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The prognostic significance of percentage of tumour involvement according to disease risk group in men treated with radical prostatectomy

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Asian Journal of Andrology 2011年第6期13卷 828-832页

作者： Jong Jin Oh Sang Cheol Lee Chang Wook Jeong Cheol yong Yoon seong Jin Jeong Sung Kyu Hong Seok-Soo Byun Yoon Kwan Rho Gheeyoung Choe Sang Eun Lee Department of Urology Seoul National University Bundang Hospital Seongnam Kyunggi-do 463-707 Korea Department of Pathology Seoul National University Bundang Hospital Seongnam Kyunggi-do 463-707 Korea

We investigated the prognostic significance of percentage of tumour involvement （PTI） according to the clinicopathological features of prostate cancer among patients who underwent radical prostatectomy （RP）. A retrospective study of 534 patients who underwent RP between September 2003 and March 2008 without any neoadjuvant or adjuvant therapy was performed. The associations of PTI with various clinicopathological features and biochemical recurrence-free survival were examined via uni- and multivariate analyses. The predictive accuracy of the multivariate model was assessed with a receiver operating characteristics-derived area under the curve. PTI was demonstrated to be significantly associated with preoperative prostate-specific antigen （PSA） level （P=0.001）, pathological Gleason score （P〈0.001）, extraprostatic tumour extension （P〈0.001）, seminal vesicle invasion （P〈0.001） and positive surgical margin （P〈0.001） in univariate analyses. When patients were stratified into disease risk groups, PTI was an independent predictor of biochemical recurrence-free survival in multivariate analysis only among the low-risk group （P=0.033） but not the intermediate- （P=0.287） or the high-risk groups （P=0.828）. The addition of the PTI did not significantly increase the accuracy of the multivariate model devised for the prediction of biochemical recurrence-free survival among both total patients （P=-0.459） and the low-risk group （P=0.268）, respectively. In conclusion, although PTI appeared to be a more significant prognostic factor among patients with low-risk disease than among those with higher risk diseases, overall, the PTI may not provide additional prognostic information beyond what can already be obtained via established prognostic factors.

关键词： biochemical recurrence-free survival percentage of tumour involvement prognosis prostate cancer prostatectomy

The 5-year functional outcomes after radical prostatectomy： a real-life experience in Korea

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Asian Journal of Andrology 2010年第6期12卷 835-840页

作者： Sung Kyu Hong Seung Hwan Doo Dae Sung Kim Won Ki Lee Hong Zoo Park Ji Hyun Park seong Jin Jeong Cheol yong Yoon Seok-Soo Byun Sang Eun Lee Department of Urology Seoul National University Bundang Hospital Seongnam Kyunggi-do 463-707 Korea

We investigated the functional outcomes regarding erectile function and urinary continence up to 5 years following radical prostatectomy （RP） in a cohort of Korean men. We retrospectively analyzed the clinicopathologic data of 85 Korean men who received open uni- or bilateral nerve-sparing RP for clinically localized prostate cancer and were followed up for at least 5 years postoperatively. From medical records, patients＇ status regarding urinary and erectile function at baseline and postoperative followups after RP was assessed. At 24 and 60 months after RP, proportions of subjects continent （no pads used） were 89.4% and 97.6%, respectively （P = 0.007）. Excluding subjects （n = 24） who preoperatively reported having severe erectile dysfunction or lacked relevant informations, proportions of subjects capable of having vaginal intercourse regardless of erectile aid usage were 47.5% and 37.7% at 24 and 60 months from RP, respectively （P = 0.022）. Patient＇s age at surgery （P = 0.047） and salvage radiation therapy （P = 0.026） were observed to be significant predictors of having erections sufficient for intercourse at 60 months from RP in multivariate analysis. Our results showed that while patients＇ postoperative status regarding urinary continence at 2 years from RP is generally maintained or improved at 5 year point, erectile function was observed to significantly declined from 2 years to 5 years following RP. Such decline in erectile function following RP may be more significant among men who were relatively older at surgery or those who received salvage therapy during postoperative follow-ups.

关键词： impotence prostatectomy prostatic neoplasm urinary incontinence

Damage Analysis and Infection Pattern of Tomato Yellow Leaf Curl Virus on Tomato

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Damage Analysis and Infection Pattern of Tomato Yellow Leaf ...

