检索结果-南通市图书馆

Pharmacokinetic comparison with different assays for simultaneous determination of cis-,trans-cefprozil diastereomers in human plasma

引用

Journal of Pharmaceutical Analysis 2021年第3期11卷 351-363页

作者： Seung-Hyun Jeong Ji-Hun Jang Hea-Young cho yong-Bok Lee College of Pharmacy Chonnam National University77 Yongbong-roBuk-guGwangju61186Republic of Korea College of Pharmacy CHA University335 Pangyo-roBundang-guSeongnam-siGyeonggi-Do13488Republic of Korea

The purpose of this study was to compare pharmacokinetic(PK)parameters obtained using two newly developed assays,HPLC-UV and UPLC-ESI-MS/*** of assay and results obtained therefrom are very important in PK studies and can have a major impact on the PK-based clinical dose and usage *** this study,we developed two new methods that are most commonly used in biosample analysis and focused on PK parameters obtained from *** HPLC-UV equipped with a Luna-C8 column using UV detector,cefprozil diastereomers were separated using water containing 2%(V/V)acetic acid and acetonitrile as a mobile *** UPLC-ESI-MS/MS equipped with a HALO-C18 column,cefprozil diastereomers were separated using 0.5%(V/V)aqueous formic acid containing 5 mM ammoniumformate buffer and methanol as a mobile *** showed high resolution,sensitivity,and selectivity without interference by plasma *** intra-and inter-day precisions(CV,%)were within 8.88%for HPLC-UV and UPLC-ESI-MS/*** of both methods was 95.67%-107.50%.These two analytical methods satisfied the criteria of international guidance and could be successfully applied to PK *** of PK parameters between two assays confirmed that there is a difference in the predicted minimum plasma concentrations at steady state,which may affect clinical dose and usage ***,we confirmed possible correlation between PK parameters and various biochemical parameters after oral administration of 1000 mg cefprozil to humans.

关键词： Cefprozil diastereomers Comparison HPLC-UV UPLC-ESI-MS/MS Pharmacokinetic parameter Biochemical parameters

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Effects of Korean ginseng berry extract （GB0710） on penile erection： evidence from in vitro and in vivo studies

引用

Asian Journal of Andrology 2013年第4期15卷 503-507,I0008页

作者： Kang Su cho Chan Woong Park Chun-Ki Kimt Hee Young Jeon Wan Gi Kim sang Jun Lee Young-Myeong Kim Joo yong Lee Young Deuk choi Department of Urology Severance Hospital Urological Science Institute Yonsei University College of Medicine Seou1120-752 Korea R&D Center Amorepacific Corporation Yongin Gyeonggi-do 446-729 Korea Vascular System Research Center and Department of Molecular and Cellular Biochemistry School of Medicine Kangwon National University Chunchon 200-701 Korea and Clinical Trial Center for Medical Devices Yonsei University College of Medicine Seoul 120-752 Korea

Several reports have promoted the root-derived Korean red ginseng （KRG; Panax ginseng） as alternative treatment for erectile dysfunction （ED）, and ginsenosides are known to be the principal active ingredients of ginseng. Recent studies showed that ginseng berries produce more ginsenosides than KRG; thus, we investigated the ability of the Korean ginseng berry extract GB0710 to relax the penile corpus cavernosum smooth muscle （CCSM） in this study. As a comparative control, the results were compared to those obtained using KRG. In addition, possible mechanisms of action for GB0710 were investigated. While KRG and GB0710 both displayed dose-dependent relaxation effects on precontracted rabbit CCSM in vitro, GB0710 was shown to be more potent than KRG. The GBO710-induced relaxation could be partially reduced by removing the endothelium. In addition, pre-treatment with several nitric oxide （NO） inhibitors significantly inhibited the relaxation of muscle strips. Furthermore, administration of GB0710 increased intracavernosal pressure （ICP） in a rat in vivo model in both a dose- and duration-dependent manner. Intracellular NO production in human microvascular endothelial cells could be induced by GB0710 and inhibited by NG-monomethyI-L-arginine. In conclusion, GB0710 had a greater relaxation effect on rabbit CCSM than did KRG extract, and increased ICP in a rat model in both a dose- and a duration-dependent manner. This relaxine effect might be mediated bv NO production.

