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Tc17 cells inautoimmune diseases

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Chinese Medical Journal 2022年第18期135卷 2167-2177页

作者： Yong Peng Xiang Deng Qiuming Zeng Yandan Tang Department of Neurology Affliated First Hospital of Hunan Traditional Chinese Medical CllegeZhuzhouHunan 412000China Department of Neurology Xiangya HospitalCentral South UniversityChangshaHunan 410008China

Multiple sclerosis(MS)and experimental autoimmune encephalomyelitis(EAE),a pathologically similar disease used to model MS in rodents,are typical CD4^(^(+))T cell-dominated autoimmune diseases.CD4^(+)interleukin(IL)17^(+)T cells(Th17 cells)have been well studied and have shown that they play a critical role in the pathogenesis of MS/EAE.However,studies have suggested that CD8^(+)IL17^(+)T cells(Tc17 cells)have a similar phenotype and cytokine and transcription factor profiles to those of Th17 cells and have been found to be crucial in the pathogenesis of autoimmune diseases,including MS/EAE,psoriasis,type I diabetes,rheumatoid arthritis,and systemic lupus erythematosus.However,the evidence for this is indirect and insufficient.Therefore,we searched for related publications and attempted to summarize the current knowledge on the role of Tc17 cells in the pathogenesis of MS/EAE,as well as in the pathogenesis of other autoimmune diseases,and to find out whether Tc17 cells or Th17 cells play a more critical role in autoimmune disease,especially in MS and EAE pathogenesis,or whether the interaction between these two cell types plays a critical role in the development of the disease.

关键词： Tc17 Autoimmune diseases Multiple sclerosis Experimental autoimmune encephalomyelitis Retinoic acid receptorrelated orphan receptor gamma Th17

Structural optimization design of a bolster based on a simulation-driven design

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Transportation Safety and Environment 2023年第4期5卷 91-99页

作者： Xinkang Li Fei peng Zeyun Yang Yong Peng Jiahao Zhou Technical Research Department CRRC Industrial Research Institute(Qingdao)Co.Ltd.Qingdao 266109ShandongChina Key Laboratory of Traffic Safety on Track of Ministry of Education School of Traffic and Transportation EngineeringCentral South UniversityChangsha 410075HunanChina

A simulation-driven design method which uses multiple optimization methods can effectively promote innovative structural design tion analysis can enormously improve the efficiency of modelling and solving.This study establishes a general workflow of structural and reduce the product development cycle.Meanwhile,the sub-model technology which has more detailed simulation and optimizaoptimization for a stainless-steel metro bolster by combining the simulation-driven design method and sub-model technology.In the sub-model definition phase,the end underframe sub-model which contains the bolster is obtained based on the whole car body finite element(FE)model,and the effectiveness of the end underframe sub-model is also proved.In the conceptual design phase,the is determined according to manufacturing processes and design experiences.In the detailed design phase,the thickness of each topology path inside the bolster is obtained by the topology method and the optimized structure of the inner ribs inside the bolster part of the bolster is determined by size optimization.The simulation analyses indicate that the requirements of static strength and can be decreased by 17.79% compared with the original bolster structure,which means that not only the lightweight design goal fatigue strength are fulfilled by the optimized bolster structure.Besides,the weight can be reduced by 11.18% and the weld length is achicved.but also the welding auantity and manufacturing difficulty are geatly reduced.The results show the effectiveness of the simulation-driven design method based on the sub-model technology in the structural optimization for key parts of rail transit vehicles.

