检索结果-南通市图书馆

Complement factor Ⅰ knockdown inhibits colon cancer development by affecting Wnt/β-catenin/c-Myc signaling pathway and glycolysis

引用

World Journal of Gastrointestinal Oncology 2024年第6期16卷 2646-2662页

作者： yong-Jun du Yue Jiang Yan-Mei Hou yong-Bo Shi Department of Proctology Hospital of Chengdu University of Traditional Chinese MedicineChengdu 610072Sichuan ProvinceChina School of Clinical Medicine Chengdu University of Traditional Chinese MedicineChengdu 610075Sichuan ProvinceChina Department of Proctology Zigong Hospital of Traditional Chinese MedicineZigong 643000Sichuan ProvinceChina

BACKGROUND Colon cancer(CC)occurrence and progression are considerably influenced by the tumor ***,the exact underlying regulatory mechanisms remain *** To investigate immune infiltration-related differentially expressed genes(DEGs)in CC and specifically explored the role and potential molecular mechanisms of complement factor I(CFI).METHODS Immune infiltration-associated DEGs were screened for CC using *** reverse transcription polymerase chain reaction was used to examine hub DEGs expression in the CC cell *** CFI-knockdown HT29 and HCT116 cell lines were constructed,and the diverse roles of CFI in vitro were assessed using CCK-8,5-ethynyl-2’-deoxyuridine,wound healing,and transwell *** and eosin staining and immunohistochemistry staining were employed to evaluate the influence of CFI on the tumorigenesis of CC xenograft models constructed using BALB/c male nude *** proteins associated with glycolysis and the Wnt pathway were measured using western *** Six key immune infiltration-related DEGs were screened,among which the expression of CFI,complement factor B,lymphoid enhancer binding factor 1,and SRY-related high-mobility-group box 4 was upregulated,whereas that of fatty acid-binding protein 1,and bone morphogenic protein-2 was ***,CFI could be used as a diagnostic biomarker for ***,CFI silencing inhibited CC cell proliferation,migration,invasion,and tumor ***,CFI knockdown downregulated the expression of key glycolysis-related proteins(glucose transporter type 1,hexokinase 2,lactate dehydrogenase A,and pyruvate kinase M2)and the Wnt pathway-related proteins(β-catenin and c-Myc).Further investigation indicated that CFI knockdown inhibited glycolysis in CC by blocking the Wnt/β-catenin/c-Myc *** The findings of the present study demonstrate that CFI plays a crucial role in CC development by influencing g

关键词： Colon cancer Immune infiltration Complement factor I Glycolysis Wnt/β-catenin/c-Myc pathway

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Understanding the dehydrogenation properties of Mg(0001)/MgH_(2)(110)interface from first principles

引用

Materials Reports(Energy) 2024年第1期4卷 89-94页

作者： Jianchuan Wang Bo Han Zhiquan Zeng Shiyi Wen Fen Xu yong du State Key Laboratory of Powder Metallurgy Central South UniversityChangsha410083PR China Powder Metallurgy Research Institute Central South UniversityChangsha410083PR China Guangxi Key Laboratory of Information Materials Guilin University of Electronic TechnologyGuilin541004PR China

Magnesium hydride is one of the most promising solid-state hydrogen storage materials for on-board *** desorption from MgH_(2) is accompanied by the formation of the Mg/MgH_(2) interfaces,which may play a key role in the further dehydrogenation *** this work,first-principles calculations have been used to understand the dehydrogenation properties of the Mg(0001)/MgH_(2)(110) *** is found that the Mg(0001)/MgH_(2)(110) interface can weaken the Mg-H *** removal energies for hydrogen atoms in the interface zone are significantly lower compared to those of bulk MgH_(2).In terms of H mobility,hydrogen diffusion within the interface as well as into the Mg matrix is *** calculated energy barriers reveal that the migration of hydrogen atoms in the interface zone is easier than that in the bulk MgH_(2).Based on the hydrogen removal energies and diffusion barriers,we conclude that the formation of the Mg(0001)/MgH_(2)(110) interface facilitates the dehydrogenation process of magnesium hydride.

