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Development of 3D bioprinting:From printing methods to biomedical applications

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Asian Journal of Pharmaceutical Sciences 2020年第5期15卷 529-557页

作者： Zeming Gu Jianzhong Fu Hui Lin yong he State Key Laboratory of Fluid Power and Mechatronic Systems School of Mechanical EngineeringZhejiang UniversityHangzhou 310027China Key Laboratory of 3D Printing Process and Equipment of Zhejiang Province School of Mechanical EngineeringZhejiang UniversityHangzhou 310027China Department of General Surgery Sir Run Run Shaw HospitalSchool of MedicineZhejiang UniversityHangzhou 310058China

Biomanufacturing of tissues/organs in vitro is our big dream,driven by two needs:organ transplantation and accurate tissue models.Over the last decades,3D bioprinting has been widely applied in the construction of many tissues/organs such as skins,vessels,hearts,etc.,which can not only lay a foundation for the grand goal of organ replacement,but also be served as in vitro models committed to pharmacokinetics,drug screening and so on.As organs are so complicated,many bioprinting methods are exploited to figure out the challenges of different applications.So the question is how to choose the suitable bioprinting method?herein,we systematically review the evolution,process and classification of 3D bioprinting with an emphasis on the fundamental printing principles and commercialized bioprinters.We summarize and classify extrusion-based,dropletbased,and photocuring-based bioprinting methods and give some advices for applications.Among them,coaxial and multi-material bioprinting are highlighted and basic principles of designing bioinks are also discussed.

关键词： 3D bioprinting Extrusion-based bioprinting Droplet-based bioprinting Photocuring-based bioprinting Bioink

Facile 3D cell culture protocol based on photocurable hydrogels

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Bio-Design and Manufacturing 2021年第1期4卷 149-153页

作者： Mingjun Xie Yating Zheng Qing Gao yong he State Key Laboratory of Fluid Power and Mechatronic Systems School of Mechanical EngineeringZhejiang UniversityHangzhou 310027China Key Laboratory of 3D Printing Process and Equipment of Zhejiang Province School of Mechanical EngineeringZhejiang UniversityHangzhou 310027China Engineering for Life Group(EFL) Suzhou 215101China

Introduction Why 3D cell culture urgently needed?Tissue engineering has extremely influenced the development process of basic biological studies and biomedical technology.For quite a long time,the vast majority of these researches have been relying on the experimental results of conventional two-dimensional(2D)cell culture in flask,petri dish or well plate.However,these 2D culture results could be very different with or even totally opposite to the actual situations in vivo where cells grow inside a 3D extracellular matrix(ECM).Therefore,3D cell culture has been playing a more and more significant role because of its higher accuracy and authenticity[1–4].

关键词： has culture quite

Modeling for mung bean variety classification using visible and near-infrared hyperspectral imaging

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International Journal of Agricultural and Biological Engineering 2018年第1期11卷 187-191页

作者： Chuanqi Xie yong he College of Biosystems Engineering and Food Science Zhejiang UniversityHangzhou 310058China

This study was carried out to investigate the feasibility of using visible and near infrared hyperspectral imaging for the variety classification of mung beans.Raw hyperspectral images of mung beans were acquired in the wavelengths of 380-1023 nm,and all images were calibrated by the white and dark reference images.The spectral reflectance values were extracted from the region of interest(ROI)of each calibrated hyperspectral image,and then they were treated as the independent variables.The dependent variables of four varieties of mung beans were set as 1,2,3 and 4,respectively.The extreme learning machine(ELM)model was established using full spectral wavelengths for classification.Modified gram-schmidt(MGS)method was used to identify effective wavelengths.Based on the selected wavelengths,the ELM and linear discriminant analysis(LDA)models were built.All models performed excellently with the correct classification rates(CCRs)covering 99.17%-99.58% in the training sets and 99.17%-100%in the testing sets.Fifteen wavelengths(432 nm,455 nm,468 nm,560 nm,705 nm,736 nm,760 nm,841 nm,861 nm,921 nm,930 nm,937 nm,938 nm,959 nm and 965 nm)were recommended by MGS.The results demonstrated that hyperspectral imaging could be used as a non-destructive method to classify mung bean varieties,and MGS was an effective wavelength selection method.