关键词： simulation driven design sub-model topology optimization size optimization stainless-steel metro bolster

Multi-Objective Optimization of Aluminum Alloy Electric Bus Frame Connectors for Enhanced Durability

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Computer Modeling in Engineering & Sciences 2024年第7期140卷 735-755页

作者： Wenjun Zhou Mingzhi Yang Qian peng Yong Peng Kui Wang Qiang Xiao Key Laboratory of Traffic Safety on Track Ministry of EducationSchool of Traffic&Transportation EngineeringCentral South UniversityChangsha410018China School of Mechanical and Automotive Engineering Xiamen University of TechnologyXiamen361024China

The widespread adoption of aluminumalloy electric buses,known for their energy efficiency and eco-friendliness,faces a challenge due to the aluminum frame’s susceptibility to deformation compared to steel.This issue is further exacerbated by the stringent requirements imposed by the flammability and explosiveness of batteries,necessitating robust frame protection.Our study aims to optimize the connectors of aluminum alloy bus frames,emphasizing durability,energy efficiency,and safety.This research delves into Multi-Objective Coordinated Optimization(MCO)techniques for lightweight design in aluminum alloy bus body connectors.Our goal is to enhance lightweighting,reinforce energy absorption,and improve deformation resistance in connector components.Three typical aluminum alloy connectors were selected and a design optimization platform was built for their MCO using a variety of software and methods.Firstly,through three-point bending experiments and finite element analysis on three types of connector components,we identified optimized design parameters based on deformation patterns.Then,employing Optimal Latin hypercube design(OLHD),parametric modeling,and neural network approximation,we developed high-precision approximate models for the design parameters of each connector component,targeting energy absorption,mass,and logarithmic strain.Lastly,utilizing the Archive-based Micro Genetic Algorithm(AMGA),Multi-Objective Particle Swarm Optimization(MOPSO),and Non-dominated SortingGenetic Algorithm(NSGA2),we explored optimized design solutions for these joint components.Subsequently,we simulated joint assembly buckling during bus rollover crash scenarios to verify and analyze the optimized solutions in three-point bending simulations.Each joint component showcased a remarkable 30%–40%mass reduction while boosting energy absorption.Our design optimization method exhibits high efficiency and costeffectiveness.Leveraging contemporary automation technology,the design optimization platform developed in this study is poised

关键词： Aluminum connectors three-point bending simulation parametric design model multi-objective collaborative optimization

Research on low carbon emission optimization operation technology of natural gas pipeline under multi-energy structure

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Petroleum Science 2022年第6期19卷 3046-3058页

作者： En-Bin Liu Yong Peng Shan-Bi peng Bin Yu Qi-Kun Chen Petroleum Engineering School Southwest Petroleum UniversityChengdu610500China School of Civil Engineering and Geomatics Southwest Petroleum UniversityChengdu610500China China Petroleum Pipeline Engineering Corporation Hebei065000China School of Engineering Cardiff UniversityCardiffCF243AAUK

In order to reduce the carbon emissions of natural gas pipelines,based on the background of different energy structures,this paper proposes a general low carbon and low consumption operation model of natural gas pipelines,which is used to fine calculate the carbon emissions and energy consumption of natural gas pipeline.In this paper,an improved particle swarm optimization(NHPSO-JTVAC)algorithm is used to solve the model and the optimal scheduling scheme is given.Taking a parallel pipeline located in western China as an example,the case is analyzed.The results show that after optimization,under the existing energy types,the pipeline system can reduce 31.14%of carbon emissions,and after introducing part of new energy,the pipeline system can reduce 34.02%of carbon emissions,but the energy consumption has increased.

关键词： Natural gas Pipeline optimization NHPSO-JTVAC algorithm Carbon emission New energy

Numerical simulation of the mechanical behavior of superconducting tape in conductor on round core cable using the cohesive zone model

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Applied Mathematics and Mechanics(English Edition) 2023年第9期44卷 1511-1532页

作者： Shengyi TANG Xubin peng Huadong yong Department of Mechanics and Engineering Sciences College of Civil Engineering and MechanicsLanzhou UniversityLanzhou 730000China Key Laboratory of Mechanics on Disaster and Environment in Western China Ministry of Education of ChinaLanzhou UniversityLanzhou 730000China Faculty of Civil Engineering and Mechanics Jiangsu UniversityZhenjiang 212013Jiangsu ProvinceChina