关键词： Magnesium hydrides First-principles calculation Hydrogen storage materials Interface Hydrogen desorption

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Construction of MnS/MoS_(2) heterostructure on two-dimensional MoS_(2) surface to regulate the reaction pathways for high-performance Li-O_(2) batteries

引用

Journal of Energy Chemistry 2024年第6期93卷 443-452,I0012页

作者： Guoliang Zhang Han Yu Xia Li Xiuqi Zhang Chuanxin Hou Shuhui Sun yong du Zhanhu Guo Feng Dang Key Laboratory for Liquid-Solid Structure Evolution and.Processing of Materials(Ministry of Education) Shandong UniversityJinan 250061ShandongChina School of Environmental and Material Engineering Yantai UniversityYantai 264005ShandongChina Institute National de la Recherche Scientifique CentreÉnergie Matériaux et TélécommunicationsVarennesQuébec J31S2Canada State Key Laboratory of Powder Metallurgy Central South UniversityChangsha 410083HunanChina Integrated Composites Lab Department of Mechanical and Construction EngineeringNorthumbria UniversityNewcastle Upon TyneNE18STUK

The inherent catalytic anisotropy of two-dimensional(2D) materials has limited the enhancement of LiO_(2) batteries(LOBs) performance due to the significantly different adsorption energies on 2D and edge *** the adsorption strength in 2D materials to the reaction intermediates is essential for achieving high-performance ***,a MnS/MoS_(2) heterostructure is designed as a cathode catalyst by adjusting the adsorption behavior at the *** from the toroidal-like discharge products on the MoS_(2) cathode,the MnS/MoS_(2) surface displays an improved adsorption energy to reaction species,thereby promoting the growth of the film-like discharge *** can disturb the layer growth of MoS_(2),in which the stack edge plane features a strong interaction with the intermediates and limits the growth of the discharge *** and theoretical results confirm that the MnS/MoS_(2) heterostructure possesses improved electron transfer kinetics at the interface and plays an important role in the adsorption process for reaction species,which finally affects the morphology of Li_2O_(2),In consequence,the MnS/MoS_(2) heterostructure exhibits a high specific capacity of 11696.0 mA h g^(-1) and good cycle stability over 1800 h with a fixed specific capacity of 600 mA h g^(-1) at current density of100 mA g^(-1) This work provides a novel interfacial engineering strategy to enhance the performance of LOBs by tuning the adsorption properties of 2D materials.

关键词： Li-O_(2)batteries Two-dimensional materials MnS/MoS_(2)heterostructure Edge plane Adsorption behavior

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Computed tomography-based multi-organ radiomics nomogram model for predicting the risk of esophagogastric variceal bleeding in cirrhosis

引用

World Journal of Gastroenterology 2024年第36期30卷 4044-4056页

作者： Yu-Jie Peng Xin Liu Ying Liu Xue Tang Qi-Peng Zhao yong du Department of Radiology The Affiliated Hospital of North Sichuan Medical CollegeNanchong 637000Sichuan ProvinceChina Department of Radiology The People’s Hospital of Chongqing Liang Jiang New AreaChongqing 401121China

BACKGROUND Radiomics has been used in the diagnosis of cirrhosis and prediction of its associated ***,most current studies predict the risk of esophageal variceal bleeding(EVB)based on image features at a single level,which results in incomplete *** studies have explored the use of global multi-organ radiomics for non-invasive prediction of EVB secondary to *** To develop a model based on clinical and multi-organ radiomic features to predict the risk of first-instance secondary EVB in patients with *** In this study,208 patients with cirrhosis were retrospectively evaluated and randomly split into training(n=145)and validation(n=63)*** areas were chosen as regions of interest for extraction of multi-organ radiomic features:The whole liver,whole spleen,and lower esophagus–gastric fundus *** the training cohort,radiomic score(Rad-score)was created by screening radiomic features using the inter-observer and intra-observer correlation coefficients and the least absolute shrinkage and selection operator *** clinical risk factors were selected using multivariate logistic regression *** radiomic features and clinical risk variables were combined to create a new radiomics-clinical model(RC model).The established models were validated using the validation *** Radiomics has been used in the diagnosis of cirrhosis and prediction of its associated ***,most current studies predict the risk of esophageal variceal bleeding(EVB)based on image features at a single level,which results in incomplete *** studies have explored the use of global multi-organ radiomics for non-invasive prediction of EVB secondary to *** To develop a model based on clinical and multi-organ radiomic features to predict the risk of first-instance secondary EVB in patients with *** In this study,208 patients with cirrhosis were retrospectively evaluated and randoml

