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Mutation of MED12 is not a frequent occurrence in prostate cancer of Korean patients

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Asian Journal of Andrology 2017年第3期19卷 346-349页

作者： Nara Yoon Sharon Lim So Young Kang Ghee Young Kwon hwang Gyun Jeon Byong Chang Jeong seong Il Seo seong Soo Jeon Hyun Moo Lee Han yong Choi Department of Pathology Samsung Medical Center Sungkyunkwan University School of Medicine Seoul 135-710 Korea Department of Urology Samsung Medical Center Sungkyunkwan University School of Medicine Seoul 135-710 Korea

Prostate cancer is one of the major health care problems, but the molecular pathogenesis has been relatively insufficiently elucidated. Recently, whole exome sequencing of prostate cancer identified recurrent mutations involving MED12 in Caucasian patients, which finding was not reproduced in one subsequent study by Sanger sequencing. Thus, we investigated mutation status of MED12 in exons 2 and 26 by Sanger sequencing in 102 radical prostatectomy cases from Korean patients. The analysis found the mutation in none of the cases. Therefore, MED12 mutation does not appear to represent a significant molecular alteration in this cohort of patients according to the analysis by the traditional ＂gold standard.＂

关键词： mediator complex subunit 12 mutation analysis prostate cancer prostate neoplasms

Pre-operative predictive factors for gallbladder cholesterol polyps using conventional diagnostic imaging

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World Journal of Gastroenterology 2008年第44期14卷 6831-6834页

作者： Ji-Hoon Choi Jung-Won Yun yong-Sung Kim Eun-A Lee Sang-Tae hwang yong-Kyun Cho Hong-Joo Kim Jung-Ho Park Dong-Il Park Chong-Il Sohn Woo-Kyu Jeon Byung-Ik Kim Hyoung-Ook Kim Jun-Ho Shin Department of Internal Medicine Kangbuk Samsung HospitalSungkyunkwan University School of MedicineSeoul 110-746South Korea Department of Surgery Kangbuk Samsung HospitalSungkyunkwan University School of MedicineSeoul 110-746South Korea

AIM： To determine the clinical data that might be useful for differentiating benign from malignant gallbladder （GB） polyps by comparing radiological methods, including abdominal ultrasonography （US） and computed tomography （CT） scanning, with postoperative pathology findings. METHODS： Fifty-nine patients underwent laparoscopic cholecystectomy for a GB polyp of around 10 ram. They were divided into two groups, one with cholesterol polyps and the other with non-cholesterol polyps. Clinical features such as gender, age, symptoms, size and number of polyps, the presence of a GB stone, the radiologically measured maximum diameter of the polyp by US and CT scanning, and the measurements of diameter from postoperative pathology were recorded for comparative analysis. RESULTS： Fifteen of the 41 cases with cholesterol polyps （36.6%） were detected with US but not CT scanning, whereas all 18 non-cholesterol polyps were observed using both methods. In the cholesterol polyp group, the maximum measured diameter of the polyp was smaller by CT scan than by ***, the discrepancy between those two scanning measurements was greater than for the non- cholesterol polyp group. CONCLUSION： The clinical signs indicative of a cholesterol polyp include：（1） a polyp observed by US but not observable by CT scanning, （2） a smaller diameter on the CT scan compared to US, and （3） a discrepancy in its maximum diameter between US and CT measurements. In addition, US and the CT scan had low accuracy in predicting the polyp diameter compared to that determined by postoperative pathology.

关键词： Cholesterol Polyps Gallbladder Computed tomography Ultrasonography

Controlling hypoxia-inducible factor-2α is critical for maintaining bone homeostasis in mice

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Bone Research 2019年第2期7卷 210-223页

作者： Sun Young Lee Ka Hyon Park Hyung-Gu Yu Eunbyul Kook Won-Hyun Song Gyuseok Lee Jeong-Tae Koh Hong-In Shin Je-yong Choi Yun Hyun Huh Je-hwang Ryu Department of Pharmacology and Dental Therapeutics School of DentistryChonnam National UniversityGwangju 61186Korea Research Center for Biomineralization Disorders School of DentistryChonnam National UniversityGwangju 61186Korea Department of Oral Pathology and IHBR School of DentistryKyungpook National UniversityDaegu 41940Korea Department of Biochemistry and Cell Biology BK21 Plus KNU Biomedical Convergence ProgramSkeletal Diseases Analysis CenterKorea Mouse Phenotyping Center (KMPC)School of MedicineKyungpook National UniversityDaegu 41944Korea School of Life Sciences Gwangju Institute of Science and TechnologyGwangju 61005Korea