Cables composed of rare-earth barium copper oxide(REBCO)tapes have been extensively used in various superconducting devices.In recent years,conductor on round core(CORC)cable has drawn the attention of researchers with its outstanding current-carrying capacity and mechanical properties.The REBCO tapes are wound spirally on the surface of CORC cable.Under extreme loadings,the REBCO tapes with layered composite structures are vulnerable,which can lead to degradation of critical current and even quenching of superconducting devices.In this paper,we simulate the deformation of CORC cable under external loads,and analyze the damage inside the tape with the cohesive zone model(CZM).Firstly,the fabrication and cabling of CORC are simulated,and the stresses and strains generated in the tape are extracted as the initial condition of the next step.Then,the tension and bending loads are applied to CORC cable,and the damage distribution inside the tape is presented.In addition,the effects of some parameters on the damage are discussed during the bending simulations.

关键词： high temperature superconducting(HTS)tape superconducting cable finite element simulation cohesive zone model(CZM) damage

Cysteine-113 covalency inspires the development of Pin1 inhibitor

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Signal Transduction and Targeted Therapy 2020年第1期5卷 643-645页

作者： Wenchen Pu Jiao Li Yong Peng Laboratory of Molecular Oncology Frontiers Science Center for Disease-related Molecular NetworkState Key Laboratory of Biotherapy and Cancer CenterWest China HospitalSichuan UniversityChengdu 610064China

Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1(Pin1)controls the functional switch of phosphoproteins and plays an oncogenic role in human cancer,but the discovery of effective Pin1 inhibitors remains challenging.A recent study by Pinch et al.developed a novel Pin1 inhibitor by endowing molecule with covalent reactivity toward Pin1 cysteine-113,1 providing new insights into the design of anticancer Pin1 inhibitors.

关键词： Pin1 al insight

Quantitative reorientation behaviors of macro-twin interfaces in shape-memory alloy under compression stimulus in situ TEM

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Journal of Materials Science & Technology 2022年第12期107卷 243-251页

作者： Bin Chen Chaoshuai Guan yong Li Chong Yang Junwei Zhang Gang Liu Lingwei Li Yong Peng School of Materials and Energy Electron Microscopy Centre of Lanzhou University and Key Laboratory of Magnetism and Magnetic Materials of the Ministry of EducationLanzhou UniversityLanzhou 730000China Key Laboratory of Novel Materials for Sensor of Zhejiang Province Institute of Advanced Magnetic MaterialsHangzhou Dianzi UniversityHangzhou 310012China School of Materials Science and Engineering Xi’an Jiaotong UniversityXi’an 710000China

Twinning stress is known to be a critical factor for the actuating performance of magnetic shape memory alloys because of the harmful deterioration of their magnetic field-induced strain effect.However,the intrinsic origin of the high twinning stress is still in debate.In this work,we firstly fill this gap by precisely probing the reorientation behaviors of A-C and A-B two common macro-twin interfaces under the stimulus of uniaxial compression in-situ transmission electron microscope.The grain boundary is proved to be the main reason for large twinning stress.The twinning stress of the A-C and A-B type interfaces quantitatively are~0.69 and 1.27 MPa within the plate respectively.The A-C type interface evidently has smaller twinning stress and larger deformation variable than the A-B interface.Under the action of compression,not only the orientations of the crystals have changed,but also the roles of the major and minor lamellae have changed for both interfaces due to the movements of twinning dislocations.Combining insitu and quasi in-situ electron diffraction data,the reorientation process is clearly and intuitively shown by the stereographic projection.Atomic models and the theory of dislocation motion are proposed to phenomenologically clarify the intrinsic mechanism.This work is believed to not only provide a deeper understanding of the deformation mechanism of magnetic shape memory alloys under uniaxial compression testing,but also discover that compression training is not the mechanical training way to decrease the twinning stress of non-modulated martensite in single crystal shape memory alloys.