关键词： corpus cavernosum erectile dysfunction (ED) ginseng berry nitric oxide (NO) smooth muscle

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Submergence promotes auxin-induced callus formation through ethylene-mediated post-transcriptional control of auxin receptors

引用

Molecular Plant 2022年第12期15卷 1947-1961页

作者： Seung yong Shin Yuri choi sang-Gyu Kim Su-Jin Park Ji-Sun Park Ki-Beom Moon Hyun-Soon Kim Jae Heung Jeon Hye Sun cho Hyo-Jun Lee Plant Systems Engineering Research Center Korea Research Institute of Bioscience and BiotechnologyDaejeon 34141Korea Department of Functional Genomics KRIBB School of BioscienceUniversity of Science and TechnologyDaejeon 34113Korea Department of Biological Sciences Korea Advanced Institute of Science and TechnologyDaejeon 34141Korea Department of Biosystems and Bioengineering KRIBB School of BiotechnologyUniversity of Science and TechnologyDaejeon 34113Korea Department of Biological Sciences Sungkyunkwan UniversitySuwon 16419Korea

Plant cells in damaged tissue can be reprogrammed to acquire pluripotency and induce callus ***,in the aboveground organs of many species,somatic cells that are distal to the wound site become less sensitive to auxin-induced callus formation,suggesting the existence of repressive regulatory mechanisms that are largely *** we reveal that submergence-induced ethylene signals promote callus formation by releasing post-transcriptional silencing of auxin receptor transcripts in non-wounded *** determined that short-term submergence of intact seedlings induces auxin-mediated cell dedifferentiation across the entirety of Arabidopsis thaliana *** constitutive triple response 1-1(ctr1-1)mutation induced callus formation in explants without submergence,suggesting that ethylene facilitates cell *** show that ETHYLENE-INSENSITIVE 2(EIN2)post-transcriptionally regulates the abundance of transcripts for auxin receptor genes by facilitating microRNA393 ***-induced calli in non-wounded regions were suitable for shoot regeneration,similar to those near the wound *** also observed submergence-promoted callus formation in Chinese cabbage(Brassica rapa),indicating that this may be a conserved mechanism in other *** study identifies previously unknown regulatory mechanisms by which ethylene promotes cell dedifferentiation and provides a new approach for boosting callus induction efficiency in shoot explants.

关键词： cell dedifferentiation auxin signaling ethylene callus formation EIN2

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Evaluating the environmental efficiency of the *** industry using a directional distance function DEA approach

引用

Journal of Management Analytics 2021年第1期8卷 1-18页

作者： Yuan Xu yong Shin Park Ju Dong Park Wonjoo cho Department of Transportation Logisticsand FinanceCollege of BusinessNorth Dakota State UniversityFargoNDUSA Department of Marketing Operationsand AnalyticsBill Munday School of BusinessSt.Edward’s UniversityAustinTXUSA Department of Maritime Police and Production System Gyeongsang National UniversityTongyeong-siGyeongsangnam-doRepublic of Korea Department of Environment and Resource Research Korea Rural Economic InstituteNaju-siJeollanam-doRepublic of Korea

This study applies a directional distance function(DDF)data envelopment analysis(DEA)model to measure the environmental efficiency of 12 *** 2013–2016 by considering flight delay and greenhouse gas(GHG)emissions as joint undesirable ***,the environmental efficiency of airlines is compared using the CCR DEA(without flight delay)and DDF DEA(with flight delay).We find that several airlines experienced substantial changes in environmental efficiency scores when flight delay is ***,a tobit regression is used to explore whether the environmental factors of fleet age,ownership type,freight traffic,market share,and carrier type affect airlines’environmental *** results demonstrate that all of these factors significantly influence airline performance.