Mechanical and electrochemical characteristics in sea water of 5052-O aluminum alloy for ship

中国植物病理学会2012年学术年会

作者： Lee Joong-Hwan Choi seong-yong Institute for Bioresources Research Gyeongsangbuk-do Agricultural Research and Extension ServicesAndong760-891Republic of Korea Department of Agricultural Environment Gyeongsangbuk-do Agricultural Research and Extension ServicesDaegu702-708Republic of Korea

＜正＞Tomato（Lycopersicon esculentum） is major fruit vegetable crop;it was grown over 7 100ha in south korea at *** yellow leaf curl virus（TYLCV） disease was spread widely in tomato growing area and caused severe income *** plastic house,Bemisia tabaci which is insect vector of TYLCV was increased faster than Trialeurodes vaporariorum during summer season（after two months breeding,rate of Bemisia tabaci is 68%and Trialeurodes vaporariorum is 32%） and increasing rate of Bemisia tabaci was 680%.When Bemisia tabaci was bred in plastic house with tomato plants infected by TYLCV,viruliferous insect rate was over 50%.In tomato plants which are susceptible to TYLCV,virus symptoms（leaf curl and chlorosis） were appeared 17 days after inoculation with viruliferous Bemisia tabaci however,the tomato plants with resistant capability to TYLCV has no *** gene was detected by PCR（using appropriate detection primer） at both（susceptible and resistant） *** symptoms were expressed in susceptible variety,plant growth and fruit yield were decreased severely. Although symptoms were not appeared in resistant variety,the plant growth and fruit yield were also decreased about 7%～20%.The net photosynthesis of infected tomato plants were decreased at the rate of 78%in susceptible and 61%in resistant varieties at 20 days after infection to TYLCV compared to that of healthy plants.

关键词： Tomato Tomato yellow leaf curl virus Bemisia tabaci

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Transactions of Nonferrous Metals Society of China 2013年第3期23卷 636-641页

作者： seong-Jong KIM Seok-Ki JANG Min-Su HAN Jae-Cheul PARK Jae-yong JEONG Sang-Ok CHONG Division of Marine Engineering Mokpo Maritime Univers ityHaeyangdaehak-ro 91 Mokpo-Si530-729Korea

The optimum corrosion protection potentials were examined for 5052-O Al alloy,which is mainly used in *** electrochemical experiments were carried out and the surface morphologies of specimens were observed by scanning electron microscopy（SEM） in order to determine the optimum corrosion protection potential to overcome pitting,corrosion,stress corrosion cracking（SCC）,and hydrogen embrittlement in sea *** optimum protection potential range of-1.3 V to-0.7 V was determined under the application of an impressed current cathodic protection（ICCP） *** low current densities were shown in the range of-1.3 V to-0.7 V in the electrochemical experiments and good specimen surface morphologies were observed after potentiostatic experiment.

关键词： aluminum alloy corrosion electrochemical characteristics stress corrosion cracking hydrogen embrittlement sea water corrosion cathodic protection

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Stress and sleep quality in doctors working on-call shifts are associated with functional gastrointestinal disorders

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World Journal of Gastroenterology 2017年第18期23卷 3330-3337页

作者： Soo-Kyung Lim Seung Jin Yoo Dae Lim Koo Chae A Park Han Jun Ryu yong Jin Jung Ji Bong Jeong Byeong Gwan Kim Kook Lae Lee seong-Joon Koh Department of Internal Medicine Seoul National University College of MedicineSeoul National University Boramae Hospital Department of Neurology Seoul National University Boramae HospitalSeoul National University College of Medicine

To investigate the role of sleep quality and psychosocial problems as predictors of functional gastrointestinal disorders (FGIDs) in doctors that work 24 hour-on-call *** this cross-sectional observation study, using the Rome III Questionnaire and Pittsburgh Sleep Quality Index (PSQI), we analyzed 170 doctors with 24 hour-on-call *** the participants that had experienced a 24 hour-on-call shift within the last 6 mo, 48 (28.2%) had FGIDs. Overall prevalence of irritable bowel syndrome (IBS) and functional dyspepsia (FD) were 16.5% and 17.1%, respectively, with 5.3% exhibiting both. Sleep scores (PSQI) (8.79 ± 2.71 vs 7.30 ± 3.43, P = 0.008), the presence of serious psychosocial alarm (83.3% vs 56.6%, P = 0.004), and the proportion of doctors who experienced over two months of recent on-call work (81.2% vs 68.9%, P = 0.044) were significantly different between individuals with or without FGIDs. Multivariate analysis revealed that presenting serious psychosocial alarm was an independent risk factor for prevalence of FD (OR = 5.47, 95%CI: 1.06-28.15, P = 0.042) and poor sleep quality (PSQI ≥ 6) was a predictor of IBS (OR = 4.17, 95%CI: 1.92-19.02, P = 0.016).CONCLUSIONPhysicians should recognize the role of sleep impairment and psychological stress in the development of FGIDs and a comprehensive approach should be considered to manage patients with FGIDs.

