因情绪劳动而换工作的意图,并寻求通过减少人员流动来提高熟练技术人员的服务质量的方法。为此,在先前的研究和Koeske和Koeske(2000)的应力应变结果(SSO)模型的基础上,建立了研究模型和假设。为了进行实证研究,... 详细信息

本研究旨在防止护理人员因情绪劳动而换工作的意图,并寻求通过减少人员流动来提高熟练技术人员的服务质量的方法。为此,在先前的研究和Koeske和Koeske(2000)的应力应变结果(SSO)模型的基础上,建立了研究模型和假设。为了进行实证研究,文章对我国福利院式养老院的883名护理人员进行了研究。结果如下:护理人员的情绪劳动对离职意图有直接影响;情绪劳动对工作压力具有直接的静态影响;工作压力对离职意图产生了静态影响。

关键词：工作压力工作压力护理人员疗养院离职意向

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Tubacin对蓝舌病毒感染的抑制作用

中国兽医学报 2019年第10期39卷 1902-1906页

作者：陈新曹雨薄宗义陈欢孙雯张志芳印春生钱莺娟 jung yong-sam 戴建君南京农业大学动物医学院教育部动物健康与食品安全国际合作联合实验室/农业部动物细菌学重点实验室江苏南京210095 中国兽医药品监察所北京100081 中国农业科学院北京畜牧兽医研究所北京100193

蓝舌病(bluetongue,BT)是由蓝舌病毒(bluetongue virus,BTV)感染反刍动物,包括山羊、绵羊、水牛和骆驼等,引起的非接触性传染病,以口腔、鼻腔及胃黏膜发生溃疡性炎症病变为主要特征,库蠓是其主要传播媒介。BTV传播相当广泛,除了南极洲... 详细信息

蓝舌病(bluetongue,BT)是由蓝舌病毒(bluetongue virus,BTV)感染反刍动物,包括山羊、绵羊、水牛和骆驼等,引起的非接触性传染病,以口腔、鼻腔及胃黏膜发生溃疡性炎症病变为主要特征,库蠓是其主要传播媒介。BTV传播相当广泛,除了南极洲外的所有洲都有发现,近20年间在欧洲肆虐传播,造成了巨大的经济损失。目前发现的BTV包含26个血清型,型间没有交叉保护作用,使用传统疫苗只能提供部分保护。虽然目前已经有针对多种血清型BTV重组疫苗的研究,但保护效果并不理想。因此,研究防治BT的药物具有重要的应用价值。本研究发现,组蛋白去乙酰化酶6(HDAC6)的特异性抑制剂Tubacin能够抑制13型BTV感染,通过半定量PCR、Western blot、TCID50等试验验证,Tubacin处理后细胞病变减轻,病毒RNA和蛋白表达水平下降,上清中病毒粒子含量减少。结果证明Tubacin可在一定程度上抑制BTV感染,Tubacin是抗BTV的候选药,HDAC6可能是抗BTV感染的靶点之一。

关键词：蓝舌病 Tubacin 抗病毒