关键词： Airline environmental efficiency directional distance function DEA airline sustainability tobit regression

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Mitochondria-targeting drug conjugates for cytotoxic, anti-oxidizing and sensing purposes:current strategies and future perspectives

引用

Acta Pharmaceutica Sinica B 2018年第6期8卷 862-880页

作者： Gantumur Battogtokh Yeon Su choi Dong Seop Kang sang Jun Park Min Suk Shim Kang Moo Huh yong-Yeon cho Joo Young Lee Hye Suk Lee Han Chang Kang Department of Pharmacy Integrated Research Institute of Pharmaceutical Sciences and BK21 PLUS Team for Creative Leader Program for Pharmacomics-based Future Pharmacy College of Pharmacy The Catholic University of Korea Division of Bioengineering Incheon National University Department of Polymer Science and Engineering Chungnam National University

mitochondrial-targeting moieties to anticancer drugs, antioxidants and sensor molecules. Among them, the most widely applied mitochondrial targeting moiety is triphenylphosphonium(TPP), which is a delocalized cationic lipid that readily accumulates and penetrates through the mitochondrial membrane due to the highly negative mitochondrial membrane potential. Other moieties, including short peptides,dequalinium, guanidine, rhodamine, and F16, are also known to be promising mitochondrial targeting agents. Direct conjugation of mitochondrial targeting moieties to anticancer drugs, antioxidants and sensors results in increased cytotoxicity, anti-oxidizing activity and sensing activity, respectively,compared with their non-targeting counterparts, especially in drug-resistant cells. Although many mitochondria-targeted anticancer drug conjugates have been investigated in vitro and in vivo, further clinical studies are still needed. On the other hand, several mitochondria-targeting antioxidants have been analyzed in clinical phases I, II and III trials, and one conjugate has been approved for treating eye disease in Russia. There are numerous ongoing studies of mitochondria-targeted sensors.

关键词： Anticancer agents Antioxidants Direct conjugation Mitochondria-targeting Sensing agents

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Comparison of linac-based fractionated stereotactic radiotherapy and tomotherapy treatment plans for intra-cranial tumors

引用

Chinese Physics C 2010年第11期34卷 1768-1774页

作者： Jang Bo Shim Suk Lee Sam Ju cho sang Hoon Lee Juree Kim Kwang Hwan cho Chul Kee Min Hyun Do Huh Rena Lee Dae Sik Yang Young Je Park Won Seob Yoon Chul yong Kim Soo Il Kwon Department of Radiation Oncology College of MedicineKorea University Department of Medical Physics Kyonggi University Department of Radiation Oncology College of MedicineEulji University Department of Radiation Oncology Cheil General Hospital & Women's Healthcare CenterKwandong University College of Medicine Department of Radiation Oncology Soonchunhyang University Boocheon Hospital Department of Radiation Oncology Konyang University Hospital Department of Radiation Oncology Inha University Hospital Department of Radiation Oncology School of MedicineEwha Womans University

This study compares and analyzes stereotactic radiotherapy using tomotherapy and linac-based fractionated stereotactic radiotherapy in the treatment of intra-cranial tumors,according to some *** this study,linac-based fractionated stereotactic radiotherapy and tomotherapy treatment were administered to five patients diagnosed with intra-cranial cancer in which the dose of 18–20 Gy was applied on 3–5 separate *** tumor dosing was decided by evaluating the inhomogeneous index （II） and conformity index （CI）.Also,the radiation-sensitive tissue was evaluated using low dose factors V1,V2,V3,V4,V5,and V10,as well as the non-irradiation ratio volume （NIV）.The values of the II for each prescription dose in the linacbased non-coplanar radiotherapy plan and tomotherapy treatment plan were （0.125±0.113） and （0.090±0.180）,respectively,and the values of the CI were （0.899±0.149） and （0.917±0.114）,*** low dose areas,V1,V2,V3,V4,V5,and V10,in radiation-sensitive tissues in the linac-based non-coplanar radiotherapy plan fell into the ranges 0.3%–95.6%,0.1%–87.6%,0.1%–78.8%,38.8%–69.9%,26.6%–65.2%,and 4.2%–39.7%,respectively,and the tomotherapy treatment plan had ranges of 13.6%–100%,3.5%–100%,0.4%–94.9%,0.2%– 82.2%,0.1%–78.5%,and 0.3%–46.3%,*** the NIV for each organ,it is possible to obtain similar values except for the irradiation area of the brain *** percentages of NIV10%,NIV20%,and NIV30%for the brain stem in each patient were 15%–99.8%,33.4%–100%,and 39.8%–100%,respectively,in the fractionated stereotactic treatment plan and 44.2%–96.5%,77.7%–99.8%,and 87.8%–100%,respectively,in the tomotherapy treatment *** order to achieve higher-quality treatment of intra-cranial tumors,treatment plans should be tailored according to the isodose target volume,inhomogeneous index,conformity index,position of the tumor upon fractionated stereotactic radiosurgery,and radiation dosage for radiation-sensitive tissues.