关键词： visible and near-infrared hyperspectral imaging mung bean classification modeling wavelength selection

水泥基复合材料固化铬污染盾构渣土性能及其机理研究

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中南大学学报（自然科学版） 2024年第2期55卷 513-524页

作者：魏贺贺勇阳栋张可能娄伟史继彪冯德山中南大学有色金属成矿预测与地质环境监测教育部重点实验室湖南长沙410083 中南大学地球科学与信息物理学院湖南长沙410083 中国建筑第五工程局有限公司湖南长沙410004 湖南省和清环境科技有限公司湖南长沙410221 徐州中矿岩土技术股份有限公司江苏徐州221116

为了实现铬污染盾构渣土的资源化利用,解决单一水泥固化材料用量大、排放量高以及固化效果不理想等问题,研制水泥基有机-无机复合固化剂固化铬污染盾构渣土。以14 d养护龄期固化土无侧限抗压强度和浸出毒性为评判指标,通过设计“五因素... 详细信息

为了实现铬污染盾构渣土的资源化利用,解决单一水泥固化材料用量大、排放量高以及固化效果不理想等问题,研制水泥基有机-无机复合固化剂固化铬污染盾构渣土。以14 d养护龄期固化土无侧限抗压强度和浸出毒性为评判指标,通过设计“五因素四水平”正交试验确定复合固化剂最佳配比;采用极差分析法对各影响因素进行主效应分析,并结合XRD和SEM试验探究复合有机-无机固化剂的作用机理。研究结果表明:无侧限抗压强度和浸出毒性评判指标的最优解均为11%(质量分数,下同)水泥、5.50%生石灰、0.25%聚丙烯酰胺、1.10%硅酸钠和0.05%海藻酸钠;14 d养护龄期的试验13(A4B1C4D4E1)固化土无侧限抗压强度达1217.58 kPa,重金属铬浸出质量浓度为2.4 mg/L,满足相关规范要求;水泥、海藻酸钠和硅酸钠为固化土无侧限抗压强度评判指标的主要影响因素,水泥、海藻酸钠和生石灰为浸出毒性评判指标的主要影响因素;固化土无侧限抗压强度与重金属铬浸出质量浓度密切相关,具体表现为固化土无侧限抗压强度越大,重金属铬的稳定化效果越明显;大量的自由水被消耗、pH升高、新矿物的生成、土体微观结构改变及土颗粒间胶结作用增强是盾构渣土性能提高的主要原因;当固化土强度增大时,重金属铬的物理封闭作用增强;此外,发生水化反应形成的较高pH也促进三价铬生成难溶于水的氢氧化物沉淀,从而降低固化土重金属铬浸出毒性。

关键词：铬污染盾构渣土复合固化材料正交试验无侧限抗压强度浸出毒性微观机制

Advances in 3D printing scaffolds for peripheral nerve and spinal cord injury repair

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International Journal of Extreme Manufacturing 2023年第3期5卷 264-300页

作者： Juqing Song Baiheng Lv Wencong Chen Peng Ding yong he School of Mechanical Engineering Dongguan University of TechnologyDongguan 523808People’s Republic of China China Nuclear Power Technology Research Institute Co. LtdShenzhen 518000People’sRepublicof China School of Mechanical Engineering Zhejiang UniversityHangzhou310058People’s Republic of China

Because of the complex nerve anatomy and limited regeneration ability of natural tissue,the current treatment effect for long-distance peripheral nerve regeneration and spinal cord injury(SCI)repair is not satisfactory.As an alternative method,tissue engineering is a promising method to regenerate peripheral nerve and spinal cord,and can provide structures and functions similar to natural tissues through scaffold materials and seed cells.Recently,the rapid development of 3D printing technology enables researchers to create novel 3D constructs with sophisticated structures and diverse functions to achieve high bionics of structures and functions.In this review,we first outlined the anatomy of peripheral nerve and spinal cord,as well as the current treatment strategies for the peripheral nerve injury and SCI in clinical.After that,the design considerations of peripheral nerve and spinal cord tissue engineering were discussed,and various 3D printing technologies applicable to neural tissue engineering were elaborated,including inkjet,extrusion-based,stereolithography,projection-based,and emerging printing technologies.Finally,we focused on the application of 3D printing technology in peripheral nerve regeneration and spinal cord repair,as well as the challenges and prospects in this research field.

关键词： peripheral nerve regeneration spinal cord repair 3D printing construct bionic structure bionic function

Solution-processed wafer-scale nanoassembly of conducting polymers enables selective ultratrace nerve agent detection at low power

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Nano Research 2023年第4期16卷 5653-5664页

作者： Bin Luo Jianan Weng Zhi Geng Qichao Pan Xilin Pei yong he Chuanzhi Chen Hongxing Zhang Renbo Wei Yupeng Yuan Jin Yang Jinyi Ma Zhengwei You Bo Zhu School of Materials Science and Engineering&Shanghai Engineering Research Center of Organ Repair Shanghai UniversityShanghai 200444China Innovation Center for Textile Science and Technology Donghua UniversityShanghai 201620China Institute of NBC Defense P.O.Box 1048Beijing 102205China School of Chemical Engineering Northwest UniversityXi’an 710069China th Institute of China Electronics Technology Group Chongqing 400060China State Key Laboratory for Modification of Chemical Fibers and Polymer Materials College of Material Science and EngineeringDonghua UniversityShanghai 201620China

