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Safety of fecal microbiota transplantation in Chinese children: A single-center retrospective study

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World Journal of Clinical Cases 2018年第16期6卷 1121-1127页

作者： Xin-Yue Zhang Yi-Zhong Wang xiao-Lu Li Hui Hu Hai-Feng Liu Dan Li yong-mei xiao Ting Zhang Department of Gastroenterology Hepatology and Nutrition Shanghai Children's Hospital Shanghai Jiao Tong University

BACKGROUND Fecal microbiota transplantation(FMT) is the administration of fecal bacterial liquid from healthy donors to a recipient's digestive tract, which is recommended as a therapeutic method for recurrent Clostridium difficile infection(CDI). Many clinical trials focusing on different diseases are in progress. To date, scarce research and long-term follow-up have been conducted on FMT in children or on the proper guidelines. Our center first performed FMT to treat a 13-month-old boy with severe CDI in 2013. Until February 2018, our center had performed 114 pediatric FMT procedures in 49 subjects. AIM To investigate the safety of FMT in children. METHODS A retrospective study was conducted on 49 patientswho underwent 114 FMT treatments at our hospital. All FMT processes followed uniform standards. Adverse events(AEs) related to FMT were divided into shortterm(48 h post-FMT) and long-term(3 mo). All potential influencing factors for AEs, such as gender, age, time of FMT infusion, route of administration, disease type, immune function state, and donor relative genetic background, were analyzed as independent factors. The significant independent factors and risk ratio with 95% confidence interval(CI) were assessed by multivariate logistic regression *** Forty-nine patients(mean age 68.1 mo, range 4 to 193 mo) were recruited. Their average follow-up time after the first FMT was 23.1 mo. The incidence of short-term AEs was 26.32%(30/114). The most common shortterm AEs were abdominal pain, diarrhea, fever, and vomiting, which were all self-limited and symptom-free within 48 h. Two severe AEs occurred, and one patient died in the fourth week after FMT. All-cause mortality was 2.04%. As independent factors, age(P = 0.006) and immune state(P = 0.002) had significant effects. Age greater than 72 mo seemed to be correlated with more AEs than age 13 to 36 mo(P = 0.04). In multivariate logistic regression analysis, immune state was an independent risk factor for

关键词： Safety Fecal microbiota transplantation Pediatrics Adverse event Immune system diseases Age factors

A Retrospective Study of 1526 Cases of Transcatheter Occlusion of Patent Ductus Arteriosus

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Chinese Medical Journal 2015年第17期128卷 2284-2289页

作者： mei Jin yong-mei Liang xiao-Fang Wang Bao-Jing Guo Ke Zheng Yan Gu Zhen-Yu Lyu Department of Pediatric Cardiology Beijing Anzhen Hospital Capital Medical University Beijing 100029 China

Background： Patent ductus arteriosus （PDA） is one of the most common congenital heart diseases and began to get treated by transcatheter occlusion since 1997 in China. Since then, several devices have been invented for occluding PDA. This study aimed to evaluate the technical feasibility, safety, and efficacy of transcatheter occlusion of PDA with different devices. Methods： One thousand five hundred and twenty-six patients （537 boys, 989 girls） with PDA from January 1997 to September 2014 underwent descending aortogram and transcatheter occlusion procedure. We retrospectively analyzed data of these patients, including gender, age, weight, size and morphology of PDA, and devices used in transcatheter occlusion, outcomes, and postoperational complications. Results： Median age and median weight were 4.0 years （range： 0.3 5-2.0 years old） and 15.3 kg （range： 4.5-91.0 kg）, respectively. Mean ductal diameter, aortic ductal diameter, ductal length, and pulmonary artery pressure were 3.50 ± 2.15 mm, 10.08 ± 2.46 ram, 7.49 ± 3.02 mm, and 30.21 ± 17.28 mmHg, respectively. Morphology of PDA assessed by descending aortogram was of type A in 1428 patients, type B in 6 patients, type C in 79 patients, type D in 4 patients, and type E in 9 patients according to the classification of Krichenko. Of all the 1526 patients, 1497 patients underwent transcatheter PDA closure, among which 1492 were successful. Devices used were Amplatzer duct occluder I （ADO I, 1280, 85.8%）, Cook detachable coils （116, 7.8%）, ADO II （ADO II, 68, 4.6%）, muscular VSD occluder （12, 0.8%）, and Amplatzer vascular plug （16, 1.0%）. Conclusions： Excellent occlusion rates with low complication rates were achieved with all devices regardless of PDA types. With transcatheter occlusion technique and devices developing, more patients with PDA can be treated with transcatheter closure both safely and efficiently.