关键词： Artificial intelligence Cirrhosis Radiomics Esophagogastric variceal bleeding

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Preoperative prediction of perineural invasion of rectal cancer based on a magnetic resonance imaging radiomics model:A dual-center study

引用

World Journal of Gastroenterology 2024年第16期30卷 2233-2248页

作者： Yan Liu Bai-Jin-Tao Sun Chuan Zhang Bing Li Xiao-Xuan Yu yong du Department of Radiology The Affiliated Hospital of North Sichuan Medical CollegeNanchong 637000Sichuan ProvinceChina Department of Radiology The Affiliated Hospital of North Sichuan Medical CollegeNanchong 637000Sichuan ProvinceChina.duyong@***

BACKGROUND Perineural invasion(PNI)has been used as an important pathological indicator and independent prognostic factor for patients with rectal cancer(RC).Preoperative prediction of PNI status is helpful for individualized treatment of ***,several radiomics studies have been used to predict the PNI status in RC,demonstrating a good predictive effect,but the results lacked *** preoperative prediction of PNI status is still challenging and needs further *** To establish and validate an optimal radiomics model for predicting PNI status preoperatively in RC *** This retrospective study enrolled 244 postoperative patients with pathologically confirmed RC from two independent *** patients underwent preoperative high-resolution magnetic resonance imaging(MRI)between May 2019 and August *** radiomics features were extracted and selected from oblique axial T2-weighted imaging(T2WI)and contrast-enhanced T1WI(T1CE)*** radiomics signatures were constructed using logistic regression analysis and the predictive potential of various sequences was compared(T2WI,T1CE and T2WI+T1CE fusion sequences).A clinical-radiomics(CR)model was established by combining the radiomics features and clinical risk *** internal and external validation groups were used to validate the proposed *** area under the receiver operating characteristic curve(AUC),DeLong test,net reclassification improvement(NRI),integrated discrimination improvement(IDI),calibration curve,and decision curve analysis(DCA)were used to evaluate the model *** Among the radiomics models,the T2WI+T1CE fusion sequences model showed the best predictive performance,in the training and internal validation groups,the AUCs of the fusion sequence model were 0.839[95%confidence interval(CI):0.757-0.921]and 0.787(95%CI:0.650-0.923),which were higher than those of the T2WI and T1CE sequence *** CR model constructed by combinin

关键词： Rectal cancer Perineural invasion Magnetic resonance imaging Radiomics Nomogram

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Potential preservative mechanisms of cardiac rehabilitation pathways on endothelial function in coronary heart disease

引用

Science China Life Sciences 2024年

作者： Wen-Tao Sun Jian-yong du Jia Wang Yi-Long Wang Er-Dan Dong Research Center for Cardiopulmonary Rehabilitation University of Health and Rehabilitation Sciences Qingdao Hospital (Qingdao Municipal Hospital)School of Health and Life SciencesUniversity of Health and Rehabilitation Sciences Department of Cardiology and Institute of Vascular Medicine Peking University Third HospitalThe Institute of Cardiovascular SciencesPeking UniversityState Key Laboratory of Vascular Homeostasis and RemodelingPeking University