关键词： fractionated stereotactic radiotherapy tomotherapy treatment plan virtual organ delineation

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Material properties of friction stir spot welded joints of dissimilar aluminum alloys

引用

中国有色金属学会会刊：英文版 2012年第S3期22卷 605-613页

作者： Chi-Sung JEON Sung-Tae HONG yong-Jai KWON Hoon-Hwe cho Heung Nam HAN Technical Research Center Hyundai Steel Company School of Mechanical Engineering University of Ulsan Department of Materials Science and Engineering University of Ulsan Department of Materials Science and Engineering Seoul National University

Mechanical properties and material mixing patterns of friction stir spot welded (FSSW) joints of dissimilar aluminum alloys were *** aluminum alloys typically used in automotive applications,5052-H32 and 6061-T6,were *** the experiment,the process parameters including the z-axis force and torque histories were measured as a function of the tool *** mechanical properties were investigated by microhardness measurements of the joint,and the material mixing in the stir zone was investigated by *** experimental results illustrate different process parameter histories,material mixing in the stir zone and material properties including microhardness distributions for FSSW joints of dissimilar aluminum alloys,likely due to different mechanical behaviors of the selected aluminum alloys in the FSSW process temperature range.

关键词： friction stir spot welding dissimilar aluminum alloys force histories torque histories microhardness

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Surgical perspectives of symptomatic omphalomesenteric duct remnants: Differences between infancy and beyond

引用

World Journal of Clinical Cases 2021年第36期9卷 11228-11236页

作者： Ayoung Kang Soo-Hong Kim yong-Hoon cho Hae-Young Kim Department of Surgery Pusan National University Yangsan HospitalYangsan 50612South Korea Department of Surgery Pusan National University School of MedicineYangsan 50612South Korea Research Institute for Convergence of Biomedical Science and Technology Pusan National University Yangsan HospitalYangsan 50612South Korea

BACKGROUND The clinical manifestations of omphalomesenteric duct remnant(OMDR)can vary with the age at diagnosis,from asymptomatic incidental findings to symptoms related to gastrointestinal *** lifelong complication rates are reported as 4%-34%,and complications are more common in patients younger than 2 years of *** authors attempted to identify different clinical features and management for the various pediatric age *** To find surgical perspectives for the pediatric age-related variants of OMDR and make recommendations for optimal *** The medical records of pediatric patients diagnosed with OMDR were reviewed *** patients diagnosed based on incidental findings during other surgeries were *** patients were divided into two groups based on age:12 mo(beyond infancy).We analyzed the demographic characteristics,clinical manifestations,diagnostic tools,surgical procedures,and clinical outcomes of the patients and compared them for the age ***-squared and Fisher's exact tests were used for nominal scales and a Mann-Whitney test was used for ratio *** A total of 35 patients(7 infants,28 children beyond infancy)were finally *** both groups,Meckel's diverticulum(MD)was the most common type of OMDR,while umbilical lesions were more common in the infant group(P=0.006).Hematochezia and abdominal pain were common in the beyond infancy group,while umbilical lesions were the most frequent symptoms in the infant *** diagnostic tools were used,but Meckel's scan was most useful in diagnosing OMDR in patients with painless rectal *** invasive surgery was more commonly performed for children than for infants(P=0.016).Single-incision laparoscopic surgery(SILS)was performed for fifteen patients who underwent laparoscopic *** were only three cases of postoperative complications,and all patients survived in good *** The cli