关键词： Congenital Heart Disease Devices Patent Ductus Arteriosus Transcatheter Occlusion

The Hilbert expansion of the Boltzmann equation in the incompressible Euler level in a channel

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Science China Mathematics 2025年第1期68卷 39-88页

作者： Feimin Huang Weiqiang Wang yong Wang Feng xiao Academy of Mathematics and Systems Science Chinese Academy of Sciences School of Mathematical Sciences University of Chinese Academy of Sciences Key Laboratory of Computing and Stochastic Mathematics (Ministry of Education) School of Mathematics and StatisticsHunan Normal University

The study of the hydrodynamic limit of the Boltzmann equation with physical boundary is a challenging problem due to the appearance of the viscous and Knudsen boundary *** this paper,the hydrodynamic limit from the Boltzmann equation with the specular reflection boundary condition to the incompressible Euler equations in a channel is *** on the multi-scaled Hilbert expansion,the equations with boundary conditions and compatibility conditions for interior solutions,and viscous and Knudsen boundary layers are derived under different scaling,***,some uniform estimates for the interior solutions,and viscous and Knudsen boundary layers are *** the help of the L2-L∞framework and the uniform estimates obtained above,the solutions to the Boltzmann equation are constructed by the truncated Hilbert expansion with multiscales,and hence the hydrodynamic limit in the incompressible Euler level is justified.

关键词： Boltzmann equation incompressible Euler equations hydrodynamic limit Hilbert expansion specular reflection boundary condition viscous boundary layer Knudsen boundary layer

Relation between eardrum flap area and healing outcome of traumatic eardrum perforation

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Chinese Journal of Traumatology 2011年第5期14卷 264-268页

作者： LOU Zheng-cai TANG yong-mei WU xiao-hong CHEN Jia-hai Department of Otorhinolaryngology Yiwu Central Hospital Yiwu 322000 Zhejiang Province China

Objective： To retrospectively study the clinical effects of eardrum flap area on the healing outcome following traumatic ***： Totally 291 traumatic eardrum perforations with in-/everted edges were included in this study. They were randomly divided into three groups and received conservative treatment, epidermal growth factor （EGF） via Gelfoam patching, or edge-approximation plus Gelfoam patching respectively. Patients in each group were further divided into two subgroups according to the eardrum flap area ≤ 1/2 or 〉1/2 of the perforation size. The healing rate and mean closure time after tympanic membrane perforation were evaluated at three ***： Of the total 291 participants, 281 were included in the final statistical analysis. The area of curled edge did not affect the healing outcome significantly in any groups （P〉0.05）. The healing rate varied slightly： 90.7% vs 92.3% in spontaneous healing group, 98.2% vs 97.4% in EGF via Gelfoam patching group, and 96.5% vs 100% in edge-approximation plus Gelfoam patching group. In addition, in all groups the area of curled edge did not affect the mean closure time significantly （P〉0.05）. The closure time was （32.3±2.4） d vs （30.6±3.1） d in sponaneous healing group, （13.4±2.5） d vs （13.1± 1.9） d in EGF via Gelfoam patching group, and （11.9±3.1） d vs （12.2±2.1） d in edge-approximation plus Gelfoam patching ***： The eardrum flap area of traumatic eardrum perforation does not significantly affect the clinical outcomes.

关键词： Tympanic membraneperforation Wounds and injuries Surgical flaps Gelatin sponge, absorbable

Probiotics for Prevention and Treatment of Respiratory Tract Infections in Children A Systematic Review and Meta-Analysis of Randomized Controlled Trials

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Probiotics for Prevention and Treatment of Respiratory Tract...

Modular assembly of complex C-alkyl glycoside enabled via cooperative NHC and photoredox catalysis

第十三届江浙沪儿科学术会议暨2016年浙江省医学会儿科学学术年会

作者： Yi zhong Wang xiao lu Li Ting Ge yong mei xiao Yang Liao Ting Zhang Department of Gastroenterology Hepatologyand NutritionShanghai Children’s HospitalShanghai Jiao Tong University Pediatric Intensive Care Unit Shanghai Children’s HospitalShanghai Jiao Tong University

Background:Respiratory tract infections(RTIs)represent one of the main health problems in *** are viable bacteria that colonize the intestine and affect the host intestinal microbial *** evidences suggest that probiotics consumption may decrease the incidence of or modify *** authors systematically reviewed data from randomized controlled trials(RCTs)to investigate the effect of probiotics

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Science China Chemistry 2025年