There is a great interest in developing microelectronic devices based on nanostructured conducting polymers that can selectively electro-couple analytes at high sensitivity and low power.Nanostructured conducting polymers have emerged as promising candidates for this technology due to their excellent stability with low redox potential,high conductivity,and selectivity endowed by chemical functionalization.However,it remains challenging to develop cost-effective and large-scale assembly approaches for functionalized conducting polymers in the practical fabrication of electronic devices.here,we reported a straightforward waferscale assembly of nanostructured hexafluoroisopropanol functionalized poly(3,4-ethylenedioxythiophene)(PEDOT-HFIP)on smooth substrates.This approach is template-free,solution-processed,and adaptable to conductive and nonconductive substrates.By this approach,the nanostructured PEDOT-HFIPs could be easily integrated onto interdigitated electrodes with intimate ohmic contact.At the optimized space-to-volume ratio,we demonstrated a low-power,sensitive,and selective nerve agent sensing technology using this platform by detecting sarin vapor with a limit of detection(LOD)of 10 ppb and signal strength of 400 times the water interference at the same concentration,offering significant advantages over existing similar technologies.We envision that its easy scale-up,micro size,small power consumption,and combination of high sensitivity and selectivity make it attractive for various wearable platforms.

关键词： conducting polymer PEDOT sensor nano nerve agent

Preemptive Semi-online Algorithms for Parallel Machine Scheduling with Known Total Size

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Acta Mathematica Sinica,English Series 2006年第2期22卷 587-594页

作者： yong he Hao ZHOU Yi Wei JIANG State Key Lab of CAD & CG Zhejiang University Department of Mathematics Zhejiang University

This paper investigates preemptive semi-online scheduling problems on m identical parallel machines, where the total size of all jobs is known in advance. The goal is to minimize the maximum machine completion time or maximize the minimum machine completion time. For the first objective, we present an optimal semi-online algorithm with competitive ratio 1. For the second objective, we show that the competitive ratio of any semi-online algorithm is at least （2m-3）/（m-1） for any m〉2 and present optimal semi-online algorithms for m = 2, 3.

关键词： Semi-online Preemptive scheduling Competitive analysis

Optimal Preemptive Online Algorithms for Scheduling with Known Largest Size on Two Uniform Machines

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Acta Mathematica Sinica,English Series 2007年第1期23卷 165-174页

作者： yong he Yi Wei JIANG Hao ZHOU Department of Mathematics Zhejiang University. Hangzhou 310027. P. R. China Faculty of Science Zhejiang Sci- Tech University Hangzhou 310018 P. R. China. Department of Mathematics Zhejiang University Hangzhou 310027. P. R. China Basic Course Department Zhejiang Shorten University Hangzhou 310015. P. R. China

In this paper, we consider the seml-online preemptive scheduling problem with known largest job sizes on two uniform machines. Our goal is to maximize the continuous period of time （starting from time zero） when both machines are busy, which is equivalent to maximizing the minimum machine completion time if idle time is not introduced. We design optimal deterministic semi-online algorithms for every machine speed ratio s ∈ [1, ∞）, and show that idle time is required to achieve the optimality during the assignment procedure of the algorithm for any s 〉（s^2 ＋ 3s ＋ 1）/（s^2 ＋ 2s ＋ 1）. The competitive ratio of the algorithms is （s^2 ＋ 3s ＋ 1）/（s^2 ＋ 2s ＋ 1）, which matches the randomized lower bound for every s ≥ 1. hence randomization does not help for the discussed preemptive scheduling problem.

关键词： semi-online preemptive scheduling uniform machines competitive ratio

Robust Fuzzy Tracking Control for Nonlinear Networked Control Systems with Integral Quadratic Constraints

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International Journal of Automation and computing 2010年第4期7卷 492-499页

作者： Zhi-Sheng Chen yong he Min Wu School of Information Science and Engineering Central South University Changsha 410083 PRC School of Energy and Powcr Engineering Changsha University of Science and Technology Changsha 410114 PRC

This paper investigates the robust tracking control problcm for a class of nonlinear networked control systems （NCSs） using the Takagi-Sugeno （T-S） fuzzy model approach. Based on a time-varying delay system transformed from the NCSs, an augmented Lyapunov function containing more useful information is constructed. A less conservative sufficient condition is established such that the closed-loop systems stability and time-domain integral quadratic constraints （IQCs） are satisfied while both time-varying network- induced delays and packet losses are taken into account. The fuzzy tracking controllers design scheme is derived in terms of linear matrix inequalities （LMIs） and parallel distributed compensation （PDC）. Furthermore, robust stabilization criterion for nonlinear NCSs is given as an extension of the tracking control result. Finally, numerical simulations are provided to illustrate the effectiveness and merits of the proposed method.

关键词： Nonlinear networked control system fuzzy model robust tracking integral quadratic constraint linear matrix inequality.