关键词： Omphalomesenteric duct remnant Age Surgical Meckel's diverticulum Single-incision laparoscopic surgery Children

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Detection of EGFR-SEPT14 fusion in cell-free DNA of a patient with advanced gastric cancer: A case report

引用

World Journal of Clinical Cases 2021年第12期9卷 2884-2889页

作者： Boyeon Kim Yoonjung Kim Inho Park Jae yong cho Kyung-A Lee Department of Laboratory Medicine Yonsei University College of MedicineSeoul 03722South Korea Department of Laboratory Medicine Gangnam Severance HospitalYonsei University College of MedicineSeoul 06273South Korea Center for Precision Medicine Gangnam Severance HospitalYonsei University College of MedicineSeoul 06273South Korea Division of Medical Oncology Department of Internal MedicineGangnam Severance HospitalYonsei University College of MedicineSeoul 06273South Korea

BACKGROUND Gastric cancer is the fifth most diagnosed cancer worldwide and the third most common cause of cancer-related *** recent decades,increasing application of next-generation sequencing has enabled detection of molecular aberrations,including *** cases where tissue is difficult to obtain,cell-free DNA(cfDNA)is used for detecting mutations to identify the molecular profile of ***,we report a rare case of EGFR-SEPT14 fusion detected from cfDNA analysis in a patient with gastric *** SUMMARY A 49-year-old female diagnosed with advanced gastric cancer in July 2019 received capecitabine and then combination chemotherapy of ramucirumab and paclitaxel,but ascites was *** therapy was switched to nivolumab,but disease progression was observed on a positron emission tomography/computed tomography scan in May *** was discontinued,and cfDNA nextgeneration sequencing was immediately *** genomic variants,including fusions,were analyzed from *** following somatic alterations were detected from the patient’s cfDNA:an APC frameshift mutation(NM_000038.5:c.6579del,p.V2194fs)with variant allele frequency of 0.5%,an EGFR amplification with a copy number of 17.3,and an EGFR-SEPT14 fusion with variant allele frequency of 45.3%.The site of the fusion was exon 24 of EGFR fused to exon 10 of *** fusion was in-frame and considered to be protooncogenic. Although the patient refused to continue therapy, we suggest thatEGFR-targeted therapies be tried in such future *** expanded applications of the cfDNA assay may open a new horizon intreatment of patients with advanced gastric cancer.

关键词： Gene fusion Cell-free DNA Liquid biopsy Gastric cancer EGFR tyrosine kinase inhibitor Case report

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Field Trial of 40 Gbit/s ETDM Prototype System over 219 km of Installed Single Mode Fiber

引用

光学学报 2003年第S1期23卷 659-660页

作者： sang Soo Lee Hyun Woo cho sang Kyu Lim Ki Ho Han Jin Soo Han Moo Jung Chu Je Soo Ko Kyeong-Mo Yoon yong-Gi Lee Optical Communication Department Electronics and Telecommunications Research Institute Deajeon KoreaOptical Communication Department Electronics and Telecommunications Research Institute Deajeon KoreaOptical Communication Department Electronics and Telecommunications Research Institute Deajeon KoreaOptical Communication Department Electronics and Telecommunications Research Institute Deajeon KoreaOptical Communication Department Electronics and Telecommunications Research Institute Deajeon KoreaOptical Communication Department Electronics and Telecommunications Research Institute Deajeon KoreaOptical Communication Department Electronics and Telecommunications Research Institute Deajeon KoreaOptical Transmission Research Team Technical Laboratory KT Deajeon KoreaOptical Transmission Research Team Technical Laboratory KT Deajeon Korea

Transmission of 40Gbit/s NRZ signal was successfully demonstrated over 219km of installed SMF in KT's Daejeon area network. After transmission, the measured power penalty was 0.5dB for all the tributary channels.

关键词： of ET be over Field Trial of 40 Gbit/s ETDM Prototype System over 219 km of Installed Single Mode Fiber

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：