Pathological bone loss is caused by an imbalance between bone formation and *** bone microenvironments are hypoxic,and hypoxia-inducible factor (HIF) is known to play notable roles in bone ***,the relevant functions of HIF-2α are not well ***,we have shown that HIF-2α deficiency in mice enhances bone mass through its effects on the differentiation of osteoblasts and *** vitro analyses revealed that HIF-2α inhibits osteoblast differentiation by targeting Twist2 and stimulates RANKL-induced osteoclastogenesis via regulation of *** addition,HIF-2α appears to contribute to the crosstalk between osteoblasts and osteoclasts by directly targeting RANKL in osteoprogenitor *** performed with osteoblast- and osteoclast-specific conditional knockout mice supported a role of HIF-2α in this ***-2α deficiency alleviated ovariectomy-induced bone loss in mice,and specific inhibition of HIF-2α with ZINC04179524 significantly blocked RANKLmediated ***,our results suggest that HIF-2α functions as a catabolic regulator in bone remodeling,which is critical for the maintenance of bone homeostasis.

关键词： is RANKL its via

Plant ABC Transporters Enable Many Unique Aspects of a Terrestrial Plant＇s Lifestyle

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Molecular Plant 2016年第3期9卷 338-355页

作者： Jae-Ung hwang Won-yong Song Daewoong Hong Donghwi Ko Yasuyo Yamaoka Sunghoon Jang Sojeong Yim Eunjung Lee Deepa Khare Kyungyoon Kim Michael Palmgren Hwan Su Yoon Enrico Martinoia Youngsook Lee Department of Life Science Pohang University of Science and Technology (POSTECH) Pohang 37673 Korea Division of Integrative Bioscience and Biotechnology POSTECH Pohang 37673 Korea Center for Membrane Pumps in Cells and Disease - PUMPKIN Danish National Research Foundation Department of Plant and Environmental Science University of Copenhagen 1871 Frederiksberg Denmark Department of Biological Sciences Sungkyunkwan University Suwon 16419 Korea Department of Plant and Microbial Biology University Zurich Zurich 8008 Zurich Switzerland

Terrestrial plants have two to four times more ATP-binding cassette （ABC） transporter genes than other organisms, including their ancestral microalgae. Recent studies found that plants harboring mutations in these transporters exhibit dramatic phenotypes, many of which are related to developmental processes and functions necessary for life on dry land. These results suggest that ABC transporters multiplied during evolution and assumed novel functions that allowed plants to adapt to terrestrial environmental conditions. Examining the literature on plant ABC transporters from this viewpoint led us to propose that diverse ABC transporters enabled many unique and essential aspects of a terrestrial plant＇s lifestyle, by transporting various compounds across specific membranes of the plant.

关键词： abscisic acid transporter adaptation to dry (and ATP-binding cassette transporters evolution lifestyle of plants

Effects of exogenous recombinant human bone morphogenic protein-7 on the corneal epithelial mesenchymal transition and fibrosis

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International Journal of Ophthalmology(English edition) 2017年第3期10卷 329-335页

作者： Jin Kwon Chung Shin Ae Park Hee Sun hwang Kwang Sung Kim Yang Je Cho yong Sung You Young Sik Kim Ju Woong Jang Sung Jin Lee Department of Ophthalmology Soonchunhyang University College of Medicine Soonchunhyang University Seoul Hospital Seou104401 Korea Eyegene Inc. Seou107528 Korea Nune Eye Hospital Seou106198 Korea Cellumed. Co. Ltd. Seoul 08501 Korea

AIM：To evaluate the effect of exogenous recombinant human bone morphogenic protein-7（rhBMP-7）on transforming growth factor-β（TGF-β）-induced epithelial mesenchymal cell transition（EMT）and assessed its antifibrotic effect via topical ***：The cytotoxic effect of rhBMP-7 was evaluated and the EMT of human corneal epithelial cells（HECEs）was induced by TGF-β. HECEs were then cultured in the presence of rhBMP-7 and/or hyaluronic acid（HA）. EMT markers,fibronectin,E-cadherin,α-smooth muscle actin（α-SMA）,and matrix metaloproteinase-9（MMP-9）,were evaluated. The level of corneal fibrosis and the reepithelization rate were evaluated using a rabbit keratectomy model. Expression of α-SMA in keratocytes were quantified following treatment with different concentrations of ***：Treatment with rhBMP-7 attenuated TGF-β-induced EMT in HECEs. It significantly attenuated fibronectin secretion（31.6%; P〈0.05）,the α-SMA protein level（72.2%; P〈0.01）,and MMP-9 expression（23.6%,P〈0.05）in HECEs compared with cells grown in the presence of TGF-β alone. E-cadherin expression was significantly enhanced（289.7%; P〈0.01）in the presence of rhBMP-7. Topical application of rhBMP-7 combined with 0.1% HA significantly reduced the amount of α-SMA~＋ cells by 43.18%（P〈0.05）at a concentration of 2.5 μg/mL and by 47.73%（P〈0.05）at 25 μg/mL,compared with the control group,without disturbing corneal ***：rhBMP-7 attenuates TGF-β-induced EMT in vitro,and topical application of rhBMP-7 reduces keratocyte myodifferentiation during the early wound healing stages in vivo without hindering reepithelization. Topical rhBMP-7 application as biological eye drops seems to be feasible in diseases involving TGF-β-related corneal fibrosis with corneal reepithelization disorders.