作者： Rui-Qiang Jiao Ming Li Xi Chen mei-Ze Xu Tian Ding xiao-Ping Gong Zhuo-mei Li Xue-Yuan Liu yong-Min Liang State Key Laboratory of Applied Organic Chemistry Lanzhou University College of Chemistry and Chemical Engineering Northwest Normal University

C-Alkyl glycosides are found in natural products and are indispensable in drug development programs,owing to their diverse range of medicinal ***-component reactions involving glycosyl radical addition are well documented and proved efficient for the C-alkyl glycosides ***,multicomponent reactions for the rapid and controllable construction of structurally diversified C-alkyl glycosides in a single step remains a significant challenge due to the issues associated with balancing reactivity,compatibility,and ***,we report an NHC and photoredox co-catalyzed three-component method to access complex and valuable C-alkyl *** protocol exhibits broad substrate scope and excellent chemoand ***,nine types of sugars are compatible with this *** addition,the generality of this catalytic strategy was further highlighted by the potential for scalable production,the feasibility of further modifications of the products and its successful application in the late-stage functionalization of pharmaceutical skeletons.

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Generation and Selection of the Immunized Fab Phage Display Library from Human B Cell Lymphoma

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Generation and Selection of the Immunized Fab Phage Display ...

别嘌呤醇对新生大鼠缺氧缺血性脑损伤的保护作用

江苏省遗传学会第七届代表大会暨学术研讨会

作者： SHEN yong-mei, YANG xiao-chun, XIE xiao-fang, DONG Ning-zheng, SHI Yi-zhen (Second Affiliated Hospital of Soochow University, Suzhou 215004, China)

＜正＞Background The approval of monoclonal antibodies as antibody-targeted therapy in the management of patients with B cell lymphoma has led to new treatment options for this group of patients. But the traditional h... 详细信息

关键词： B cell lymphoma Fab Phage display library pComb3H-SS vector

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复旦学报（医学版） 2004年第4期31卷 347-350,F002页

作者：胡勇邵肖梅张旭东复旦大学附属儿科医院新生儿科上海200032

目的　探讨别嘌呤醇 (ALLO)对新生大鼠缺氧缺血性脑损伤 (HIBD)的影响。方法　将新生 7日龄SD大鼠 14 3只随机分为别嘌呤醇治疗组、缺氧缺血对照组和假手术组 ,缺氧缺血后即刻、2 4和 4 8h分别腹腔注射ALLO或生理盐水 ,然后观察ALLO对H... 详细信息

目的　探讨别嘌呤醇 (ALLO)对新生大鼠缺氧缺血性脑损伤 (HIBD)的影响。方法　将新生 7日龄SD大鼠 14 3只随机分为别嘌呤醇治疗组、缺氧缺血对照组和假手术组 ,缺氧缺血后即刻、2 4和 4 8h分别腹腔注射ALLO或生理盐水 ,然后观察ALLO对HIBD模型鼠缺氧缺血 (HI)后 4 2h脑含水量、72h脑神经元凋亡(TUNEL法 )及超微结构改变、14d体质量增长率、脑病理改变 (海马神经元死亡率 )、30d学习分辨能力和记忆保持能力 (三臂迷宫试验 )等的影响。结果　脑含水量 :治疗组缺血侧 [( 84 .75± 4 .5 2 ) % ]含水量较对照组[( 92 .32± 3.75 ) % ]明显减少 (P 0 .0

关键词：别嘌呤醇新生大鼠缺氧缺血性脑损伤保护作用别嘌呤醇

De novo synthesis of atropisomeric benzofurans via Cu/SPDO complex catalyzed asymmetric formal [3 + 2] annulation

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Science China Chemistry 2025年第1期68卷 174-180页

作者： Fan-xiao Meng Xing-Yu Wang Ka Lu Ju-Song Yang Fu-Min Zhang Ai-Jun Ma Bao Du yong-Qiang Tu State Key Laboratory of Applied Organic Chemistry College of Chemistry and Chemical Engineering Lanzhou University School of Chemistry and Chemical Engineering Shanghai Jiao Tong University School of Biotechnology and Health Sciences Wuyi University

Herein, the de novo synthesis of atropisomeric benzofurans through the Cu/spirocyclic-pyrrolidine-oxazoline(SPDO) complex catalyze asymmetric formal [3 + 2] cycloaddition between quinones and ynamides is explored, producing a range of structurally diverse axially chiral benzofurans in satisfactory yields with good to excellent enantioselectivities. Furthermore, density functional theory calculations were applied to explain the possible reaction mechanism.

关键词： benzofuran atropisomers novel de novo synthetic strategy asymmetric formal [3 + 2] cycladdition Cu/SPDO complex DFT calculations