Cardiac rehabilitation, a comprehensive exercise-based lifestyle and medical management, is effective in decreasing morbidity and improving life quality in patients with coronary heart disease. Endothelial function, an irreplaceable indicator in coronary heart disease progression, is measured by various methods in traditional cardiac rehabilitation pathways, including medicinal treatment, aerobic training, and smoking cessation. Nevertheless, studies on the effect of some emerging cardiac rehabilitation programs on endothelial function are limited. This article briefly reviewed the endothelium-beneficial effects of different cardiac rehabilitation pathways, including exercise training, lifestyle modification and psychological intervention in patients with coronary heart disease, and related experimental models, and summarized both uncovered and potential cellular and molecular mechanisms of the beneficial roles of various cardiac rehabilitation pathways on endothelial function. In exercise training and some lifestyle interventions, the enhanced bioavailability of nitric oxide, increased circulating endothelial progenitor cells(EPCs), and decreased oxidative stress are major contributors to preventing endothelial dysfunction in coronary heart disease. Moreover, the preservation of endothelial-dependent hyperpolarizing factors and inflammatory suppression play roles. On the one hand, to develop more endothelium-protective rehabilitation methods in coronary heart disease, adequately designed and sized randomized multicenter clinical trials should be advanced using standardized cardiac rehabilitation programs and existing assessment methods. On the other hand, additional studies using suitable experimental models are warranted to elucidate the relationship between some new interventions and endothelial protection in both macro-and microvasculature.

关键词：

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

科技型企业如何踏上数据机遇跳板实现生态位跃迁——基于不同创业背景企业的双案例研究

引用

中国工业经济 2024年第1期 170-188页

作者：杜勇曹磊西南大学经济管理学院同济大学经济与管理学院

作为一种新的生产要素,数据为企业生态位跃迁提供了重要机遇。本文基于资源编排的理论视角,对比分析了2家不同创业背景的科技型企业如何借助数据机遇实现生态位跃迁。研究发现:科技型企业通过数字机会洞察与数据资源编排两个阶段,锚定... 详细信息

作为一种新的生产要素,数据为企业生态位跃迁提供了重要机遇。本文基于资源编排的理论视角,对比分析了2家不同创业背景的科技型企业如何借助数据机遇实现生态位跃迁。研究发现:科技型企业通过数字机会洞察与数据资源编排两个阶段,锚定跃迁方向、实现跃迁转变,最终到达新生态位;自主创业型企业基于“压力—机会—能力”的驱动式探索实现了数字机会洞察,并借助以数字信任关系构建为核心机制的数据资源编排行动,破解数据资源链接难题;内部孵化型企业的数字机会洞察呈现出“需求—机会—支持”的选择式探索过程,通过以跨越式价值激活为核心机制的数据资源编排行动,突破数据的价值创造瓶颈;数据机遇的实现过程反映出一种新型资源编排逻辑,即企业先通过常规的资源编排来构建支撑数据资源利用的要素平台与能力框架,再通过跨层级的资源编排将数据资源的整合嵌入能力价值化过程,借助数据困境破解机制实现数据价值的释放。本文的结论揭示了数据时代的资源编排新规律,为企业如何利用数据获取竞争优势提供了管理启示。

关键词：生态位跃迁数据机遇资源编排数字信任价值激活

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

地方政府环境治理与企业产能过剩

引用

财经论丛 2024年第9期 80-90页

作者：杜勇孙帆西南大学经济管理学院重庆400715

通过环境治理淘汰落后产能是新时代有效化解企业产能过剩的重要举措,相较于被动执行中央环境保护政策,地方政府工作报告中的环境治理目标和措施不仅可以有效发挥本级相关部门环境治理的主观能动性,还可以结合地区实际制定适宜的环境保... 详细信息