关键词： bone morphogenic protein-7 corneal fibrosis epithelial mesenchymal transition myodifferentiation transforming growth factor-β

Clinical Experience with the Fifth-Generation of a Breast Implant with a Smooth, Fine Surface from a Korean Manufacturer in Asian Women

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Journal of Biosciences and Medicines 2022年第6期10卷 132-144页

作者： Dong Yeon hwang Sang Wha Kim Joon yong Jung Robert Kim NANA Plastic Surgery Seoul Korea Department of Plastic and Reconstructive Surgery Seoul National University Hospital College of Medicine Seoul National University Seoul Korea Department of Radiology Seoul St. Mary’s Hospital College of Medicine The Catholic University of Korea Seoul Korea Department of Medical and Pharmaceutical Affairs Doctor CONSULT Seoul Korea

Background: In this study, we describe our clinical experience with the fifth-generation of a breast implant with a smooth, fine surface from a Korean manufacturer (BellaGel® SmoothFine;HansBiomed Co. Ltd., Seoul, Korea) in Asian women. Methods: We analyzed 223 women (mean age = 35.28 ± 9.45 years and mean follow-up period = 12.03 ± 2.48 months), comprising 118 bilateral cases and 109 unilateral ones, who received breast augmentation using the BellaGel® SmoothFine at our hospital between June 4, 2018 and February 28, 2019. For safety assessment, we analyzed frequencies of postoperative complications and overall survival of the BellaGel® SmoothFine. Results: Postoperatively, complications (12 cases, 5.38%) include asymmetry (3 cases, 1.35%), hematoma (2 cases, 0.90%), hypertrophic scars (2 cases, 0.90%), wound disruption (2 cases, 0.90%), rippling (1 case, 0.45%), capsular contracture (1 case, 0.45%), stretch deformities with skin excess (1 case, 0.45%). In addition, time-to-events were calculated as 10.94 ± 0.64 months (95% CI 9.69 - 12.19) and the survival rate reached 0.290 ± 0.168 (95% CI 0.094 - 0.901) at 12 months postoperatively. Conclusions: Here, we describe our clinical experience with the BellaGel® SmoothFine. Our results are of significance in that this is the first report about the fifth-generation of a breast implant with a smooth, fine surface from a Korean manufacturer for Asian women.

关键词： Clinical Study Retrospective Studies Surgical Procedures Operative Postoperative Period Follow-Up Studies

Protective effects of electroacupuncture on acetylsalicylic acid-induced acute gastritis in rats

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World Journal of Gastroenterology 2009年第8期15卷 973-977页

作者： Hye Suk hwang Kyung-Ju Han Yeon Hee Ryu Eun Jin Yang Yoo Sung Kim Sang yong Jeong Young-Seop Lee Myeong Soo Lee Sung Tae Koo Sun-Mi Choi Department of Medica Research Korea Institute of Oriental Medicine Daejeon 305-811 South Korea Division of Meridian and Structural Medicine School of Oriental Medicine Pusan National University Pusan 609-735 South Korea

AIM: To investigate the protective effects of electroacupuncture (EA) pretreatment on acetylsalicylic acid (ASA)-induced ulceration in rats. METHODS: We randomly divided 72 rats into three groups including control (administered with distilled water), ASA group (administered 100 mg/kg ASA) and EA group (administered EA + 100 mg/kg ASA). Each rat was fasted for 18 to 24 h before experimentation, and lesion scores, gastric acidity, cyclooxygenase (COX)-1 and -2 mRNA levels, and total nitric oxide (NO) concentration were measured. RESULTS: The lesion scores of the EA group were significantly lower than those of the ASA group. Gastric acidity of the ASA and EA groups was reduced compared to the control group. COX-1 and -2 mRNA levels were significantly increased in the EA group as compared to the control and ASA groups, and NO levels were also significantly increased in the EA group as compared to the ASA group. CONCLUSION: These results suggest that EA-mediated protection against ASA-induced ulceration in rats may occur via gastric defense components.

