Comparison of linac-based fractionated stereotactic radiotherapy and tomotherapy treatment plans for intra-cranial tumors

作     者：Jang Bo Shim Suk Lee Sam Ju Cho Sang Hoon Lee Juree Kim Kwang Hwan Cho Chul Kee Min Hyun Do Huh Rena Lee Dae Sik Yang Young Je Park Won Seob Yoon Chul Yong Kim Soo Il Kwon 

作者机构：Department of Radiation OncologyCollege of MedicineKorea University Department of Medical PhysicsKyonggi University Department of Radiation OncologyCollege of MedicineEulji University Department of Radiation OncologyCheil General Hospital & Women's Healthcare CenterKwandong University College of Medicine Department of Radiation OncologySoonchunhyang University Boocheon Hospital Department of Radiation OncologyKonyang University Hospital Department of Radiation OncologyInha University Hospital Department of Radiation OncologySchool of MedicineEwha Womans University 

出 版 物：《Chinese Physics C》 (中国物理C（英文版）)

年 卷 期：2010年第34卷第11期

页      面：1768-1774页

核心收录：

学科分类：0709[理学-地质学] 08[工学] 0708[理学-地球物理学] 0804[工学-仪器科学与技术] 0827[工学-核科学与技术] 082701[工学-核能科学与工程] 0703[理学-化学] 0704[理学-天文学] 0702[理学-物理学] 

基　　金：Supported by Nuclear R&D Programs from Ministry of Education Science and Technology in Republic of Korea 

主　　题：fractionated stereotactic radiotherapy tomotherapy treatment plan virtual organ delineation 

摘      要：This study compares and analyzes stereotactic radiotherapy using tomotherapy and linac-based fractionated stereotactic radiotherapy in the treatment of intra-cranial tumors,according to some cases.In this study,linac-based fractionated stereotactic radiotherapy and tomotherapy treatment were administered to five patients diagnosed with intra-cranial cancer in which the dose of 18–20 Gy was applied on 3–5 separate occasions.The tumor dosing was decided by evaluating the inhomogeneous index （II） and conformity index （CI）.Also,the radiation-sensitive tissue was evaluated using low dose factors V1,V2,V3,V4,V5,and V10,as well as the non-irradiation ratio volume （NIV）.The values of the II for each prescription dose in the linacbased non-coplanar radiotherapy plan and tomotherapy treatment plan were （0.125±0.113） and （0.090±0.180）,respectively,and the values of the CI were （0.899±0.149） and （0.917±0.114）,respectively.The low dose areas,V1,V2,V3,V4,V5,and V10,in radiation-sensitive tissues in the linac-based non-coplanar radiotherapy plan fell into the ranges 0.3%–95.6%,0.1%–87.6%,0.1%–78.8%,38.8%–69.9%,26.6%–65.2%,and 4.2%–39.7%,respectively,and the tomotherapy treatment plan had ranges of 13.6%–100%,3.5%–100%,0.4%–94.9%,0.2%– 82.2%,0.1%–78.5%,and 0.3%–46.3%,respectively.Regarding the NIV for each organ,it is possible to obtain similar values except for the irradiation area of the brain stem.The percentages of NIV10%,NIV20%,and NIV30%for the brain stem in each patient were 15%–99.8%,33.4%–100%,and 39.8%–100%,respectively,in the fractionated stereotactic treatment plan and 44.2%–96.5%,77.7%–99.8%,and 87.8%–100%,respectively,in the tomotherapy treatment plan.In order to achieve higher-quality treatment of intra-cranial tumors,treatment plans should be tailored according to the isodose target volume,inhomogeneous index,conformity index,position of the tumor upon fractionated stereotactic radiosurgery,and radiation dosage for radiation-sensitive tissues.