通过环境治理淘汰落后产能是新时代有效化解企业产能过剩的重要举措,相较于被动执行中央环境保护政策,地方政府工作报告中的环境治理目标和措施不仅可以有效发挥本级相关部门环境治理的主观能动性,还可以结合地区实际制定适宜的环境保护政策。然而,基于地方政府环境治理视角的研究较为匮乏。本文通过Python提取各地区政府工作报告中与环境保护相关词频,构建地方政府环境治理指标,实证检验了地方政府环境治理对企业产能过剩的影响。研究发现:第一,地方政府环境治理显著提升了企业产能利用率,该结果在采用工具变量法等方法进行内生性和稳健性检验后依然成立。第二,地方政府环境治理通过发挥“遵循成本效应”抑制企业过度投资,以及发挥“创新补偿效应”倒逼企业绿色技术创新,从而迫使企业淘汰落后产能、提升产能利用率。第三,地方政府环境治理的去产能效应在“产能攀比”激烈行业和市场化程度较高地区更为显著,且地方政府环境治理的去产能效应带动了企业价值提升。本文的研究不仅为产能过剩的政府干预理论提供了新证据,也延伸了政府环境治理化解产能过剩的理论框架,还为当前去产能政策的制定提供了借鉴。

关键词：地方政府环境治理产能过剩产能利用率政府干预

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

清华简《四告》所见周公告祭皋陶新解

引用

江汉考古 2024年第4期 140-146,151页

作者：杜勇旷开源山东大学历史学院山东济南250100 天津师范大学历史文化学院天津300387

告祭是商周时期常见的临时祭祀活动之一,其对象的选择往往取决于神灵的神性、权能及政治教化意义。清华简《四告》所记周公告祭的司慎皋陶,是天神系统中执掌降罚、降祸且象征用刑公正的刑罚之神。皋陶本为偃姓部族的祖神,相传他曾辅佐尧... 详细信息

告祭是商周时期常见的临时祭祀活动之一,其对象的选择往往取决于神灵的神性、权能及政治教化意义。清华简《四告》所记周公告祭的司慎皋陶,是天神系统中执掌降罚、降祸且象征用刑公正的刑罚之神。皋陶本为偃姓部族的祖神,相传他曾辅佐尧舜,担任刑官,兼掌戎事,为尧舜共同体的发展做出过重大贡献,于是从部族祖神转化为了天下共同崇祀的天神。在周公致政、成王亲政后,为了推进国家法制建设,维护天下安宁的政治局面,周公在会同典礼前告祭司慎皋陶,除了祈求神灵皋陶佑助成王,光大周邦事业外,同时意在发挥祭祀刑罚之神的政治教化作用,采取德刑并用的治国措施,内重法治,外征不庭,实施拓土开疆战略,以确保周人统治的长治久安。

关键词：清华简《四告》周公司慎皋陶告祭

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

饱和非时齐泊松失效过程下网络系统连边交互机理分析

引用

控制与决策 2024年第1期39卷 180-188页

作者：杜永军张攀蔡志强兰州理工大学经济管理学院兰州730050 西北工业大学机电学院西安710072

给定由若干连边和节点组成的网络系统,为了有效、经济地提升整个网络的可靠性,一些耦合的2条连边关于整个网络失效的交互机理需要加以分析.首先,采用饱和非时齐泊松过程刻画连边的失效过程,基于组合计数的思想,导出2条连边处于4种不同... 详细信息

给定由若干连边和节点组成的网络系统,为了有效、经济地提升整个网络的可靠性,一些耦合的2条连边关于整个网络失效的交互机理需要加以分析.首先,采用饱和非时齐泊松过程刻画连边的失效过程,基于组合计数的思想,导出2条连边处于4种不同状态的概率公式,并结合2条连边的联合D-谱,发展联合失效重要度的计算公式,用于分析2条连边关于网络失效的交互机理.理论分析表明,当时间t趋于0或趋于无穷大时, 2条连边的交互效果越来越微弱.然后,由于精确的计算联合失效重要度的值是NP-难问题,设计蒙特卡洛近似算法求其值.最后,提供一个路网的算例,其数值结果表明,所提出联合失效重要度计算方法能够有效地阐释2条连边关于网络失效的交互机理.

关键词：网络可靠性饱和非时齐泊松过程联合失效重要度交互机理蒙特卡洛

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：