关键词： Electroacupuncture Acute gastritis Cyclooxygenase Nitric Oxide

Histologic characteristics of gastric polyps in Korea: Emphasis on discrepancy between endoscopic forceps biopsy and endoscopic mucosal resection specimen

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World Journal of Gastroenterology 2006年第25期12卷 4029-4032页

作者： Won Jae Yoon Dong Ho Lee yong Jin Jung Ji Bong Jeong Ji Won Kim Byeong Gwan Kim Kook Lae Lee Kwang Hyuck Lee Young Soo Park Jin-Hyeok hwang Jin-Wook Kim Nayoung Kim Jun Kyu Lee Hyun Chae Jung yong Bum Yoon In Sung Song Department of Internal Medicine Seoul National University College of Medicine SeoulKorea

AIM： To investigate histological characteristics of gastric polyps in the Korean population. METHODS： We reviewed endoscopic photographs and medical records of patients with gastric polyps who underwent endoscopic mucosal resection from April 1996 through February 2003. RESULTS： A total of 85 gastric polyps from 74 patients were reviewed, Male-to-female ratio was 1：1,96, Mean age was 59.9 =1：10,8 years. Multiple polyps were observed in 10,8%, Gastric polyps occurred most frequently in the antrum （58.8%）, Pathological results on resected specimens were as follows： tubular adenoma 45.9%, hyperplastic polyp 31.8%, inflammatory polyp 9.4%, hamartoma 3.5%, fundic gland polyp 2.4%, tubulovillous adenoma 2.4%, adenocarcinoma 2.4%, dysplasia 1.1%, and mucosal pseudolipomatosis 1.1%. Discrepancy rate between endoscopic biopsy and pathology of resected specimens was 27.1%. There was no relationship between the size of the polyp and concordance rate. CONCLUSION： There is considerable discrepancy in histologic findings between endoscopic forceps biopsy and resected specimens. Approaches to review of the histology of an entire polyp should be performed, especially when an adenoma is suspected.

关键词： Polyp Gastric Histology

Risk of lymph node metastasis in mixed-type early gastric cancer determined by the extent of the poorly differentiated component

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World Journal of Gastroenterology 2016年第15期22卷 4020-4026页

作者： Chung-Su hwang Sangjeong Ahn Bong-Eun Lee So-Jeong Lee Ahrong Kim Chang In Choi Dae Hwan Kim Tae-yong Jeon Gwang Ha Kim Geum Am Song Do Youn Park Department of Pathology Pusan National University Hospital and Pusan National University School of Medicine Biomedical Research Institute Pusan National University Hospital Internal medicine Pusan National University Hospital and Pusan National University School of Medicine Surgery Pusan National University Hospital

AIM: To predict the rate of lymph node(LN) metastasis in diffuse- and mixed-type early gastric cancers(EGC) for guidelines of the ***: We reviewed 550 cases of EGC withdiffuse- and mixed-type histology. We investigated the clinicopathological factors and histopathological components that influence the probability of LN metastasis, including sex, age, site, gross type, presence of ulceration, tumour size, depth of invasion, perineural invasion, lymphovascular invasion, and LN metastasis status. We reviewed all slides and estimated the proportions of each tumour component; pure diffuse type, mixed-predominantly diffuse type(diffuse > intestinal type), mixed-predominantly intestinal type(intestinal > diffuse type), and mixed diffuse = intestinal type. We calculated the extents of the respective ***: LN metastasis was observed in 12.9%(71/550) of early gastric cancers cases [15/288 mucosal EGCs(5.2%) and 56/262 submucosal EGCs(21.4%)]. Of 550 cases, 302 were diffuse-type and 248 were mixed-type EGCs. Of 248 mixed-type EGCs, 163 were mixed-predominantly diffuse type, 82 were mixed-predominantly intestinal type, and 3 were mixed diffuse = intestinal type. Mixed-type cases with predominantly diffuse type histology showed a higher frequency of LN metastasis(20.2%) than cases of pure diffuse type(9.3%) and predominantly intestinal type(12.2%) histology. We measured the dimensions of each component(intestinal and diffuse type) to determine the association of the extent of each component with LN metastasis in mixed-type gastric carcinoma. The total tumour size and the extent of poorly differentiated components was associated with LN metastasis, while that of signet ring cell components was ***: We recommend careful identification and quantitative evaluation of mixed-type early gastric cancer components after endoscopic resection to determine the intensity of the treatment.

关键词： Lymph nodes Metastasis Gastric cancer Histology Endoscopic gastrointestinal surgery