Tc17 cells inautoimmune diseases

作     者：Yong Peng Xiang Deng Qiuming Zeng Yandan Tang Yong Peng;Xiang Deng;Qiuming Zeng;Yandan Tang

作者机构：Department of NeurologyAffliated First Hospital of Hunan Traditional Chinese Medical CllegeZhuzhouHunan 412000China Department of NeurologyXiangya HospitalCentral South UniversityChangshaHunan 410008China 

出 版 物：《Chinese Medical Journal》 (中华医学杂志（英文版）)

年 卷 期：2022年第135卷第18期

页      面：2167-2177页

核心收录：

学科分类：1002[医学-临床医学] 10[医学] 

基　　金：Fund for Creative Research Group of Affiliated First Hospital of Hunan Traditional Chinese Medical College, China(No. 2021B-003) Key Plans of Hunan Administration Traditional Chinese Medicine, China(No. 201915) Natural Science Foundation of Hunan Province, China(No. 2018JJ6043) Health and Family Planning Commission of Hunan Province, China(No. B20180815) Technology Plan Project of Zhuzhou City, Hunan Province, China(No. 2021-003) 

主　　题：Tc17 Autoimmune diseases Multiple sclerosis Experimental autoimmune encephalomyelitis Retinoic acid receptorrelated orphan receptor gamma Th17 

摘      要：Multiple sclerosis(MS)and experimental autoimmune encephalomyelitis(EAE),a pathologically similar disease used to model MS in rodents,are typical CD4^(^(+))T cell-dominated autoimmune diseases.CD4^(+)interleukin(IL)17^(+)T cells(Th17 cells)have been well studied and have shown that they play a critical role in the pathogenesis of MS/EAE.However,studies have suggested that CD8^(+)IL17^(+)T cells(Tc17 cells)have a similar phenotype and cytokine and transcription factor profiles to those of Th17 cells and have been found to be crucial in the pathogenesis of autoimmune diseases,including MS/EAE,psoriasis,type I diabetes,rheumatoid arthritis,and systemic lupus erythematosus.However,the evidence for this is indirect and insufficient.Therefore,we searched for related publications and attempted to summarize the current knowledge on the role of Tc17 cells in the pathogenesis of MS/EAE,as well as in the pathogenesis of other autoimmune diseases,and to find out whether Tc17 cells or Th17 cells play a more critical role in autoimmune disease,especially in MS and EAE pathogenesis,or whether the interaction between these two cell types plays a critical role in the development of the disease.