关键词： Psychosocial stress Sleep 24 hour-on-call shift Doctors Functional gastrointestinal disorders

Clinical implications of fatty pancreas:Correlations between fatty pancreas and metabolic syndrome

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World Journal of Gastroenterology 2009年第15期15卷 1869-1875页

作者： Jun Seok Lee Sang Heum Kim Dae Won Jun Jee Hye Han Eun Chul Jang Ji Young Park Byung Kwan Son seong Hwan Kim Yoon Ju Jo Young Sook Park yong Soo Kim Department of Internal Medicine Eulji University School of Medicine Department of Radiology Eulji University School of Medicine Department of Family Medicine Eulji University School of Medicine Department of Occupational and Environmental Medicine College of MedicineSoonchunhyang University Department of Radiology Hanyang University School of Medicine

AIM:To investigate the clinical implications of lipid deposition in the pancreas(fatty pancreas). METHODS:The subjects of this study were 293 patients who had undergone abdominal computed tomography(CT)and *** pancreas was diagnosed by sonographic findings and subdivided into mild,moderate,and severe fatty pancreas groups comparing to the retroperitoneal fat echogenicity. RESULTS:Fatty pancreas was associated with higher levels for visceral fat,waist circumference,aspartate aminotransferase(AST),alanine aminotransferase (ALT),total cholesterol,triglyceride,high density lipoprotein,free fatty acid,γ-GTP,insulin,and the homeostasis model assessment of insulin resistance (HOMA-IR)than the control group(P<0.05).HOMAIR,visceral fat,triglyceride,and ALT also tended to increase with the degree of fat deposition in the pancreas on *** a multivariate logistic regression analysis,HOMA-IR,visceral fat,and ALT level were independently related to fatty pancreas after adjustment for age,body mass index,and lipid *** incidence of metabolic syndrome in the fatty pancreas group was significantly higher than in the control group,and the numbers of metabolic syndrome parameters were significantly higher in the fatty pancreas group(P<0.05).CONCLUSION:Sonographic fatty pancrease showed higher insulin resistance,visceral fat area,triglyceride, and ALT levels than normal *** pancreas also showed a strong correlation with metabolic syndrome.

关键词： Fatty pancreas Metabolic syndrome Insulin resistance

Comparative effects of artemisia vulgaris and charcoal moxa stimulating Zhongwan(CV 12) on body temperature in healthy participants:a cross-over single-blind randomized study

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Journal of Traditional Chinese Medicine 2015年第5期35卷 551-557页

作者： Ho-Yeon Go Ju Ah Lee Sunyoung Park Sunju Park Jeong-Su Park Chunhoo Cheon seong-Gyu Ko Kyung-Hwan Kong Chan-yong Jun Jong-hyeong Park Mi-Ran Shin Se-Hoon Lee Department of Internal Medicine College of Korean MedicineSemyung University Department of Public Health The Catholic University of Korea Medical Research Division Korea Institute of Oriental Medicine Department of Physiology College of Korean MedicineSemyung University Department of Preventive Medicine College of Korean MedicineDaejeon University Center for Clin ical Research and Genomics College of Oriental Medicine and Institu te of Oriental MedicineKyung Hee University Department of Internal Medicine College of Korean MedicineGachon University Department of Sasang Constitutional Medicine College of Korean MedicineSemyung University