关键词： Magnetic shape memory alloys Non-modulated martensite Reorientation behavior Twinning stress In-situ TEM

DTCC:Multi-level dilated convolution with transformer for weakly-supervised crowd counting

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Computational Visual Media 2023年第4期9卷 859-873页

作者： Zhuangzhuang Miao yong Zhang Yuan peng Haocheng peng Baocai Yin Beijing Key Laboratory of Multimedia and Intelligent Software Technology Beijing Institute of Artificial IntelligenceFaculty of Information TechnologyBeijing University of TechnologyBeijing 100124China Taiji Computer Corporation Ltd. China

Crowd counting provides an important foundation for public security and urban management.Due to the existence of small targets and large density variations in crowd images,crowd counting is a challenging task.Mainstream methods usually apply convolution neural networks(CNNs)to regress a density map,which requires annotations of individual persons and counts.Weakly-supervised methods can avoid detailed labeling and only require counts as annotations of images,but existing methods fail to achieve satisfactory performance because a global perspective field and multi-level information are usually ignored.We propose a weakly-supervised method,DTCC,which effectively combines multi-level dilated convolution and transformer methods to realize end-to-end crowd counting.Its main components include a recursive swin transformer and a multi-level dilated convolution regression head.The recursive swin transformer combines a pyramid visual transformer with a fine-tuned recursive pyramid structure to capture deep multi-level crowd features,including global features.The multi-level dilated convolution regression head includes multi-level dilated convolution and a linear regression head for the feature extraction module.This module can capture both low-and high-level features simultaneously to enhance the receptive field.In addition,two regression head fusion mechanisms realize dynamic and mean fusion counting.Experiments on four well-known benchmark crowd counting datasets(UCF_CC_50,ShanghaiTech,UCF_QNRF,and JHU-Crowd++)show that DTCC achieves results superior to other weakly-supervised methods and comparable to fully-supervised methods.

关键词： crowd counting transformer dilated convolution global perspective field pyramid

Research on the comfort degradation mechanism of high-speed railway passengers:a field study using dynamic interface pressure

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Transportation Safety and Environment 2022年第4期4卷 51-63页

作者： Yong Peng Dayan Sun Chaojie Fan Zhifa Wu Shengen Yi Yuexiang peng Yingjun Liu Key Laboratory of Traffic Safety on Track of Ministry of Education School of Traffic&Transportation EngineeringCentral South UniversityChangsha 410075HunanChina Joint International Research Laboratory of Key Technology for Rail Traffic Safety Central South UniversityChangsha 410075HunanChina Research Laboratory of Hepatobiliary Diseases General Surgical Department The Second Xiangya HospitalCentral South UniversityChangsha 410011HunanChina Hunan Industry Polytechnic Changsha 410208HunanChina Locomotive Department China Railway Guangzhou Group Co.Ltd.Guangzhou 510088GuangdongChina.

Discomfort caused by long-term sitting decreases the passenger experience and may lead to musculoskeletal diseases, and this hasbecome one of the main problems for passengers of high-speed railways. However, the comfort degradation mechanism during longtermsitting in high-speed railways is still unknown. This study aimed to reveal passengers’ sitting comfort degradation mechanismin high-speed railways. By carrying out long-term sitting tests on high-speed trains running on the Shanghai-Kunming line, the dynamicinterface pressure and subjective comfort including overall and regional comfort of seven participants were obtained.Machinelearning models and statistical analysis methods were combined for data analysis to reveal the effect of regional comfort and thecontribution of sitting duration during the process of sitting comfort degradation. The results show that overall comfort is most significantlyinfluenced by the comfort of the shoulders, waist and buttocks. The seats play different roles before and after 20 minutesduring long-term sitting and there is a lag between the fatigue occurring and being offset. Therefore, the structure of seats affectsoverall comfort by affecting important regional comfort, and a long-term sitting test is necessary for accurate seat assessment. Thecomfort degradation mechanism can be used to define standards for long-term sitting comfort or provide guidance for seat evaluation,and the design and evaluation plan mentioned in this article for second-class seats can be applied to other cases with limitedaccommodating space.

关键词： High-speed railways pressure distribution seat comfort machine learning sitting fatigue