OBJECTIVE:To evaluate the efficacy,safety,satisfaction,discomfort and patient preference of moxa cones of artemisia vulgaris and charcoal ***:This comparative study of moxibustion treatment with Artemisia vulgaris and charcoal moxa cone stimulating Zhongwan(CV 12) is a cross-over single-blinded,randomized clinical trial.A total of 40 healthy subjects(24 males and 16females) participated in this *** subjects dropped out of the ***-eight subjects were treated with Artemisia vulgaris and charcoal moxa cones for 30 min in a cross-over *** treatment,the patients underwent a 30 minute waiting period,and then the temperatures at Tanzhong(CV 17),Zhongwan(CV 12) and Guanyuan(CV 4) were measured using digital infrared thermal ***:After the use of Artemisia vulgaris moxa,the patients' body temperatures were slightly lowered at Tanzhong(CV 17),Zhongwan(CV 12)and Guanyuan(CV 4),but the changes were not statistically *** the use of charcoal moxa,the patients' body temperatures were somewhat increased at Zhongwan(CV 12) and Guanyuan(CV 4),but the changes were not statistically *** Artemisia vulgaris moxa use,the body temperature difference between Zhongwan(CV 12) and Guanyuan(CV 4)was significantly *** charcoal moxa use,the body temperature difference between Tanzhong(CV 17) and Zhongwan(CV 12) was significantly decreased in males and in the whole *** change was caused by the difference in the moxibustion type and by gender ***:This pilot study found that moxibustion did not raise the body temperature,but temperature differences between acupoints were *** large-scale randomized controlled trials are needed for the effect of moxibustion on body temperature.

关键词： Moxibustion Point CV12(Zhongwan) Artemisia Body temperature Cross-over studies Single-blind method Randomized controlled trial

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Asymmetrical response of summer rainfall in East Asia to CO_(2)forcing

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Science Bulletin 2022年第2期67卷 213-222,M0004页

作者： Se-yong Song Sang-Wook Yeh Soon-Il An Jong-seong Kug Seung-Ki Min Seok-Woo Son Jongsoo Shin Department of Marine Sciences and Convergence Technology Hanyang UniversityAnsan 15588South Korea Department of Atmospheric Sciences/Irreversible Climate Change Research Center Yonsei UniversitySeoul 03722South Korea Division of Environmental Science and Engineering Pohang University of Science and TechnologyPohang 37673South Korea Institute for Convergence Research and Education in Advanced Technology Yonsei UniversityIncheon 21983South Korea School of Earth and Environmental Science Seoul National UniversitySeoul 08826South Korea

Understanding the regional hydrological response to varying CO_(2)concentration is critical for cost-benefit analysis of mitigation and adaptation polices in the near future. To characterize summer monsoon rainfall change in East Asia in a changing CO_(2)pathway, we used the Community Earth System Model(CESM) with28 ensemble members in which the CO_(2)concentration increases at a rate of 1% per year until its quadrupling peak, i.e., 1468 ppm(ramp-up period), followed by a decrease of 1% per year until the present-day climate conditions, i.e., 367 ppm(ramp-down period). Although the CO_(2)concentration change is symmetric in time, the amount of summer rainfall anomaly in East Asia is increased 42% during a rampdown period than that during a ramp-up period when the two periods of the same CO_(2)concentration are compared. This asymmetrical rainfall response is mainly due to an enhanced El Ni?o-like warming pattern as well as its associated increase in the sea surface temperature in the western North Pacific during a ramp-down period. These sea surface temperature patterns enhance the atmospheric teleconnections and the local meridional circulations around East Asia, resulting in more rainfall over East Asia during a ramp-down period. This result implies that the removal of CO_(2)does not guarantee the return of regional rainfall to the previous climate state with the same CO_(2)concentration.

关键词： CO_(2)concentration East Asian summer monsoon Asymmetric rainfall El Ni?o-like warming

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Hepatectomy vs radiofrequency ablation for colorectal liver metastasis:A propensity score analysis

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World Journal of Gastroenterology 2015年第11期21卷 3300-3307页

作者： Huisong Lee Jin Seok Heo yong Beom Cho seong Hyeon Yun Hee Cheol Kim Woo yong Lee seong Ho Choi Dong Wook Choi Department of Surgery Samsung Medical CenterSungkyunkwan University School of Medicine

AIM:To compare outcomes from radiofrequency ablation(RFA) and hepatectomy for treatment of colorectal liver metastasis(CRLM).METHODS:From January 2000 to December 2009,408 patients underwent curative intent treatment for *** excluded patients using the criteria:size of CRLM > 3 cm,number of CRLM ≥ 5,percutaneous RFA,follow-up period 2 cm) CRLM(P = 0.034).However,survival curves were similar for single or small(≤ 2 cm) CRLM(P = 0.714,P = 0.740).CONCLUSION:Hepatectomy is better than RFA for the treatment of ***,RFA might be suitable for selected patients with single,small(≤ 2 cm) CRLM.

关键词： Colorectal neoplasm Metastasis Catheter ablation H